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Showing 877 to 883 of 883 entries
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Advances and Perspectives in Prostate Cancer Biomarker Discovery in the Last 5 Years through Tissue and Urine Metabolomics.

Metabolites

Lima AR, Pinto J, Amaro F, Bastos ML, Carvalho M, Guedes de Pinho P.
PMID: 33808897
Metabolites. 2021 Mar 19;11(3). doi: 10.3390/metabo11030181.

Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its screening, serum prostate specific antigen (PSA) test has been largely performed over the past decade, despite its lack of accuracy and inability to distinguish indolent...

Do age, fitness, and concomitant medications influence management and outcomes of patients with CLL treated with ibrutinib?.

Blood advances

Tedeschi A, Frustaci AM, Mauro FR, Chiarenza A, Coscia M, Ciolli S, Reda G, Laurenti L, Varettoni M, Murru R, Baratè C, Sportoletti P, Greco A, Borella C, Rossi V, Deodato M, Biagi A, Zamprogna G, Pelle AC, Lapietra G, Vitale C, Morelli F, Cassin R, Fresa A, Cavalloni C, Postorino M, Ielo C, Cairoli R, Di Raimondo F, Montillo M, Del Poeta G.
PMID: 34525181
Blood Adv. 2021 Dec 28;5(24):5490-5500. doi: 10.1182/bloodadvances.2021004824.

Functional reserve of organs and systems is known to be relevant in predicting immunochemotherapy tolerance. Age and comorbidities, assessed by the cumulative illness rating scale (CIRS), have been used to address chemotherapy intensity. In the ibrutinib era, it is...

International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.

Nature reviews. Gastroenterology & hepatology

Olivera PA, Zuily S, Kotze PG, Regnault V, Al Awadhi S, Bossuyt P, Gearry RB, Ghosh S, Kobayashi T, Lacolley P, Louis E, Magro F, Ng SC, Papa A, Raine T, Teixeira FV, Rubin DT, Danese S, Peyrin-Biroulet L.
PMID: 34453143
Nat Rev Gastroenterol Hepatol. 2021 Dec;18(12):857-873. doi: 10.1038/s41575-021-00492-8. Epub 2021 Aug 27.

Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available evidence and to provide practical recommendations...

Role of Long-range Allosteric Communication in Determining the Stability and Disassembly of SARS-COV-2 in Complex with ACE2.

bioRxiv : the preprint server for biology

Mugnai ML, Templeton C, Elber R, Thirumalai D.
PMID: 33299995
bioRxiv. 2020 Dec 01; doi: 10.1101/2020.11.30.405340.

Severe acute respiratory syndrome (SARS) and novel coronavirus disease (COVID-19) are caused by two closely related beta-coronaviruses, SARS-CoV and SARS-CoV-2, respectively. The envelopes surrounding these viruses are decorated with spike proteins, whose receptor binding domains (RBDs) initiate invasion by...

Dose optimisation for Loss of Response to Vedolizumab- Pharmacokinetics and Immune Mechanisms.

Journal of Crohn's & colitis

Ungar B, Malickova K, Hanžel J, Abu Arisha M, Paul S, Rocha C, Ben Shatach Z, Abitbol CM, Haj Natour O, Selinger L, Yavzori M, Fudim E, Picard O, Shoval I, Eliakim R, Kopylov U, Magro F, Roblin X, Chowers Y, Drobne D, Lukas M, Ben Horin S.
PMID: 33837762
J Crohns Colitis. 2021 Oct 07;15(10):1707-1719. doi: 10.1093/ecco-jcc/jjab067.

BACKGROUND: Real life data regarding pharmacokinetics of vedolizumab in patients needing dose optimisation are scarce. We set to examine whether pre-optimisation vedolizumab levels associate with therapy outcomes and which mechanisms explain the associations.METHODS: A multicentre observational study assessed the...

Subclinical Persistent Inflammation as risk factor for Crohn's Disease progression: findings from a prospective real-world study of 2 years.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

F M, D M, M P, B A, P L, I R, Ht S, P M, I M, A V, J C, J M, J R, C E, P S, F P, L C, M S, S D, C A, J A, S D, L PB, Cc D.
PMID: 34896644
Clin Gastroenterol Hepatol. 2021 Dec 09; doi: 10.1016/j.cgh.2021.12.004. Epub 2021 Dec 09.

BACKGROUND AND AIMS: Subclinical intestinal inflammation is common in Crohn's disease (CD). We aimed to explore its impact in the disease progression of infliximab-treated patients and the usefulness of fecal calprotectin (FC) and C-reactive protein (CRP) as surrogate minimally...

Early survey with bibliometric analysis on machine learning approaches in controlling COVID-19 outbreaks.

PeerJ. Computer science

Chiroma H, Ezugwu AE, Jauro F, Al-Garadi MA, Abdullahi IN, Shuib L.
PMID: 33816964
PeerJ Comput Sci. 2020 Nov 23;6:e313. doi: 10.7717/peerj-cs.313. eCollection 2020.

BACKGROUND AND OBJECTIVE: The COVID-19 pandemic has caused severe mortality across the globe, with the USA as the current epicenter of the COVID-19 epidemic even though the initial outbreak was in Wuhan, China. Many studies successfully applied machine learning...

Showing 877 to 883 of 883 entries