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Showing 529 to 540 of 540 entries
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Robust decomposition of cell type mixtures in spatial transcriptomics.

Nature biotechnology

Cable DM, Murray E, Zou LS, Goeva A, Macosko EZ, Chen F, Irizarry RA.
PMID: 33603203
Nat Biotechnol. 2021 Feb 18; doi: 10.1038/s41587-021-00830-w. Epub 2021 Feb 18.

A limitation of spatial transcriptomics technologies is that individual measurements may contain contributions from multiple cells, hindering the discovery of cell-type-specific spatial patterns of localization and expression. Here, we develop robust cell type decomposition (RCTD), a computational method that...

Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor.

Antioxidants (Basel, Switzerland)

Ayala JC, Grismaldo A, Sequeda-Castañeda LG, Aristizábal-Pachón AF, Morales L.
PMID: 34943015
Antioxidants (Basel). 2021 Nov 29;10(12). doi: 10.3390/antiox10121912.

Lipid peroxidation, protein oxidation, and mutations in mitochondrial DNA generate reactive oxygen species (ROS) that are involved in cell death and inflammatory response syndrome. ROS can also act as a signal in the intracellular pathways involved in normal cell...

The Use of Augmented Reality to Guide the Intraoperative Frozen Section During Robot-assisted Radical Prostatectomy.

European urology

Bianchi L, Chessa F, Angiolini A, Cercenelli L, Lodi S, Bortolani B, Molinaroli E, Casablanca C, Droghetti M, Gaudiano C, Mottaran A, Porreca A, Golfieri R, Romagnoli D, Giunchi F, Fiorentino M, Piazza P, Puliatti S, Diciotti S, Marcelli E, Mottrie A, Schiavina R.
PMID: 34332759
Eur Urol. 2021 Oct;80(4):480-488. doi: 10.1016/j.eururo.2021.06.020. Epub 2021 Jul 29.

BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) can guide the surgical plan during robot-assisted radical prostatectomy (RARP), and intraoperative frozen section (IFS) can facilitate real-time surgical margin assessment.OBJECTIVE: To assess a novel technique of IFS targeted to the index lesion...

Calcium-independent phospholipase A2 inhibitor produces an analgesic effect in a rat model of neuropathic pain by reducing central sensitization in the dorsal horn.

Neurological research

Gwak YS, Chen G, Abdi S, Kim HK.
PMID: 33866950
Neurol Res. 2021 Aug;43(8):683-692. doi: 10.1080/01616412.2021.1915079. Epub 2021 Apr 18.

OBJECTIVE: Phospholipase A2 (PLA2) plays an important role in regulating the production of arachidonic acid and various eicosanoids. The aim of our study was to investigate the analgesic mechanisms of calcium-dependent cytosolic phospholipase A2 and calcium-independent PLA2 (iPLA2) inhibitors...

Epidural Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Comprehensive Evidence-Based Guidelines.

Pain physician

Manchikanti L, Knezevic NN, Navani A, Christo PJ, Limerick G, Calodney AK, Grider J, Harned ME, Cintron L, Gharibo CG, Shah S, Nampiaparampil DE, Candido KD, Soin A, Kaye AD, Kosanovic R, Magee TR, Beall DP, Atluri S, Gupta M, Helm Ii S, Wargo BW, Diwan S, Aydin SM, Boswell MV, Haney BW, Albers SL, Latchaw R, Abd-Elsayed A, Conn A, Hansen H, Simopoulos TT, Swicegood JR, Bryce DA, Singh V, Abdi S, Bakshi S, Buenaventura RM, Cabaret JA, Jameson J, Jha S, Kaye AM, Pasupuleti R, Rajput K, Sanapati MR, Sehgal N, Trescot AM, Racz GB, Gupta S, Sharma ML, Grami V, Parr AT, Knezevic E, Datta S, Patel KG, Tracy DH, Cordner HJ, Snook LT, Benyamin RM, Hirsch JA.
PMID: 33492918
Pain Physician. 2021 Jan;24:S27-S208.

BACKGROUND: Chronic spinal pain is the most prevalent chronic disease with employment of multiple modes of interventional techniques including epidural interventions. Multiple randomized controlled trials (RCTs), observational studies, systematic reviews, and guidelines have been published. The recent review of...

Bartonella gabonensis sp. nov., a new bartonella species from savannah rodent Lophuromys sp. in Franceville, Gabon.

New microbes and new infections

Mangombi JB, N'Dilimabaka N, Medkour H, Banga OL, Tall ML, Ben Khedher M, Terras J, Abdi S, Bourgarel M, Leroy E, Fenollar F, Mediannikov O.
PMID: 33294192
New Microbes New Infect. 2020 Oct 27;38:100796. doi: 10.1016/j.nmni.2020.100796. eCollection 2020 Nov.

We describe a new strain named Bartonella gabonensis sp. nov. strain 669

Subtyping Schizophrenia Patients Based on Patterns of Structural Brain Alterations.

Schizophrenia bulletin

Xiao Y, Liao W, Long Z, Tao B, Zhao Q, Luo C, Tamminga CA, Keshavan MS, Pearlson GD, Clementz BA, Gershon ES, Ivleva EI, Keedy SK, Biswal BB, Mechelli A, Lencer R, Sweeney JA, Lui S, Gong Q.
PMID: 34508358
Schizophr Bull. 2021 Sep 11; doi: 10.1093/schbul/sbab110. Epub 2021 Sep 11.

Schizophrenia is a complex and heterogeneous syndrome. Whether quantitative imaging biomarkers can identify discrete subgroups of patients as might be used to foster personalized medicine approaches for patient care remains unclear. Cross-sectional structural MR images of 163 never-treated first-episode...

Enhancing Linkage to Hepatitis C Virus Treatment Following Pregnancy in Women Identified During Perinatal Care.

Hepatology communications

Epstein RL, Moloney C, Garfinkel J, Saia K, Wachman EM, Lodi S, Pelton SI.
PMID: 34510828
Hepatol Commun. 2021 Sep;5(9):1543-1554. doi: 10.1002/hep4.1748. Epub 2021 Jul 01.

Amid the current US opioid crisis, hepatitis C virus (HCV) infection rates continue to rise in young adults, including among pregnant women, yet few studies describe linkage to care and treatment in pregnant or postpartum women with HCV infection....

Distinct hippocampal subfield atrophy in Parkinson's disease regarding motor subtypes.

Parkinsonism & related disorders

Luo C, Gao Y, Hu N, Wei X, Xiao Y, Wang W, Lui S, Gong Q.
PMID: 34808520
Parkinsonism Relat Disord. 2021 Dec;93:66-70. doi: 10.1016/j.parkreldis.2021.11.011. Epub 2021 Nov 16.

INTRODUCTION: Global hippocampal atrophy has been repeatedly reported in patients with Parkinson's disease (PD). However, there is limited literature on the differential involvement of hippocampal subfields among PD motor subtypes. This study aimed to investigate hippocampal subfield alterations in...

Height-adjusted lean body mass and its associations with physical activity and kidney function in pediatric kidney transplantation.

Pediatric transplantation

Ahmed A, Cote A, Lui S, Blydt-Hansen TD.
PMID: 34486205
Pediatr Transplant. 2022 Feb;26(1):e14128. doi: 10.1111/petr.14128. Epub 2021 Sep 05.

BACKGROUND: Although LBM is positively associated with health outcomes, studies assessing determinants for the accrual of ht-LBM, such as physical activity, are limited. This study aimed to assess ht-LBM levels in pediatric kidney transplant recipients and test its association...

Age-associated network controllability changes in first episode drug-naïve schizophrenia.

BMC psychiatry

Tang B, Zhang W, Deng S, Liu J, Hu N, Gong Q, Gu S, Lui S.
PMID: 35012507
BMC Psychiatry. 2022 Jan 10;22(1):26. doi: 10.1186/s12888-021-03674-5.

BACKGROUND: Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain's structural connectivity lead to dynamic function changes in schizophrenia with age remains poorly understood.METHODS:...

A JBrick: Accessible Robotics Programming for Visually Impaired Users.

Ludi S, Jordan S.
UIID-AD: 3887
2015;157-168. doi: 10.1007/978-3-319-20684-4_16.

Despite advances in assistive technology, challenges remain in precollege computer science outreach and university programs for visually impaired students. The use of robotics has been popular in pre-college classrooms and outreach programs, including those that serve underrepresented groups. This...

Showing 529 to 540 of 540 entries