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Showing 13 to 24 of 316 entries
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Reactive oxygen species in NMDA receptor-mediated glutamate neurotoxicity.

Parkinsonism & related disorders

Akaike A, Katsuki H, Kume T, Maeda T.
PMID: 18591141
Parkinsonism Relat Disord. 1999 Dec;5(4):203-7. doi: 10.1016/s1353-8020(99)00038-3.

In search of endogenous protective substances that inhibit neurotoxic action of glutamate and nitric oxide (NO), we found that brain-derived neurotrophic factor (BDNF), acting on TrkB receptor tyrosine kinase, inhibited neurotoxicity induced by glutamate and NO donors in cultured...

Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.

Nutrition & metabolism

Oosterveer MH, Koolman AH, de Boer PT, Bos T, Bleeker A, van Dijk TH, Bloks VW, Kuipers F, Sauer PJ, van Dijk G.
PMID: 22201701
Nutr Metab (Lond). 2011 Dec 27;8:93. doi: 10.1186/1743-7075-8-93.

BACKGROUND: Overactivity and/or dysregulation of the endocannabinoid system (ECS) contribute to development of obesity. In vitro studies indicate a regulatory role for the cannabinoid receptor 1 (CB1) in adipocyte function and CB1-receptor deficient (CB1-/-) mice are resistant to high...

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.

Blood cancer journal

Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S.
PMID: 22852048
Blood Cancer J. 2012 Jul;2(7):e79. doi: 10.1038/bcj.2012.26. Epub 2012 Jul 20.

The IRE1α-XBP1 pathway, a key component of the endoplasmic reticulum (ER) stress response, is considered to be a critical regulator for survival of multiple myeloma (MM) cells. Therefore, the availability of small-molecule inhibitors targeting this pathway would offer a...

Search for long-lived exotic particles in 12-GeV proton-nucleus interactions.

Physical review. D, Particles and fields

Imai K, Kobayashi H, Konaka A, Masaike A, Miyake K, Nagamine T, Nakamura TT, Sasao N, Yamada Y, Yamauchi I.
PMID: 9959775
Phys Rev D Part Fields. 1989 Mar 01;39(5):1261-1266. doi: 10.1103/physrevd.39.1261.

No abstract available.

A comparative study of PD-L1 immunohistochemical assays with four reliable antibodies in thymic carcinoma.

Oncotarget

Sakane T, Murase T, Okuda K, Takino H, Masaki A, Oda R, Watanabe T, Kawano O, Haneda H, Moriyama S, Saito Y, Yamada T, Nakanishi R, Inagaki H.
PMID: 29467945
Oncotarget. 2018 Jan 08;9(6):6993-7009. doi: 10.18632/oncotarget.24075. eCollection 2018 Jan 23.

Currently, four immunohistochemical assays are registered with the US Food and Drug Administration to detect the expression of PD-L1. We investigated the PD-L1 expression in thymic carcinomas using these four diagnostic assays. The cases of 53 patients were reviewed...

Seroprevalence of HIV, hepatitis b, and hepatitis c among opioid drug users on methadone treatment in the netherlands.

Harm reduction journal

Schreuder I, van der Sande MA, de Wit M, Bongaerts M, Boucher CA, Croes EA, van Veen MG.
PMID: 20977742
Harm Reduct J. 2010 Oct 26;7:25. doi: 10.1186/1477-7517-7-25.

BACKGROUND: Injecting drug users (IDU) remain an important population at risk for blood-borne infections such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV). In the Netherlands, a program is being implemented to offer...

Prevalence of changes in personality and behavior in adult glioma patients: a systematic review.

Neuro-oncology practice

Zwinkels H, Dirven L, Vissers T, Habets EJJ, Vos MJ, Reijneveld JC, van den Bent MJ, Taphoorn MJB.
PMID: 31386058
Neurooncol Pract. 2016 Dec;3(4):222-231. doi: 10.1093/nop/npv040. Epub 2015 Sep 29.

BACKGROUND: Gliomas are rare, with a dismal outcome and an obvious impact on quality of life, because of neurological, physical and cognitive problems, as well as personality and behavioral changes. These latter changes may affect the lives of both...

An .

Frontiers in oncology

van de Merbel AF, van der Horst G, van der Mark MH, van Uhm JIM, van Gennep EJ, Kloen P, Beimers L, Pelger RCM, van der Pluijm G.
PMID: 30333957
Front Oncol. 2018 Oct 02;8:400. doi: 10.3389/fonc.2018.00400. eCollection 2018.

Urological malignancies, including prostate and bladder carcinoma, represent a major clinical problem due to the frequent occurrence of therapy resistance and the formation of incurable distant metastases. As a result, there is an urgent need for versatile and predictive...

Laboratory Evolution of a .

Frontiers in genetics

Gorter de Vries AR, Voskamp MA, van Aalst ACA, Kristensen LH, Jansen L, van den Broek M, Salazar AN, Brouwers N, Abeel T, Pronk JT, Daran JG.
PMID: 31001314
Front Genet. 2019 Mar 29;10:242. doi: 10.3389/fgene.2019.00242. eCollection 2019.

No abstract available.

Mutation analysis of the EGFR pathway genes, .

Oncotarget

Saida K, Murase T, Ito M, Fujii K, Takino H, Masaki A, Kawakita D, Ijichi K, Tada Y, Kusafuka K, Iida Y, Onitsuka T, Yatabe Y, Hanai N, Hasegawa Y, Shinomiya H, Nibu KI, Shimozato K, Inagaki H.
PMID: 29682203
Oncotarget. 2018 Mar 30;9(24):17043-17055. doi: 10.18632/oncotarget.24818. eCollection 2018 Mar 30.

Adenoid cystic carcinoma (AdCC), one of the most common salivary gland carcinomas, usually has a fatal outcome. Epidermal growth factor receptor (EGFR) pathway gene mutations are important in predicting a patient's prognosis and estimating the efficacy of molecular therapy...

A centrifuge method to determine the solid-liquid phase behavior of eutectic mixtures.

The Journal of chemical physics

van den Bruinhorst A, Kollau LJBM, Kroon MC, Meuldijk J, Tuinier R, Esteves ACC.
PMID: 30553256
J Chem Phys. 2018 Dec 14;149(22):224505. doi: 10.1063/1.5051515.

The centrifuge method is a novel, equilibrium-based, analytical procedure that allows the construction of solid-liquid phase diagrams of binary eutectic mixtures. In this paper, the development, optimization, and successful verification of the centrifuge method are described. Contrary to common...

A novel pathophysiologic link between upper and lower airways in patients with chronic rhinosinusitis: Association of sputum periostin levels with upper airway inflammation and olfactory function.

The World Allergy Organization journal

Kanemitsu Y, Suzuki M, Fukumitsu K, Asano T, Takeda N, Nakamura Y, Ozawa Y, Masaki A, Ono J, Kurokawa R, Yap J, Nishiyama H, Fukuda S, Ohkubo H, Maeno K, Ito Y, Oguri T, Izuhara K, Takemura M, Niimi A.
PMID: 32015784
World Allergy Organ J. 2020 Jan 06;13(1):100094. doi: 10.1016/j.waojou.2019.100094. eCollection 2020 Jan.

BACKGROUND: Chronic rhinosinusitis (CRS) and asthma are collectively called unified airway diseases. Periostin has been implicated in the pathophysiologic link of these conditions but only by serum measurements. We sought to investigate sputum levels of periostin and their association...

Showing 13 to 24 of 316 entries