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Showing 13 to 24 of 210 entries
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Clinical and molecular features associated with cystic visceral lesions in von hippel-lindau disease.

The open ophthalmology journal

Taylor SR, Singh J, Sagoo MS, Lightman SL.
PMID: 23002415
Open Ophthalmol J. 2012;6:83-5. doi: 10.2174/1874364101206010083. Epub 2012 Sep 07.

BACKGROUND: Von Hippel-Lindau (VHL) is an uncommon oncogenic disorder which occurs as a result of genetic mutations on chromosome 3p. Retinal capillary haemangiomas and CNS haemangioblastomas have been well-characterised in genotypic-phenotypic analyses, but cystic visceral lesions are less common...

Cerebral Amyloid Angiopathy Related Inflammation With Prominent Meningeal Involvement. A Report of 2 Cases.

Frontiers in neurology

Aghetti A, Sène D, Polivka M, Shor N, Lechtman S, Chabriat H, Jouvent E, Guey S.
PMID: 31608002
Front Neurol. 2019 Sep 23;10:984. doi: 10.3389/fneur.2019.00984. eCollection 2019.

Cerebral amyloid angiopathy related inflammation (CAA-RI) is a rare form of CAA characterized by subacute encephalitic symptoms (cognitive decline, seizures, focal deficits) associated with extensive and confluent white matter lesions co-localizing with lobar microbleeds on brain MRI. We report...

Bile Acid Synthesis Defect and Hyperinsulinism.

ACG case reports journal

Rogers M, Sylvester F, Lichtman S.
PMID: 30775392
ACG Case Rep J. 2018 Dec 05;5:e89. doi: 10.14309/crj.2018.89. eCollection 2018.

Congenital defects of bile acid synthesis are rare disorders that cause progressive liver dysfunction. Prolonged neonatal hyperinsulism (PNH) is a separate entity that leads to persistent hypoglycemia secondary to stress. We present a 4-month-old infant who presented with liver...

Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices.

Neuropharmacology

Eapen AV, Fernández-Fernández D, Georgiou J, Bortolotto ZA, Lightman S, Jane DE, Volianskis A, Collingridge GL.
PMID: 34637787
Neuropharmacology. 2021 Dec 15;201:108833. doi: 10.1016/j.neuropharm.2021.108833. Epub 2021 Oct 09.

The GluN2 subunits of N-methyl-d-aspartate receptors (NMDARs) are key drivers of synaptic plasticity in the brain, where the particular GluN2 composition endows the NMDAR complex with distinct pharmacological and physiological properties. Compared to GluN2A and GluN2B subunits, far less...

Socio-demographic and psychosocial predictors of salivary cortisol from older male participants in the Speedwell prospective cohort study.

Psychoneuroendocrinology

Spiga F, Lawton MA, Lightman SL, Smith GD, Ben-Shlomo Y.
PMID: 34823140
Psychoneuroendocrinology. 2022 Jan;135:105577. doi: 10.1016/j.psyneuen.2021.105577. Epub 2021 Oct 28.

INTRODUCTION: Associations between measures of socio-economic position and cortisol remain controversial. We examined the association between social class and cortisol reactivity in an aging male population.METHODS: The Speedwell cohort study recruited 2348 men aged 45-59 years from primary care...

The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells.

Cancer immunology research

Paavola KJ, Roda JM, Lin VY, Chen P, O'Hollaren KP, Ventura R, Crawley SC, Li B, Chen HH, Malmersjö S, Sharkov NA, Horner G, Guo W, Kutach AK, Mondal K, Zhang Z, Lichtman JS, Song C, Rivera LB, Liu W, Luo J, Wang Y, Solloway MJ, Allan BB, Kekatpure A, Starck SR, Haldankar R, Fan B, Chu C, Tang J, Molgora M, Colonna M, Kaplan DD, Hsu JY.
PMID: 34426457
Cancer Immunol Res. 2021 Nov;9(11):1283-1297. doi: 10.1158/2326-6066.CIR-21-0240. Epub 2021 Aug 23.

Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated myeloid cells and promotes their suppressive phenotype. However, the ligand that engages ILT3 within the tumor...

Chemogenetic activation of endogenous arginine vasopressin exerts anorexigenic effects via central nesfatin-1/NucB2 pathway.

The journal of physiological sciences : JPS

Sanada K, Yoshimura M, Ikeda N, Baba K, Nishimura H, Nishimura K, Nonaka Y, Maruyama T, Miyamoto T, Mori M, Conway-Campbell B, Lightman S, Kataoka M, Ueta Y.
PMID: 34134629
J Physiol Sci. 2021 Jun 16;71(1):18. doi: 10.1186/s12576-021-00802-4.

We examined whether the chemogenetic activation of endogenous arginine vasopressin (AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was previously generated. Saline (1 mL/kg) or clozapine-N-oxide (CNO, 1 mg/mL/kg), an agonist for hM3Dq, was subcutaneously administered...

Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial.

Psychoneuroendocrinology

Kalafatakis K, Russell GM, Ferguson SG, Grabski M, Harmer CJ, Munafò MR, Marchant N, Wilson A, Brooks JC, Thakrar J, Murphy P, Thai NJ, Lightman SL.
PMID: 33296841
Psychoneuroendocrinology. 2021 Feb;124:105096. doi: 10.1016/j.psyneuen.2020.105096. Epub 2020 Dec 01.

Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short duration hormonal pulses. To elucidate the potential neurobiological...

The Long-term Effect of Standardized Anal Dilatation for Chronic Anal Fissure on Anal Continence.

Annals of coloproctology

Pinsk I, Czeiger D, Lichtman D, Reshef A.
PMID: 32178506
Ann Coloproctol. 2021 Apr;37(2):115-119. doi: 10.3393/ac.2020.03.16. Epub 2020 Mar 16.

PURPOSE: For the past several decades, internal anal sphincterotomy has generally been considered to be the standard operation for an anal fissure. However, wound complications inherent in this operation forced surgeons to look for an alternative form of treatment....

Maternal and child health service delivery in conflict-affected settings: a case study example from Upper Nile and Unity states, South Sudan.

Conflict and health

Sami S, Mayai A, Sheehy G, Lightman N, Boerma T, Wild H, Tappis H, Ochan W, Wanyama J, Spiegel P.
PMID: 32514299
Confl Health. 2020 May 27;14:34. doi: 10.1186/s13031-020-00272-2. eCollection 2020.

BACKGROUND: Decades of war left the Republic of South Sudan with a fragile health system that has remained deprived of resources since the country's independence. We describe the coverage of interventions for women's and children's health in Upper Nile...

Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Performance Status Work Group.

Clinical cancer research : an official journal of the American Association for Cancer Research

Magnuson A, Bruinooge SS, Singh H, Wilner KD, Jalal S, Lichtman SM, Kluetz PG, Lyman GH, Klepin HD, Fleury ME, Hirsch B, Melemed A, Arnaldez FI, Basu Roy U, Schenkel C, Sherwood S, Garrett-Mayer E.
PMID: 33563633
Clin Cancer Res. 2021 May 01;27(9):2424-2429. doi: 10.1158/1078-0432.CCR-20-3868. Epub 2021 Feb 09.

PURPOSE: Performance status (PS) is one of the most common eligibility criteria. Many trials are limited to patients with high-functioning PS, resulting in important differences between trial participants and patient populations with the disease. In addition, existing PS measures...

Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices.

Neuropharmacology

Eapen AV, Fernández-Fernández D, Georgiou J, Bortolotto ZA, Lightman S, Jane DE, Volianskis A, Collingridge GL.
PMID: 34637787
Neuropharmacology. 2021 Dec 15;201:108833. doi: 10.1016/j.neuropharm.2021.108833. Epub 2021 Oct 09.

The GluN2 subunits of N-methyl-d-aspartate receptors (NMDARs) are key drivers of synaptic plasticity in the brain, where the particular GluN2 composition endows the NMDAR complex with distinct pharmacological and physiological properties. Compared to GluN2A and GluN2B subunits, far less...

Showing 13 to 24 of 210 entries