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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.

Nature communications

Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, Hu W, Pei J, Zhang Q, Zhou S, Khan S, Zhang X, Hua N, Yang Q, Arango S, Zhang W, Nayak D, Olsen SK, Weintraub ST, Hromas R, Konopleva M, Yuan Y, Zheng G, Zhou D.
PMID: 34824248
Nat Commun. 2021 Nov 25;12(1):6896. doi: 10.1038/s41467-021-27210-x.

PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because many determinants of PROTAC specificity and activity remain elusive. Through computational modelling of the entire NEDD8-VHL Cullin RING E3 ubiquitin...

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Lv D, Pal P, Liu X, et al. Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021;12(1):6896doi: 10.1038/s41467-021-27210-x.
Lv, D., Pal, P., Liu, X., Jia, Y., Thummuri, D., Zhang, P., Hu, W., Pei, J., Zhang, Q., Zhou, S., Khan, S., Zhang, X., Hua, N., Yang, Q., Arango, S., Zhang, W., Nayak, D., Olsen, S. K., Weintraub, S. T., Hromas, R., Konopleva, M., Yuan, Y., Zheng, G., & Zhou, D. (2021). Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nature communications, 12(1), 6896. https://doi.org/10.1038/s41467-021-27210-x
Lv, Dongwen, et al. "Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity." Nature communications vol. 12,1 (2021): 6896. doi: https://doi.org/10.1038/s41467-021-27210-x
Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, Hu W, Pei J, Zhang Q, Zhou S, Khan S, Zhang X, Hua N, Yang Q, Arango S, Zhang W, Nayak D, Olsen SK, Weintraub ST, Hromas R, Konopleva M, Yuan Y, Zheng G, Zhou D. Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 Nov 25;12(1):6896. doi: 10.1038/s41467-021-27210-x. PMID: 34824248; PMCID: PMC8617031.
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Exploring equity in accessing diabetes management treatment: A healthcare gap analysis.

Social science & medicine (1982)

Tapager I, Olsen KR, Vrangbæk K.
PMID: 34837828
Soc Sci Med. 2021 Nov 17;292:114550. doi: 10.1016/j.socscimed.2021.114550. Epub 2021 Nov 17.

Healthcare inequities are often investigated empirically as associations between socio-economic characteristics and differences between observed healthcare utilisation and estimates of needs-based utilisation. However, the concept of 'need' is tricky to operationalise and utilisation may be contingent on inequities arising...

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Tapager I, Olsen KR, Vrangbæk K. Exploring equity in accessing diabetes management treatment: A healthcare gap analysis. Soc Sci Med. 2021;292:114550doi: 10.1016/j.socscimed.2021.114550.
Tapager, I., Olsen, K. R., & Vrangbæk, K. (2021). Exploring equity in accessing diabetes management treatment: A healthcare gap analysis. Social science & medicine (1982), 292114550. https://doi.org/10.1016/j.socscimed.2021.114550
Tapager, Ina, et al. "Exploring equity in accessing diabetes management treatment: A healthcare gap analysis." Social science & medicine (1982) vol. 292 (2021): 114550. doi: https://doi.org/10.1016/j.socscimed.2021.114550
Tapager I, Olsen KR, Vrangbæk K. Exploring equity in accessing diabetes management treatment: A healthcare gap analysis. Soc Sci Med. 2021 Nov 17;292:114550. doi: 10.1016/j.socscimed.2021.114550. Epub 2021 Nov 17. PMID: 34837828.
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Red light activates a chloroplast-dependent ion uptake mechanism for stomatal opening under reduced CO.

The New phytologist

Olsen RL, Pratt RB, Gump P, Kemper A, Tallman G.
PMID: 33863228
New Phytol. 2002 Mar;153(3):497-508. doi: 10.1046/j.0028-646X.2001.00337.x. Epub 2002 Mar 05.

•  Under red light in ambient CO

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Olsen RL, Pratt RB, Gump P, et al. Red light activates a chloroplast-dependent ion uptake mechanism for stomatal opening under reduced CO. New Phytol. 2002;153(3):497-508doi: 10.1046/j.0028-646X.2001.00337.x.
Olsen, R. L., Pratt, R. B., Gump, P., Kemper, A., & Tallman, G. (2002). Red light activates a chloroplast-dependent ion uptake mechanism for stomatal opening under reduced CO. The New phytologist, 153(3), 497-508. https://doi.org/10.1046/j.0028-646X.2001.00337.x
Olsen, Rebecca L, et al. "Red light activates a chloroplast-dependent ion uptake mechanism for stomatal opening under reduced CO." The New phytologist vol. 153,3 (2002): 497-508. doi: https://doi.org/10.1046/j.0028-646X.2001.00337.x
Olsen RL, Pratt RB, Gump P, Kemper A, Tallman G. Red light activates a chloroplast-dependent ion uptake mechanism for stomatal opening under reduced CO. New Phytol. 2002 Mar;153(3):497-508. doi: 10.1046/j.0028-646X.2001.00337.x. Epub 2002 Mar 05. PMID: 33863228.
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Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling.

Diabetologia

Karhunen V, Daghlas I, Zuber V, Vujkovic M, Olsen AK, Knudsen LB, Haynes WG, Howson JMM, Gill D.
PMID: 34505161
Diabetologia. 2021 Dec;64(12):2773-2778. doi: 10.1007/s00125-021-05564-7. Epub 2021 Sep 09.

AIMS/HYPOTHESIS: The aim of this study was to leverage human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide (GIP) signalling.METHODS: Data were obtained from summary statistics of large-scale genome-wide association studies. We examined whether genetic associations...

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Karhunen V, Daghlas I, Zuber V, et al. Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling. Diabetologia. 2021;64(12):2773-2778doi: 10.1007/s00125-021-05564-7.
Karhunen, V., Daghlas, I., Zuber, V., Vujkovic, M., Olsen, A. K., Knudsen, L. B., Haynes, W. G., Howson, J. M. M., & Gill, D. (2021). Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling. Diabetologia, 64(12), 2773-2778. https://doi.org/10.1007/s00125-021-05564-7
Karhunen, Ville, et al. "Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling." Diabetologia vol. 64,12 (2021): 2773-2778. doi: https://doi.org/10.1007/s00125-021-05564-7
Karhunen V, Daghlas I, Zuber V, Vujkovic M, Olsen AK, Knudsen LB, Haynes WG, Howson JMM, Gill D. Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling. Diabetologia. 2021 Dec;64(12):2773-2778. doi: 10.1007/s00125-021-05564-7. Epub 2021 Sep 09. PMID: 34505161; PMCID: PMC8563538.
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Open Pharma recommendations for plain language summaries of peer-reviewed medical journal publications.

Current medical research and opinion

Rosenberg A, Baróniková S, Feighery L, Gattrell W, Olsen RE, Watson A, Koder T, Winchester C.
PMID: 34511020
Curr Med Res Opin. 2021 Nov;37(11):2015-2016. doi: 10.1080/03007995.2021.1971185. Epub 2021 Sep 12.

Plain language summaries of peer-reviewed medical journal publications are a means of sharing research with a broad range of audiences and may improve the transparency, accountability, accessibility, discoverability, and inclusivity of medical research. There is currently an ongoing, industry-wide...

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Rosenberg A, Baróniková S, Feighery L, et al. Open Pharma recommendations for plain language summaries of peer-reviewed medical journal publications. Curr Med Res Opin. 2021;37(11):2015-2016doi: 10.1080/03007995.2021.1971185.
Rosenberg, A., Baróniková, S., Feighery, L., Gattrell, W., Olsen, R. E., Watson, A., Koder, T., & Winchester, C. (2021). Open Pharma recommendations for plain language summaries of peer-reviewed medical journal publications. Current medical research and opinion, 37(11), 2015-2016. https://doi.org/10.1080/03007995.2021.1971185
Rosenberg, Adeline, et al. "Open Pharma recommendations for plain language summaries of peer-reviewed medical journal publications." Current medical research and opinion vol. 37,11 (2021): 2015-2016. doi: https://doi.org/10.1080/03007995.2021.1971185
Rosenberg A, Baróniková S, Feighery L, Gattrell W, Olsen RE, Watson A, Koder T, Winchester C. Open Pharma recommendations for plain language summaries of peer-reviewed medical journal publications. Curr Med Res Opin. 2021 Nov;37(11):2015-2016. doi: 10.1080/03007995.2021.1971185. Epub 2021 Sep 12. PMID: 34511020.
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Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures.

Frontiers in oncology

Xia C, Olsen TK, Zirakzadeh AA, Almamoun R, Sjöholm LK, Dahlström J, Sjöberg J, Claesson HE, Johnsen JI, Winqvist O, Xu D, Ekström TJ, Björkholm M, Strååt K.
PMID: 33363029
Front Oncol. 2020 Dec 09;10:598872. doi: 10.3389/fonc.2020.598872. eCollection 2020.

We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets...

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Xia C, Olsen TK, Zirakzadeh AA, et al. Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures. Front Oncol. 2020;10:598872doi: 10.3389/fonc.2020.598872.
Xia, C., Olsen, T. K., Zirakzadeh, A. A., Almamoun, R., Sjöholm, L. K., Dahlström, J., Sjöberg, J., Claesson, H. E., Johnsen, J. I., Winqvist, O., Xu, D., Ekström, T. J., Björkholm, M., & Strååt, K. (2020). Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures. Frontiers in oncology, 10598872. https://doi.org/10.3389/fonc.2020.598872
Xia, Chuanyou, et al. "Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures." Frontiers in oncology vol. 10 (2020): 598872. doi: https://doi.org/10.3389/fonc.2020.598872
Xia C, Olsen TK, Zirakzadeh AA, Almamoun R, Sjöholm LK, Dahlström J, Sjöberg J, Claesson HE, Johnsen JI, Winqvist O, Xu D, Ekström TJ, Björkholm M, Strååt K. Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures. Front Oncol. 2020 Dec 09;10:598872. doi: 10.3389/fonc.2020.598872. eCollection 2020. PMID: 33363029; PMCID: PMC7756121.
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Novel Small-Molecule Hybrid-Antibacterial Agents against .

Molecules (Basel, Switzerland)

Gehrmann R, Hertlein T, Hopke E, Ohlsen K, Lalk M, Hilgeroth A.
PMID: 35011293
Molecules. 2021 Dec 23;27(1). doi: 10.3390/molecules27010061.

Ongoing resistance developments against antibiotics that also affect last-resort antibiotics require novel antibacterial compounds. Strategies to discover such novel structures have been dimerization or hybridization of known antibacterial agents. We found novel antibacterial agents by dimerization of indols and...

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Gehrmann R, Hertlein T, Hopke E, et al. Novel Small-Molecule Hybrid-Antibacterial Agents against . Molecules. 2021;27(1)doi: 10.3390/molecules27010061.
Gehrmann, R., Hertlein, T., Hopke, E., Ohlsen, K., Lalk, M., & Hilgeroth, A. (2021). Novel Small-Molecule Hybrid-Antibacterial Agents against . Molecules (Basel, Switzerland), 27(1), . https://doi.org/10.3390/molecules27010061
Gehrmann, Robin, et al. "Novel Small-Molecule Hybrid-Antibacterial Agents against ." Molecules (Basel, Switzerland) vol. 27,1 (2021). doi: https://doi.org/10.3390/molecules27010061
Gehrmann R, Hertlein T, Hopke E, Ohlsen K, Lalk M, Hilgeroth A. Novel Small-Molecule Hybrid-Antibacterial Agents against . Molecules. 2021 Dec 23;27(1). doi: 10.3390/molecules27010061. PMID: 35011293; PMCID: PMC8746393.
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Showing 397 to 403 of 403 entries