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Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model.

Biology open

Sabaté-Brescó M, Berset CM, Zeiter S, Stanic B, Thompson K, Ziegler M, Richards RG, O'Mahony L, Moriarty TF.
PMID: 34240122
Biol Open. 2021 Sep 15;10(9). doi: 10.1242/bio.057315. Epub 2021 Oct 01.

Biomechanical stability plays an important role in fracture healing, with unstable fixation being associated with healing disturbances. A lack of stability is also considered a risk factor for fracture-related infection (FRI), although confirmatory studies and an understanding of the...

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Sabaté-Brescó M, Berset CM, Zeiter S, et al. Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model. Biol Open. 2021;10(9)doi: 10.1242/bio.057315.
Sabaté-Brescó, M., Berset, C. M., Zeiter, S., Stanic, B., Thompson, K., Ziegler, M., Richards, R. G., O'Mahony, L., & Moriarty, T. F. (2021). Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model. Biology open, 10(9), . https://doi.org/10.1242/bio.057315
Sabaté-Brescó, Marina, et al. "Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model." Biology open vol. 10,9 (2021). doi: https://doi.org/10.1242/bio.057315
Sabaté-Brescó M, Berset CM, Zeiter S, Stanic B, Thompson K, Ziegler M, Richards RG, O'Mahony L, Moriarty TF. Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model. Biol Open. 2021 Sep 15;10(9). doi: 10.1242/bio.057315. Epub 2021 Oct 01. PMID: 34240122; PMCID: PMC8496694.
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Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity.

Drugs & aging

Sallevelt BTGM, Huibers CJA, Heij JMJO, Egberts TCG, van Puijenbroek EP, Shen Z, Spruit MR, Jungo KT, Rodondi N, Dalleur O, Spinewine A, Jennings E, O'Mahony D, Wilting I, Knol W.
PMID: 34877629
Drugs Aging. 2021 Dec 08; doi: 10.1007/s40266-021-00904-z. Epub 2021 Dec 08.

BACKGROUND: The Screening Tool of Older Persons' Prescriptions (STOPP)/Screening Tool to Alert to Right Treatment (START) instrument is used to evaluate the appropriateness of medication in older people. STOPP/START criteria have been converted into software algorithms and implemented in...

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Sallevelt BTGM, Huibers CJA, Heij JMJO, et al. Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity. Drugs Aging. 2021;doi: 10.1007/s40266-021-00904-z.
Sallevelt, B. T. G. M., Huibers, C. J. A., Heij, J. M. J. O., Egberts, T. C. G., van Puijenbroek, E. P., Shen, Z., Spruit, M. R., Jungo, K. T., Rodondi, N., Dalleur, O., Spinewine, A., Jennings, E., O'Mahony, D., Wilting, I., & Knol, W. (2021). Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity. Drugs & aging, . https://doi.org/10.1007/s40266-021-00904-z
Sallevelt, Bastiaan T G M, et al. "Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity." Drugs & aging vol. (2021). doi: https://doi.org/10.1007/s40266-021-00904-z
Sallevelt BTGM, Huibers CJA, Heij JMJO, Egberts TCG, van Puijenbroek EP, Shen Z, Spruit MR, Jungo KT, Rodondi N, Dalleur O, Spinewine A, Jennings E, O'Mahony D, Wilting I, Knol W. Frequency and Acceptance of Clinical Decision Support System-Generated STOPP/START Signals for Hospitalised Older Patients with Polypharmacy and Multimorbidity. Drugs Aging. 2021 Dec 08; doi: 10.1007/s40266-021-00904-z. Epub 2021 Dec 08. PMID: 34877629.
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A multi-purpose pilot-scale molten metal & molten salt pyrolysis reactor.

MethodsX

Riedewald F, Povey I, O'Mahoney M, Sousa-Gallagher M.
PMID: 34984175
MethodsX. 2021 Dec 16;9:101606. doi: 10.1016/j.mex.2021.101606. eCollection 2022.

This paper describes the design features and operational details of a molten metal pyrolysis reactor. Such a reactor allows pyrolysis experimentation on biomass, aluminium-laminated plastics, mixed plastics, carbon fibre materials, etc. Experimental results on biodegradable plastic, carbon fibre composites,...

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Riedewald F, Povey I, O'Mahoney M, et al. A multi-purpose pilot-scale molten metal & molten salt pyrolysis reactor. MethodsX. 2021;9:101606doi: 10.1016/j.mex.2021.101606.
Riedewald, F., Povey, I., O'Mahoney, M., & Sousa-Gallagher, M. (2022). A multi-purpose pilot-scale molten metal & molten salt pyrolysis reactor. MethodsX, 9101606. https://doi.org/10.1016/j.mex.2021.101606
Riedewald, Frank, et al. "A multi-purpose pilot-scale molten metal & molten salt pyrolysis reactor." MethodsX vol. 9 (2022): 101606. doi: https://doi.org/10.1016/j.mex.2021.101606
Riedewald F, Povey I, O'Mahoney M, Sousa-Gallagher M. A multi-purpose pilot-scale molten metal & molten salt pyrolysis reactor. MethodsX. 2021 Dec 16;9:101606. doi: 10.1016/j.mex.2021.101606. eCollection 2022. PMID: 34984175; PMCID: PMC8693002.
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The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study.

Allergy

Venter C, Palumbo MP, Glueck DH, Sauder KA, O'Mahony L, Fleischer DM, Ben-Abdallah M, Ringham BM, Dabelea D.
PMID: 34018205
Allergy. 2022 Jan;77(1):162-172. doi: 10.1111/all.14949. Epub 2021 Jun 09.

BACKGROUND: A systematic review showed limited associations between pregnancy diet and offspring allergy. We developed a maternal diet index during pregnancy that was associated with offspring allergy outcomes.METHODS: Data came from Healthy Start, a Colorado pre-birth cohort of mother/offspring...

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Venter C, Palumbo MP, Glueck DH, et al. The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study. Allergy. 2021;77(1):162-172doi: 10.1111/all.14949.
Venter, C., Palumbo, M. P., Glueck, D. H., Sauder, K. A., O'Mahony, L., Fleischer, D. M., Ben-Abdallah, M., Ringham, B. M., & Dabelea, D. (2022). The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study. Allergy, 77(1), 162-172. https://doi.org/10.1111/all.14949
Venter, Carina, et al. "The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study." Allergy vol. 77,1 (2022): 162-172. doi: https://doi.org/10.1111/all.14949
Venter C, Palumbo MP, Glueck DH, Sauder KA, O'Mahony L, Fleischer DM, Ben-Abdallah M, Ringham BM, Dabelea D. The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study. Allergy. 2022 Jan;77(1):162-172. doi: 10.1111/all.14949. Epub 2021 Jun 09. PMID: 34018205.
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EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old.

Allergy

Agache I, Akdis CA, Akdis M, Brockow K, Chivato T, Del Giacco S, Eiwegger T, Eyerich K, Giménez-Arnau A, Gutermuth J, Guttman-Yassky E, Maurer M, Ogg G, Ong PY, O'Mahony L, Schwarze J, Warner A, Werfel T, Palomares O, Jutel M.
PMID: 34324716
Allergy. 2022 Jan;77(1):17-38. doi: 10.1111/all.15030. Epub 2021 Aug 08.

Chronic spontaneous urticaria (CSU) imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity and insufficient efficacy of classical drugs such as H

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Agache I, Akdis CA, Akdis M, et al. EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old. Allergy. 2021;77(1):17-38doi: 10.1111/all.15030.
Agache, I., Akdis, C. A., Akdis, M., Brockow, K., Chivato, T., Del Giacco, S., Eiwegger, T., Eyerich, K., Giménez-Arnau, A., Gutermuth, J., Guttman-Yassky, E., Maurer, M., Ogg, G., Ong, P. Y., O'Mahony, L., Schwarze, J., Warner, A., Werfel, T., Palomares, O., & Jutel, M. (2022). EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old. Allergy, 77(1), 17-38. https://doi.org/10.1111/all.15030
Agache, Ioana, et al. "EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old." Allergy vol. 77,1 (2022): 17-38. doi: https://doi.org/10.1111/all.15030
Agache I, Akdis CA, Akdis M, Brockow K, Chivato T, Del Giacco S, Eiwegger T, Eyerich K, Giménez-Arnau A, Gutermuth J, Guttman-Yassky E, Maurer M, Ogg G, Ong PY, O'Mahony L, Schwarze J, Warner A, Werfel T, Palomares O, Jutel M. EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old. Allergy. 2022 Jan;77(1):17-38. doi: 10.1111/all.15030. Epub 2021 Aug 08. PMID: 34324716.
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Microbiome-immune interactions and relationship to asthma severity.

The Journal of allergy and clinical immunology

Trujillo J, Lunjani N, Ryan D, O'Mahony L.
PMID: 34953788
J Allergy Clin Immunol. 2021 Dec 22; doi: 10.1016/j.jaci.2021.12.774. Epub 2021 Dec 22.

No abstract available.

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Trujillo J, Lunjani N, Ryan D, et al. Microbiome-immune interactions and relationship to asthma severity. J Allergy Clin Immunol. 2021;doi: 10.1016/j.jaci.2021.12.774.
Trujillo, J., Lunjani, N., Ryan, D., & O'Mahony, L. (2021). Microbiome-immune interactions and relationship to asthma severity. The Journal of allergy and clinical immunology, . https://doi.org/10.1016/j.jaci.2021.12.774
Trujillo, Juan, et al. "Microbiome-immune interactions and relationship to asthma severity." The Journal of allergy and clinical immunology vol. (2021). doi: https://doi.org/10.1016/j.jaci.2021.12.774
Trujillo J, Lunjani N, Ryan D, O'Mahony L. Microbiome-immune interactions and relationship to asthma severity. J Allergy Clin Immunol. 2021 Dec 22; doi: 10.1016/j.jaci.2021.12.774. Epub 2021 Dec 22. PMID: 34953788.
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Three decades' analysis of pediatric liver transplantation outcomes reveals limited long-term improvements.

Pediatric transplantation

Bakhtiyar S, Batra A, Malik T, Cotton R, Galvan NT, O'Mahony C, Goss J, Rana A.
PMID: 34698432
Pediatr Transplant. 2021 Oct 26;e14158. doi: 10.1111/petr.14158. Epub 2021 Oct 26.

BACKGROUND: The aim of this study was to assess improvements in long-term survival of pediatric patients after liver transplantation by analyzing outcomes in transplant recipients who survived beyond 1 year after transplantation. There has been a marked increase in...

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Bakhtiyar S, Batra A, Malik T, et al. Three decades' analysis of pediatric liver transplantation outcomes reveals limited long-term improvements. Pediatr Transplant. 2021;e14158doi: 10.1111/petr.14158.
Bakhtiyar, S., Batra, A., Malik, T., Cotton, R., Galvan, N. T., O'Mahony, C., Goss, J., & Rana, A. (2021). Three decades' analysis of pediatric liver transplantation outcomes reveals limited long-term improvements. Pediatric transplantation, e14158. https://doi.org/10.1111/petr.14158
Bakhtiyar, Syed, et al. "Three decades' analysis of pediatric liver transplantation outcomes reveals limited long-term improvements." Pediatric transplantation vol. (2021): e14158. doi: https://doi.org/10.1111/petr.14158
Bakhtiyar S, Batra A, Malik T, Cotton R, Galvan NT, O'Mahony C, Goss J, Rana A. Three decades' analysis of pediatric liver transplantation outcomes reveals limited long-term improvements. Pediatr Transplant. 2021 Oct 26;e14158. doi: 10.1111/petr.14158. Epub 2021 Oct 26. PMID: 34698432.
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Patient-relevant health outcomes for hemophilia care: Development of an international standard outcomes set.

Research and practice in thrombosis and haemostasis

van Balen EC, O'Mahony B, Cnossen MH, Dolan G, Blanchette VS, Fischer K, Gue D, O'Hara J, Iorio A, Jackson S, Konkle BA, Nugent DJ, Coffin D, Skinner MW, Smit C, Srivastava A, van Eenennaam F, van der Bom JG, Gouw SC.
PMID: 34027286
Res Pract Thromb Haemost. 2021 Mar 06;5(4):e12488. doi: 10.1002/rth2.12488. eCollection 2021 May.

BACKGROUND: Patient-relevant health outcomes for persons with hemophilia should be identified and prioritized to optimize and individualize care for persons with hemophilia. Therefore, an international group of persons with hemophilia and multidisciplinary health care providers set out to identify...

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van Balen EC, O'Mahony B, Cnossen MH, et al. Patient-relevant health outcomes for hemophilia care: Development of an international standard outcomes set. Res Pract Thromb Haemost. 2021;5(4):e12488doi: 10.1002/rth2.12488.
van Balen, E. C., O'Mahony, B., Cnossen, M. H., Dolan, G., Blanchette, V. S., Fischer, K., Gue, D., O'Hara, J., Iorio, A., Jackson, S., Konkle, B. A., Nugent, D. J., Coffin, D., Skinner, M. W., Smit, C., Srivastava, A., van Eenennaam, F., van der Bom, J. G., & Gouw, S. C. (2021). Patient-relevant health outcomes for hemophilia care: Development of an international standard outcomes set. Research and practice in thrombosis and haemostasis, 5(4), e12488. https://doi.org/10.1002/rth2.12488
van Balen, Erna C, et al. "Patient-relevant health outcomes for hemophilia care: Development of an international standard outcomes set." Research and practice in thrombosis and haemostasis vol. 5,4 (2021): e12488. doi: https://doi.org/10.1002/rth2.12488
van Balen EC, O'Mahony B, Cnossen MH, Dolan G, Blanchette VS, Fischer K, Gue D, O'Hara J, Iorio A, Jackson S, Konkle BA, Nugent DJ, Coffin D, Skinner MW, Smit C, Srivastava A, van Eenennaam F, van der Bom JG, Gouw SC. Patient-relevant health outcomes for hemophilia care: Development of an international standard outcomes set. Res Pract Thromb Haemost. 2021 Mar 06;5(4):e12488. doi: 10.1002/rth2.12488. eCollection 2021 May. PMID: 34027286; PMCID: PMC8117824.
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Mechanisms of microbe-immune system dialogue within the skin.

Genes and immunity

Lunjani N, Ahearn-Ford S, Dube FS, Hlela C, O'Mahony L.
PMID: 33993202
Genes Immun. 2021 Oct;22(5):276-288. doi: 10.1038/s41435-021-00133-9. Epub 2021 May 15.

The prevalence and severity of dermatological conditions such as atopic dermatitis have increased dramatically during recent decades. Many of the factors associated with an altered risk of developing inflammatory skin disorders have also been shown to alter the composition...

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Lunjani N, Ahearn-Ford S, Dube FS, et al. Mechanisms of microbe-immune system dialogue within the skin. Genes Immun. 2021;22(5):276-288doi: 10.1038/s41435-021-00133-9.
Lunjani, N., Ahearn-Ford, S., Dube, F. S., Hlela, C., & O'Mahony, L. (2021). Mechanisms of microbe-immune system dialogue within the skin. Genes and immunity, 22(5), 276-288. https://doi.org/10.1038/s41435-021-00133-9
Lunjani, Nonhlanhla, et al. "Mechanisms of microbe-immune system dialogue within the skin." Genes and immunity vol. 22,5 (2021): 276-288. doi: https://doi.org/10.1038/s41435-021-00133-9
Lunjani N, Ahearn-Ford S, Dube FS, Hlela C, O'Mahony L. Mechanisms of microbe-immune system dialogue within the skin. Genes Immun. 2021 Oct;22(5):276-288. doi: 10.1038/s41435-021-00133-9. Epub 2021 May 15. PMID: 33993202; PMCID: PMC8497273.
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Spotlight on International Quality: COVID-19 and Its Impact on Quality Improvement in Cancer Care.

JCO global oncology

Blayney DW, Bariani G, Das D, Dawood S, Gnant M, De Guzman R, Martin SE, O'Mahony D, Roach A, Ruff P, Sampaio C, Sanchez JA, Vanderpuye V, Kamal A, Hendricks C.
PMID: 34714666
JCO Glob Oncol. 2021 Sep;7:1513-1521. doi: 10.1200/GO.21.00281.

This report from ASCO's International Quality Steering Group summarizes early learnings on how the COVID-19 pandemic and its stresses have disproportionately affected cancer care delivery and its delivery systems across the world. This article shares perspectives from eight different...

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Blayney DW, Bariani G, Das D, et al. Spotlight on International Quality: COVID-19 and Its Impact on Quality Improvement in Cancer Care. JCO Glob Oncol. 2021;7:1513-1521doi: 10.1200/GO.21.00281.
Blayney, D. W., Bariani, G., Das, D., Dawood, S., Gnant, M., De Guzman, R., Martin, S. E., O'Mahony, D., Roach, A., Ruff, P., Sampaio, C., Sanchez, J. A., Vanderpuye, V., Kamal, A., & Hendricks, C. (2021). Spotlight on International Quality: COVID-19 and Its Impact on Quality Improvement in Cancer Care. JCO global oncology, 71513-1521. https://doi.org/10.1200/GO.21.00281
Blayney, Douglas W, et al. "Spotlight on International Quality: COVID-19 and Its Impact on Quality Improvement in Cancer Care." JCO global oncology vol. 7 (2021): 1513-1521. doi: https://doi.org/10.1200/GO.21.00281
Blayney DW, Bariani G, Das D, Dawood S, Gnant M, De Guzman R, Martin SE, O'Mahony D, Roach A, Ruff P, Sampaio C, Sanchez JA, Vanderpuye V, Kamal A, Hendricks C. Spotlight on International Quality: COVID-19 and Its Impact on Quality Improvement in Cancer Care. JCO Glob Oncol. 2021 Sep;7:1513-1521. doi: 10.1200/GO.21.00281. PMID: 34714666; PMCID: PMC8563078.
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Splenic Artery Transposition for Liver Transplantation: An Underutilized Technique?.

Transplantation direct

Goss MB, Galván NTN, Geha JD, Moreno NF, Cotton RT, Rana A, O'Mahony CA, Goss JA.
PMID: 33521250
Transplant Direct. 2021 Jan 26;7(2):e661. doi: 10.1097/TXD.0000000000001103. eCollection 2021 Feb.

BACKGROUND: Successful liver transplantation is dependent on restoration of hepatic arterial (HA) flow. Although uncommon, some native recipient HAs are not suitable or inadequate for anastomosis, thereby necessitating extra-anatomic HA reconstruction. Splenic artery transposition (SAT) is 1 method of...

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Goss MB, Galván NTN, Geha JD, et al. Splenic Artery Transposition for Liver Transplantation: An Underutilized Technique?. Transplant Direct. 2021;7(2):e661doi: 10.1097/TXD.0000000000001103.
Goss, M. B., Galván, N. T. N., Geha, J. D., Moreno, N. F., Cotton, R. T., Rana, A., O'Mahony, C. A., & Goss, J. A. (2021). Splenic Artery Transposition for Liver Transplantation: An Underutilized Technique?. Transplantation direct, 7(2), e661. https://doi.org/10.1097/TXD.0000000000001103
Goss, Matthew B, et al. "Splenic Artery Transposition for Liver Transplantation: An Underutilized Technique?." Transplantation direct vol. 7,2 (2021): e661. doi: https://doi.org/10.1097/TXD.0000000000001103
Goss MB, Galván NTN, Geha JD, Moreno NF, Cotton RT, Rana A, O'Mahony CA, Goss JA. Splenic Artery Transposition for Liver Transplantation: An Underutilized Technique?. Transplant Direct. 2021 Jan 26;7(2):e661. doi: 10.1097/TXD.0000000000001103. eCollection 2021 Feb. PMID: 33521250; PMCID: PMC7838009.
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Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes.

Current research in pharmacology and drug discovery

Skagen C, Nyman TA, Peng XR, O'Mahony G, Kase ET, Rustan AC, Thoresen GH.
PMID: 34909668
Curr Res Pharmacol Drug Discov. 2021 Jun 11;2:100039. doi: 10.1016/j.crphar.2021.100039. eCollection 2021.

METHODS: Human cultured myotubes were exposed to terbutaline in various concentrations (0.01-30 ​μM) for 4 or 96 ​h. Thereafter uptake of [RESULTS: The results showed that 4 ​h treatment with terbutaline in concentrations up to 1 ​μM increased glucose...

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Skagen C, Nyman TA, Peng XR, et al. Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes. Curr Res Pharmacol Drug Discov. 2021;2:100039doi: 10.1016/j.crphar.2021.100039.
Skagen, C., Nyman, T. A., Peng, X. R., O'Mahony, G., Kase, E. T., Rustan, A. C., & Thoresen, G. H. (2021). Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes. Current research in pharmacology and drug discovery, 2100039. https://doi.org/10.1016/j.crphar.2021.100039
Skagen, Christine, et al. "Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes." Current research in pharmacology and drug discovery vol. 2 (2021): 100039. doi: https://doi.org/10.1016/j.crphar.2021.100039
Skagen C, Nyman TA, Peng XR, O'Mahony G, Kase ET, Rustan AC, Thoresen GH. Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes. Curr Res Pharmacol Drug Discov. 2021 Jun 11;2:100039. doi: 10.1016/j.crphar.2021.100039. eCollection 2021. PMID: 34909668; PMCID: PMC8663959.
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