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Showing 25 to 36 of 127 entries
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Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography.

Bioactive materials

Shi H, Wu X, Sun S, Wang C, Vangelatos Z, Ash-Shakoor A, Grigoropoulos CP, Mather PT, Henderson JH, Ma Z.
PMID: 34901553
Bioact Mater. 2021 Aug 28;10:367-377. doi: 10.1016/j.bioactmat.2021.08.028. eCollection 2022 Apr.

Focal adhesion complexes function as the mediators of cell-extracellular matrix interactions to sense and transmit the extracellular signals. Previous studies have demonstrated that cardiomyocyte focal adhesions can be modulated by surface topographic features. However, the response of focal adhesions...

Clinical perspectives on the microcirculation.

Microcirculation (New York, N.Y. : 1994)

Mendelson AA, Lam F, Peirce SM, Murfee WL.
PMID: 33629399
Microcirculation. 2021 Apr;28(3):e12688. doi: 10.1111/micc.12688.

No abstract available.

Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model.

Disease models & mechanisms

Elzinga SE, Savelieff MG, O'Brien PD, Mendelson FE, Hayes JM, Feldman EL.
PMID: 33692086
Dis Model Mech. 2021 Apr 01;14(4). doi: 10.1242/dmm.048909. Epub 2021 Apr 15.

Peripheral neuropathy (PN) is a common complication of prediabetes and diabetes and is an increasing problem worldwide. Existing PN treatments rely solely on glycemic control, which is effective in type 1 but not type 2 diabetes. Sex differences in...

Patient engagement in preclinical laboratory research: A scoping review.

EBioMedicine

Fox G, Fergusson DA, Daham Z, Youssef M, Foster M, Poole E, Sharif A, Richards DP, Hendrick K, Mendelson AA, Macala KF, Monfaredi Z, Montroy J, Fiest KM, Presseau J, Lalu MM.
PMID: 34280783
EBioMedicine. 2021 Aug;70:103484. doi: 10.1016/j.ebiom.2021.103484. Epub 2021 Jul 17.

BACKGROUND: 'Patient engagement' involves meaningful collaboration between researchers and 'patient partners' to co-create research. It helps ensure that research being conducted is relevant to its ultimate end-users. Although patient engagement within clinical research has been well documented, the prevalence...

Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study.

Journal of clinical monitoring and computing

Mendelson AA, Rajaram A, Bainbridge D, Lawrence KS, Bentall T, Sharpe M, Diop M, Ellis CG.
PMID: 33104968
J Clin Monit Comput. 2021 Dec;35(6):1453-1465. doi: 10.1007/s10877-020-00611-x. Epub 2020 Oct 26.

PURPOSE:  There is a need for bedside methods to monitor oxygen delivery in the microcirculation. Near-infrared spectroscopy commonly measures tissue oxygen saturation, but does not reflect the time-dependent variability of microvascular hemoglobin content (MHC) that attempts to match oxygen...

Transforming an orthopaedic unit into an "Age-Friendly" unit through implementation of the American Geriatrics Society's CoCare®: Ortho program.

Journal of orthopaedic trauma

Shen JY, Mendelson DA, Lang VJ.
PMID: 34629392
J Orthop Trauma. 2021 Oct 08; doi: 10.1097/BOT.0000000000002279. Epub 2021 Oct 08.

OBJECTIVE: Transform an inpatient orthopaedic unit into an age-friendly unit for geriatric fracture center (GFC) patients.DESIGN: Pragmatic dissemination study of a continuous quality improvement intervention with episodic data review.SETTING: Large quaternary care university hospital with no on-site geriatrics and...

National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research.

Intensive care medicine experimental

Mendelson AA, Lansdell C, Fox-Robichaud AE, Liaw P, Arora J, Cailhier JF, Cepinskas G, Charbonney E, Dos Santos C, Dwivedi D, Ellis CG, Fergusson D, Fiest K, Gill SE, Hendrick K, Hunniford VT, Kowalewska PM, Krewulak K, Lehmann C, Macala K, Marshall JC, Mawdsley L, McDonald B, McDonald E, Medeiros SK, Muniz VS, Osuchowski M, Presseau J, Sharma N, Sohrabipour S, Sunohara-Neilson J, Vázquez-Grande G, Veldhuizen RAW, Welsh D, Winston BW, Zarychanski R, Zhang H, Zhou J, Lalu MM.
PMID: 33738642
Intensive Care Med Exp. 2021 Mar 19;9(1):14. doi: 10.1186/s40635-020-00366-4.

Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical models of the complex human condition of...

Innovative clinical trials for development of personalized cancer medicine.

Molecular oncology

Mendelsohn J, Ringborg U, Schilsky R.
PMID: 25772590
Mol Oncol. 2015 May;9(5):933-4. doi: 10.1016/j.molonc.2015.02.013. Epub 2015 Mar 05.

No abstract available.

FIFTY YEARS AS A PLANT PHYSIOLOGIST.

Annual review of plant physiology and plant molecular biology

Henderson JH.
PMID: 11337390
Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:1-28. doi: 10.1146/annurev.arplant.52.1.1.

This chapter is a chronological and biographical sketch of the professional life of a botanist-plant physiologist. He just happens to be of African-American descent. He cites his early education and through college and graduate school, as well as his...

Interaction of habit strength and drug effects.

Journal of comparative and physiological psychology

BINDRA D, MENDELSON J.
PMID: 13869248
J Comp Physiol Psychol. 1962 Apr;55:217-9. doi: 10.1037/h0040936.

No abstract available.

Diurnal patterns of cocaine and heroin self-administration in rhesus monkeys responding under a schedule of multiple daily sessions.

Behavioural pharmacology

Negus SS, Mello NK, Lukas SE, Mendelson JH.
PMID: 11224379
Behav Pharmacol. 1995 Dec;6(8):763-775.

A number of non-pharmacological factors have been shown to influence drug self-administration in experimental animals. This report examines diurnal changes in drug self-administration by rhesus monkeys trained to self-administer food (1gm fruit-flavored pellets) and cocaine (0.01 or 0.032mg/kg/injection) under...

High-Resolution 3D Printing of Stretchable Hydrogel Structures Using Optical Projection Lithography.

ACS applied materials & interfaces

Kunwar P, Jannini AVS, Xiong Z, Ransbottom MJ, Perkins JS, Henderson JH, Hasenwinkel JM, Soman P.
PMID: 31833757
ACS Appl Mater Interfaces. 2020 Jan 08;12(1):1640-1649. doi: 10.1021/acsami.9b19431. Epub 2019 Dec 27.

Double-network (DN) hydrogels, with their unique combination of mechanical strength and toughness, have emerged as promising materials for soft robotics and tissue engineering. In the past decade, significant effort has been devoted to synthesizing DN hydrogels with high stretchability...

Showing 25 to 36 of 127 entries