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Showing 2785 to 2790 of 2790 entries
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Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Wada K, Sonoda M, Firestone E, Sakakura K, Kuroda N, Takayama Y, Iijima K, Iwasaki M, Mihara T, Goto T, Asano E, Miyazaki T.
PMID: 34922194
Clin Neurophysiol. 2021 Dec 01;134:1-8. doi: 10.1016/j.clinph.2021.11.004. Epub 2021 Dec 01.

OBJECTIVE: Phase-amplitude coupling between high-frequency (≥150 Hz) and delta (3-4 Hz) oscillations - modulation index (MI) - is a promising, objective biomarker of epileptogenicity. We determined whether sevoflurane anesthesia preferentially enhances this metric within the epileptogenic zone.METHODS: This is...

Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases.

Thoracic cancer

Mitsumura T, Kumaki Y, Takahashi K, Matsudera S, Sakakibara R, Honda T, Ishizuka M, Iijima Y, Shirai T, Okamoto T, Tateishi T, Sakashita H, Miyake S, Ikeda S, Miyazaki Y.
PMID: 34378333
Thorac Cancer. 2021 Sep;12(18):2508-2512. doi: 10.1111/1759-7714.14098. Epub 2021 Aug 10.

Of the 80 solid tumor cases in which liquid biopsy (LB) was performed using Guardant360 in the PROFILE study, nine were lung cancer cases. Here, we review three cases in which LB was useful in diagnosing ALK fusion-positive lung...

Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia.

Cancers

Fujioka Y, Sugiyama D, Matsumura I, Minami Y, Miura M, Atsuta Y, Ohtake S, Kiyoi H, Miyazaki Y, Nishikawa H, Takahashi N.
PMID: 34885012
Cancers (Basel). 2021 Nov 24;13(23). doi: 10.3390/cancers13235904.

Treatment-free remission (TFR) has become a therapeutic goal in chronic myeloid leukemia (CML), and approximately half of the patients with chronic phase-CML (CML-CP) with deep molecular remission (DMR) by tyrosine-kinase inhibitors (TKIs) have achieved TFR. However, the mechanism of...

Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice.

International journal of tryptophan research : IJTR

Yajima Y, Okuno A, Nakamura I, Miyazaki T, Honda A, Toyoda A.
PMID: 35002254
Int J Tryptophan Res. 2022 Jan 04;15:11786469211066285. doi: 10.1177/11786469211066285. eCollection 2022.

The kynurenine (Kyn) pathway plays crucial roles in several inflammation-induced disorders such as depression. In this study, we measured Kyn and other related molecules in the blood plasma, brain, and urine of male C57BL/6J mice (B6) fed non-purified (MF)...

The CLOCK 3111T/C polymorphism is associated with hour-by-hour physical activity levels only on weekends among Japanese male and female university students.

Physiology & behavior

Miyazaki R, Ando H, Ayabe M, Hamasaki T, Higuchi Y, Oshita K, Sakane N.
PMID: 35032497
Physiol Behav. 2022 Jan 12;113705. doi: 10.1016/j.physbeh.2022.113705. Epub 2022 Jan 12.

BACKGROUND: CLOCK 3111T/C has been shown to be closely associated with morningness-eveningness, such as sleep-wake rhythms in healthy humans. However, previous studies examined the physical activity (PA) in a single day, and no study has investigated the relationships between...

FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells.

iScience

Kamasaki T, Miyazaki Y, Ishikawa S, Hoshiba K, Kuromiya K, Tanimura N, Mori Y, Tsutsumi M, Nemoto T, Uehara R, Suetsugu S, Itoh T, Fujita Y.
PMID: 34485872
iScience. 2021 Aug 18;24(9):102994. doi: 10.1016/j.isci.2021.102994. eCollection 2021 Sep 24.

At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-transformed cells are surrounded by...

Showing 2785 to 2790 of 2790 entries