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ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data.

BMC bioinformatics

Mann L, Seibt KM, Weber B, Heitkam T.
PMID: 35030991
BMC Bioinformatics. 2022 Jan 14;23(1):40. doi: 10.1186/s12859-021-04545-2.

BACKGROUND: Extrachromosomal circular DNAs (eccDNAs) are ring-like DNA structures physically separated from the chromosomes with 100 bp to several megabasepairs in size. Apart from carrying tandemly repeated DNA, eccDNAs may also harbor extra copies of genes or recently activated...

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Mann L, Seibt KM, Weber B, et al. ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data. BMC Bioinformatics. 2022;23(1):40doi: 10.1186/s12859-021-04545-2.
Mann, L., Seibt, K. M., Weber, B., & Heitkam, T. (2022). ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data. BMC bioinformatics, 23(1), 40. https://doi.org/10.1186/s12859-021-04545-2
Mann, Ludwig, et al. "ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data." BMC bioinformatics vol. 23,1 (2022): 40. doi: https://doi.org/10.1186/s12859-021-04545-2
Mann L, Seibt KM, Weber B, Heitkam T. ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data. BMC Bioinformatics. 2022 Jan 14;23(1):40. doi: 10.1186/s12859-021-04545-2. PMID: 35030991.
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Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells.

Physiological reports

Mann G, Adegoke OAJ.
PMID: 33400857
Physiol Rep. 2021 Jan;9(1):e14673. doi: 10.14814/phy2.14673.

Branched-chain amino acids (BCAAs) are regulators of protein metabolism. However, elevated levels of BCAAs and their metabolites are linked to insulin resistance. We previously demonstrated that the leucine metabolite, α-ketoisocaproate (KIC), inhibited insulin-stimulated glucose transport in myotubes. Like KIC,...

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Mann G, Adegoke OAJ. Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells. Physiol Rep. 2021;9(1):e14673doi: 10.14814/phy2.14673.
Mann, G., & Adegoke, O. A. J. (2021). Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells. Physiological reports, 9(1), e14673. https://doi.org/10.14814/phy2.14673
Mann, Gagandeep, and Adegoke, Olasunkanmi A J. "Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells." Physiological reports vol. 9,1 (2021): e14673. doi: https://doi.org/10.14814/phy2.14673
Mann G, Adegoke OAJ. Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells. Physiol Rep. 2021 Jan;9(1):e14673. doi: 10.14814/phy2.14673. PMID: 33400857; PMCID: PMC7785050.
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Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice.

JVS-vascular science

Kunath A, Unosson J, Friederich-Persson M, Bjarnegård N, Becirovic-Agic M, Björck M, Mani K, Wanhainen A, Wågsäter D.
PMID: 34617056
JVS Vasc Sci. 2021 Mar 03;2:33-42. doi: 10.1016/j.jvssci.2020.11.031. eCollection 2021.

OBJECTIVE: Metformin is associated with a reduced incidence and growth of abdominal aortic aneurysms (AAAs). The aim of the present study was to investigate the inhibitory effects of metformin on AAA development and possible underlying mechanisms in experimentally induced...

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Kunath A, Unosson J, Friederich-Persson M, et al. Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice. JVS Vasc Sci. 2021;2:33-42doi: 10.1016/j.jvssci.2020.11.031.
Kunath, A., Unosson, J., Friederich-Persson, M., Bjarnegård, N., Becirovic-Agic, M., Björck, M., Mani, K., Wanhainen, A., & Wågsäter, D. (2021). Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice. JVS-vascular science, 233-42. https://doi.org/10.1016/j.jvssci.2020.11.031
Kunath, Anne, et al. "Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice." JVS-vascular science vol. 2 (2021): 33-42. doi: https://doi.org/10.1016/j.jvssci.2020.11.031
Kunath A, Unosson J, Friederich-Persson M, Bjarnegård N, Becirovic-Agic M, Björck M, Mani K, Wanhainen A, Wågsäter D. Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice. JVS Vasc Sci. 2021 Mar 03;2:33-42. doi: 10.1016/j.jvssci.2020.11.031. eCollection 2021. PMID: 34617056; PMCID: PMC8489247.
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Long-Term Relapse-Free Survival by Interdisciplinary Collaboration in a Patient with Metastatic Pancreatic Cancer (UICC IV).

Case reports in oncology

Roehrig S, Wein A, Albrecht H, Maennlein G, Wolff K, Muskoski D, Amann K, Janka R, Hohenberger W, Hahn EG, Siebler J, Neurath MF, Boxberger F.
PMID: 21941491
Case Rep Oncol. 2011 May;4(2):413-9. doi: 10.1159/000331239. Epub 2011 Aug 24.

INTRODUCTION: The prognostic outlook for patients suffering from pancreatic cancer is generally poor. Particularly in cases of advanced and metastatic disease, long-term relapse-free survival may be achieved only in a few cases.CASE REPORT: A 45-year-old patient presented with metastatic...

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Roehrig S, Wein A, Albrecht H, et al. Long-Term Relapse-Free Survival by Interdisciplinary Collaboration in a Patient with Metastatic Pancreatic Cancer (UICC IV). Case Rep Oncol. 2011;4(2):413-9doi: 10.1159/000331239.
Roehrig, S., Wein, A., Albrecht, H., Maennlein, G., Wolff, K., Muskoski, D., Amann, K., Janka, R., Hohenberger, W., Hahn, E. G., Siebler, J., Neurath, M. F., & Boxberger, F. (2011). Long-Term Relapse-Free Survival by Interdisciplinary Collaboration in a Patient with Metastatic Pancreatic Cancer (UICC IV). Case reports in oncology, 4(2), 413-9. https://doi.org/10.1159/000331239
Roehrig, Sandra, et al. "Long-Term Relapse-Free Survival by Interdisciplinary Collaboration in a Patient with Metastatic Pancreatic Cancer (UICC IV)." Case reports in oncology vol. 4,2 (2011): 413-9. doi: https://doi.org/10.1159/000331239
Roehrig S, Wein A, Albrecht H, Maennlein G, Wolff K, Muskoski D, Amann K, Janka R, Hohenberger W, Hahn EG, Siebler J, Neurath MF, Boxberger F. Long-Term Relapse-Free Survival by Interdisciplinary Collaboration in a Patient with Metastatic Pancreatic Cancer (UICC IV). Case Rep Oncol. 2011 May;4(2):413-9. doi: 10.1159/000331239. Epub 2011 Aug 24. PMID: 21941491; PMCID: PMC3177798.
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Design and Rationale for a Phase III, Double-Blind, Placebo-Controlled Study of Neoadjuvant Durvalumab + Chemotherapy Followed by Adjuvant Durvalumab for the Treatment of Patients With Resectable Stages II and III non-small-cell Lung Cancer: The AEGEAN Trial.

Clinical lung cancer

Heymach JV, Mitsudomi T, Harpole D, Aperghis M, Jones S, Mann H, Fouad TM, Reck M.
PMID: 34819266
Clin Lung Cancer. 2021 Oct 10; doi: 10.1016/j.cllc.2021.09.010. Epub 2021 Oct 10.

For patients with resectable, early-stage non-small-cell lung cancer (NSCLC), surgery is the primary treatment; however, 5-year survival rates remain poor. Postoperative adjuvant platinum-doublet chemotherapy is associated with a statistically significant but modest improvement in survival of ∼5% at 5...

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Heymach JV, Mitsudomi T, Harpole D, et al. Design and Rationale for a Phase III, Double-Blind, Placebo-Controlled Study of Neoadjuvant Durvalumab + Chemotherapy Followed by Adjuvant Durvalumab for the Treatment of Patients With Resectable Stages II and III non-small-cell Lung Cancer: The AEGEAN Trial. Clin Lung Cancer. 2021;doi: 10.1016/j.cllc.2021.09.010.
Heymach, J. V., Mitsudomi, T., Harpole, D., Aperghis, M., Jones, S., Mann, H., Fouad, T. M., & Reck, M. (2021). Design and Rationale for a Phase III, Double-Blind, Placebo-Controlled Study of Neoadjuvant Durvalumab + Chemotherapy Followed by Adjuvant Durvalumab for the Treatment of Patients With Resectable Stages II and III non-small-cell Lung Cancer: The AEGEAN Trial. Clinical lung cancer, . https://doi.org/10.1016/j.cllc.2021.09.010
Heymach, John V, et al. "Design and Rationale for a Phase III, Double-Blind, Placebo-Controlled Study of Neoadjuvant Durvalumab + Chemotherapy Followed by Adjuvant Durvalumab for the Treatment of Patients With Resectable Stages II and III non-small-cell Lung Cancer: The AEGEAN Trial." Clinical lung cancer vol. (2021). doi: https://doi.org/10.1016/j.cllc.2021.09.010
Heymach JV, Mitsudomi T, Harpole D, Aperghis M, Jones S, Mann H, Fouad TM, Reck M. Design and Rationale for a Phase III, Double-Blind, Placebo-Controlled Study of Neoadjuvant Durvalumab + Chemotherapy Followed by Adjuvant Durvalumab for the Treatment of Patients With Resectable Stages II and III non-small-cell Lung Cancer: The AEGEAN Trial. Clin Lung Cancer. 2021 Oct 10; doi: 10.1016/j.cllc.2021.09.010. Epub 2021 Oct 10. PMID: 34819266.
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Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity.

Vaccines

Schneider CG, Taylor JA, Sibilo MQ, Miura K, Mallory KL, Mann C, Karch C, Beck Z, Matyas GR, Long CA, Bergmann-Leitner E, Burkhard P, Angov E.
PMID: 33572803
Vaccines (Basel). 2021 Jan 29;9(2). doi: 10.3390/vaccines9020103.

Self-assembling protein nanoparticles (SAPN) serve as a repetitive antigen delivery platform with high-density epitope display; however, antigen characteristics such as size and epitope presentation can influence the immunogenicity of the assembled particle and are aspects to consider for a...

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Schneider CG, Taylor JA, Sibilo MQ, et al. Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity. Vaccines (Basel). 2021;9(2)doi: 10.3390/vaccines9020103.
Schneider, C. G., Taylor, J. A., Sibilo, M. Q., Miura, K., Mallory, K. L., Mann, C., Karch, C., Beck, Z., Matyas, G. R., Long, C. A., Bergmann-Leitner, E., Burkhard, P., & Angov, E. (2021). Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity. Vaccines, 9(2), . https://doi.org/10.3390/vaccines9020103
Schneider, Cosette G, et al. "Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity." Vaccines vol. 9,2 (2021). doi: https://doi.org/10.3390/vaccines9020103
Schneider CG, Taylor JA, Sibilo MQ, Miura K, Mallory KL, Mann C, Karch C, Beck Z, Matyas GR, Long CA, Bergmann-Leitner E, Burkhard P, Angov E. Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity. Vaccines (Basel). 2021 Jan 29;9(2). doi: 10.3390/vaccines9020103. PMID: 33572803; PMCID: PMC7911071.
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Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice.

Acta pharmacologica Sinica

Wörner S, Bohnert BN, Wörn M, Xiao M, Janessa A, Birkenfeld AL, Amann K, Daniel C, Artunc F.
PMID: 33758357
Acta Pharmacol Sin. 2022 Jan;43(1):111-120. doi: 10.1038/s41401-021-00628-1. Epub 2021 Mar 23.

Treatment with aprotinin, a broad-spectrum serine protease inhibitor with a molecular weight of 6512 Da, was associated with acute kidney injury, which was one of the reasons for withdrawal from the market in 2007. Inhibition of renal serine proteases...

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Wörner S, Bohnert BN, Wörn M, et al. Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice. Acta Pharmacol Sin. 2021;43(1):111-120doi: 10.1038/s41401-021-00628-1.
Wörner, S., Bohnert, B. N., Wörn, M., Xiao, M., Janessa, A., Birkenfeld, A. L., Amann, K., Daniel, C., & Artunc, F. (2022). Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice. Acta pharmacologica Sinica, 43(1), 111-120. https://doi.org/10.1038/s41401-021-00628-1
Wörner, Stefan, et al. "Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice." Acta pharmacologica Sinica vol. 43,1 (2022): 111-120. doi: https://doi.org/10.1038/s41401-021-00628-1
Wörner S, Bohnert BN, Wörn M, Xiao M, Janessa A, Birkenfeld AL, Amann K, Daniel C, Artunc F. Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice. Acta Pharmacol Sin. 2022 Jan;43(1):111-120. doi: 10.1038/s41401-021-00628-1. Epub 2021 Mar 23. PMID: 33758357.
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Novel cattail fiber composites: converting waste biomass into reinforcement for composites.

Bioresources and bioprocessing

Shadhin M, Rahman M, Jayaraman R, Mann D.
PMID: 34760436
Bioresour Bioprocess. 2021;8(1):101. doi: 10.1186/s40643-021-00453-8. Epub 2021 Oct 13.

Vacuum-assisted resin transfer molding (VARTM), used in manufacturing medium to large-sized composites for transportation industries, requires non-woven mats. While non-woven glass mats used in these applications are optimized for resin impregnation and properties, such optimized mats for natural fibers...

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Shadhin M, Rahman M, Jayaraman R, et al. Novel cattail fiber composites: converting waste biomass into reinforcement for composites. Bioresour Bioprocess. 2021;8(1):101doi: 10.1186/s40643-021-00453-8.
Shadhin, M., Rahman, M., Jayaraman, R., & Mann, D. (2021). Novel cattail fiber composites: converting waste biomass into reinforcement for composites. Bioresources and bioprocessing, 8(1), 101. https://doi.org/10.1186/s40643-021-00453-8
Shadhin, Md, et al. "Novel cattail fiber composites: converting waste biomass into reinforcement for composites." Bioresources and bioprocessing vol. 8,1 (2021): 101. doi: https://doi.org/10.1186/s40643-021-00453-8
Shadhin M, Rahman M, Jayaraman R, Mann D. Novel cattail fiber composites: converting waste biomass into reinforcement for composites. Bioresour Bioprocess. 2021;8(1):101. doi: 10.1186/s40643-021-00453-8. Epub 2021 Oct 13. PMID: 34760436; PMCID: PMC8570348.
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Development of a computer-aided text message platform for user engagement with a digital Diabetes Prevention Program: a case study.

Journal of the American Medical Informatics Association : JAMIA

Rodriguez DV, Lawrence K, Luu S, Yu JL, Feldthouse DM, Gonzalez J, Mann D.
PMID: 34664647
J Am Med Inform Assoc. 2021 Dec 28;29(1):155-162. doi: 10.1093/jamia/ocab206.

Digital Diabetes Prevention Programs (dDPP) are novel mHealth applications that leverage digital features such as tracking and messaging to support behavior change for diabetes prevention. Despite their clinical effectiveness, long-term engagement to these programs remains a challenge, creating barriers...

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Rodriguez DV, Lawrence K, Luu S, et al. Development of a computer-aided text message platform for user engagement with a digital Diabetes Prevention Program: a case study. J Am Med Inform Assoc. 2021;29(1):155-162doi: 10.1093/jamia/ocab206.
Rodriguez, D. V., Lawrence, K., Luu, S., Yu, J. L., Feldthouse, D. M., Gonzalez, J., & Mann, D. (2021). Development of a computer-aided text message platform for user engagement with a digital Diabetes Prevention Program: a case study. Journal of the American Medical Informatics Association : JAMIA, 29(1), 155-162. https://doi.org/10.1093/jamia/ocab206
Rodriguez, Danissa V, et al. "Development of a computer-aided text message platform for user engagement with a digital Diabetes Prevention Program: a case study." Journal of the American Medical Informatics Association : JAMIA vol. 29,1 (2021): 155-162. doi: https://doi.org/10.1093/jamia/ocab206
Rodriguez DV, Lawrence K, Luu S, Yu JL, Feldthouse DM, Gonzalez J, Mann D. Development of a computer-aided text message platform for user engagement with a digital Diabetes Prevention Program: a case study. J Am Med Inform Assoc. 2021 Dec 28;29(1):155-162. doi: 10.1093/jamia/ocab206. PMID: 34664647; PMCID: PMC8714274.
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Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging.

Bioorganic chemistry

Mann G, Kadiyala KG, Thirumal M, Tiwari AK, Datta A.
PMID: 34736134
Bioorg Chem. 2021 Dec;117:105429. doi: 10.1016/j.bioorg.2021.105429. Epub 2021 Oct 13.

This study aimed at assessing 2-methoxyphenyl piperazine derivative for its binding specificity and suitability in mapping metabotropic glutamate receptor subtype 1, which is implicated in several neuropsychiatric disorders. N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-methylpyridin-2-amine was synthesised and evaluated for brain imaging subsequent to radiolabelling...

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Mann G, Kadiyala KG, Thirumal M, et al. Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging. Bioorg Chem. 2021;117:105429doi: 10.1016/j.bioorg.2021.105429.
Mann, G., Kadiyala, K. G., Thirumal, M., Tiwari, A. K., & Datta, A. (2021). Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging. Bioorganic chemistry, 117105429. https://doi.org/10.1016/j.bioorg.2021.105429
Mann, Garima, et al. "Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging." Bioorganic chemistry vol. 117 (2021): 105429. doi: https://doi.org/10.1016/j.bioorg.2021.105429
Mann G, Kadiyala KG, Thirumal M, Tiwari AK, Datta A. Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging. Bioorg Chem. 2021 Dec;117:105429. doi: 10.1016/j.bioorg.2021.105429. Epub 2021 Oct 13. PMID: 34736134.
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My Colleagues Will Be as My Family.

Academic medicine : journal of the Association of American Medical Colleges

Amann K.
PMID: 33570846
Acad Med. 2021 Feb 09; doi: 10.1097/ACM.0000000000003978. Epub 2021 Feb 09.

No abstract available.

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Amann K. My Colleagues Will Be as My Family. Acad Med. 2021;doi: 10.1097/ACM.0000000000003978.
Amann, K. (2021). My Colleagues Will Be as My Family. Academic medicine : journal of the Association of American Medical Colleges, . https://doi.org/10.1097/ACM.0000000000003978
Amann, Kassaundra. "My Colleagues Will Be as My Family." Academic medicine : journal of the Association of American Medical Colleges vol. (2021). doi: https://doi.org/10.1097/ACM.0000000000003978
Amann K. My Colleagues Will Be as My Family. Acad Med. 2021 Feb 09; doi: 10.1097/ACM.0000000000003978. Epub 2021 Feb 09. PMID: 33570846.
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The Association of Posttraumatic Stress Disorder With Longitudinal Change in Glomerular Filtration Rate in World Trade Center Responders.

Psychosomatic medicine

Koraishy FM, Coca SG, Cohen BE, Scherrer JF, Mann F, Kuan PF, Luft BJ, Clouston SAP.
PMID: 34297009
Psychosom Med. 2021 Nov-Dec 01;83(9):978-986. doi: 10.1097/PSY.0000000000000968.

OBJECTIVE: High levels of psychological distress increase the risk of a wide range of medical diseases. In this study, we investigated the association between posttraumatic stress disorder (PTSD) and kidney disease.METHODS: World Trade Center (WTC) responders were included if...

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Koraishy FM, Coca SG, Cohen BE, et al. The Association of Posttraumatic Stress Disorder With Longitudinal Change in Glomerular Filtration Rate in World Trade Center Responders. Psychosom Med. 2021;83(9):978-986doi: 10.1097/PSY.0000000000000968.
Koraishy, F. M., Coca, S. G., Cohen, B. E., Scherrer, J. F., Mann, F., Kuan, P. F., Luft, B. J., & Clouston, S. A. P. (2021). The Association of Posttraumatic Stress Disorder With Longitudinal Change in Glomerular Filtration Rate in World Trade Center Responders. Psychosomatic medicine, 83(9), 978-986. https://doi.org/10.1097/PSY.0000000000000968
Koraishy, Farrukh M, et al. "The Association of Posttraumatic Stress Disorder With Longitudinal Change in Glomerular Filtration Rate in World Trade Center Responders." Psychosomatic medicine vol. 83,9 (2021): 978-986. doi: https://doi.org/10.1097/PSY.0000000000000968
Koraishy FM, Coca SG, Cohen BE, Scherrer JF, Mann F, Kuan PF, Luft BJ, Clouston SAP. The Association of Posttraumatic Stress Disorder With Longitudinal Change in Glomerular Filtration Rate in World Trade Center Responders. Psychosom Med. 2021 Nov-Dec 01;83(9):978-986. doi: 10.1097/PSY.0000000000000968. PMID: 34297009; PMCID: PMC8578353.
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Showing 1477 to 1488 of 1510 entries