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Whole-exome sequencing and human leukocyte antigen analysis in familial myasthenia gravis with thymoma: Case report and literature review.

Clinical neurology and neurosurgery

Nakamura Y, Sato H, Miyano Y, Murakami R, Motoki M, Shigekiyo T, Sugino M, Arawaka S.
PMID: 34388596
Clin Neurol Neurosurg. 2021 Sep;208:106864. doi: 10.1016/j.clineuro.2021.106864. Epub 2021 Aug 03.

Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neurotransmission at the neuromuscular junction. MG is generally non-inherited but is rarely inherited. Here, we report two patients with MG in the same pedigree: a 62-year-old Japanese man and...

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Nakamura Y, Sato H, Miyano Y, et al. Whole-exome sequencing and human leukocyte antigen analysis in familial myasthenia gravis with thymoma: Case report and literature review. Clin Neurol Neurosurg. 2021;208:106864doi: 10.1016/j.clineuro.2021.106864.
Nakamura, Y., Sato, H., Miyano, Y., Murakami, R., Motoki, M., Shigekiyo, T., Sugino, M., & Arawaka, S. (2021). Whole-exome sequencing and human leukocyte antigen analysis in familial myasthenia gravis with thymoma: Case report and literature review. Clinical neurology and neurosurgery, 208106864. https://doi.org/10.1016/j.clineuro.2021.106864
Nakamura, Yoshitsugu, et al. "Whole-exome sequencing and human leukocyte antigen analysis in familial myasthenia gravis with thymoma: Case report and literature review." Clinical neurology and neurosurgery vol. 208 (2021): 106864. doi: https://doi.org/10.1016/j.clineuro.2021.106864
Nakamura Y, Sato H, Miyano Y, Murakami R, Motoki M, Shigekiyo T, Sugino M, Arawaka S. Whole-exome sequencing and human leukocyte antigen analysis in familial myasthenia gravis with thymoma: Case report and literature review. Clin Neurol Neurosurg. 2021 Sep;208:106864. doi: 10.1016/j.clineuro.2021.106864. Epub 2021 Aug 03. PMID: 34388596.
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Comparison of Brachial Blood Pressure and Central Blood Pressure in Attended, Unattended, and Unattended Standing Situations.

Hypertension research : official journal of the Japanese Society of Hypertension

Mizuno H, Hoshide S, Yano Y, Nozue R, Kario K.
PMID: 34331029
Hypertens Res. 2021 Oct;44(10):1283-1290. doi: 10.1038/s41440-021-00694-2. Epub 2021 Jul 30.

Central systolic blood pressure (cSBP) is an independent predictor of future cardiovascular disease. Unattended brachial SBP (bSBP) can eliminate the white-coat effect. However, unattended cSBP and unattended standing cSBP have never been reported. We aimed to compare bSBP and...

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Mizuno H, Hoshide S, Yano Y, et al. Comparison of Brachial Blood Pressure and Central Blood Pressure in Attended, Unattended, and Unattended Standing Situations. Hypertens Res. 2021;44(10):1283-1290doi: 10.1038/s41440-021-00694-2.
Mizuno, H., Hoshide, S., Yano, Y., Nozue, R., & Kario, K. (2021). Comparison of Brachial Blood Pressure and Central Blood Pressure in Attended, Unattended, and Unattended Standing Situations. Hypertension research : official journal of the Japanese Society of Hypertension, 44(10), 1283-1290. https://doi.org/10.1038/s41440-021-00694-2
Mizuno, Hiroyuki, et al. "Comparison of Brachial Blood Pressure and Central Blood Pressure in Attended, Unattended, and Unattended Standing Situations." Hypertension research : official journal of the Japanese Society of Hypertension vol. 44,10 (2021): 1283-1290. doi: https://doi.org/10.1038/s41440-021-00694-2
Mizuno H, Hoshide S, Yano Y, Nozue R, Kario K. Comparison of Brachial Blood Pressure and Central Blood Pressure in Attended, Unattended, and Unattended Standing Situations. Hypertens Res. 2021 Oct;44(10):1283-1290. doi: 10.1038/s41440-021-00694-2. Epub 2021 Jul 30. PMID: 34331029.
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Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Kohno Y, Koga H, Ozeki N, Matsuda J, Mizuno M, Katano H, Sekiya I.
PMID: 34314533
J Orthop Res. 2021 Jul 27; doi: 10.1002/jor.25146. Epub 2021 Jul 27.

The recently developed arthroscopic centralization for lateral meniscal extrusion has obtained satisfactory short-term clinical and radiological results and improves the meniscus biomechanical properties. However, the effectiveness of treatment for meniscus extrusion after partial meniscectomy still requires elucidation. This study...

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Kohno Y, Koga H, Ozeki N, et al. Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints. J Orthop Res. 2021;doi: 10.1002/jor.25146.
Kohno, Y., Koga, H., Ozeki, N., Matsuda, J., Mizuno, M., Katano, H., & Sekiya, I. (2021). Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, . https://doi.org/10.1002/jor.25146
Kohno, Yuji, et al. "Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints." Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol. (2021). doi: https://doi.org/10.1002/jor.25146
Kohno Y, Koga H, Ozeki N, Matsuda J, Mizuno M, Katano H, Sekiya I. Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints. J Orthop Res. 2021 Jul 27; doi: 10.1002/jor.25146. Epub 2021 Jul 27. PMID: 34314533.
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Astronauts well-being and possibly anti-aging improved during long-duration spaceflight.

Scientific reports

Otsuka K, Cornelissen G, Furukawa S, Kubo Y, Shibata K, Mizuno K, Ohshima H, Mukai C.
PMID: 34290387
Sci Rep. 2021 Jul 21;11(1):14907. doi: 10.1038/s41598-021-94478-w.

This study assesses how circadian rhythms of heart rate (HR), HR variability (HRV) and activity change during long-term missions in space and how they relate to sleep quality. Ambulatory 48-h ECG and 96-h actigraphy were performed four times on...

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Otsuka K, Cornelissen G, Furukawa S, et al. Astronauts well-being and possibly anti-aging improved during long-duration spaceflight. Sci Rep. 2021;11(1):14907doi: 10.1038/s41598-021-94478-w.
Otsuka, K., Cornelissen, G., Furukawa, S., Kubo, Y., Shibata, K., Mizuno, K., Ohshima, H., & Mukai, C. (2021). Astronauts well-being and possibly anti-aging improved during long-duration spaceflight. Scientific reports, 11(1), 14907. https://doi.org/10.1038/s41598-021-94478-w
Otsuka, Kuniaki, et al. "Astronauts well-being and possibly anti-aging improved during long-duration spaceflight." Scientific reports vol. 11,1 (2021): 14907. doi: https://doi.org/10.1038/s41598-021-94478-w
Otsuka K, Cornelissen G, Furukawa S, Kubo Y, Shibata K, Mizuno K, Ohshima H, Mukai C. Astronauts well-being and possibly anti-aging improved during long-duration spaceflight. Sci Rep. 2021 Jul 21;11(1):14907. doi: 10.1038/s41598-021-94478-w. PMID: 34290387; PMCID: PMC8295322.
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Optimal surgical treatment for paratesticular leiomyosarcoma: retrospective analysis of 217 reported cases.

BMC cancer

Kamitani R, Matsumoto K, Takeda T, Mizuno R, Oya M.
PMID: 34980039
BMC Cancer. 2022 Jan 03;22(1):15. doi: 10.1186/s12885-021-09122-7.

BACKGROUND: Paratesticular leiomyosarcoma (LMS) is a rare tumor. Conventionally, tumor resection by high inguinal orchiectomy is performed as the preferred treatment approach for paratesticular sarcoma. On the other hand, testis-sparing surgery has recently attracted attention as a less-invasive treatment...

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Kamitani R, Matsumoto K, Takeda T, et al. Optimal surgical treatment for paratesticular leiomyosarcoma: retrospective analysis of 217 reported cases. BMC Cancer. 2022;22(1):15doi: 10.1186/s12885-021-09122-7.
Kamitani, R., Matsumoto, K., Takeda, T., Mizuno, R., & Oya, M. (2022). Optimal surgical treatment for paratesticular leiomyosarcoma: retrospective analysis of 217 reported cases. BMC cancer, 22(1), 15. https://doi.org/10.1186/s12885-021-09122-7
Kamitani, Rei, et al. "Optimal surgical treatment for paratesticular leiomyosarcoma: retrospective analysis of 217 reported cases." BMC cancer vol. 22,1 (2022): 15. doi: https://doi.org/10.1186/s12885-021-09122-7
Kamitani R, Matsumoto K, Takeda T, Mizuno R, Oya M. Optimal surgical treatment for paratesticular leiomyosarcoma: retrospective analysis of 217 reported cases. BMC Cancer. 2022 Jan 03;22(1):15. doi: 10.1186/s12885-021-09122-7. PMID: 34980039; PMCID: PMC8722180.
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Potential Role of Twitter at an Annual Congress in Japan　- Narrative Literature Review of "Tweet the Meeting".

Circulation reports

Mizuno A, Kishi T, Matsumoto C, Kawai F, Ishida M, Sanada S, Hokimoto S, Saito Y, Yamauchi-Takihara K, Komuro I, Node K.
PMID: 33693076
Circ Rep. 2019 Sep 19;1(10):401-404. doi: 10.1253/circrep.CR-19-0046.

No abstract available.

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Mizuno A, Kishi T, Matsumoto C, et al. Potential Role of Twitter at an Annual Congress in Japan　- Narrative Literature Review of "Tweet the Meeting". Circ Rep. 2019;1(10):401-404doi: 10.1253/circrep.CR-19-0046.
Mizuno, A., Kishi, T., Matsumoto, C., Kawai, F., Ishida, M., Sanada, S., Hokimoto, S., Saito, Y., Yamauchi-Takihara, K., Komuro, I., & Node, K. (2019). Potential Role of Twitter at an Annual Congress in Japan　- Narrative Literature Review of "Tweet the Meeting". Circulation reports, 1(10), 401-404. https://doi.org/10.1253/circrep.CR-19-0046
Mizuno, Atsushi, et al. "Potential Role of Twitter at an Annual Congress in Japan　- Narrative Literature Review of "Tweet the Meeting"." Circulation reports vol. 1,10 (2019): 401-404. doi: https://doi.org/10.1253/circrep.CR-19-0046
Mizuno A, Kishi T, Matsumoto C, Kawai F, Ishida M, Sanada S, Hokimoto S, Saito Y, Yamauchi-Takihara K, Komuro I, Node K. Potential Role of Twitter at an Annual Congress in Japan　- Narrative Literature Review of "Tweet the Meeting". Circ Rep. 2019 Sep 19;1(10):401-404. doi: 10.1253/circrep.CR-19-0046. PMID: 33693076; PMCID: PMC7897545.
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The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia.

Annals of hematology

Yanada M, Konuma T, Yamasaki S, Mizuno S, Hirabayashi S, Nishiwaki S, Uchida N, Doki N, Tanaka M, Ozawa Y, Sawa M, Eto T, Kawakita T, Ota S, Fukuda T, Onizuka M, Kimura T, Atsuta Y, Kako S, Yano S.
PMID: 34477952
Ann Hematol. 2021 Dec;100(12):3017-3027. doi: 10.1007/s00277-021-04661-2. Epub 2021 Sep 03.

This study aimed to compare the effect of disease status at the time of allogeneic hematopoietic cell transplantation (HCT) on post-transplant outcomes between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Japanese nationwide registry data for 6901 patients...

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Yanada M, Konuma T, Yamasaki S, et al. The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia. Ann Hematol. 2021;100(12):3017-3027doi: 10.1007/s00277-021-04661-2.
Yanada, M., Konuma, T., Yamasaki, S., Mizuno, S., Hirabayashi, S., Nishiwaki, S., Uchida, N., Doki, N., Tanaka, M., Ozawa, Y., Sawa, M., Eto, T., Kawakita, T., Ota, S., Fukuda, T., Onizuka, M., Kimura, T., Atsuta, Y., Kako, S., & Yano, S. (2021). The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia. Annals of hematology, 100(12), 3017-3027. https://doi.org/10.1007/s00277-021-04661-2
Yanada, Masamitsu, et al. "The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia." Annals of hematology vol. 100,12 (2021): 3017-3027. doi: https://doi.org/10.1007/s00277-021-04661-2
Yanada M, Konuma T, Yamasaki S, Mizuno S, Hirabayashi S, Nishiwaki S, Uchida N, Doki N, Tanaka M, Ozawa Y, Sawa M, Eto T, Kawakita T, Ota S, Fukuda T, Onizuka M, Kimura T, Atsuta Y, Kako S, Yano S. The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia. Ann Hematol. 2021 Dec;100(12):3017-3027. doi: 10.1007/s00277-021-04661-2. Epub 2021 Sep 03. PMID: 34477952.
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Rate of change in acetylcholine receptor antibody levels predicts myasthenia gravis outcome.

Journal of neurology, neurosurgery, and psychiatry

Kojima Y, Uzawa A, Ozawa Y, Yasuda M, Onishi Y, Akamine H, Kawaguchi N, Himuro K, Noto YI, Mizuno T, Kuwabara S.
PMID: 33766920
J Neurol Neurosurg Psychiatry. 2021 Sep;92(9):963-968. doi: 10.1136/jnnp-2020-325511. Epub 2021 Mar 25.

OBJECTIVE: To investigate the association between changes in anti-acetylcholine receptor antibody (AChR Ab) levels induced by immunosuppressive treatment and myasthenia gravis (MG) prognosis at 1-year post-treatment in patients with MG.METHODS: We included 53 consecutive AChR Ab-positive patients with MG...

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Kojima Y, Uzawa A, Ozawa Y, et al. Rate of change in acetylcholine receptor antibody levels predicts myasthenia gravis outcome. J Neurol Neurosurg Psychiatry. 2021;92(9):963-968doi: 10.1136/jnnp-2020-325511.
Kojima, Y., Uzawa, A., Ozawa, Y., Yasuda, M., Onishi, Y., Akamine, H., Kawaguchi, N., Himuro, K., Noto, Y. I., Mizuno, T., & Kuwabara, S. (2021). Rate of change in acetylcholine receptor antibody levels predicts myasthenia gravis outcome. Journal of neurology, neurosurgery, and psychiatry, 92(9), 963-968. https://doi.org/10.1136/jnnp-2020-325511
Kojima, Yuta, et al. "Rate of change in acetylcholine receptor antibody levels predicts myasthenia gravis outcome." Journal of neurology, neurosurgery, and psychiatry vol. 92,9 (2021): 963-968. doi: https://doi.org/10.1136/jnnp-2020-325511
Kojima Y, Uzawa A, Ozawa Y, Yasuda M, Onishi Y, Akamine H, Kawaguchi N, Himuro K, Noto YI, Mizuno T, Kuwabara S. Rate of change in acetylcholine receptor antibody levels predicts myasthenia gravis outcome. J Neurol Neurosurg Psychiatry. 2021 Sep;92(9):963-968. doi: 10.1136/jnnp-2020-325511. Epub 2021 Mar 25. PMID: 33766920.
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Spherical micro-hole grid for high-resolution retarding field analyzer.

Journal of synchrotron radiation

Muro T, Matsushita T, Sawamura K, Mizuno J.
PMID: 34475314
J Synchrotron Radiat. 2021 Sep 01;28:1669-1671. doi: 10.1107/S1600577521007773. Epub 2021 Aug 19.

A wide-acceptance-angle spherical grid composed of numerous micro cylindrical holes was developed to be used for the retarding grid of a display-type retarding field analyzer (RFA) and to enhance the energy resolution (E/ΔE). Each cylindrical hole with a diameter...

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Muro T, Matsushita T, Sawamura K, et al. Spherical micro-hole grid for high-resolution retarding field analyzer. J Synchrotron Radiat. 2021;28:1669-1671doi: 10.1107/S1600577521007773.
Muro, T., Matsushita, T., Sawamura, K., & Mizuno, J. (2021). Spherical micro-hole grid for high-resolution retarding field analyzer. Journal of synchrotron radiation, 281669-1671. https://doi.org/10.1107/S1600577521007773
Muro, Takayuki, et al. "Spherical micro-hole grid for high-resolution retarding field analyzer." Journal of synchrotron radiation vol. 28 (2021): 1669-1671. doi: https://doi.org/10.1107/S1600577521007773
Muro T, Matsushita T, Sawamura K, Mizuno J. Spherical micro-hole grid for high-resolution retarding field analyzer. J Synchrotron Radiat. 2021 Sep 01;28:1669-1671. doi: 10.1107/S1600577521007773. Epub 2021 Aug 19. PMID: 34475314.
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Muscle Strains in the Lower Extremity of Japanese Professional Baseball Players.

Orthopaedic journal of sports medicine

Kokubu T, Mifune Y, Kanzaki N, Hoshino Y, Kakutani K, Inui A, Hashimoto S, Kuroda R.
PMID: 33195709
Orthop J Sports Med. 2020 Oct 30;8(10):2325967120956569. doi: 10.1177/2325967120956569. eCollection 2020 Oct.

BACKGROUND: Predicting when athletes can return to play after muscle strains is not always simple because of difficulties in evaluating the severity of such injuries.PURPOSE/HYPOTHESIS: The purpose of this study was to evaluate the use of magnetic resonance imaging...

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Kokubu T, Mifune Y, Kanzaki N, et al. Muscle Strains in the Lower Extremity of Japanese Professional Baseball Players. Orthop J Sports Med. 2020;8(10):2325967120956569doi: 10.1177/2325967120956569.
Kokubu, T., Mifune, Y., Kanzaki, N., Hoshino, Y., Kakutani, K., Inui, A., Hashimoto, S., & Kuroda, R. (2020). Muscle Strains in the Lower Extremity of Japanese Professional Baseball Players. Orthopaedic journal of sports medicine, 8(10), 2325967120956569. https://doi.org/10.1177/2325967120956569
Kokubu, Takeshi, et al. "Muscle Strains in the Lower Extremity of Japanese Professional Baseball Players." Orthopaedic journal of sports medicine vol. 8,10 (2020): 2325967120956569. doi: https://doi.org/10.1177/2325967120956569
Kokubu T, Mifune Y, Kanzaki N, Hoshino Y, Kakutani K, Inui A, Hashimoto S, Kuroda R. Muscle Strains in the Lower Extremity of Japanese Professional Baseball Players. Orthop J Sports Med. 2020 Oct 30;8(10):2325967120956569. doi: 10.1177/2325967120956569. eCollection 2020 Oct. PMID: 33195709; PMCID: PMC7607777.
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Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses.

The Journal of investigative dermatology

Tanaka R, Ichimura Y, Kubota N, Saito A, Nakamura Y, Ishitsuka Y, Watanabe R, Fujisawa Y, Mizuno S, Takahashi S, Fujimoto M, Okiyama N.
PMID: 34310947
J Invest Dermatol. 2022 Jan;142(1):145-154.e8. doi: 10.1016/j.jid.2021.06.026. Epub 2021 Jul 24.

PD-1 is an immunoregulatory receptor that can bind PD-L1 or PD-L2 expressed on stimulated antigen-presenting cells. In this study, isolated antigen-presenting cells (macrophages and dendritic cells) were cultured with IFN-γ, IL-4, or IL-17A, and the expression of PD-L1 and...

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Tanaka R, Ichimura Y, Kubota N, et al. Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses. J Invest Dermatol. 2021;142(1):145-154.e8doi: 10.1016/j.jid.2021.06.026.
Tanaka, R., Ichimura, Y., Kubota, N., Saito, A., Nakamura, Y., Ishitsuka, Y., Watanabe, R., Fujisawa, Y., Mizuno, S., Takahashi, S., Fujimoto, M., & Okiyama, N. (2022). Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses. The Journal of investigative dermatology, 142(1), 145-154.e8. https://doi.org/10.1016/j.jid.2021.06.026
Tanaka, Ryota, et al. "Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses." The Journal of investigative dermatology vol. 142,1 (2022): 145-154.e8. doi: https://doi.org/10.1016/j.jid.2021.06.026
Tanaka R, Ichimura Y, Kubota N, Saito A, Nakamura Y, Ishitsuka Y, Watanabe R, Fujisawa Y, Mizuno S, Takahashi S, Fujimoto M, Okiyama N. Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses. J Invest Dermatol. 2022 Jan;142(1):145-154.e8. doi: 10.1016/j.jid.2021.06.026. Epub 2021 Jul 24. PMID: 34310947.
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PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells.

Endocrinology

Kusama K, Fukushima Y, Yoshida K, Azumi M, Yoshie M, Mizuno Y, Kajihara T, Tamura K.
PMID: 34606582
Endocrinology. 2021 Dec 01;162(12). doi: 10.1210/endocr/bqab207.

Endometriosis is characterized by inflammation and fibrotic changes. Our previous study using a mouse model showed that proinflammatory factors present in peritoneal hemorrhage exacerbated inflammation in endometriosis-like grafts, at least in part through the activation of prostaglandin (PG) E2...

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Kusama K, Fukushima Y, Yoshida K, et al. PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells. Endocrinology. 2021;162(12)doi: 10.1210/endocr/bqab207.
Kusama, K., Fukushima, Y., Yoshida, K., Azumi, M., Yoshie, M., Mizuno, Y., Kajihara, T., & Tamura, K. (2021). PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells. Endocrinology, 162(12), . https://doi.org/10.1210/endocr/bqab207
Kusama, Kazuya, et al. "PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells." Endocrinology vol. 162,12 (2021). doi: https://doi.org/10.1210/endocr/bqab207
Kusama K, Fukushima Y, Yoshida K, Azumi M, Yoshie M, Mizuno Y, Kajihara T, Tamura K. PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells. Endocrinology. 2021 Dec 01;162(12). doi: 10.1210/endocr/bqab207. PMID: 34606582.
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