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Showing 13 to 24 of 56 entries
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In Memoriam: Professor Folke Sjöqvist.

Therapeutic drug monitoring

Christians U, Henthorn TK, Walson PD, Oellerich M, Eliasson E.
PMID: 32304489
Ther Drug Monit. 2020 Jun;42(3):353. doi: 10.1097/FTD.0000000000000762.

No abstract available.

The influence of disease categories on gene candidate predictions from model organism phenotypes.

Journal of biomedical semantics

Oellrich A, Koehler S, Washington N, Mungall C, Lewis S, Haendel M, Robinson PN, Smedley D.
PMID: 25093073
J Biomed Semantics. 2014 Jun 03;5:S4. doi: 10.1186/2041-1480-5-S1-S4. eCollection 2014.

BACKGROUND: The molecular etiology is still to be identified for about half of the currently described Mendelian diseases in humans, thereby hindering efforts to find treatments or preventive measures. Advances, such as new sequencing technologies, have led to increasing...

Ontology design patterns to disambiguate relations between genes and gene products in GENIA.

Journal of biomedical semantics

Hoehndorf R, Ngonga Ngomo AC, Pyysalo S, Ohta T, Oellrich A, Rebholz-Schuhmann D.
PMID: 22166341
J Biomed Semantics. 2011 Oct 06;2:S1. doi: 10.1186/2041-1480-2-S5-S1.

MOTIVATION: Annotated reference corpora play an important role in biomedical information extraction. A semantic annotation of the natural language texts in these reference corpora using formal ontologies is challenging due to the inherent ambiguity of natural language. The provision...

CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess.

International journal of molecular epidemiology and genetics

von Ahsen N, Tzvetkov M, Karunajeewa HA, Gomorrai S, Ura A, Brockmöller J, Davis TM, Mueller I, Ilett KF, Oellerich M.
PMID: 21532842
Int J Mol Epidemiol Genet. 2010 Aug 18;1(4):310-9.

PURPOSE: A high frequency of previously unknown CYP2D6 alleles have been reported in Oceania populations. Genetic and functional properties of these alleles remain unknown.METHODS: We performed analyses of the genetic variability of CYP2D6 and CYP2C19 genes using AmpliChip genotyping...

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.

Journal of experimental & clinical cancer research : CR

Rothenburger T, Thomas D, Schreiber Y, Wratil PR, Pflantz T, Knecht K, Digianantonio K, Temple J, Schneider C, Baldauf HM, McLaughlin KM, Rothweiler F, Bilen B, Farmand S, Bojkova D, Costa R, Ferreirós N, Geisslinger G, Oellerich T, Xiong Y, Keppler OT, Wass MN, Michaelis M, Cinatl J.
PMID: 34641952
J Exp Clin Cancer Res. 2021 Oct 12;40(1):317. doi: 10.1186/s13046-021-02093-4.

BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMHD1 inhibitors are promising candidates for the sensitisation of leukaemia...

Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry.

The journal of pathology. Clinical research

Richter A, Fichtner A, Joost J, Brockmeyer P, Kauffmann P, Schliephake H, Hammerstein-Equord A, Kueffer S, Urlaub H, Oellerich T, Ströbel P, Bohnenberger H, Bremmer F.
PMID: 34647699
J Pathol Clin Res. 2022 Jan;8(1):33-47. doi: 10.1002/cjp2.244. Epub 2021 Oct 14.

The differentiation between a pulmonary metastasis and a newly developed squamous cell carcinoma of the lung in patients with prior head and neck squamous cell carcinoma (HNSCC) is difficult due to a lack of biomarkers but is crucially important...

New developments in corneal endothelial cell replacement.

Acta ophthalmologica

Spinozzi D, Miron A, Bruinsma M, Dapena I, Kocaba V, Jager MJ, Melles GRJ, Ni Dhubhghaill S, Oellerich S.
PMID: 33369235
Acta Ophthalmol. 2021 Nov;99(7):712-729. doi: 10.1111/aos.14722. Epub 2020 Dec 24.

Corneal transplantation is currently the most effective treatment to restore corneal clarity in patients with endothelial disorders. Endothelial transplantation, either by Descemet membrane endothelial keratoplasty (DMEK) or by Descemet stripping (automated) endothelial keratoplasty (DS(A)EK), is a surgical approach that...

Molecular Approaches to Transplant Monitoring; Is the Horizon Here?.

Clinical chemistry

Agbor-Enoh S, Oellerich M, Wu A, Halloran PF, De Vlaminck I, Keller M.
PMID: 34632495
Clin Chem. 2021 Nov 01;67(11):1443-1449. doi: 10.1093/clinchem/hvab183.

No abstract available.

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.

Blood

Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnuetgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T.
PMID: 34624079
Blood. 2020 Oct 08; doi: 10.1182/blood.2021012081. Epub 2020 Oct 08.

Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive chemoimmunotherapy. Despite the favorable clinical outcome of the majority of BL patients, chemotherapy-related toxicity and disease relapse remain as major clinical challenges, emphasizing the need...

Gut proteases target Yersinia invasin in vivo.

BMC research notes

Trček J, Oellerich MF, Niedung K, Ebel F, Freund S, Trülzsch K.
PMID: 21501502
BMC Res Notes. 2011 Apr 18;4:129. doi: 10.1186/1756-0500-4-129.

BACKGROUND: Yersinia enterocolitica is a common cause of food borne gastrointestinal disease. After oral uptake, yersiniae invade Peyer's patches of the distal ileum. This is accomplished by the binding of the Yersinia invasin to β1 integrins on the apical...

Graft-Derived Cell-Free DNA as a Noninvasive Biomarker of Cardiac Allograft Rejection: a Cohort Study on Clinical Validity and Confounding Factors.

Transplantation

Knüttgen F, Beck J, Dittrich M, Oellerich M, Zittermann A, Schulz U, Fuchs U, Knabbe C, Schütz E, Gummert J, Birschmann I.
PMID: 33653997
Transplantation. 2021 Feb 25; doi: 10.1097/TP.0000000000003725. Epub 2021 Feb 25.

BACKGROUND: Circulating graft-derived cell-free DNA (dd-cfDNA) is a new marker of cardiac allograft damage that is used for noninvasive rejection diagnostics. We performed dd-cfDNA (%) in heart transplant recipients during the first post-transplant year.METHODS: In 87 patients, serial dd-cfDNA...

An ontology approach to comparative phenomics in plants.

Plant methods

Oellrich A, Walls RL, Cannon EK, Cannon SB, Cooper L, Gardiner J, Gkoutos GV, Harper L, He M, Hoehndorf R, Jaiswal P, Kalberer SR, Lloyd JP, Meinke D, Menda N, Moore L, Nelson RT, Pujar A, Lawrence CJ, Huala E.
PMID: 25774204
Plant Methods. 2015 Feb 25;11:10. doi: 10.1186/s13007-015-0053-y. eCollection 2015.

BACKGROUND: Plant phenotype datasets include many different types of data, formats, and terms from specialized vocabularies. Because these datasets were designed for different audiences, they frequently contain language and details tailored to investigators with different research objectives and backgrounds....

Showing 13 to 24 of 56 entries