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Showing 361 to 372 of 3217 entries
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Systemic Therapy Decision Making in Advanced Cancer: A Qualitative Analysis of Patient-Oncologist Encounters.

JCO oncology practice

Wasp GT, Knutzen KE, Murray GF, Brody-Bizar OC, Liu MA, Pollak KI, Tulsky JA, Schenker Y, Barnato AE.
PMID: 34855459
JCO Oncol Pract. 2021 Dec 02;OP2100377. doi: 10.1200/OP.21.00377. Epub 2021 Dec 02.

PURPOSE: We sought to characterize patient-oncologist communication and decision making about continuing or limiting systemic therapy in encounters after an initial consultation, with a particular focus on whether and how oncologists foster shared decision making (SDM).METHODS: We performed content...

Identification of an IRES within the coding region of the structural protein of human rhinovirus 16.

Journal of medical virology

Shi B, Song Q, Luo X, Song J, Xia D, Xia Z, Liu M, Wang W, Wang R, Du H, Wei Q, Han J.
PMID: 34873729
J Med Virol. 2021 Dec 06; doi: 10.1002/jmv.27507. Epub 2021 Dec 06.

As an alternative mechanism for cap-dependent (m7GpppN) translation, IRES-dependent translation has been observed in the 5' untranslated regions (5' UTR) and coding regions of a number of viral and eukaryotic mRNAs. In this study, a series of 5' terminal...

Predictors of health-related quality of life in older New Zealanders with cardiovascular health problems.

Australasian journal on ageing

Montayre J, Ho MH, Chang HR, Liu MF, Chang CC, Fernandez R.
PMID: 34873808
Australas J Ageing. 2021 Dec 06; doi: 10.1111/ajag.13021. Epub 2021 Dec 06.

OBJECTIVE: With longer life expectancies, cardiovascular diseases are increasingly common among older adults, which also leads to functional changes that severely impact their quality of life. This study aimed to identify the predictors of health-related quality of life (HRQOL)...

Comparison of contrast-enhanced T1-weighted imaging using DANTE-SPACE, PETRA, and MPRAGE: a clinical evaluation of brain tumors at 3 Tesla.

Quantitative imaging in medicine and surgery

Fu Q, Cheng QG, Kong XC, Liu DX, Guo YH, Grinstead J, Zhang XY, Lei ZQ, Zheng CS.
PMID: 34993104
Quant Imaging Med Surg. 2022 Jan;12(1):592-607. doi: 10.21037/qims-21-107.

BACKGROUND: We aimed to compare the performance of three contrast-enhanced T1-weighted three-dimensional (3D) magnetic resonance (MR) sequences to detect brain tumors at 3 Tesla. The three sequences were: (I) delay alternating with nutation for tailored excitation sampling perfection with...

Clinical outcomes of pediatric patients with autism spectrum disorder and other neurodevelopmental disorders and intracranial germ cell tumors.

Pediatric blood & cancer

Liu KX, Sethi RV, Pulsifer MB, D'Gama AM, LaVally B, Ebb DH, Tarbell NJ, Yock TI, MacDonald SM.
PMID: 33694260
Pediatr Blood Cancer. 2021 Aug;68(8):e28935. doi: 10.1002/pbc.28935. Epub 2021 Mar 10.

INTRODUCTION: Intracranial germ cell tumors (IGCTs) are rare tumors of the central nervous system with peak incidence around puberty. Given the developmental origins of IGCTs, we investigated the prevalence of neurodevelopmental disorders (NDDs) in patients with IGCTs and characterized...

Tetrodecadazinone, a novel tetrodecamycin-pyridazinone hybrid with anti-liver fibrosis activity from Streptomyces sp. HU051.

Bioorganic chemistry

Liu RX, Ma SF, Chen YL, Ma LF, Wang JD, Zhan ZJ.
PMID: 34952245
Bioorg Chem. 2021 Dec 16;119:105573. doi: 10.1016/j.bioorg.2021.105573. Epub 2021 Dec 16.

Tetrodecadazinone (1), a novel tetrodecamycin-pyridazinone hybrid possessing a new 1,2-dimethyl-1-(2-methylnonyl)decahydronaphthalene skeleton, and 4-hydroxydihydrotetrodecamycin (2) were separated from a culture of Streptomyces sp. HU051, together with a known compound, dihydrotetrodecamycin (3). Diverse spectroscopic approaches were applied to assign the structures...

Thoracic full-endoscopic unilateral laminotomy with bilateral decompression for treating ossification of the ligamentum flavum with myelopathy.

Annals of translational medicine

Lin YP, Lin R, Chen S, Rao SY, Zhao S, Wen T, Wang HS, Hu WX, Liu BX, Li XY, Li YJ, Chen BL.
PMID: 34277777
Ann Transl Med. 2021 Jun;9(12):977. doi: 10.21037/atm-21-2181.

BACKGROUND: The aim of the present study was to evaluate the curative effect and safety of thoracic full-endoscopic unilateral laminotomy with bilateral decompression (TE-ULBD) for treating ossification of the ligamentum flavum (OLF) with myelopathy.METHODS: Between January 2015 and December...

Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve .

Bioactive materials

Ma YX, Jiao K, Wan QQ, Li J, Liu MY, Zhang ZB, Qin W, Wang KY, Wang YZ, Tay FR, Niu LN.
PMID: 34820584
Bioact Mater. 2021 Jul 27;9:475-490. doi: 10.1016/j.bioactmat.2021.07.016. eCollection 2022 Mar.

Sensory nerves promote osteogenesis through the release of neuropeptides. However, the potential application and mechanism in which sensory nerves promote healing of bone defects in the presence of biomaterials remain elusive. The present study identified that new bone formation...

Impact of baseline clinical asthma characteristics on the response to mepolizumab: a post hoc meta-analysis of two Phase III trials.

Respiratory research

Lemiere C, Taillé C, Lee JK, Smith SG, Mallett S, Albers FC, Bradford ES, Yancey SW, Liu MC.
PMID: 34158028
Respir Res. 2021 Jun 22;22(1):184. doi: 10.1186/s12931-021-01767-z.

BACKGROUND: Severe asthma is associated with a broad range of phenotypes and clinical characteristics. This analysis assessed whether select baseline patient characteristics could prognosticate mepolizumab efficacy in severe eosinophilic asthma.METHODS: This was a post hoc meta-analysis of data from...

Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation?.

Frontiers in oncology

Gao XH, Zhai BZ, Li J, Kabemba JLT, Gong HF, Bai CG, Liu ML, Zhang ST, Shen F, Liu LJ, Zhang W.
PMID: 33643920
Front Oncol. 2021 Feb 12;10:625459. doi: 10.3389/fonc.2020.625459. eCollection 2020.

BACKGROUND: In most guidelines, upper rectal cancers (URC) are not recommended to take neoadjuvant or adjuvant radiation. However, the definitions of URC vary greatly. Five definitions had been commonly used to define URC: 1) >10 cm from the anal...

Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.

Experimental neurology

Liu MX, Luo L, Fu JH, He JY, Chen MY, He ZJ, Jia J.
PMID: 34921847
Exp Neurol. 2021 Dec 16;349:113952. doi: 10.1016/j.expneurol.2021.113952. Epub 2021 Dec 16.

As a primary nonpharmacological tool, exercise training is neuroprotective after experimental ischemic stroke by relieving neuroinflammation. However, the specific mechanism of which and anti-inflammatory effect of exercise at different intensities require in-depth investigations. To explore the issue, middle cerebral...

Germline Variants and Genetic Interactions of Several EMT Regulatory Genes Increase the Risk of HBV-Related Hepatocellular Carcinoma.

Frontiers in oncology

Liu WX, Yang L, Yan HM, Yan LN, Zhang XL, Ma N, Tang LM, Gao X, Liu DW.
PMID: 34178612
Front Oncol. 2021 Jun 11;11:564477. doi: 10.3389/fonc.2021.564477. eCollection 2021.

Epithelial-mesenchymal transition (EMT) plays an important role in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). We hypothesized that germline variants in the major EMT regulatory genes (

Showing 361 to 372 of 3217 entries