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Showing 13 to 24 of 2402 entries
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The degradation of proteins in pinniped skeletal muscle: viability of post-mortem tissue in physiological research.

Conservation physiology

Moore CD, Fahlman A, Crocker DE, Robbins KA, Trumble SJ.
PMID: 27293704
Conserv Physiol. 2015 May 25;3(1):cov019. doi: 10.1093/conphys/cov019. eCollection 2015.

As marine divers, pinnipeds have a high capacity for exercise at depth while holding their breath. With finite access to oxygen, these species need to be capable of extended aerobic exercise and conservation of energy. Pinnipeds must deal with...

Determining the location and nearest neighbours of aluminium in zeolites with atom probe tomography.

Nature communications

Perea DE, Arslan I, Liu J, Ristanović Z, Kovarik L, Arey BW, Lercher JA, Bare SR, Weckhuysen BM.
PMID: 26133270
Nat Commun. 2015 Jul 02;6:7589. doi: 10.1038/ncomms8589.

Zeolite catalysis is determined by a combination of pore architecture and Brønsted acidity. As Brønsted acid sites are formed by the substitution of AlO4 for SiO4 tetrahedra, it is of utmost importance to have information on the number as...

Biosimilars and the extrapolation of indications for inflammatory conditions.

Biologics : targets & therapy

Tesser JR, Furst DE, Jacobs I.
PMID: 28255229
Biologics. 2017 Feb 17;11:5-11. doi: 10.2147/BTT.S124476. eCollection 2017.

Extrapolation is the approval of a biosimilar for use in an indication held by the originator biologic not directly studied in a comparative clinical trial with the biosimilar. Extrapolation is a scientific rationale that bridges all the data collected...

Stress-coping skills and neuroticism in apical ballooning syndrome (Takotsubo/stress cardiomyopathy).

Open heart

Scantlebury DC, Rohe DE, Best PJ, Lennon RJ, Lerman A, Prasad A.
PMID: 26870388
Open Heart. 2016 Feb 05;3(1):e000312. doi: 10.1136/openhrt-2015-000312. eCollection 2016.

INTRODUCTION: Apical ballooning syndrome (ABS) is typically associated with an antecedent stressful situation. Affected patients have been reported to have higher frequencies of premorbid affective disorders. We hypothesised that patients with ABS would have elevated levels of neuroticism (tendency...

The renal compartment: a hydraulic view.

Intensive care medicine experimental

Cruces P, Salas C, Lillo P, Salomon T, Lillo F, Hurtado DE.
PMID: 26266923
Intensive Care Med Exp. 2014 Dec;2(1):26. doi: 10.1186/s40635-014-0026-x. Epub 2014 Oct 23.

BACKGROUND: The hydraulic behavior of the renal compartment is poorly understood. In particular, the role of the renal capsule on the intrarenal pressure has not been thoroughly addressed to date. We hypothesized that pressure and volume in the renal...

An R Package for Open, Reproducible Analysis of Urban Water Systems, With Application to Chicago.

Open water

Erban LE, Balogh SB, Campbell DE, Walker HA.
PMID: 29546883
Open Water. 2018 Feb 01;5(1):26-40.

Urban water systems consist of natural and engineered flows of water interacting in complex ways. System complexity can be understood via mass conservative models that account for the interrelationships among all major flows and storages. We have developed a...

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.

ACS medicinal chemistry letters

Salla M, Butler MS, Pelingon R, Kaeslin G, Croker DE, Reid JC, Baek JM, Bernhardt PV, Gillam EM, Cooper MA, Robertson AA.
PMID: 27994733
ACS Med Chem Lett. 2016 Sep 27;7(12):1034-1038. doi: 10.1021/acsmedchemlett.6b00198. eCollection 2016 Dec 08.

MCC950 is an orally bioavailable small molecule inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome that exhibits remarkable activity in multiple models of inflammatory disease. Incubation of MCC950 with human liver microsomes, and subsequent analysis by...

Mechanism of the Polymerization of rac-Lactide by Fast Zinc Alkoxide Catalysts.

Inorganic chemistry

Stasiw DE, Luke AM, Rosen T, League AB, Mandal M, Neisen BD, Cramer CJ, Kol M, Tolman WB.
PMID: 29116765
Inorg Chem. 2017 Nov 20;56(22):14366-14372. doi: 10.1021/acs.inorgchem.7b02544. Epub 2017 Nov 08.

The ring-opening transesterification polymerization (ROTEP) of rac-lactide (rac-LA) using L

Instrument to detect syncope and the onset of shock.

Proceedings of SPIE--the International Society for Optical Engineering

McAdams DR, Kolodziejski NJ, Stapels CJ, Fernandez DE, Podolsky MJ, Farkas D, Christian JF, Joyner MJ, Johnson CP, Paradis NA.
PMID: 29056812
Proc SPIE Int Soc Opt Eng. 2016 Feb;9708. doi: 10.1117/12.2212803. Epub 2016 Mar 17.

Currently the diagnosis of hemorrhagic shock is essentially clinical, relying on the expertise of nurses and doctors. One of the first measurable physiological changes that marks the onset of hemorrhagic shock is a decrease in capillary blood flow. Diffuse...

Globe stability during simulated vitrectomy with valved and non-valved trocar cannulas.

Clinical ophthalmology (Auckland, N.Z.)

Abulon DJ, Charles M, Charles DE.
PMID: 26445520
Clin Ophthalmol. 2015 Sep 21;9:1745-52. doi: 10.2147/OPTH.S86326. eCollection 2015.

PURPOSE: To compare the effects of valved and non-valved cannulas on intraocular pressure (IOP), fluid leakage, and vitreous incarceration during simulated vitrectomy.METHODS: Three-port pars plana incisions were generated in six rubber eyes using 23-, 25-, and 27-gauge valved and...

Correction to "Electroanalysis of Neutral Precursors in Protic Ionic Liquids and Synthesis of High-Ionicity Ionic Liquids".

Langmuir : the ACS journal of surfaces and colloids

Goodwin SE, Smith DE, Gibson JS, Jones RG, Walsh DA.
PMID: 29154549
Langmuir. 2017 Dec 05;33(48):13902. doi: 10.1021/acs.langmuir.7b03820. Epub 2017 Nov 20.

No abstract available.

Longer durations of antitumour necrosis factor treatment are associated with reduced risk of cardiovascular events in patients with rheumatoid arthritis.

RMD open

Nurmohamed M, Bao Y, Signorovitch J, Trahey A, Mulani P, Furst DE.
PMID: 26535138
RMD Open. 2015 May 21;1(1):e000080. doi: 10.1136/rmdopen-2015-000080. eCollection 2015.

OBJECTIVE: To assess the effects of treatment with antitumour necrosis factor (TNF) agents, methotrexate, or other non-biological disease-modifying antirheumatic drugs (DMARDs) on cardiovascular event risks among patients with rheumatoid arthritis (RA).METHODS: We conducted a retrospective study using data from...

Showing 13 to 24 of 2402 entries