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Toward a definition of pharmaceutical innovation.

Open medicine : a peer-reviewed, independent, open-access journal

Morgan S, Lopert R, Greyson D.
PMID: 21602949
Open Med. 2008;2(1):e4-7. Epub 2008 Jan 30.

ONGOING DEBATES IN THE PHARMACEUTICAL SECTOR ABOUT INTELLECTUAL PROPERTY, PRICING AND REIMBURSEMENT, AND PUBLIC RESEARCH INVESTMENTS HAVE A COMMON DENOMINATOR: the pursuit of innovation. However, there is little clarity about what constitutes a true pharmaceutical innovation, and as a...

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Morgan S, Lopert R, Greyson D. Toward a definition of pharmaceutical innovation. Open Med. 2008;2(1):e4-7
Morgan, S., Lopert, R., & Greyson, D. (2008). Toward a definition of pharmaceutical innovation. Open medicine : a peer-reviewed, independent, open-access journal, 2(1), e4-7.
Morgan, Steven, et al. "Toward a definition of pharmaceutical innovation." Open medicine : a peer-reviewed, independent, open-access journal vol. 2,1 (2008): e4-7.
Morgan S, Lopert R, Greyson D. Toward a definition of pharmaceutical innovation. Open Med. 2008;2(1):e4-7. Epub 2008 Jan 30. PMID: 21602949; PMCID: PMC3091590.
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Soft-x-ray imaging with toroidally curved thallium Acid phthalate crystals in the water window.

Applied optics

Vollbrecht M, Treichel O, Uschmann I, Gäbel K, Lebert R, Förster E.
PMID: 18273091
Appl Opt. 1998 Apr 01;37(10):1803-7. doi: 10.1364/ao.37.001803.

Two-dimensional imaging in the wavelength region of the water window (N Ly alpha) is demonstrated with a toroidally curved thallium acid phthalate crystal. Direct imaging of a plasma pinch line, as well as imaging of a mesh with plasma...

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Vollbrecht M, Treichel O, Uschmann I, et al. Soft-x-ray imaging with toroidally curved thallium Acid phthalate crystals in the water window. Appl Opt. 1998;37(10):1803-7doi: 10.1364/ao.37.001803.
Vollbrecht, M., Treichel, O., Uschmann, I., Gäbel, K., Lebert, R., & Förster, E. (1998). Soft-x-ray imaging with toroidally curved thallium Acid phthalate crystals in the water window. Applied optics, 37(10), 1803-7. https://doi.org/10.1364/ao.37.001803
Vollbrecht, M, et al. "Soft-x-ray imaging with toroidally curved thallium Acid phthalate crystals in the water window." Applied optics vol. 37,10 (1998): 1803-7. doi: https://doi.org/10.1364/ao.37.001803
Vollbrecht M, Treichel O, Uschmann I, Gäbel K, Lebert R, Förster E. Soft-x-ray imaging with toroidally curved thallium Acid phthalate crystals in the water window. Appl Opt. 1998 Apr 01;37(10):1803-7. doi: 10.1364/ao.37.001803. PMID: 18273091.
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Rapid assessment of age-related differences in standing balance.

Journal of aging research

Kalisch T, Kattenstroth JC, Noth S, Tegenthoff M, Dinse HR.
PMID: 21629742
J Aging Res. 2011;2011:160490. doi: 10.4061/2011/160490. Epub 2011 May 12.

As life expectancy continues to rise, in the future there will be an increasing number of older people prone to falling. Accordingly, there is an urgent need for comprehensive testing of older individuals to collect data and to identify...

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Kalisch T, Kattenstroth JC, Noth S, et al. Rapid assessment of age-related differences in standing balance. J Aging Res. 2011;2011:160490doi: 10.4061/2011/160490.
Kalisch, T., Kattenstroth, J. C., Noth, S., Tegenthoff, M., & Dinse, H. R. (2011). Rapid assessment of age-related differences in standing balance. Journal of aging research, 2011160490. https://doi.org/10.4061/2011/160490
Kalisch, Tobias, et al. "Rapid assessment of age-related differences in standing balance." Journal of aging research vol. 2011 (2011): 160490. doi: https://doi.org/10.4061/2011/160490
Kalisch T, Kattenstroth JC, Noth S, Tegenthoff M, Dinse HR. Rapid assessment of age-related differences in standing balance. J Aging Res. 2011;2011:160490. doi: 10.4061/2011/160490. Epub 2011 May 12. PMID: 21629742; PMCID: PMC3100560.
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Secondary .beta.-deuterium isotope effects in decarboxylation and elimination reactions of .alpha.-lactylthiamin: intrinsic isotope effects of pyruvate decarboxylase.

Journal of the American Chemical Society

Kluger R, Brandl M.
PMID: 22283294
J Am Chem Soc. 1986 Nov 01;108(24):7828-32. doi: 10.1021/ja00284a056.

No abstract available.

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Kluger R, Brandl M. Secondary .beta.-deuterium isotope effects in decarboxylation and elimination reactions of .alpha.-lactylthiamin: intrinsic isotope effects of pyruvate decarboxylase. J Am Chem Soc. 1986;108(24):7828-32doi: 10.1021/ja00284a056.
Kluger, R., & Brandl, M. (1986). Secondary .beta.-deuterium isotope effects in decarboxylation and elimination reactions of .alpha.-lactylthiamin: intrinsic isotope effects of pyruvate decarboxylase. Journal of the American Chemical Society, 108(24), 7828-32. https://doi.org/10.1021/ja00284a056
Kluger, R, and Brandl, M. "Secondary .beta.-deuterium isotope effects in decarboxylation and elimination reactions of .alpha.-lactylthiamin: intrinsic isotope effects of pyruvate decarboxylase." Journal of the American Chemical Society vol. 108,24 (1986): 7828-32. doi: https://doi.org/10.1021/ja00284a056
Kluger R, Brandl M. Secondary .beta.-deuterium isotope effects in decarboxylation and elimination reactions of .alpha.-lactylthiamin: intrinsic isotope effects of pyruvate decarboxylase. J Am Chem Soc. 1986 Nov 01;108(24):7828-32. doi: 10.1021/ja00284a056. PMID: 22283294.
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The Effect of Psychoactive Drugs on in vitro Platelet Function.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Schedel A, Thornton S, Klüter H, Bugert P.
PMID: 21113253
Transfus Med Hemother. 2010;37(5):293-298. doi: 10.1159/000319841. Epub 2010 Aug 25.

BACKGROUND: Neuro-hormonal and hemostatic mechanisms are important in a wide range of psychological and cardiovascular diseases. The use of psychoactive drugs in mental illnesses is often involved with hematologic side effects including impaired platelet function. Subsequently, the risk for...

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Schedel A, Thornton S, Klüter H, et al. The Effect of Psychoactive Drugs on in vitro Platelet Function. Transfus Med Hemother. 2010;37(5):293-298doi: 10.1159/000319841.
Schedel, A., Thornton, S., Klüter, H., & Bugert, P. (2010). The Effect of Psychoactive Drugs on in vitro Platelet Function. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 37(5), 293-298. https://doi.org/10.1159/000319841
Schedel, Angelika, et al. "The Effect of Psychoactive Drugs on in vitro Platelet Function." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 37,5 (2010): 293-298. doi: https://doi.org/10.1159/000319841
Schedel A, Thornton S, Klüter H, Bugert P. The Effect of Psychoactive Drugs on in vitro Platelet Function. Transfus Med Hemother. 2010;37(5):293-298. doi: 10.1159/000319841. Epub 2010 Aug 25. PMID: 21113253; PMCID: PMC2980515.
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Analysis of claims of enhanced enzyme catalysis by inorganic colloidosomes.

Bioorganic chemistry

Kluger R.
PMID: 23886373
Bioorg Chem. 2013 Aug;49:59-60. doi: 10.1016/j.bioorg.2013.06.004. Epub 2013 Jun 20.

Ester hydrolysis reactions in the presence of enzymes have been reported to occur within inorganic colloidsomes that contain water in organic solvents. Analysis of reported data plots that were used to obtain values for Km and Vmax that led...

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Kluger R. Analysis of claims of enhanced enzyme catalysis by inorganic colloidosomes. Bioorg Chem. 2013;49:59-60doi: 10.1016/j.bioorg.2013.06.004.
Kluger, R. (2013). Analysis of claims of enhanced enzyme catalysis by inorganic colloidosomes. Bioorganic chemistry, 4959-60. https://doi.org/10.1016/j.bioorg.2013.06.004
Kluger, Ronald. "Analysis of claims of enhanced enzyme catalysis by inorganic colloidosomes." Bioorganic chemistry vol. 49 (2013): 59-60. doi: https://doi.org/10.1016/j.bioorg.2013.06.004
Kluger R. Analysis of claims of enhanced enzyme catalysis by inorganic colloidosomes. Bioorg Chem. 2013 Aug;49:59-60. doi: 10.1016/j.bioorg.2013.06.004. Epub 2013 Jun 20. PMID: 23886373.
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Interim analyses from a randomised controlled trial to improve visual processing speed in older adults: the Iowa Healthy and Active Minds Study.

BMJ open

Wolinsky FD, Vander Weg MW, Howren MB, Jones MP, Martin R, Luger TM, Duff K, Dotson MM.
PMID: 22106377
BMJ Open. 2011 Nov 21;1(2):e000225. doi: 10.1136/bmjopen-2011-000225. Print 2011.

Objectives The Iowa Healthy and Active Minds Study is a four-arm randomised controlled trial of a visual processing speed training programme (Road Tour). This article presents the preplanned interim results immediately after training (6-8 weeks post-randomisation) for the primary...

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Wolinsky FD, Vander Weg MW, Howren MB, et al. Interim analyses from a randomised controlled trial to improve visual processing speed in older adults: the Iowa Healthy and Active Minds Study. BMJ Open. 2011;1(2):e000225doi: 10.1136/bmjopen-2011-000225.
Wolinsky, F. D., Vander Weg, M. W., Howren, M. B., Jones, M. P., Martin, R., Luger, T. M., Duff, K., & Dotson, M. M. (2011). Interim analyses from a randomised controlled trial to improve visual processing speed in older adults: the Iowa Healthy and Active Minds Study. BMJ open, 1(2), e000225. https://doi.org/10.1136/bmjopen-2011-000225
Wolinsky, Fredric D, et al. "Interim analyses from a randomised controlled trial to improve visual processing speed in older adults: the Iowa Healthy and Active Minds Study." BMJ open vol. 1,2 (2011): e000225. doi: https://doi.org/10.1136/bmjopen-2011-000225
Wolinsky FD, Vander Weg MW, Howren MB, Jones MP, Martin R, Luger TM, Duff K, Dotson MM. Interim analyses from a randomised controlled trial to improve visual processing speed in older adults: the Iowa Healthy and Active Minds Study. BMJ Open. 2011 Nov 21;1(2):e000225. doi: 10.1136/bmjopen-2011-000225. Print 2011. PMID: 22106377; PMCID: PMC3225585.
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Pressure-monitored headspace analysis combined with compound-specific isotope analysis to measure isotope fractionation in gas-producing reactions.

Rapid communications in mass spectrometry : RCM

Mundle SO, Vandersteen AA, Lacrampe-Couloume G, Kluger R, Sherwood Lollar B.
PMID: 23821571
Rapid Commun Mass Spectrom. 2013 Aug 15;27(15):1778-84. doi: 10.1002/rcm.6625.

RATIONALE: Processes that lead to pressure changes in closed experimental systems can dramatically increase the total uncertainty in enrichment factors (ε) based on headspace analysis and compound-specific isotope analysis (CSIA). We report: (1) A new technique to determine ε...

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Mundle SO, Vandersteen AA, Lacrampe-Couloume G, et al. Pressure-monitored headspace analysis combined with compound-specific isotope analysis to measure isotope fractionation in gas-producing reactions. Rapid Commun Mass Spectrom. 2013;27(15):1778-84doi: 10.1002/rcm.6625.
Mundle, S. O., Vandersteen, A. A., Lacrampe-Couloume, G., Kluger, R., & Sherwood Lollar, B. (2013). Pressure-monitored headspace analysis combined with compound-specific isotope analysis to measure isotope fractionation in gas-producing reactions. Rapid communications in mass spectrometry : RCM, 27(15), 1778-84. https://doi.org/10.1002/rcm.6625
Mundle, Scott O C, et al. "Pressure-monitored headspace analysis combined with compound-specific isotope analysis to measure isotope fractionation in gas-producing reactions." Rapid communications in mass spectrometry : RCM vol. 27,15 (2013): 1778-84. doi: https://doi.org/10.1002/rcm.6625
Mundle SO, Vandersteen AA, Lacrampe-Couloume G, Kluger R, Sherwood Lollar B. Pressure-monitored headspace analysis combined with compound-specific isotope analysis to measure isotope fractionation in gas-producing reactions. Rapid Commun Mass Spectrom. 2013 Aug 15;27(15):1778-84. doi: 10.1002/rcm.6625. PMID: 23821571.
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The gears keep turning: current progress in platelet function testing.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Bugert P.
PMID: 23653568
Transfus Med Hemother. 2013 Apr;40(2):71. doi: 10.1159/000350692.

No abstract available.

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Bugert P. The gears keep turning: current progress in platelet function testing. Transfus Med Hemother. 2013;40(2):71doi: 10.1159/000350692.
Bugert, P. (2013). The gears keep turning: current progress in platelet function testing. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 40(2), 71. https://doi.org/10.1159/000350692
Bugert, Peter. "The gears keep turning: current progress in platelet function testing." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 40,2 (2013): 71. doi: https://doi.org/10.1159/000350692
Bugert P. The gears keep turning: current progress in platelet function testing. Transfus Med Hemother. 2013 Apr;40(2):71. doi: 10.1159/000350692. PMID: 23653568; PMCID: PMC3638922.
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Peridural Anesthesia or Ultrasound-Guided Continuous 3-in-1 Block: Which Is Indicated for Analgesia in Very Elderly Patients With Hip Fracture in the Emergency Department?.

Geriatric orthopaedic surgery & rehabilitation

Luger TJ, Kammerlander C, Benz M, Luger MF, Garoscio I.
PMID: 23569705
Geriatr Orthop Surg Rehabil. 2012 Sep;3(3):121-8. doi: 10.1177/2151458512470953.

PURPOSE: The aim of our study was to investigate the clinical relevance of preoperative acute pain management and cardiovascular stability by ultrasound-guided continuous 3-in-1 nerve block in very elderly patients with hip fracture when compared to epidural anesthesia (PDA).METHODS:...

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Luger TJ, Kammerlander C, Benz M, et al. Peridural Anesthesia or Ultrasound-Guided Continuous 3-in-1 Block: Which Is Indicated for Analgesia in Very Elderly Patients With Hip Fracture in the Emergency Department?. Geriatr Orthop Surg Rehabil. 2012;3(3):121-8doi: 10.1177/2151458512470953.
Luger, T. J., Kammerlander, C., Benz, M., Luger, M. F., & Garoscio, I. (2012). Peridural Anesthesia or Ultrasound-Guided Continuous 3-in-1 Block: Which Is Indicated for Analgesia in Very Elderly Patients With Hip Fracture in the Emergency Department?. Geriatric orthopaedic surgery & rehabilitation, 3(3), 121-8. https://doi.org/10.1177/2151458512470953
Luger, Thomas J, et al. "Peridural Anesthesia or Ultrasound-Guided Continuous 3-in-1 Block: Which Is Indicated for Analgesia in Very Elderly Patients With Hip Fracture in the Emergency Department?." Geriatric orthopaedic surgery & rehabilitation vol. 3,3 (2012): 121-8. doi: https://doi.org/10.1177/2151458512470953
Luger TJ, Kammerlander C, Benz M, Luger MF, Garoscio I. Peridural Anesthesia or Ultrasound-Guided Continuous 3-in-1 Block: Which Is Indicated for Analgesia in Very Elderly Patients With Hip Fracture in the Emergency Department?. Geriatr Orthop Surg Rehabil. 2012 Sep;3(3):121-8. doi: 10.1177/2151458512470953. PMID: 23569705; PMCID: PMC3598445.
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Chemotaxis in Campylobacter jejuni.

European journal of microbiology & immunology

Zautner AE, Tareen AM, Groß U, Lugert R.
PMID: 24611118
Eur J Microbiol Immunol (Bp). 2012 Mar;2(1):24-31. doi: 10.1556/EuJMI.2.2012.1.5. Epub 2012 Mar 17.

Chemotaxis is the common way of flagellated bacteria to direct their locomotion to sites of most favourable living conditions, that are sites with the highest concentrations of energy sources and the lowest amounts of bacteriotoxic substances. The general prerequisites...

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Zautner AE, Tareen AM, Groß U, et al. Chemotaxis in Campylobacter jejuni. Eur J Microbiol Immunol (Bp). 2012;2(1):24-31doi: 10.1556/EuJMI.2.2012.1.5.
Zautner, A. E., Tareen, A. M., Groß, U., & Lugert, R. (2012). Chemotaxis in Campylobacter jejuni. European journal of microbiology & immunology, 2(1), 24-31. https://doi.org/10.1556/EuJMI.2.2012.1.5
Zautner, A E, et al. "Chemotaxis in Campylobacter jejuni." European journal of microbiology & immunology vol. 2,1 (2012): 24-31. doi: https://doi.org/10.1556/EuJMI.2.2012.1.5
Zautner AE, Tareen AM, Groß U, Lugert R. Chemotaxis in Campylobacter jejuni. Eur J Microbiol Immunol (Bp). 2012 Mar;2(1):24-31. doi: 10.1556/EuJMI.2.2012.1.5. Epub 2012 Mar 17. PMID: 24611118; PMCID: PMC3933987.
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A Novel ABO Gene Variant Leads to Discrepant Results in Forward/Reverse and Molecular Blood Grouping.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Goebel M, Halm-Heinrich I, Parkner A, Rink G, Heim MU, Bugert P.
PMID: 24474897
Transfus Med Hemother. 2013 Dec;40(6):454-8. doi: 10.1159/000356378. Epub 2013 Oct 27.

BACKGROUND: Discrepant results in antigen and reverse ABO blood typing are often caused by a variant ABO gene. Molecular analysis can help to characterize such variants. Here, we describe the identification of a novel ABO gene variant in a...

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Goebel M, Halm-Heinrich I, Parkner A, et al. A Novel ABO Gene Variant Leads to Discrepant Results in Forward/Reverse and Molecular Blood Grouping. Transfus Med Hemother. 2013;40(6):454-8doi: 10.1159/000356378.
Goebel, M., Halm-Heinrich, I., Parkner, A., Rink, G., Heim, M. U., & Bugert, P. (2013). A Novel ABO Gene Variant Leads to Discrepant Results in Forward/Reverse and Molecular Blood Grouping. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 40(6), 454-8. https://doi.org/10.1159/000356378
Goebel, Meike, et al. "A Novel ABO Gene Variant Leads to Discrepant Results in Forward/Reverse and Molecular Blood Grouping." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 40,6 (2013): 454-8. doi: https://doi.org/10.1159/000356378
Goebel M, Halm-Heinrich I, Parkner A, Rink G, Heim MU, Bugert P. A Novel ABO Gene Variant Leads to Discrepant Results in Forward/Reverse and Molecular Blood Grouping. Transfus Med Hemother. 2013 Dec;40(6):454-8. doi: 10.1159/000356378. Epub 2013 Oct 27. PMID: 24474897; PMCID: PMC3901630.
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Showing 13 to 24 of 207 entries