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Showing 781 to 792 of 792 entries
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Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205.

ACS medicinal chemistry letters

Woodley CM, Nixon GL, Basilico N, Parapini S, Hong WD, Ward SA, Biagini GA, Leung SC, Taramelli D, Onuma K, Hasebe T, O'Neill PM.
PMID: 34267877
ACS Med Chem Lett. 2021 Jun 24;12(7):1077-1085. doi: 10.1021/acsmedchemlett.1c00031. eCollection 2021 Jul 08.

Synthetic endoperoxide antimalarials, such as 1,2,4-trioxolanes and 1,2,4,5-tetraoxanes, are promising successors for current front-line antimalarials, semisynthetic artemisinin derivatives. However, limited solubility of second-generation analogues in biological-relevant media represents a barrier in clinical development. We present methodology for the synthesis...

Five-year outcomes after state-of-the-art percutaneous coronary revascularization in patients with de novo three-vessel disease: final results of the SYNTAX II study.

European heart journal

Banning AP, Serruys P, De Maria GL, Ryan N, Walsh S, Gonzalo N, Jan van Geuns R, Onuma Y, Sabate M, Davies J, Lesiak M, Moreno R, Cruz-Gonzalez I, Hoole SP, Piek JJ, Appleby C, Fath-Ordoubadi F, Zaman A, Van Mieghem NM, Uren N, Zueco J, Buszman P, Iniguez A, Goicolea J, Hildick-Smith D, Ochala A, Dudek D, de Vries T, Taggart D, Farooq V, Spitzer E, Tijssen J, Escaned J.
PMID: 34617993
Eur Heart J. 2021 Oct 07; doi: 10.1093/eurheartj/ehab703. Epub 2021 Oct 07.

AIMS: The SYNTAX II study evaluated the impact of advances in percutaneous coronary intervention (PCI), integrated into a single revascularization strategy, on outcomes of patients with de novo three-vessel disease. The study employed decision-making utilizing the SYNTAX score II,...

Porphyromonas gingivalis Mfa1 fimbria putatively binds to TLR2 and induces both IL-6 and IL-8 production in human bronchial epithelial cells.

Biochemical and biophysical research communications

Takahashi Y, Cueno ME, Kamio N, Iinuma T, Hasegawa Y, Imai K.
PMID: 34891039
Biochem Biophys Res Commun. 2021 Dec 03;589:35-40. doi: 10.1016/j.bbrc.2021.12.003. Epub 2021 Dec 03.

Porphyromonas gingivalis (Pg) a major periodontal pathogen involved in periodontal disease development and progression. Moreover, Pg has two fimbriae surface proteins (FimA and Mfa1) that are genetically distinct and make-up the fimbrial shaft which in-turn form crucial attachment to...

The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia.

Annals of hematology

Yanada M, Konuma T, Yamasaki S, Mizuno S, Hirabayashi S, Nishiwaki S, Uchida N, Doki N, Tanaka M, Ozawa Y, Sawa M, Eto T, Kawakita T, Ota S, Fukuda T, Onizuka M, Kimura T, Atsuta Y, Kako S, Yano S.
PMID: 34477952
Ann Hematol. 2021 Dec;100(12):3017-3027. doi: 10.1007/s00277-021-04661-2. Epub 2021 Sep 03.

This study aimed to compare the effect of disease status at the time of allogeneic hematopoietic cell transplantation (HCT) on post-transplant outcomes between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Japanese nationwide registry data for 6901 patients...

Performance of using opposing homozygotes for paternity testing in Japanese Black cattle.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie

Komiya R, Ogawa S, Aonuma T, Satoh M.
PMID: 34499371
J Anim Breed Genet. 2021 Sep 09; doi: 10.1111/jbg.12649. Epub 2021 Sep 09.

Genome-wide single nucleotide polymorphism (SNP) markers in Japanese Black cattle enable genomic prediction and verifying parent-offspring relationships. We assessed the performance of opposing homozygotes (OH) for paternity testing in Japanese Black cattle, using SNP genotype information of 50 sires...

Albuminuria Intensifies the Link Between Urinary Sodium Excretion and Central Pulse Pressure in the General Population: The Wakuya Study.

American journal of hypertension

Tagawa K, Tsuru Y, Yokoi K, Aonuma T, Hashimoto J.
PMID: 33893813
Am J Hypertens. 2021 Aug 09;34(8):851-857. doi: 10.1093/ajh/hpab057.

BACKGROUND: Central pulse pressure (cPP) is responsible for the hemodynamics of vital organs, and monitoring this parameter is important for cardiovascular disease (CVD) prevention. Excess sodium intake and (micro)albuminuria (a manifestation of renal microvascular damage) are known to be...

Effects of Static Stretching With High-Intensity and Short-Duration or Low-Intensity and Long-Duration on Range of Motion and Muscle Stiffness.

Frontiers in physiology

Fukaya T, Kiyono R, Sato S, Yahata K, Yasaka K, Onuma R, Nakamura M.
PMID: 33329054
Front Physiol. 2020 Nov 20;11:601912. doi: 10.3389/fphys.2020.601912. eCollection 2020.

This study investigated the effects of static stretching (SS) delivered with the same load but using two protocols - high-intensity and short-duration and low-intensity and long-duration - on range of motion (ROM) and muscle stiffness. A total of 18...

State-Selective Observation of Radiative Cooling of Vibrationally Excited C.

The journal of physical chemistry letters

Iida S, Kuma S, Tanuma H, Azuma T, Shiromaru H.
PMID: 33289570
J Phys Chem Lett. 2020 Dec 17;11(24):10526-10531. doi: 10.1021/acs.jpclett.0c03196. Epub 2020 Dec 08.

We have observed radiative cooling of vibrationally excited C

Development of receptive vocabulary and verbal intelligence in Japanese children with unilateral hearing loss.

Auris, nasus, larynx

Takeyama T, Shimada A, Sakamoto Y, Aoki T, Kondo E, Nakano S, Fukuda J, Azuma T, Sato G, Okamoto H, Kitamura Y, Udaka J, Takeda N.
PMID: 34511300
Auris Nasus Larynx. 2021 Sep 09; doi: 10.1016/j.anl.2021.08.002. Epub 2021 Sep 09.

OBJECTIVE: In the past, it was believed that unilateral hearing loss has a minimal impact on the speech and language development in children. However, several studies have suggested that some school-age children with unilateral hearing loss have learning impairments...

Factors associated with postpartum smoking relapse among women who quit in early pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Journal of epidemiology

Murakami K, Ishikuro M, Ueno F, Noda A, Onuma T, Obara T, Kuriyama S.
PMID: 33907065
J Epidemiol. 2021 Apr 28; doi: 10.2188/jea.JE20200609. Epub 2021 Apr 28.

BACKGROUND: While a wide range of predictors of postpartum smoking relapse have been suggested, population-based studies have rarely examined these factors exclusively among women who quit in early pregnancy. Furthermore, workplace secondhand smoke (SHS) exposure has never been examined.METHODS:...

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group.

NPJ breast cancer

El Bairi K, Haynes HR, Blackley E, Fineberg S, Shear J, Turner S, de Freitas JR, Sur D, Amendola LC, Gharib M, Kallala A, Arun I, Azmoudeh-Ardalan F, Fujimoto L, Sua LF, Liu SW, Lien HC, Kirtani P, Balancin M, El Attar H, Guleria P, Yang W, Shash E, Chen IC, Bautista V, Do Prado Moura JF, Rapoport BL, Castaneda C, Spengler E, Acosta-Haab G, Frahm I, Sanchez J, Castillo M, Bouchmaa N, Md Zin RR, Shui R, Onyuma T, Yang W, Husain Z, Willard-Gallo K, Coosemans A, Perez EA, Provenzano E, Ericsson PG, Richardet E, Mehrotra R, Sarancone S, Ehinger A, Rimm DL, Bartlett JMS, Viale G, Denkert C, Hida AI, Sotiriou C, Loibl S, Hewitt SM, Badve S, Symmans WF, Kim RS, Pruneri G, Goel S, Francis PA, Inurrigarro G, Yamaguchi R, Garcia-Rivello H, Horlings H, Afqir S, Salgado R, Adams S, Kok M, Dieci MV, Michiels S, Demaria S, Loi S.
PMID: 34853355
NPJ Breast Cancer. 2021 Dec 01;7(1):150. doi: 10.1038/s41523-021-00346-1.

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients...

Porphyromonas gingivalis Mfa1 fimbria putatively binds to TLR2 and induces both IL-6 and IL-8 production in human bronchial epithelial cells.

Biochemical and biophysical research communications

Takahashi Y, Cueno ME, Kamio N, Iinuma T, Hasegawa Y, Imai K.
PMID: 34891039
Biochem Biophys Res Commun. 2021 Dec 03;589:35-40. doi: 10.1016/j.bbrc.2021.12.003. Epub 2021 Dec 03.

Porphyromonas gingivalis (Pg) a major periodontal pathogen involved in periodontal disease development and progression. Moreover, Pg has two fimbriae surface proteins (FimA and Mfa1) that are genetically distinct and make-up the fimbrial shaft which in-turn form crucial attachment to...

Showing 781 to 792 of 792 entries