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Flow Dominance and Factorization of Transverse Momentum Correlations in Pb-Pb Collisions at the LHC.

Physical review letters

Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad S, Ahn SU, Aiola S, Akindinov A, Alam SN, Albuquerque DSD, Aleksandrov D, Alessandro B, Alexandre D, Alfaro Molina R, Alici A, Alkin A, Alme J, Alt T, Altinpinar S, Altsybeev I, Alves Garcia Prado C, An M, Andrei C, Andrews HA, Andronic A, Anguelov V, Anson C, Antičić T, Antinori F, Antonioli P, Anwar R, Aphecetche L, Appelshäuser H, Arcelli S, Arnaldi R, Arnold OW, Arsene IC, Arslandok M, Audurier B, Augustinus A, Averbeck R, Azmi MD, Badalà A, Baek YW, Bagnasco S, Bailhache R, Bala R, Baldisseri A, Baral RC, Barbano AM, Barbera R, Barile F, Barioglio L, Barnaföldi GG, Barnby LS, Barret V, Bartalini P, Barth K, Bartke J, Bartsch E, Basile M, Bastid N, Basu S, Bathen B, Batigne G, Batista Camejo A, Batyunya B, Batzing PC, Bearden IG, Beck H, Bedda C, Behera NK, Belikov I, Bellini F, Bello Martinez H, Bellwied R, Beltran LGE, Belyaev V, Bencedi G, Beole S, Bercuci A, Berdnikov Y, Berenyi D, Bertens RA, Berzano D, Betev L, Bhasin A, Bhat IR, Bhati AK, Bhattacharjee B, Bhom J, Bianchi L, Bianchi N, Bianchin C, Bielčík J, Bielčíková J, Bilandzic A, Biro G, Biswas R, Biswas S, Blair JT, Blau D, Blume C, Bock F, Bogdanov A, Boldizsár L, Bombara M, Bonora M, Book J, Borel H, Borissov A, Borri M, Botta E, Bourjau C, Braun-Munzinger P, Bregant M, Broker TA, Browning TA, Broz M, Brucken EJ, Bruna E, Bruno GE, Budnikov D, Buesching H, Bufalino S, Buhler P, Buitron SAI, Buncic P, Busch O, Buthelezi Z, Butt JB, Buxton JT, Cabala J, Caffarri D, Caines H, Caliva A, Calvo Villar E, Camerini P, Capon AA, Carena F, Carena W, Carnesecchi F, Castillo Castellanos J, Castro AJ, Casula EAR, Ceballos Sanchez C, Cerello P, Cerkala J, Chang B, Chapeland S, Chartier M, Charvet JL, Chattopadhyay S, Chattopadhyay S, Chauvin A, Cherney M, Cheshkov C, Cheynis B, Chibante Barroso V, Chinellato DD, Cho S, Chochula P, Choi K, Chojnacki M, Choudhury S, Christakoglou P, Christensen CH, Christiansen P, Chujo T, Chung SU, Cicalo C, Cifarelli L, Cindolo F, Cleymans J, Colamaria F, Colella D, Collu A, Colocci M, Conesa Balbastre G, Conesa Del Valle Z, Connors ME, Contreras JG, Cormier TM, Corrales Morales Y, Cortés Maldonado I, Cortese P, Cosentino MR, Costa F, Crkovská J, Crochet P, Cruz Albino R, Cuautle E, Cunqueiro L, Dahms T, Dainese A, Danisch MC, Danu A, Das D, Das I, Das S, Dash A, Dash S, De S, De Caro A, de Cataldo G, de Conti C, de Cuveland J, De Falco A, De Gruttola D, De Marco N, De Pasquale S, De Souza RD, Degenhardt HF, Deisting A, Deloff A, Deplano C, Dhankher P, Di Bari D, Di Mauro A, Di Nezza P, Di Ruzza B, Diaz Corchero MA, Dietel T, Dillenseger P, Divià R, Djuvsland Ø, Dobrin A, Domenicis Gimenez D, Dönigus B, Dordic O, Drozhzhova T, Dubey AK, Dubla A, Ducroux L, Duggal AK, Dupieux P, Ehlers RJ, Elia D, Endress E, Engel H, Epple E, Erazmus B, Erhardt F, Espagnon B, Esumi S, Eulisse G, Eum J, Evans D, Evdokimov S, Fabbietti L, Fabris D, Faivre J, Fantoni A, Fasel M, Feldkamp L, Feliciello A, Feofilov G, Ferencei J, Fernández Téllez A, Ferreiro EG, Ferretti A, Festanti A, Feuillard VJG, Figiel J, Figueredo MAS, Filchagin S, Finogeev D, Fionda FM, Fiore EM, Floris M, Foertsch S, Foka P, Fokin S, Fragiacomo E, Francescon A, Francisco A, Frankenfeld U, Fronze GG, Fuchs U, Furget C, Furs A, Fusco Girard M, Gaardhøje JJ, Gagliardi M, Gago AM, Gajdosova K, Gallio M, Galvan CD, Gangadharan DR, Ganoti P, Gao C, Garabatos C, Garcia-Solis E, Garg K, Garg P, Gargiulo C, Gasik P, Gauger EF, Gay Ducati MB, Germain M, Ghosh P, Ghosh SK, Gianotti P, Giubellino P, Giubilato P, Gladysz-Dziadus E, Glässel P, Goméz Coral DM, Gomez Ramirez A, Gonzalez AS, Gonzalez V, González-Zamora P, Gorbunov S, Görlich L, Gotovac S, Grabski V, Graczykowski LK, Graham KL, Greiner L, Grelli A, Grigoras C, Grigoriev V, Grigoryan A, Grigoryan S, Grion N, Gronefeld JM, Grosa F, Grosse-Oetringhaus JF, Grosso R, Gruber L, Grull FR, Guber F, Guernane R, Guerzoni B, Gulbrandsen K, Gunji T, Gupta A, Gupta R, Guzman IB, Haake R, Hadjidakis C, Hamagaki H, Hamar G, Hamon JC, Harris JW, Harton A, Hatzifotiadou D, Hayashi S, Heckel ST, Hellbär E, Helstrup H, Herghelegiu A, Herrera Corral G, Herrmann F, Hess BA, Hetland KF, Hillemanns H, Hippolyte B, Hladky J, Horak D, Hosokawa R, Hristov P, Hughes C, Humanic TJ, Hussain N, Hussain T, Hutter D, Hwang DS, Ilkaev R, Inaba M, Ippolitov M, Irfan M, Isakov V, Islam MS, Ivanov M, Ivanov V, Izucheev V, Jacak B, Jacazio N, Jacobs PM, Jadhav MB, Jadlovska S, Jadlovsky J, Jahnke C, Jakubowska MJ, Janik MA, Jayarathna PHSY, Jena C, Jena S, Jercic M, Jimenez Bustamante RT, Jones PG, Jusko A, Kalinak P, Kalweit A, Kang JH, Kaplin V, Kar S, Karasu Uysal A, Karavichev O, Karavicheva T, Karayan L, Karpechev E, Kebschull U, Keidel R, Keijdener DLD, Keil M, Mohisin Khan M, Khan P, Khan SA, Khanzadeev A, Kharlov Y, Khatun A, Khuntia A, Kielbowicz MM, Kileng B, Kim DW, Kim DJ, Kim D, Kim H, Kim JS, Kim J, Kim M, Kim M, Kim S, Kim T, Kirsch S, Kisel I, Kiselev S, Kisiel A, Kiss G, Klay JL, Klein C, Klein J, Klein-Bösing C, Klewin S, Kluge A, Knichel ML, Knospe AG, Kobdaj C, Kofarago M, Kollegger T, Kolojvari A, Kondratiev V, Kondratyeva N, Kondratyuk E, Konevskikh A, Kopcik M, Kour M, Kouzinopoulos C, Kovalenko O, Kovalenko V, Kowalski M, Koyithatta Meethaleveedu G, Králik I, Kravčáková A, Krivda M, Krizek F, Kryshen E, Krzewicki M, Kubera AM, Kučera V, Kuhn C, Kuijer PG, Kumar A, Kumar J, Kumar L, Kumar S, Kundu S, Kurashvili P, Kurepin A, Kurepin AB, Kuryakin A, Kushpil S, Kweon MJ, Kwon Y, La Pointe SL, La Rocca P, Lagana Fernandes C, Lakomov I, Langoy R, Lapidus K, Lara C, Lardeux A, Lattuca A, Laudi E, Lavicka R, Lazaridis L, Lea R, Leardini L, Lee S, Lehas F, Lehner S, Lehrbach J, Lemmon RC, Lenti V, Leogrande E, León Monzón I, Lévai P, Li S, Li X, Lien J, Lietava R, Lindal S, Lindenstruth V, Lippmann C, Lisa MA, Litichevskyi V, Ljunggren HM, Llope WJ, Lodato DF, Loenne PI, Loginov V, Loizides C, Loncar P, Lopez X, López Torres E, Lowe A, Luettig P, Lunardon M, Luparello G, Lupi M, Lutz TH, Maevskaya A, Mager M, Mahajan S, Mahmood SM, Maire A, Majka RD, Malaev M, Maldonado Cervantes I, Malinina L, Mal'Kevich D, Malzacher P, Mamonov A, Manko V, Manso F, Manzari V, Mao Y, Marchisone M, Mareš J, Margagliotti GV, Margotti A, Margutti J, Marín A, Markert C, Marquard M, Martin NA, Martinengo P, Martinez JAL, Martínez MI, Martínez García G, Martinez Pedreira M, Mas A, Masciocchi S, Masera M, Masoni A, Mastroserio A, Mathis AM, Matyja A, Mayer C, Mazer J, Mazzilli M, Mazzoni MA, Meddi F, Melikyan Y, Menchaca-Rocha A, Meninno E, Mercado Pérez J, Meres M, Mhlanga S, Miake Y, Mieskolainen MM, Mihaylov D, Mikhaylov K, Milano L, Milosevic J, Mischke A, Mishra AN, Mishra T, Miśkowiec D, Mitra J, Mitu CM, Mohammadi N, Mohanty B, Montes E, Moreira De Godoy DA, Moreno LAP, Moretto S, Morreale A, Morsch A, Muccifora V, Mudnic E, Mühlheim D, Muhuri S, Mukherjee M, Mulligan JD, Munhoz MG, Münning K, Munzer RH, Murakami H, Murray S, Musa L, Musinsky J, Myers CJ, Naik B, Nair R, Nandi BK, Nania R, Nappi E, Naru MU, Natal da Luz H, Nattrass C, Navarro SR, Nayak K, Nayak R, Nayak TK, Nazarenko S, Nedosekin A, Negrao De Oliveira RA, Nellen L, Nesbo SV, Ng F, Nicassio M, Niculescu M, Niedziela J, Nielsen BS, Nikolaev S, Nikulin S, Nikulin V, Noferini F, Nomokonov P, Nooren G, Noris JCC, Norman J, Nyanin A, Nystrand J, Oeschler H, Oh S, Ohlson A, Okubo T, Olah L, Oleniacz J, Oliveira Da Silva AC, Oliver MH, Onderwaater J, Oppedisano C, Orava R, Oravec M, Ortiz Velasquez A, Oskarsson A, Otwinowski J, Oyama K, Ozdemir M, Pachmayer Y, Pacik V, Pagano D, Pagano P, Paić G, Pal SK, Palni P, Pan J, Pandey AK, Panebianco S, Papikyan V, Pappalardo GS, Pareek P, Park J, Park WJ, Parmar S, Passfeld A, Paticchio V, Patra RN, Paul B, Pei H, Peitzmann T, Peng X, Pereira LG, Pereira Da Costa H, Peresunko D, Perez Lezama E, Peskov V, Pestov Y, Petráček V, Petrov V, Petrovici M, Petta C, Pezzi RP, Piano S, Pikna M, Pillot P, Pimentel LODL, Pinazza O, Pinsky L, Piyarathna DB, Płoskoń M, Planinic M, Pluta J, Pochybova S, Podesta-Lerma PLM, Poghosyan MG, Polichtchouk B, Poljak N, Poonsawat W, Pop A, Poppenborg H, Porteboeuf-Houssais S, Porter J, Pospisil J, Pozdniakov V, Prasad SK, Preghenella R, Prino F, Pruneau CA, Pshenichnov I, Puccio M, Puddu G, Pujahari P, Punin V, Putschke J, Qvigstad H, Rachevski A, Raha S, Rajput S, Rak J, Rakotozafindrabe A, Ramello L, Rami F, Rana DB, Raniwala R, Raniwala S, Räsänen SS, Rascanu BT, Rathee D, Ratza V, Ravasenga I, Read KF, Redlich K, Rehman A, Reichelt P, Reidt F, Ren X, Renfordt R, Reolon AR, Reshetin A, Reygers K, Riabov V, Ricci RA, Richert T, Richter M, Riedler P, Riegler W, Riggi F, Ristea C, Rodríguez Cahuantzi M, Røed K, Rogochaya E, Rohr D, Röhrich D, Ronchetti F, Ronflette L, Rosnet P, Rossi A, Roukoutakis F, Roy A, Roy C, Roy P, Rubio Montero AJ, Rui R, Russo R, Ryabinkin E, Ryabov Y, Rybicki A, Saarinen S, Sadhu S, Sadovsky S, Šafařík K, Sahlmuller B, Sahoo B, Sahoo P, Sahoo R, Sahoo S, Sahu PK, Saini J, Sakai S, Saleh MA, Salzwedel J, Sambyal S, Samsonov V, Sandoval A, Sarkar D, Sarkar N, Sarma P, Sas MHP, Scapparone E, Scarlassara F, Scharenberg RP, Schiaua C, Schicker R, Schmidt C, Schmidt HR, Schmidt MO, Schmidt M, Schukraft J, Schutz Y, Schwarz K, Schweda K, Scioli G, Scomparin E, Scott R, Šefčík M, Seger JE, Sekiguchi Y, Sekihata D, Selyuzhenkov I, Senosi K, Senyukov S, Serradilla E, Sett P, Sevcenco A, Shabanov A, Shabetai A, Shadura O, Shahoyan R, Shangaraev A, Sharma A, Sharma A, Sharma M, Sharma M, Sharma N, Sheikh AI, Shigaki K, Shou Q, Shtejer K, Sibiriak Y, Siddhanta S, Sielewicz KM, Siemiarczuk T, Silvermyr D, Silvestre C, Simatovic G, Simonetti G, Singaraju R, Singh R, Singhal V, Sinha T, Sitar B, Sitta M, Skaali TB, Slupecki M, Smirnov N, Snellings RJM, Snellman TW, Song J, Song M, Soramel F, Sorensen S, Sozzi F, Spiriti E, Sputowska I, Srivastava BK, Stachel J, Stan I, Stankus P, Stenlund E, Stiller JH, Stocco D, Strmen P, Suaide AAP, Sugitate T, Suire C, Suleymanov M, Suljic M, Sultanov R, Šumbera M, Sumowidagdo S, Suzuki K, Swain S, Szabo A, Szarka I, Szczepankiewicz A, Szymanski M, Tabassam U, Takahashi J, Tambave GJ, Tanaka N, Tarhini M, Tariq M, Tarzila MG, Tauro A, Tejeda Muñoz G, Telesca A, Terasaki K, Terrevoli C, Teyssier B, Thakur D, Thomas D, Tieulent R, Tikhonov A, Timmins AR, Toia A, Tripathy S, Trogolo S, Trombetta G, Trubnikov V, Trzaska WH, Trzeciak BA, Tsuji T, Tumkin A, Turrisi R, Tveter TS, Ullaland K, Umaka EN, Uras A, Usai GL, Utrobicic A, Vala M, Van Der Maarel J, Van Hoorne JW, van Leeuwen M, Vanat T, Vande Vyvre P, Varga D, Vargas A, Vargyas M, Varma R, Vasileiou M, Vasiliev A, Vauthier A, Vázquez Doce O, Vechernin V, Veen AM, Velure A, Vercellin E, Vergara Limón S, Vernet R, Vértesi R, Vickovic L, Vigolo S, Viinikainen J, Vilakazi Z, Villalobos Baillie O, Villatoro Tello A, Vinogradov A, Vinogradov L, Virgili T, Vislavicius V, Vodopyanov A, Völkl MA, Voloshin K, Voloshin SA, Volpe G, von Haller B, Vorobyev I, Voscek D, Vranic D, Vrláková J, Wagner B, Wagner J, Wang H, Wang M, Watanabe D, Watanabe Y, Weber M, Weber SG, Weiser DF, Wessels JP, Westerhoff U, Whitehead AM, Wiechula J, Wikne J, Wilk G, Wilkinson J, Willems GA, Williams MCS, Windelband B, Witt WE, Yalcin S, Yang P, Yano S, Yin Z, Yokoyama H, Yoo IK, Yoon JH, Yurchenko V, Zaccolo V, Zaman A, Zampolli C, Zanoli HJC, Zaporozhets S, Zardoshti N, Zarochentsev A, Závada P, Zaviyalov N, Zbroszczyk H, Zhalov M, Zhang H, Zhang X, Zhang Y, Zhang C, Zhang Z, Zhao C, Zhigareva N, Zhou D, Zhou Y, Zhou Z, Zhu H, Zhu J, Zhu X, Zichichi A, Zimmermann A, Zimmermann MB, Zimmermann S, Zinovjev G, Zmeskal J.
PMID: 28474923
Phys Rev Lett. 2017 Apr 21;118(16):162302. doi: 10.1103/PhysRevLett.118.162302. Epub 2017 Apr 21.

We present the first measurement of the two-particle transverse momentum differential correlation function, P_{2}≡⟨Δp_{T}Δp_{T}⟩/⟨p_{T}⟩^{2}, in Pb-Pb collisions at sqrt[s_{NN}]=2.76  TeV. Results for P_{2} are reported as a function of the relative pseudorapidity (Δη) and azimuthal angle (Δφ) between two...

Gelatinase-a/mmp-2 serum levels and neoplastic progression in breast-cancer patients.

International journal of oncology

Leone A, Correale M, Dragone C, Paradiso A, Delena M, Stetlerstevenson W, Liotta L, Masiero L, Garbisa S.
PMID: 21566957
Int J Oncol. 1994 Mar;4(3):551-4. doi: 10.3892/ijo.4.3.551.

The metastatic potential of cancer cells has been associated to their ability to elaborate and secrete basement membrane degradative enzymes. In this process a major role appears to be played by a protease known as gelatinase A (72 kDa...

Local allergic rhinitis: entopy or spontaneous response?.

The World Allergy Organization journal

Gelardi M, Guglielmi AV, Iannuzzi L, Quaranta VN, Quaranta N, Landi M, Correale M, Sonnante A, Rossini M, Mariggiò MA, Canonica GW, Passalacqua G.
PMID: 27980704
World Allergy Organ J. 2016 Dec 06;9(1):39. doi: 10.1186/s40413-016-0126-z. eCollection 2016.

BACKGROUND: The existence of a local allergic rhintis was proposed on the basis of the detection of nasal IgE in the absence of a systemic sensitization. Nevertheless, the significance of this phenomenon remains still unclear. We assessed the presence...

H-magnetic resonance spectroscopy: diagnostic tool in recurrent headache in systemic lupus erythematosus. A case report.

Radiology case reports

Tinelli E, Pontecorvo S, Morreale M, Caramia F, Francia A.
PMID: 30425768
Radiol Case Rep. 2018 Nov 06;14(2):175-178. doi: 10.1016/j.radcr.2018.10.020. eCollection 2019 Feb.

We describe serial MR-spectroscopy studies in a patient with systemic lupus erythematosus and headache. We used MR-spectroscopy to monitor disease activity during periods with and without headache. MR-spectroscopy investigates metabolic alterations and was used to explore the pathophysiological mechanism...

Radiomics predicts survival of patients with advanced non-small cell lung cancer undergoing PD-1 blockade using Nivolumab.

Oncology letters

Nardone V, Tini P, Pastina P, Botta C, Reginelli A, Carbone SF, Giannicola R, Calabrese G, Tebala C, Guida C, Giudice A, Barbieri V, Tassone P, Tagliaferri P, Cappabianca S, Capasso R, Luce A, Caraglia M, Mazzei MA, Pirtoli L, Correale P.
PMID: 31966081
Oncol Lett. 2020 Feb;19(2):1559-1566. doi: 10.3892/ol.2019.11220. Epub 2019 Dec 16.

Immune checkpoint blockade is an emerging anticancer strategy, and Nivolumab is a human mAb to PD-1 that is used in the treatment of a number of different malignancies, including non-small cell lung cancer (NSCLC), kidney cancer, urothelial carcinoma and...

Don't stop at first glance: pulmonary artery angiosarcoma mimicking chronic thromboembolic pulmonary hypertension.

Pulmonary circulation

Correale M, Tarantino N, Ieva R, Gravina M, Casavecchia G, Strazzella C, Di Biase M, Brunetti ND.
PMID: 29873586
Pulm Circ. 2018 Jul-Sep;8(3):2045894018785047. doi: 10.1177/2045894018785047. Epub 2018 Jun 06.

We report the case of an incomplete diagnosis of chronic thromboembolic pulmonary hypertension, with relevant prognostic implications, missing the presence of a primary pulmonary artery angiosarcoma. After the late neoplasm diagnosis, the patient, treated for months with riociguat, was...

Acting centrally or peripherally: A renewed interest in the central nervous system penetration of disease-modifying drugs in multiple sclerosis.

Multiple sclerosis and related disorders

Correale J, Halfon MJ, Jack D, Rubstein A, Villa A.
PMID: 34547609
Mult Scler Relat Disord. 2021 Nov;56:103264. doi: 10.1016/j.msard.2021.103264. Epub 2021 Sep 14.

With the recent approval of cladribine tablets, siponimod and ozanimod, there has been a renewed interest into the extent to which these current generation disease-modifying therapies (DMTs) are able to cross into the central nervous system (CNS), and how...

The central vein sign is present in most infratentorial multiple sclerosis plaques.

Multiple sclerosis and related disorders

Gaitán MI, Paday Formenti ME, Calandri I, Ysrraelit MC, Yañez P, Correale J.
PMID: 35007822
Mult Scler Relat Disord. 2022 Jan 03;58:103484. doi: 10.1016/j.msard.2021.103484. Epub 2022 Jan 03.

BACKGROUND AND PURPOSE: There is growing evidence supporting the presence of the central vein sign (CVS) in the supratentorial brain as an imaging biomarker for multiple sclerosis (MS) diagnosis. Recently, using optimized susceptibility-weighted angiography (SWAN-venule), we detected CVS in...

The Evolving Phenotypes of Cardiovascular Disease during COVID-19 Pandemic.

Cardiovascular drugs and therapy

Correale M, Croella F, Leopizzi A, Mazzeo P, Tricarico L, Mallardi A, Fortunato M, Magnesa M, Ceci V, Puteo A, Iacoviello M, Di Biase M, Brunetti ND.
PMID: 34328581
Cardiovasc Drugs Ther. 2021 Jul 30; doi: 10.1007/s10557-021-07217-8. Epub 2021 Jul 30.

COVID-19 pandemic has negatively impacted the management of patients with acute and chronic cardiovascular disease: acute coronary syndrome patients were often not timely reperfused, heart failure patients not adequately followed up and titrated, atrial arrhythmias not efficaciously treated and...

Case Report: Can Inhaled Adenosine Attenuate COVID-19?.

Frontiers in pharmacology

Spiess BD, Sitkovsky M, Correale P, Gravenstein N, Garvan C, Morey TE, Fahy BG, Hendeles L, Pliura TJ, Martin TD, Wu V, Astrom C, Nelson DS.
PMID: 34434105
Front Pharmacol. 2021 Aug 09;12:676577. doi: 10.3389/fphar.2021.676577. eCollection 2021.

This case report demonstrates a small repetition of the case series carried out in Italy wherein inhaled adenosine was administered to patients experiencing severe and worsening coronavirus disease-2019 (COVID-19). The two cases are important not only because they were...

Psychiatry's Identity: Scope, Complexity, and Humility.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

Brenner AM, Coverdale J, Morreale MK, Guerrero APS, Aggarwal R, Balon R, Beresin EV, Louie AK.
PMID: 33580880
Acad Psychiatry. 2021 Apr;45(2):137-141. doi: 10.1007/s40596-021-01412-3.

No abstract available.

Mechanisms of Immune Evasion in Multiple Myeloma: Open Questions and Therapeutic Opportunities.

Cancers

Botta C, Mendicino F, Martino EA, Vigna E, Ronchetti D, Correale P, Morabito F, Neri A, Gentile M.
PMID: 34203150
Cancers (Basel). 2021 Jun 28;13(13). doi: 10.3390/cancers13133213.

Multiple myeloma (MM) is the second most common hematologic malignancy, characterized by a multi-step evolutionary path, which starts with an early asymptomatic stage, defined as monoclonal gammopathy of undetermined significance (MGUS) evolving to overt disease in 1% of cases...

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