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Showing 13 to 24 of 372 entries
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Therapeutic management of uncomplicated gastroesophageal reflux disease in france in 2005: Potential cost savings of omeprazole substitution.

Current therapeutic research, clinical and experimental

Mouly S, Charlemagne A, Lejeunne P, Fagnani F.
PMID: 24683238
Curr Ther Res Clin Exp. 2009 Aug;70(4):282-98. doi: 10.1016/j.curtheres.2009.07.001.

BACKGROUND: Proton pump inhibitors (PPIs) cost the French health care system >€1 billion in 2005, and ~50% of PPI prescriptions were for the treatment of gastroesophageal reflux disease (GERD).OBJECTIVES: This study aimed to describe the current use of PPIs...

Polyethlyene Glycol 200 can Protect Rats against Drug-Induced Kidney Toxicity through Inhibition of the Renal Organic Anion Transporter 3.

Toxicological sciences : an official journal of the Society of Toxicology

Gu YZ, Chu X, Houle R, Vlasakova K, Koeplinger KA, Bourgeois I, Palyada K, Anderson KD, Brynczka C, Bhatt B, Chen F, Smith R, Amin R, Glaab WE, Lebron J, Cox K, Sistare FD.
PMID: 31406999
Toxicol Sci. 2019 Aug 12; doi: 10.1093/toxsci/kfz186. Epub 2019 Aug 12.

MK-7680, a cyclic nucleotide prodrug, caused significant kidney tubule injury in female rats when administered orally at 1000 mg/kg/day for 2 weeks using 10% Polysorbate 80 as vehicle. However, kidney injury was absent when MK-7680 was administered at the...

A Computable Definition of Sepsis Facilitates Screening and Performance Improvement Tracking.

Pediatric quality & safety

Alessi LJ, Warmus HR, Schaffner EK, Kantawala S, Carcillo J, Rosen J, Horvat CM.
PMID: 29732457
Pediatr Qual Saf. 2018 Mar;3(2):e067. doi: 10.1097/pq9.0000000000000067. Epub 2018 Apr 10.

BACKGROUND: Sepsis kills almost 5,000 children annually, accounting for 16% of pediatric health care spending in the United States.OBJECTIVES: We sought to identify sepsis within the Electronic Health Record (EHR) of a quaternary children's hospital to characterize disease incidence,...

Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer.

Frontiers in pharmacology

Kosgodage US, Mould R, Henley AB, Nunn AV, Guy GW, Thomas EL, Inal JM, Bell JD, Lange S.
PMID: 30150937
Front Pharmacol. 2018 Aug 13;9:889. doi: 10.3389/fphar.2018.00889. eCollection 2018.

Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with various pathologies, including cancer, where increased EMV release is amongst...

Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.

ACS medicinal chemistry letters

Chen HY, Plummer CW, Xiao D, Chobanian HR, DeMong D, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Di Salvo J, Thomas-Fowlkes B, Souza S, Tatosian DA, Chen Q, Hafey MJ, Houle R, Nolting AF, Orr R, Ehrhart J, Weinglass AB, Tschirret-Guth R, Howard AD, Colletti SL.
PMID: 30034601
ACS Med Chem Lett. 2018 Jun 14;9(7):685-690. doi: 10.1021/acsmedchemlett.8b00149. eCollection 2018 Jul 12.

A series of biaryl chromans exhibiting potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM) were discovered as potential therapeutics for the treatment of type II diabetes. Optimization of physicochemical properties through...

High quality chalcogenide-silica hybrid wedge resonator.

Optics express

Kang G, Krogstad MR, Grayson M, Kim DG, Lee H, Gopinath JT, Park W.
PMID: 28788980
Opt Express. 2017 Jun 26;25(13):15581-15589. doi: 10.1364/OE.25.015581.

Chalcogenide glasses, with high nonlinearity and low loss, have captured research interest as an integrated device platform for near- and mid-infrared nonlinear optical devices. Compared to silicon-based microfabrication technologies, chalcogenide fabrication processes are less mature and a major challenge...

Drug Repurposing for Duchenne Muscular Dystrophy: The Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in .

Frontiers in physiology

Vitiello L, Marabita M, Sorato E, Nogara L, Forestan G, Mouly V, Salviati L, Acosta M, Blaauw B, Canton M.
PMID: 30154729
Front Physiol. 2018 Aug 14;9:1087. doi: 10.3389/fphys.2018.01087. eCollection 2018.

Oxidative stress and mitochondrial dysfunction play a crucial role in the pathophysiology of muscular dystrophies. We previously reported that the mitochondrial enzyme monoamine oxidase (MAO) is a relevant source of reactive oxygen species (ROS) not only in murine models...

Transcriptome assembly and candidate genes involved in nutritional programming in the swordtail fish .

PeerJ

Lu Y, Klimovich CM, Robeson KZ, Boswell W, Ríos-Cardenas O, Walter RB, Morris MR.
PMID: 28480144
PeerJ. 2017 May 02;5:e3275. doi: 10.7717/peerj.3275. eCollection 2017.

BACKGROUND: Nutritional programming takes place in early development. Variation in the quality and/or quantity of nutrients in early development can influence long-term health and viability. However, little is known about the mechanisms of nutritional programming. The live-bearing fish METHODS:...

Augmented Cardiopulmonary Baroreflex Sensitivity in Intradialytic Hypertension.

Kidney international reports

Park SH, Fonkoue IT, Li Y, DaCosta DR, Middlekauff HR, Park J.
PMID: 30450466
Kidney Int Rep. 2018 Aug 17;3(6):1394-1402. doi: 10.1016/j.ekir.2018.07.025. eCollection 2018 Nov.

INTRODUCTION: End-stage renal disease (ESRD) patients with a paradoxical increase in blood pressure (BP) during hemodialysis (HD), termed intradialytic hypertension (ID-HTN), are at significantly increased risk for mortality and adverse cardiovascular events. ID-HTN affects up to 15% of all...

Simplified in vitro engineering of neuromuscular junctions between rat embryonic motoneurons and immortalized human skeletal muscle cells.

Stem cells and cloning : advances and applications

Saini J, Faroni A, Abd Al Samid M, Reid AJ, Lightfoot AP, Mamchaoui K, Mouly V, Butler-Browne G, McPhee JS, Degens H, Al-Shanti N.
PMID: 30863121
Stem Cells Cloning. 2019 Feb 20;12:1-9. doi: 10.2147/SCCAA.S187655. eCollection 2019.

BACKGROUND: Neuromuscular junctions (NMJs) consist of the presynaptic cholinergic motoneuron terminals and the corresponding postsynaptic motor endplates on skeletal muscle fibers. At the NMJ the action potential of the neuron leads, via release of acetylcholine, to muscle membrane depolarization...

Complete Measurement of the Λ Electromagnetic Form Factors.

Physical review letters

Ablikim M, Achasov MN, Adlarson P, Ahmed S, Albrecht M, Alekseev M, Amoroso A, An FF, An Q, Bai Y, Bakina O, Baldini Ferroli R, Ban Y, Begzsuren K, Bennett JV, Berger N, Bertani M, Bettoni D, Bianchi F, Biernat J, Bloms J, Boyko I, Briere RA, Cai H, Cai X, Calcaterra A, Cao GF, Cao N, Cetin SA, Chai J, Chang JF, Chang WL, Chelkov G, Chen DY, Chen G, Chen HS, Chen JC, Chen ML, Chen SJ, Chen YB, Cheng W, Cibinetto G, Cossio F, Cui XF, Dai HL, Dai JP, Dai XC, Dbeyssi A, Dedovich D, Deng ZY, Denig A, Denysenko I, Destefanis M, De Mori F, Ding Y, Dong C, Dong J, Dong LY, Dong MY, Dou ZL, Du SX, Fan JZ, Fang J, Fang SS, Fang Y, Farinelli R, Fava L, Feldbauer F, Felici G, Feng CQ, Fritsch M, Fu CD, Fu Y, Gao Q, Gao XL, Gao Y, Gao Y, Gao YG, Gao Z, Garillon B, Garzia I, Gersabeck EM, Gilman A, Goetzen K, Gong L, Gong WX, Gradl W, Greco M, Gu LM, Gu MH, Gu S, Gu YT, Guo AQ, Guo LB, Guo RP, Guo YP, Guskov A, Han S, Hao XQ, Harris FA, He KL, Heinsius FH, Held T, Heng YK, Hou YR, Hou ZL, Hu HM, Hu JF, Hu T, Hu Y, Huang GS, Huang JS, Huang XT, Huang XZ, Huesken N, Hussain T, Ikegami Andersson W, Imoehl W, Irshad M, Ji Q, Ji QP, Ji XB, Ji XL, Jiang HL, Jiang XS, Jiang XY, Jiao JB, Jiao Z, Jin DP, Jin S, Jin Y, Johansson T, Kalantar-Nayestanaki N, Kang XS, Kappert R, Kavatsyuk M, Ke BC, Keshk IK, Khan T, Khoukaz A, Kiese P, Kiuchi R, Kliemt R, Koch L, Kolcu OB, Kopf B, Kuemmel M, Kuessner M, Kupsc A, Kurth M, Kurth MG, Kühn W, Lange JS, Larin P, Lavezzi L, Leithoff H, Lenz T, Li C, Li C, Li DM, Li F, Li FY, Li G, Li HB, Li HJ, Li JC, Li JW, Li K, Li LK, Li L, Li PL, Li PR, Li QY, Li WD, Li WG, Li XH, Li XL, Li XN, Li XQ, Li ZB, Li ZY, Liang H, Liang H, Liang YF, Liang YT, Liao GR, Liao LZ, Libby J, Lin CX, Lin DX, Lin YJ, Liu B, Liu BJ, Liu CX, Liu D, Liu DY, Liu FH, Liu F, Liu F, Liu HB, Liu HM, Liu H, Liu H, Liu JB, Liu JY, Liu KY, Liu K, Liu Q, Liu SB, Liu T, Liu X, Liu XY, Liu YB, Liu ZA, Liu Z, Long YF, Lou XC, Lu HJ, Lu JD, Lu JG, Lu Y, Lu YP, Luo CL, Luo MX, Luo PW, Luo T, Luo XL, Lusso S, Lyu XR, Ma FC, Ma HL, Ma LL, Ma MM, Ma QM, Ma XN, Ma XX, Ma XY, Ma YM, Maas FE, Maggiora M, Maldaner S, Malde S, Malik QA, Mangoni A, Mao YJ, Mao ZP, Marcello S, Meng ZX, Messchendorp JG, Mezzadri G, Min J, Min TJ, Mitchell RE, Mo XH, Mo YJ, Morales Morales C, Muchnoi NY, Muramatsu H, Mustafa A, Nakhoul S, Nefedov Y, Nerling F, Nikolaev IB, Ning Z, Nisar S, Niu SL, Olsen SL, Ouyang Q, Pacetti S, Pan Y, Papenbrock M, Patteri P, Pelizaeus M, Peng HP, Peters K, Pettersson J, Ping JL, Ping RG, Pitka A, Poling R, Prasad V, Qi M, Qi TY, Qian S, Qiao CF, Qin N, Qin XP, Qin XS, Qin ZH, Qiu JF, Qu SQ, Rashid KH, Redmer CF, Richter M, Ripka M, Rivetti A, Rodin V, Rolo M, Rong G, Rosner C, Rump M, Sarantsev A, Savrié M, Schoenning K, Shan W, Shan XY, Shao M, Shen CP, Shen PX, Shen XY, Sheng HY, Shi X, Shi XD, Song JJ, Song QQ, Song XY, Sosio S, Sowa C, Spataro S, Sui FF, Sun GX, Sun JF, Sun L, Sun SS, Sun XH, Sun YJ, Sun YK, Sun YZ, Sun ZJ, Sun ZT, Tan YT, Tang CJ, Tang GY, Tang X, Thoren V, Tsednee B, Uman I, Wang B, Wang BL, Wang CW, Wang DY, Wang HH, Wang K, Wang LL, Wang LS, Wang M, Wang MZ, Wang M, Wang PL, Wang RM, Wang WP, Wang X, Wang XF, Wang XL, Wang Y, Wang Y, Wang YF, Wang Z, Wang ZG, Wang ZY, Wang Z, Weber T, Wei DH, Weidenkaff P, Wen HW, Wen SP, Wiedner U, Wilkinson G, Wolke M, Wu LH, Wu LJ, Wu Z, Xia L, Xia Y, Xiao SY, Xiao YJ, Xiao ZJ, Xie YG, Xie YH, Xing TY, Xiong XA, Xiu QL, Xu GF, Xu JJ, Xu L, Xu QJ, Xu W, Xu XP, Yan F, Yan L, Yan WB, Yan WC, Yan YH, Yang HJ, Yang HX, Yang L, Yang RX, Yang SL, Yang YH, Yang YX, Yang Y, Yang ZQ, Ye M, Ye MH, Yin JH, You ZY, Yu BX, Yu CX, Yu JS, Yuan CZ, Yuan XQ, Yuan Y, Yuncu A, Zafar AA, Zeng Y, Zhang BX, Zhang BY, Zhang CC, Zhang DH, Zhang HH, Zhang HY, Zhang J, Zhang JL, Zhang JQ, Zhang JW, Zhang JY, Zhang JZ, Zhang K, Zhang L, Zhang SF, Zhang TJ, Zhang XY, Zhang Y, Zhang YH, Zhang YT, Zhang Y, Zhang Y, Zhang Y, Zhang Y, Zhang ZH, Zhang ZP, Zhang ZY, Zhao G, Zhao JW, Zhao JY, Zhao JZ, Zhao L, Zhao L, Zhao MG, Zhao Q, Zhao SJ, Zhao TC, Zhao YB, Zhao ZG, Zhemchugov A, Zheng B, Zheng JP, Zheng Y, Zheng YH, Zhong B, Zhou L, Zhou LP, Zhou Q, Zhou X, Zhou XK, Zhou XR, Zhou X, Zhou X, Zhu AN, Zhu J, Zhu J, Zhu K, Zhu KJ, Zhu SH, Zhu WJ, Zhu XL, Zhu YC, Zhu YS, Zhu ZA, Zhuang J, Zou BS, Zou JH.
PMID: 31633986
Phys Rev Lett. 2019 Sep 20;123(12):122003. doi: 10.1103/PhysRevLett.123.122003.

The exclusive process e^{+}e^{-}→ΛΛ[over ¯], with Λ→pπ^{-} and Λ[over ¯]→p[over ¯]π^{+}, has been studied at sqrt[s]=2.396  GeV for measurement of the timelike Λ electric and magnetic form factors, G_{E} and G_{M}. A data sample, corresponding to an integrated luminosity...

Harnessing centred identity transformation to reduce executive function burden for maintenance of health behaviour change: the Maintain IT model.

Health psychology review

Caldwell AE, Masters KS, Peters JC, Bryan AD, Grigsby J, Hooker SA, Wyatt HR, Hill JO.
PMID: 29402182
Health Psychol Rev. 2018 Sep;12(3):231-253. doi: 10.1080/17437199.2018.1437551. Epub 2018 Feb 19.

The inability to produce sustainable lifestyle modifications (e.g., physical activity, healthy diet) remains a major barrier to reducing morbidity and mortality from prevalent, preventable conditions. The objective of this paper is to present a model that builds on and...

Showing 13 to 24 of 372 entries