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Showing 13 to 24 of 155 entries
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Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial.

Free radical biology & medicine

Larsen EL, Kjær LK, Lundby-Christensen L, Boesgaard TW, Breum L, Gluud C, Hedetoft C, Krarup T, Lund SS, Mathiesen ER, Perrild H, Sneppen SB, Tarnow L, Thorsteinsson B, Vestergaard H, Poulsen HE, Madsbad S, Almdal TP.
PMID: 34823018
Free Radic Biol Med. 2022 Jan;178:18-25. doi: 10.1016/j.freeradbiomed.2021.11.028. Epub 2021 Nov 22.

Formation of reactive oxygen species has been linked to the development of diabetes complications. Treatment with metformin has been associated with a lower risk of developing diabetes complications, including when used in combination with insulin. Metformin inhibits Complex 1...

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Frontiers in immunology

Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
PMID: 34691048
Front Immunol. 2021 Oct 08;12:744509. doi: 10.3389/fimmu.2021.744509. eCollection 2021.

Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction. Several studies have highlighted the implication of circulating and exosomal microRNAs (miRNAs) in type 1 diabetes,...

Parental needs among children with birth defects: defining a parent-to-parent support network.

Journal of genetic counseling

Mathiesen AM, Frost CJ, Dent KM, Feldkamp ML.
PMID: 22825406
J Genet Couns. 2012 Dec;21(6):862-72. doi: 10.1007/s10897-012-9518-6. Epub 2012 Jul 24.

The objective of this study was to explore how a parent-to-parent support network could impact parents of a child with a structural birth defect by specifically looking at parents' continued needs, aspects influencing their participation in support networks, and...

Improved Cognitive Function in the Tromsø Study in Norway From 2001 to 2016.

Neurology. Clinical practice

Johnsen B, Strand BH, Martinaityte I, Mathiesen EB, Schirmer H.
PMID: 34992969
Neurol Clin Pract. 2021 Dec;11(6):e856-e866. doi: 10.1212/CPJ.0000000000001115.

BACKGROUND AND OBJECTIVES: Physical capacity and cardiovascular risk profiles seem to be improving in the population. Cognition has been improving due to a birth cohort effect, but evidence is conflicting on whether this improvement remains in the latest decades...

Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice.

Journal of hepatology

Pihl AF, Feng S, Offersgaard A, Alzua GP, Augestad EH, Mathiesen CK, Jensen TB, Krarup H, Law M, Prentoe J, Christensen JP, Bukh J, Gottwein JM.
PMID: 34990750
J Hepatol. 2022 Jan 03; doi: 10.1016/j.jhep.2021.12.026. Epub 2022 Jan 03.

BACKGROUND AND AIMS: A prophylactic vaccine is required to eliminate hepatitis C virus (HCV) as a global public health threat, causing 400,000 deaths annually due to HCV-related liver diseases. We developed whole virus inactivated HCV vaccine candidates employing a...

Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses.

Scandinavian journal of public health

Varmdal T, Løchen ML, Wilsgaard T, Njølstad I, Nyrnes A, Grimsgaard S, Mathiesen EB.
PMID: 34120523
Scand J Public Health. 2021 Jun 14;14034948211021191. doi: 10.1177/14034948211021191. Epub 2021 Jun 14.

AIM: To assess whether stroke diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for the Tromsø Study, a population-based epidemiological study.METHOD: Using the Tromsø Study Cardiovascular Disease Register for 2013-2014...

Obesity Does Not Protect From Subarachnoid Hemorrhage: Pooled Analyses of 3 Large Prospective Nordic Cohorts.

Stroke

Rautalin I, Kaprio J, Ingebrigtsen T, Jousilahti P, Løchen ML, Romundstad PR, Salomaa V, Vik A, Wilsgaard T, Mathiesen EB, Sandvei M, Korja M.
PMID: 34753302
Stroke. 2021 Nov 10;STROKEAHA121034782. doi: 10.1161/STROKEAHA.121.034782. Epub 2021 Nov 10.

BACKGROUND AND PURPOSE: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether the previously reported inverse association can be...

Thrombospondin 1 (THBS1) Promotes Follicular Angiogenesis, Luteinization, and Ovulation in Primates.

Frontiers in endocrinology

Bender HR, Campbell GE, Aytoda P, Mathiesen AH, Duffy DM.
PMID: 31787928
Front Endocrinol (Lausanne). 2019 Nov 07;10:727. doi: 10.3389/fendo.2019.00727. eCollection 2019.

Angiogenesis is essential to both ovulation and the formation of the corpus luteum. The thrombospondin (THBS) family of glycoproteins plays diverse roles in regulation of angiogenesis, but the role of these vascular regulators in ovulation and luteinization remain to...

Germline .

Frontiers in endocrinology

Hansen AR, Borgwardt L, Rasmussen ÅK, Godballe C, Poulsen MM, Vieira FG, Mathiesen JS, Rossing M.
PMID: 34925234
Front Endocrinol (Lausanne). 2021 Dec 01;12:764512. doi: 10.3389/fendo.2021.764512. eCollection 2021.

Activating variants in the receptor tyrosine kinase

Imaging microstructural dynamics and strain fields in electro-active materials in situ with dark field x-ray microscopy.

The Review of scientific instruments

Ormstrup J, Østergaard EV, Detlefs C, Mathiesen RH, Yildirim C, Kutsal M, Cook PK, Watier Y, Cosculluela C, Simons H.
PMID: 32611058
Rev Sci Instrum. 2020 Jun 01;91(6):065103. doi: 10.1063/1.5142319.

The electric-field-induced and temperature induced dynamics of domains, defects, and phases play an important role in determining the macroscopic functional response of ferroelectric and piezoelectric materials. However, distinguishing and quantifying these phenomena remains a persistent challenge that inhibits our...

Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial.

Free radical biology & medicine

Larsen EL, Kjær LK, Lundby-Christensen L, Boesgaard TW, Breum L, Gluud C, Hedetoft C, Krarup T, Lund SS, Mathiesen ER, Perrild H, Sneppen SB, Tarnow L, Thorsteinsson B, Vestergaard H, Poulsen HE, Madsbad S, Almdal TP.
PMID: 34823018
Free Radic Biol Med. 2021 Nov 22;178:18-25. doi: 10.1016/j.freeradbiomed.2021.11.028. Epub 2021 Nov 22.

Formation of reactive oxygen species has been linked to the development of diabetes complications. Treatment with metformin has been associated with a lower risk of developing diabetes complications, including when used in combination with insulin. Metformin inhibits Complex 1...

Ocrelizumab treatment in multiple sclerosis: A Danish population-based cohort study.

European journal of neurology

Pontieri L, Blinkenberg M, Bramow S, Papp V, Rasmussen PV, Kant M, Schäfer J, Mathiesen HK, Jensen MB, Sirakov G, Berg JM, Kopp TI, Joensen H, Sellebjerg F, Magyari M.
PMID: 34644452
Eur J Neurol. 2021 Oct 13; doi: 10.1111/ene.15142. Epub 2021 Oct 13.

BACKGROUND AND PURPOSE: Real-world evidence regarding the effectiveness and safety of ocrelizumab for the treatment of multiple sclerosis (MS) is limited. The aim was to evaluate the effectiveness and safety of ocrelizumab treatment for MS in a real-world setting.METHODS:...

Showing 13 to 24 of 155 entries