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Showing 217 to 227 of 227 entries
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Lin28 paralogs regulate lung branching morphogenesis.

Cell reports

Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ.
PMID: 34289374
Cell Rep. 2021 Jul 20;36(3):109408. doi: 10.1016/j.celrep.2021.109408.

The molecular mechanisms that govern the choreographed timing of organ development remain poorly understood. Our investigation of the role of the Lin28a and Lin28b paralogs during the developmental process of branching morphogenesis establishes that dysregulation of Lin28a/b leads to...

Spatially organized multicellular immune hubs in human colorectal cancer.

Cell

Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, Bejnood A, Dionne D, Ge WH, Xu KH, Chao SX, Zollinger DR, Lieb DJ, Reeves JW, Fuhrman CA, Hoang ML, Delorey T, Nguyen LT, Waldman J, Klapholz M, Wakiro I, Cohen O, Albers J, Smillie CS, Cuoco MS, Wu J, Su MJ, Yeung J, Vijaykumar B, Magnuson AM, Asinovski N, Moll T, Goder-Reiser MN, Applebaum AS, Brais LK, DelloStritto LK, Denning SL, Phillips ST, Hill EK, Meehan JK, Frederick DT, Sharova T, Kanodia A, Todres EZ, Jané-Valbuena J, Biton M, Izar B, Lambden CD, Clancy TE, Bleday R, Melnitchouk N, Irani J, Kunitake H, Berger DL, Srivastava A, Hornick JL, Ogino S, Rotem A, Vigneau S, Johnson BE, Corcoran RB, Sharpe AH, Kuchroo VK, Ng K, Giannakis M, Nieman LT, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N.
PMID: 34450029
Cell. 2021 Sep 02;184(18):4734-4752.e20. doi: 10.1016/j.cell.2021.08.003. Epub 2021 Aug 26.

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent...

Botulinum Toxin for the Treatment of Intractable Raynaud Phenomenon.

Cutis

Shwe S, Sharma AA, Chahal HS, Doan LT, Rojek NW.
PMID: 34826285
Cutis. 2021 Sep;108(3):E11-E14. doi: 10.12788/cutis.0355.

No abstract available.

Surface Water Intrusion, Land Use Impacts, and Bacterial Community Composition in Shallow Groundwater Wells Supplying Potable Water in Sparsely Populated Areas of a Boreal Region.

Microbiology spectrum

Lyons KJ, Hokajärvi AM, Ikonen J, Kauppinen A, Miettinen IT, Pitkänen T, Rossi PM, Kujala K.
PMID: 34730413
Microbiol Spectr. 2021 Dec 22;9(3):e0017921. doi: 10.1128/Spectrum.00179-21. Epub 2021 Nov 03.

Rural communities often rely on groundwater for potable water supply. In this study, untreated groundwater samples from 28 shallow groundwater wells in Finland (

Precise Measurement of the D^{0} and D^{+} Lifetimes at Belle II.

Physical review letters

Abudinén F, Adachi I, Adamczyk K, Aggarwal L, Ahmed H, Aihara H, Akopov N, Aloisio A, Anh Ky N, Asner DM, Atmacan H, Aushev V, Babu V, Bacher S, Bae H, Baehr S, Bahinipati S, Bambade P, Banerjee S, Bansal S, Barrett M, Baudot J, Bauer M, Baur A, Becker J, Behera PK, Bennett JV, Bernieri E, Bernlochner FU, Bertemes M, Bertholet E, Bessner M, Bettarini S, Bhardwaj V, Bianchi F, Bilka T, Bilokin S, Biswas D, Bobrov A, Bodrov D, Bolz A, Bozek A, Bračko M, Branchini P, Braun N, Briere RA, Browder TE, Budano A, Bussino S, Campajola M, Cao L, Casarosa G, Cecchi C, Červenkov D, Chang MC, Chang P, Cheaib R, Chekelian V, Chen C, Chen YT, Cheon BG, Chilikin K, Chirapatpimol K, Cho HE, Cho K, Cho SJ, Choi SK, Choudhury S, Cinabro D, Corona L, Cremaldi LM, Cunliffe S, Czank T, Dattola F, De La Cruz-Burelo E, de Marino G, De Nardo G, De Pietro G, de Sangro R, Destefanis M, Dey S, De Yta-Hernandez A, Di Canto A, Di Capua F, Dingfelder J, Doležal Z, Domínguez Jiménez I, Dong TV, Dorigo M, Dort K, Dossett D, Dubey S, Duell S, Dujany G, Ecker P, Epifanov D, Ferber T, Ferlewicz D, Finocchiaro G, Flood K, Fodor A, Forti F, Fulsom BG, Gabrielli A, Gabyshev N, Gaz A, Gellrich A, Giakoustidis G, Giordano R, Giri A, Glazov A, Gobbo B, Godang R, Goldenzweig P, Golob B, Gradl W, Graziani E, Greenwald D, Gu T, Guan Y, Gudkova K, Guilliams J, Hadjivasiliou C, Halder S, Hara K, Hara T, Hartbrich O, Hayasaka K, Hayashii H, Hazra S, Hearty C, Heredia de la Cruz I, Hernández Villanueva M, Hershenhorn A, Higuchi T, Hill EC, Hirata H, Hoek M, Hohmann M, Hsu CL, Humair T, Iijima T, Inami K, Inguglia G, Ishikawa A, Itoh R, Iwasaki M, Iwasaki Y, Jacobs WW, Jaffe DE, Jang EJ, Jia S, Jin Y, Junkerkalefeld H, Kakuno H, Kaliyar AB, Kandra J, Kang KH, Karl R, Karyan G, Kato Y, Kawasaki T, Kiesling C, Kim CH, Kim DY, Kim YK, Kim Y, Kimmel TD, Kinoshita K, Kodyš P, Koga T, Kohani S, Konno T, Korpar S, Kovalenko E, Kowalewski R, Kraetzschmar TMG, Krinner F, Križan P, Krokovny P, Kuhr T, Kumar J, Kumar M, Kumar R, Kumara K, Kurz S, Kuzmin A, Kwon YJ, Lacaprara S, Lalwani K, Lam T, Lanceri L, Lange JS, Laurenza M, Lautenbach K, Le Diberder FR, Lee SC, Leitl P, Levit D, Li C, Li LK, Libby J, Lieret K, Liptak Z, Liu QY, Liventsev D, Longo S, Lueck T, Lyu C, Manfredi R, Manoni E, Marinas C, Martini A, Matsuda T, Matsuoka K, Matvienko D, McKenna JA, Meier F, Merola M, Metzner F, Miller C, Miyabayashi K, Mizuk R, Mohanty GB, Molina-Gonzalez N, Moon H, Moser HG, Mrvar M, Murphy C, Mussa R, Nakamura I, Nakamura KR, Nakao M, Nakazawa H, Natkaniec Z, Natochii A, Nazaryan G, Niebuhr C, Niiyama M, Nisar NK, Nishida S, Nishimura K, Ogawa S, Onishchuk Y, Ono H, Onuki Y, Oskin P, Oxford ER, Ozaki H, Pakhlov P, Paladino A, Pang T, Panta A, Paoloni E, Pardi S, Park H, Park SH, Paschen B, Passeri A, Pathak A, Patra S, Paul S, Pedlar TK, Peruzzi I, Peschke R, Pestotnik R, Pham F, Piccolo M, Piilonen LE, Pinna Angioni G, Podesta-Lerma PLM, Podobnik T, Pokharel S, Polat G, Popov V, Praz C, Prell S, Prencipe E, Prim MT, Purohit MV, Purwar H, Rad N, Rados P, Raiz S, Reiter S, Remnev M, Ripp-Baudot I, Rizzo G, Rizzuto LB, Robertson SH, Roney JM, Rostomyan A, Rout N, Rozanska M, Sahoo D, Sanders DA, Sandilya S, Sangal A, Santelj L, Sato Y, Savinov V, Scavino B, Schueler J, Schwanda C, Schwartz AJ, Seino Y, Selce A, Senyo K, Serrano J, Sfienti C, Shiu JG, Shwartz B, Sibidanov A, Simon F, Sobie RJ, Soffer A, Sokolov A, Solovieva E, Spataro S, Spruck B, Starič M, Stefkova S, Stottler ZS, Stroili R, Strube J, Sumihama M, Sutcliffe W, Suzuki SY, Svidras H, Tabata M, Takizawa M, Tamponi U, Tanaka S, Tanida K, Tanigawa H, Taniguchi N, Tenchini F, Tiwary R, Tonelli D, Torassa E, Toutounji N, Trabelsi K, Tsuboyama T, Ueda I, Uehara S, Uematsu Y, Uglov T, Unger K, Unno Y, Uno K, Uno S, Urquijo P, Ushiroda Y, Usov YV, Vahsen SE, van Tonder R, Varner GS, Vinokurova A, Vitale L, Vossen A, Waheed E, Wakeling HM, Wang E, Wang MZ, Wang XL, Warburton A, Watanabe M, Welsch M, Wessel C, Wiechczynski J, Won E, Xu XP, Yabsley BD, Yamada S, Yan W, Yang SB, Ye H, Yelton J, Yin JH, Yoshihara K, Yusa Y, Zani L, Zhilich V, Zhou QD, Zhou XY, Zhukova VI, Žlebčík R.
PMID: 34860075
Phys Rev Lett. 2021 Nov 19;127(21):211801. doi: 10.1103/PhysRevLett.127.211801.

We report a measurement of the D^{0} and D^{+} lifetimes using D^{0}→K^{-}π^{+} and D^{+}→K^{-}π^{+}π^{+} decays reconstructed in e^{+}e^{-}→cc[over ¯] data recorded by the Belle II experiment at the SuperKEKB asymmetric-energy e^{+}e^{-} collider. The data, collected at center-of-mass energies at...

Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer.

NPJ breast cancer

Liu YL, Bager CL, Willumsen N, Ramchandani D, Kornhauser N, Ling L, Cobham M, Andreopoulou E, Cigler T, Moore A, LaPolla D, Fitzpatrick V, Ward M, Warren JD, Fischbach C, Mittal V, Vahdat LT.
PMID: 34426581
NPJ Breast Cancer. 2021 Aug 23;7(1):108. doi: 10.1038/s41523-021-00313-w.

Tetrathiomolybdate (TM) is a novel, copper-depleting compound associated with promising survival in a phase II study of patients with high-risk and triple-negative breast cancer. We sought to elucidate the mechanism of TM by exploring its effects on collagen processing...

Active RB causes visible changes in nuclear organization.

The Journal of cell biology

Krishnan B, Yasuhara T, Rumde P, Stanzione M, Lu C, Lee H, Lawrence MS, Zou L, Nieman LT, Sanidas I, Dyson NJ.
PMID: 35019938
J Cell Biol. 2022 Mar 07;221(3). doi: 10.1083/jcb.202102144. Epub 2022 Jan 12.

RB restricts G1/S progression by inhibiting E2F. Here, we show that sustained expression of active RB, and prolonged G1 arrest, causes visible changes in chromosome architecture that are not directly associated with E2F inhibition. Using FISH probes against two...

Lin28 paralogs regulate lung branching morphogenesis.

Cell reports

Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ.
PMID: 34289374
Cell Rep. 2021 Jul 20;36(3):109408. doi: 10.1016/j.celrep.2021.109408.

The molecular mechanisms that govern the choreographed timing of organ development remain poorly understood. Our investigation of the role of the Lin28a and Lin28b paralogs during the developmental process of branching morphogenesis establishes that dysregulation of Lin28a/b leads to...

Active RB causes visible changes in nuclear organization.

The Journal of cell biology

Krishnan B, Yasuhara T, Rumde P, Stanzione M, Lu C, Lee H, Lawrence MS, Zou L, Nieman LT, Sanidas I, Dyson NJ.
PMID: 35019938
J Cell Biol. 2022 Mar 07;221(3). doi: 10.1083/jcb.202102144. Epub 2022 Jan 12.

RB restricts G1/S progression by inhibiting E2F. Here, we show that sustained expression of active RB, and prolonged G1 arrest, causes visible changes in chromosome architecture that are not directly associated with E2F inhibition. Using FISH probes against two...

Downregulation of the .

Antioxidants (Basel, Switzerland)

Šilhavý J, Malínská H, Hüttl M, Marková I, Oliyarnyk O, Mlejnek P, Šimáková M, Liška F, Kazdová L, Moravcová R, Novotný J, Pravenec M.
PMID: 33255888
Antioxidants (Basel). 2020 Nov 26;9(12). doi: 10.3390/antiox9121179.

Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase system in which glyoxalase 1, coded by the

High Sensitivity of the Circadian Clock in the Hippocampal Dentate Gyrus to Glucocorticoid- and GSK3-Beta-Dependent Signals.

Neuroendocrinology

Liška K, Sládek M, Houdek P, Shrestha N, Lužná V, Ralph MR, Sumová A.
PMID: 34111876
Neuroendocrinology. 2021 Jun 10; doi: 10.1159/000517689. Epub 2021 Jun 10.

AIMS: Circadian clocks in the hippocampus (HPC) align memory processing with appropriate time of day. Our study was aimed at ascertaining the specificity of glycogen synthase kinase 3-beta (GSK3β)- and glucocorticoid (GC)-dependent pathways in the entrainment of clocks in...

Showing 217 to 227 of 227 entries