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Pulmonary Arterial Hypertension in Connective Tissue Disorders: The emerging role of screening and early diagnosis. A position paper for Greek Rheumatologists.

Mediterranean journal of rheumatology

Demerouti E, Tsangaris I, Dimitroulas T, Giannakoulas G, Katsimpri P, Mitrouska I, Orfanos S, Skoularigkis I, Voulgari P, Sfikakis P.
PMID: 32185347
Mediterr J Rheumatol. 2019 Jun 29;30(2):90-93. doi: 10.31138/mjr.30.2.90. eCollection 2019 Jun.

Pulmonary Arterial Hypertension is regarded as a devastating disease, complicating Connective Tissue Diseases. Although much progress has been achieved in the last 20 years, several unfulfilled needs in diagnosis and management of PAH in these patients may still be...

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Demerouti E, Tsangaris I, Dimitroulas T, et al. Pulmonary Arterial Hypertension in Connective Tissue Disorders: The emerging role of screening and early diagnosis. A position paper for Greek Rheumatologists. Mediterr J Rheumatol. 2019;30(2):90-93doi: 10.31138/mjr.30.2.90.
Demerouti, E., Tsangaris, I., Dimitroulas, T., Giannakoulas, G., Katsimpri, P., Mitrouska, I., Orfanos, S., Skoularigkis, I., Voulgari, P., & Sfikakis, P. (2019). Pulmonary Arterial Hypertension in Connective Tissue Disorders: The emerging role of screening and early diagnosis. A position paper for Greek Rheumatologists. Mediterranean journal of rheumatology, 30(2), 90-93. https://doi.org/10.31138/mjr.30.2.90
Demerouti, Eftychia, et al. "Pulmonary Arterial Hypertension in Connective Tissue Disorders: The emerging role of screening and early diagnosis. A position paper for Greek Rheumatologists." Mediterranean journal of rheumatology vol. 30,2 (2019): 90-93. doi: https://doi.org/10.31138/mjr.30.2.90
Demerouti E, Tsangaris I, Dimitroulas T, Giannakoulas G, Katsimpri P, Mitrouska I, Orfanos S, Skoularigkis I, Voulgari P, Sfikakis P. Pulmonary Arterial Hypertension in Connective Tissue Disorders: The emerging role of screening and early diagnosis. A position paper for Greek Rheumatologists. Mediterr J Rheumatol. 2019 Jun 29;30(2):90-93. doi: 10.31138/mjr.30.2.90. eCollection 2019 Jun. PMID: 32185347; PMCID: PMC7045968.
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A series of five population-specific Indian brain templates and atlases spanning ages 6-60 years.

Human brain mapping

Holla B, Taylor PA, Glen DR, Lee JA, Vaidya N, Mehta UM, Venkatasubramanian G, Pal PK, Saini J, Rao NP, Ahuja CK, Kuriyan R, Krishna M, Basu D, Kalyanram K, Chakrabarti A, Orfanos DP, Barker GJ, Cox RW, Schumann G, Bharath RD, Benegal V.
PMID: 32845057
Hum Brain Mapp. 2020 Dec 15;41(18):5164-5175. doi: 10.1002/hbm.25182. Epub 2020 Aug 26.

Anatomical brain templates are commonly used as references in neurological MRI studies, for bringing data into a common space for group-level statistics and coordinate reporting. Given the inherent variability in brain morphology across age and geography, it is important...

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Holla B, Taylor PA, Glen DR, et al. A series of five population-specific Indian brain templates and atlases spanning ages 6-60 years. Hum Brain Mapp. 2020;41(18):5164-5175doi: 10.1002/hbm.25182.
Holla, B., Taylor, P. A., Glen, D. R., Lee, J. A., Vaidya, N., Mehta, U. M., Venkatasubramanian, G., Pal, P. K., Saini, J., Rao, N. P., Ahuja, C. K., Kuriyan, R., Krishna, M., Basu, D., Kalyanram, K., Chakrabarti, A., Orfanos, D. P., Barker, G. J., Cox, R. W., Schumann, G., Bharath, R. D., & Benegal, V. (2020). A series of five population-specific Indian brain templates and atlases spanning ages 6-60 years. Human brain mapping, 41(18), 5164-5175. https://doi.org/10.1002/hbm.25182
Holla, Bharath, et al. "A series of five population-specific Indian brain templates and atlases spanning ages 6-60 years." Human brain mapping vol. 41,18 (2020): 5164-5175. doi: https://doi.org/10.1002/hbm.25182
Holla B, Taylor PA, Glen DR, Lee JA, Vaidya N, Mehta UM, Venkatasubramanian G, Pal PK, Saini J, Rao NP, Ahuja CK, Kuriyan R, Krishna M, Basu D, Kalyanram K, Chakrabarti A, Orfanos DP, Barker GJ, Cox RW, Schumann G, Bharath RD, Benegal V. A series of five population-specific Indian brain templates and atlases spanning ages 6-60 years. Hum Brain Mapp. 2020 Dec 15;41(18):5164-5175. doi: 10.1002/hbm.25182. Epub 2020 Aug 26. PMID: 32845057; PMCID: PMC7670651.
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Observational study of the use of recombinant tissue-type plasminogen activator in COVID-19 shows a decrease in physiological dead space.

ERJ open research

Orfanos S, El Husseini I, Nahass T, Radbel J, Hussain S.
PMID: 33043052
ERJ Open Res. 2020 Oct 05;6(4). doi: 10.1183/23120541.00455-2020. eCollection 2020 Oct.

No abstract available.

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Orfanos S, El Husseini I, Nahass T, et al. Observational study of the use of recombinant tissue-type plasminogen activator in COVID-19 shows a decrease in physiological dead space. ERJ Open Res. 2020;6(4)doi: 10.1183/23120541.00455-2020.
Orfanos, S., El Husseini, I., Nahass, T., Radbel, J., & Hussain, S. (2020). Observational study of the use of recombinant tissue-type plasminogen activator in COVID-19 shows a decrease in physiological dead space. ERJ open research, 6(4), . https://doi.org/10.1183/23120541.00455-2020
Orfanos, Sarah, et al. "Observational study of the use of recombinant tissue-type plasminogen activator in COVID-19 shows a decrease in physiological dead space." ERJ open research vol. 6,4 (2020). doi: https://doi.org/10.1183/23120541.00455-2020
Orfanos S, El Husseini I, Nahass T, Radbel J, Hussain S. Observational study of the use of recombinant tissue-type plasminogen activator in COVID-19 shows a decrease in physiological dead space. ERJ Open Res. 2020 Oct 05;6(4). doi: 10.1183/23120541.00455-2020. eCollection 2020 Oct. PMID: 33043052; PMCID: PMC7533378.
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Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE).

Journal of clinical medicine

Demerouti E, Karyofyllis P, Voudris V, Boutsikou M, Anastasiadis G, Anthi A, Arvanitaki A, Athanassopoulos G, Avgeropoulou A, Brili S, Feloukidis C, Frantzeskaki F, Karatasakis G, Karvounis H, Konstantonis D, Mitrouska I, Mouratoglou S, Naka KK, Orfanos SE, Panagiotidou E, Pitsiou G, Pitsis A, Stamatopoulou V, Stanopoulos I, Thomaidis A, Tsangaris I, Tsiapras D, Giannakoulas G, Manginas A, On Behalf Of The Hellenic Society For The Study Of Pulmonary Hypertension Hssph.
PMID: 34640577
J Clin Med. 2021 Sep 30;10(19). doi: 10.3390/jcm10194547.

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a rare disease with poor prognosis if left untreated, characterized by pulmonary vascular bed obstruction due to unresolving thromboembolic material. The Hellenic pulmonary hypertension registry (HOPE) was launched in Greece in early 2015...

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Demerouti E, Karyofyllis P, Voudris V, et al. Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE). J Clin Med. 2021;10(19)doi: 10.3390/jcm10194547.
Demerouti, E., Karyofyllis, P., Voudris, V., Boutsikou, M., Anastasiadis, G., Anthi, A., Arvanitaki, A., Athanassopoulos, G., Avgeropoulou, A., Brili, S., Feloukidis, C., Frantzeskaki, F., Karatasakis, G., Karvounis, H., Konstantonis, D., Mitrouska, I., Mouratoglou, S., Naka, K. K., Orfanos, S. E., Panagiotidou, E., Pitsiou, G., Pitsis, A., Stamatopoulou, V., Stanopoulos, I., Thomaidis, A., Tsangaris, I., Tsiapras, D., Giannakoulas, G., Manginas, A., & On Behalf Of The Hellenic Society For The Study Of Pulmonary Hypertension Hssph. (2021). Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE). Journal of clinical medicine, 10(19), . https://doi.org/10.3390/jcm10194547
Demerouti, Eftychia, et al. "Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)." Journal of clinical medicine vol. 10,19 (2021). doi: https://doi.org/10.3390/jcm10194547
Demerouti E, Karyofyllis P, Voudris V, Boutsikou M, Anastasiadis G, Anthi A, Arvanitaki A, Athanassopoulos G, Avgeropoulou A, Brili S, Feloukidis C, Frantzeskaki F, Karatasakis G, Karvounis H, Konstantonis D, Mitrouska I, Mouratoglou S, Naka KK, Orfanos SE, Panagiotidou E, Pitsiou G, Pitsis A, Stamatopoulou V, Stanopoulos I, Thomaidis A, Tsangaris I, Tsiapras D, Giannakoulas G, Manginas A, On Behalf Of The Hellenic Society For The Study Of Pulmonary Hypertension Hssph. Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE). J Clin Med. 2021 Sep 30;10(19). doi: 10.3390/jcm10194547. PMID: 34640577; PMCID: PMC8509504.
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Primary retroperitoneal mucinous cystadenoma. A rare case with two cysts and review of the literature.

Hippokratia

Paraskevakou H, Orfanos S, Diamantis T, Konstantinidou A, Patsouris E.
PMID: 25694766
Hippokratia. 2014 Jul-Sep;18(3):278-81.

BACKGROUND: Primary retroperitoneal mucinous cystadenoma is a rare neoplasm, with benign biological behavior. Delay in diagnosis and treatment of this tumor may be fatal for the patient, because of complications, such as rupture, infection and malignant transformation.CASE PRESENTATION: We...

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Paraskevakou H, Orfanos S, Diamantis T, et al. Primary retroperitoneal mucinous cystadenoma. A rare case with two cysts and review of the literature. Hippokratia. 2014;18(3):278-81
Paraskevakou, H., Orfanos, S., Diamantis, T., Konstantinidou, A., & Patsouris, E. (2014). Primary retroperitoneal mucinous cystadenoma. A rare case with two cysts and review of the literature. Hippokratia, 18(3), 278-81.
Paraskevakou, H, et al. "Primary retroperitoneal mucinous cystadenoma. A rare case with two cysts and review of the literature." Hippokratia vol. 18,3 (2014): 278-81.
Paraskevakou H, Orfanos S, Diamantis T, Konstantinidou A, Patsouris E. Primary retroperitoneal mucinous cystadenoma. A rare case with two cysts and review of the literature. Hippokratia. 2014 Jul-Sep;18(3):278-81. PMID: 25694766; PMCID: PMC4309152.
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The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients.

Infectious diseases and therapy

Vassiliou AG, Kotanidou A, Mastora Z, Tascini C, Cardinali G, Orfanos SE.
PMID: 29549653
Infect Dis Ther. 2018 Mar;7:3-14. doi: 10.1007/s40121-018-0193-2. Epub 2018 Mar 16.

INTRODUCTION: A soluble (s) form of the endothelial protein C receptor (EPCR) circulates in plasma and inhibits activated protein C (APC) activities. The clinical impact of sEPCR and its involvement in the septic process is under investigation. This study...

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Vassiliou AG, Kotanidou A, Mastora Z, et al. The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients. Infect Dis Ther. 2018;7:3-14doi: 10.1007/s40121-018-0193-2.
Vassiliou, A. G., Kotanidou, A., Mastora, Z., Tascini, C., Cardinali, G., & Orfanos, S. E. (2018). The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients. Infectious diseases and therapy, 73-14. https://doi.org/10.1007/s40121-018-0193-2
Vassiliou, Alice G, et al. "The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients." Infectious diseases and therapy vol. 7 (2018): 3-14. doi: https://doi.org/10.1007/s40121-018-0193-2
Vassiliou AG, Kotanidou A, Mastora Z, Tascini C, Cardinali G, Orfanos SE. The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients. Infect Dis Ther. 2018 Mar;7:3-14. doi: 10.1007/s40121-018-0193-2. Epub 2018 Mar 16. PMID: 29549653; PMCID: PMC5856733.
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Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis.

Liver cancer

Vogel A, Rimassa L, Sun HC, Abou-Alfa GK, El-Khoueiry A, Pinato DJ, Sanchez Alvarez J, Daigl M, Orfanos P, Leibfried M, Blanchet Zumofen MH, Gaillard VE, Merle P.
PMID: 34239810
Liver Cancer. 2021 Jun;10(3):240-248. doi: 10.1159/000515302. Epub 2021 May 06.

BACKGROUND: Most phase 3 clinical trials of systemic therapy for first-line unresectable hepatocellular carcinoma (HCC) have failed, with the exception of SHARP, REFLECT, and IMbrave150. We conducted indirect comparisons of therapies evaluated for first-line HCC treatment.SUMMARY: We conducted a...

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Vogel A, Rimassa L, Sun HC, et al. Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis. Liver Cancer. 2021;10(3):240-248doi: 10.1159/000515302.
Vogel, A., Rimassa, L., Sun, H. C., Abou-Alfa, G. K., El-Khoueiry, A., Pinato, D. J., Sanchez Alvarez, J., Daigl, M., Orfanos, P., Leibfried, M., Blanchet Zumofen, M. H., Gaillard, V. E., & Merle, P. (2021). Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis. Liver cancer, 10(3), 240-248. https://doi.org/10.1159/000515302
Vogel, Arndt, et al. "Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis." Liver cancer vol. 10,3 (2021): 240-248. doi: https://doi.org/10.1159/000515302
Vogel A, Rimassa L, Sun HC, Abou-Alfa GK, El-Khoueiry A, Pinato DJ, Sanchez Alvarez J, Daigl M, Orfanos P, Leibfried M, Blanchet Zumofen MH, Gaillard VE, Merle P. Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis. Liver Cancer. 2021 Jun;10(3):240-248. doi: 10.1159/000515302. Epub 2021 May 06. PMID: 34239810; PMCID: PMC8237801.
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Similarity and stability of face network across populations and throughout adolescence and adulthood.

NeuroImage

Liao Z, Banaschewski T, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Paus T.
PMID: 34560271
Neuroimage. 2021 Dec 01;244:118587. doi: 10.1016/j.neuroimage.2021.118587. Epub 2021 Sep 21.

The ability to extract cues from faces is fundamental for social animals, including humans. An individual's profile of functional connectivity across a face network can be shaped by common organizing principles, stable individual traits, and time-varying mental states. In...

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Liao Z, Banaschewski T, Bokde ALW, et al. Similarity and stability of face network across populations and throughout adolescence and adulthood. Neuroimage. 2021;244:118587doi: 10.1016/j.neuroimage.2021.118587.
Liao, Z., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J. L., Martinot, M. P., Artiges, E., Nees, F., Orfanos, D. P., Poustka, L., Hohmann, S., Millenet, S., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Schumann, G., Paus, T. (2021). Similarity and stability of face network across populations and throughout adolescence and adulthood. NeuroImage, 244118587. https://doi.org/10.1016/j.neuroimage.2021.118587
Liao, Zhijie, et al. "Similarity and stability of face network across populations and throughout adolescence and adulthood." NeuroImage vol. 244 (2021): 118587. doi: https://doi.org/10.1016/j.neuroimage.2021.118587
Liao Z, Banaschewski T, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Paus T. Similarity and stability of face network across populations and throughout adolescence and adulthood. Neuroimage. 2021 Dec 01;244:118587. doi: 10.1016/j.neuroimage.2021.118587. Epub 2021 Sep 21. PMID: 34560271.
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Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast.

Oncotarget

Mohammad K, Orfanos E, Titorenko VI.
PMID: 34853658
Oncotarget. 2021 Nov 23;12(24):2351-2374. doi: 10.18632/oncotarget.28133. eCollection 2021 Nov 23.

After budding yeast cells cultured in a nutrient-rich liquid medium with 0.2% glucose (under caloric restriction conditions) or 2% glucose (under non-caloric restriction conditions), ferment glucose to ethanol and then consume ethanol, they enter the stationary phase. The process...

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Mohammad K, Orfanos E, Titorenko VI. Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast. Oncotarget. 2021;12(24):2351-2374doi: 10.18632/oncotarget.28133.
Mohammad, K., Orfanos, E., & Titorenko, V. I. (2021). Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast. Oncotarget, 12(24), 2351-2374. https://doi.org/10.18632/oncotarget.28133
Mohammad, Karamat, et al. "Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast." Oncotarget vol. 12,24 (2021): 2351-2374. doi: https://doi.org/10.18632/oncotarget.28133
Mohammad K, Orfanos E, Titorenko VI. Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast. Oncotarget. 2021 Nov 23;12(24):2351-2374. doi: 10.18632/oncotarget.28133. eCollection 2021 Nov 23. PMID: 34853658; PMCID: PMC8629408.
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FLNC-Associated Myofibrillar Myopathy: New Clinical, Functional, and Proteomic Data.

Neurology. Genetics

Kley RA, Leber Y, Schrank B, Zhuge H, Orfanos Z, Kostan J, Onipe A, Sellung D, Güttsches AK, Eggers B, Jacobsen F, Kress W, Marcus K, Djinovic-Carugo K, van der Ven PFM, Fürst DO, Vorgerd M.
PMID: 34235269
Neurol Genet. 2021 May 18;7(3):e590. doi: 10.1212/NXG.0000000000000590. eCollection 2021 Jun.

OBJECTIVE: To determine whether a new indel mutation in the dimerization domain of filamin C (FLNc) causes a hereditary myopathy with protein aggregation in muscle fibers, we clinically and molecularly studied a German family with autosomal dominant myofibrillar myopathy...

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Kley RA, Leber Y, Schrank B, et al. FLNC-Associated Myofibrillar Myopathy: New Clinical, Functional, and Proteomic Data. Neurol Genet. 2021;7(3):e590doi: 10.1212/NXG.0000000000000590.
Kley, R. A., Leber, Y., Schrank, B., Zhuge, H., Orfanos, Z., Kostan, J., Onipe, A., Sellung, D., Güttsches, A. K., Eggers, B., Jacobsen, F., Kress, W., Marcus, K., Djinovic-Carugo, K., van der Ven, P. F. M., Fürst, D. O., & Vorgerd, M. (2021). FLNC-Associated Myofibrillar Myopathy: New Clinical, Functional, and Proteomic Data. Neurology. Genetics, 7(3), e590. https://doi.org/10.1212/NXG.0000000000000590
Kley, Rudolf Andre, et al. "FLNC-Associated Myofibrillar Myopathy: New Clinical, Functional, and Proteomic Data." Neurology. Genetics vol. 7,3 (2021): e590. doi: https://doi.org/10.1212/NXG.0000000000000590
Kley RA, Leber Y, Schrank B, Zhuge H, Orfanos Z, Kostan J, Onipe A, Sellung D, Güttsches AK, Eggers B, Jacobsen F, Kress W, Marcus K, Djinovic-Carugo K, van der Ven PFM, Fürst DO, Vorgerd M. FLNC-Associated Myofibrillar Myopathy: New Clinical, Functional, and Proteomic Data. Neurol Genet. 2021 May 18;7(3):e590. doi: 10.1212/NXG.0000000000000590. eCollection 2021 Jun. PMID: 34235269; PMCID: PMC8237399.
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