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Showing 37 to 39 of 39 entries
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Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group.

Cancers

Van Bockstal MR, Cooks M, Nederlof I, Brinkhuis M, Dutman A, Koopmans M, Kooreman L, van der Vegt B, Verhoog L, Vreuls C, Westenend P, Kok M, van Diest PJ, Nauwelaers I, Laudus N, Denkert C, Rimm D, Siziopikou KP, Ely S, Zardavas D, Roberts M, Floris G, Hartman J, Acs B, Peeters D, Bartlett JMS, Dequeker E, Salgado R, Giudici F, Michiels S, Horlings H, van Deurzen CHM.
PMID: 34638394
Cancers (Basel). 2021 Sep 29;13(19). doi: 10.3390/cancers13194910.

Patients with advanced triple-negative breast cancer (TNBC) benefit from treatment with atezolizumab, provided that the tumor contains ≥1% of PD-L1/SP142-positive immune cells. Numbers of tumor-infiltrating lymphocytes (TILs) vary strongly according to the anatomic localization of TNBC metastases. We investigated...

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Van Bockstal MR, Cooks M, Nederlof I, et al. Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group. Cancers (Basel). 2021;13(19)doi: 10.3390/cancers13194910.
Van Bockstal, M. R., Cooks, M., Nederlof, I., Brinkhuis, M., Dutman, A., Koopmans, M., Kooreman, L., van der Vegt, B., Verhoog, L., Vreuls, C., Westenend, P., Kok, M., van Diest, P. J., Nauwelaers, I., Laudus, N., Denkert, C., Rimm, D., Siziopikou, K. P., Ely, S., Zardavas, D., Roberts, M., Floris, G., Hartman, J., Acs, B., Peeters, D., Bartlett, J. M. S., Dequeker, E., Salgado, R., Giudici, F., Michiels, S., Horlings, H., & van Deurzen, C. H. M. (2021). Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group. Cancers, 13(19), . https://doi.org/10.3390/cancers13194910
Van Bockstal, Mieke R, et al. "Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group." Cancers vol. 13,19 (2021). doi: https://doi.org/10.3390/cancers13194910
Van Bockstal MR, Cooks M, Nederlof I, Brinkhuis M, Dutman A, Koopmans M, Kooreman L, van der Vegt B, Verhoog L, Vreuls C, Westenend P, Kok M, van Diest PJ, Nauwelaers I, Laudus N, Denkert C, Rimm D, Siziopikou KP, Ely S, Zardavas D, Roberts M, Floris G, Hartman J, Acs B, Peeters D, Bartlett JMS, Dequeker E, Salgado R, Giudici F, Michiels S, Horlings H, van Deurzen CHM. Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group. Cancers (Basel). 2021 Sep 29;13(19). doi: 10.3390/cancers13194910. PMID: 34638394; PMCID: PMC8507620.
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The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury.

Cardiovascular drugs and therapy

Xiao Y, Yim K, Zhang H, Bakker D, Nederlof R, Smeitink JAM, Renkema H, Hollmann MW, Weber NC, Zuurbier CJ.
PMID: 33914182
Cardiovasc Drugs Ther. 2021 Aug;35(4):745-758. doi: 10.1007/s10557-021-07189-9. Epub 2021 Apr 29.

PURPOSE: Sonlicromanol is a phase IIB clinical stage compound developed for treatment of mitochondrial diseases. Its active component, KH176m, functions as an antioxidant, directly scavenging reactive oxygen species (ROS), and redox activator, boosting the peroxiredoxin-thioredoxin system. Here, we examined...

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Xiao Y, Yim K, Zhang H, et al. The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury. Cardiovasc Drugs Ther. 2021;35(4):745-758doi: 10.1007/s10557-021-07189-9.
Xiao, Y., Yim, K., Zhang, H., Bakker, D., Nederlof, R., Smeitink, J. A. M., Renkema, H., Hollmann, M. W., Weber, N. C., & Zuurbier, C. J. (2021). The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury. Cardiovascular drugs and therapy, 35(4), 745-758. https://doi.org/10.1007/s10557-021-07189-9
Xiao, Yang, et al. "The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury." Cardiovascular drugs and therapy vol. 35,4 (2021): 745-758. doi: https://doi.org/10.1007/s10557-021-07189-9
Xiao Y, Yim K, Zhang H, Bakker D, Nederlof R, Smeitink JAM, Renkema H, Hollmann MW, Weber NC, Zuurbier CJ. The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury. Cardiovasc Drugs Ther. 2021 Aug;35(4):745-758. doi: 10.1007/s10557-021-07189-9. Epub 2021 Apr 29. PMID: 33914182; PMCID: PMC8266721.
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Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice.

International journal of molecular sciences

Kessler EL, Wang JW, Kok B, Brans MA, Nederlof A, van Stuijvenberg L, Huang C, Vink A, Arslan F, Efimov IR, Lam CSP, Vos MA, de Kleijn DPV, Fontes MSC, van Veen TAB.
PMID: 34769252
Int J Mol Sci. 2021 Oct 30;22(21). doi: 10.3390/ijms222111823.

Involvement of the Toll-like receptor 4 (TLR4) in maladaptive cardiac remodeling and heart failure (HF) upon pressure overload has been studied extensively, but less is known about the role of TLR2. Interplay and redundancy of TLR4 with TLR2 have...

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Kessler EL, Wang JW, Kok B, et al. Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice. Int J Mol Sci. 2021;22(21)doi: 10.3390/ijms222111823.
Kessler, E. L., Wang, J. W., Kok, B., Brans, M. A., Nederlof, A., van Stuijvenberg, L., Huang, C., Vink, A., Arslan, F., Efimov, I. R., Lam, C. S. P., Vos, M. A., de Kleijn, D. P. V., Fontes, M. S. C., & van Veen, T. A. B. (2021). Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice. International journal of molecular sciences, 22(21), . https://doi.org/10.3390/ijms222111823
Kessler, Elise L, et al. "Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice." International journal of molecular sciences vol. 22,21 (2021). doi: https://doi.org/10.3390/ijms222111823
Kessler EL, Wang JW, Kok B, Brans MA, Nederlof A, van Stuijvenberg L, Huang C, Vink A, Arslan F, Efimov IR, Lam CSP, Vos MA, de Kleijn DPV, Fontes MSC, van Veen TAB. Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice. Int J Mol Sci. 2021 Oct 30;22(21). doi: 10.3390/ijms222111823. PMID: 34769252; PMCID: PMC8583975.
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Showing 37 to 39 of 39 entries