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Showing 1921 to 1927 of 1927 entries
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Factors associated with pain resolution in those with knee pain: the MOST study.

Osteoarthritis and cartilage

Felson D, Rabasa G, Jafarzadeh SR, Nevitt M, Lewis CE, Segal N, White DK.
PMID: 33901642
Osteoarthritis Cartilage. 2021 Apr 24; doi: 10.1016/j.joca.2021.03.017. Epub 2021 Apr 24.

OBJECTIVES: To determine how many persons with knee pain have subsequent pain resolution and what factors are associated with resolution, focusing especially on types of physical activity.METHODS: Using data from MOST, an NIH funded longitudinal cohort study of persons...

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Felson D, Rabasa G, Jafarzadeh SR, et al. Factors associated with pain resolution in those with knee pain: the MOST study. Osteoarthritis Cartilage. 2021;doi: 10.1016/j.joca.2021.03.017.
Felson, D., Rabasa, G., Jafarzadeh, S. R., Nevitt, M., Lewis, C. E., Segal, N., & White, D. K. (2021). Factors associated with pain resolution in those with knee pain: the MOST study. Osteoarthritis and cartilage, . https://doi.org/10.1016/j.joca.2021.03.017
Felson, D, et al. "Factors associated with pain resolution in those with knee pain: the MOST study." Osteoarthritis and cartilage vol. (2021). doi: https://doi.org/10.1016/j.joca.2021.03.017
Felson D, Rabasa G, Jafarzadeh SR, Nevitt M, Lewis CE, Segal N, White DK. Factors associated with pain resolution in those with knee pain: the MOST study. Osteoarthritis Cartilage. 2021 Apr 24; doi: 10.1016/j.joca.2021.03.017. Epub 2021 Apr 24. PMID: 33901642.
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Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives.

Bioorganic & medicinal chemistry

Muslimin R, Nishiura N, Teshima A, Do KM, Kodama T, Morita H, Lewis CW, Chan G, Ayoub AT, Arakawa K.
PMID: 34883453
Bioorg Med Chem. 2021 Dec 05;53:116551. doi: 10.1016/j.bmc.2021.116551. Epub 2021 Dec 05.

We investigated the importance of the δ-lactone ring (C1-C5) in lankacidin C using chemoenzymatic synthesis and computational prediction and assessing biological activity, including antitumor activity. Pyrroloquinoline quinone-dependent dehydrogenase (Orf23) in Streptomyces rochei was used in the chemoenzymatic synthesis of...

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Muslimin R, Nishiura N, Teshima A, et al. Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives. Bioorg Med Chem. 2021;53:116551doi: 10.1016/j.bmc.2021.116551.
Muslimin, R., Nishiura, N., Teshima, A., Do, K. M., Kodama, T., Morita, H., Lewis, C. W., Chan, G., Ayoub, A. T., & Arakawa, K. (2021). Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives. Bioorganic & medicinal chemistry, 53116551. https://doi.org/10.1016/j.bmc.2021.116551
Muslimin, Rukman, et al. "Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives." Bioorganic & medicinal chemistry vol. 53 (2021): 116551. doi: https://doi.org/10.1016/j.bmc.2021.116551
Muslimin R, Nishiura N, Teshima A, Do KM, Kodama T, Morita H, Lewis CW, Chan G, Ayoub AT, Arakawa K. Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives. Bioorg Med Chem. 2021 Dec 05;53:116551. doi: 10.1016/j.bmc.2021.116551. Epub 2021 Dec 05. PMID: 34883453.
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Decision-making, attitudes, and understanding among patients and relatives invited to undergo genome sequencing in the 100,000 Genomes Project: A multisite survey study.

Genetics in medicine : official journal of the American College of Medical Genetics

Sanderson SC, Lewis C, Hill M, Peter M, McEntagart M, Gale D, Morris H, Moosajee M, Searle B, Hunter A, Patch C, Chitty LS.
PMID: 34906473
Genet Med. 2022 Jan;24(1):61-74. doi: 10.1016/j.gim.2021.08.010. Epub 2021 Nov 30.

PURPOSE: The purpose of this study was to assess decisions, attitudes, and understanding of participants (patients, parents, relatives) having genome sequencing for rare disease diagnosis.METHODS: This study involved a cross-sectional observational survey with participants in the 100,000 Genomes Project.RESULTS:...

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Sanderson SC, Lewis C, Hill M, et al. Decision-making, attitudes, and understanding among patients and relatives invited to undergo genome sequencing in the 100,000 Genomes Project: A multisite survey study. Genet Med. 2021;24(1):61-74doi: 10.1016/j.gim.2021.08.010.
Sanderson, S. C., Lewis, C., Hill, M., Peter, M., McEntagart, M., Gale, D., Morris, H., Moosajee, M., Searle, B., Hunter, A., Patch, C., & Chitty, L. S. (2022). Decision-making, attitudes, and understanding among patients and relatives invited to undergo genome sequencing in the 100,000 Genomes Project: A multisite survey study. Genetics in medicine : official journal of the American College of Medical Genetics, 24(1), 61-74. https://doi.org/10.1016/j.gim.2021.08.010
Sanderson, Saskia C, et al. "Decision-making, attitudes, and understanding among patients and relatives invited to undergo genome sequencing in the 100,000 Genomes Project: A multisite survey study." Genetics in medicine : official journal of the American College of Medical Genetics vol. 24,1 (2022): 61-74. doi: https://doi.org/10.1016/j.gim.2021.08.010
Sanderson SC, Lewis C, Hill M, Peter M, McEntagart M, Gale D, Morris H, Moosajee M, Searle B, Hunter A, Patch C, Chitty LS. Decision-making, attitudes, and understanding among patients and relatives invited to undergo genome sequencing in the 100,000 Genomes Project: A multisite survey study. Genet Med. 2022 Jan;24(1):61-74. doi: 10.1016/j.gim.2021.08.010. Epub 2021 Nov 30. PMID: 34906473.
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Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons.

Marine drugs

Pierre O, Fouchard M, Le Goux N, Buscaglia P, Leschiera R, Lewis RJ, Mignen O, Fluhr JW, Misery L, Le Garrec R.
PMID: 34356812
Mar Drugs. 2021 Jul 06;19(7). doi: 10.3390/md19070387.

Ciguatera fish poisoning (CFP) and neurotoxic shellfish poisoning syndromes are induced by the consumption of seafood contaminated by ciguatoxins and brevetoxins. Both toxins cause sensory symptoms such as paresthesia, cold dysesthesia and painful disorders. An intense pruritus, which may...

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Pierre O, Fouchard M, Le Goux N, et al. Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons. Mar Drugs. 2021;19(7)doi: 10.3390/md19070387.
Pierre, O., Fouchard, M., Le Goux, N., Buscaglia, P., Leschiera, R., Lewis, R. J., Mignen, O., Fluhr, J. W., Misery, L., & Le Garrec, R. (2021). Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons. Marine drugs, 19(7), . https://doi.org/10.3390/md19070387
Pierre, Ophélie, et al. "Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons." Marine drugs vol. 19,7 (2021). doi: https://doi.org/10.3390/md19070387
Pierre O, Fouchard M, Le Goux N, Buscaglia P, Leschiera R, Lewis RJ, Mignen O, Fluhr JW, Misery L, Le Garrec R. Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons. Mar Drugs. 2021 Jul 06;19(7). doi: 10.3390/md19070387. PMID: 34356812; PMCID: PMC8306505.
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Making large changes or small changes to prevent weight gain in young adulthood: which is preferred and by whom?.

Translational behavioral medicine

Hayes JF, Tate DF, Espeland MA, LaRose JG, Gorin AA, Lewis CE, Jelalian E, Bahnson J, Dunsiger SI, Wing RR.
PMID: 34293164
Transl Behav Med. 2021 Dec 14;11(12):2081-2090. doi: 10.1093/tbm/ibab099.

Knowledge of participant treatment preferences can inform decision-making regarding treatment dissemination and future participant adoption. To compare participant perceptions of two evidence-based approaches for weight gain prevention in young adults to identify the intervention with the greatest likelihood of...

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Hayes JF, Tate DF, Espeland MA, et al. Making large changes or small changes to prevent weight gain in young adulthood: which is preferred and by whom?. Transl Behav Med. 2021;11(12):2081-2090doi: 10.1093/tbm/ibab099.
Hayes, J. F., Tate, D. F., Espeland, M. A., LaRose, J. G., Gorin, A. A., Lewis, C. E., Jelalian, E., Bahnson, J., Dunsiger, S. I., Wing, R. R. (2021). Making large changes or small changes to prevent weight gain in young adulthood: which is preferred and by whom?. Translational behavioral medicine, 11(12), 2081-2090. https://doi.org/10.1093/tbm/ibab099
Hayes, Jacqueline F, et al. "Making large changes or small changes to prevent weight gain in young adulthood: which is preferred and by whom?." Translational behavioral medicine vol. 11,12 (2021): 2081-2090. doi: https://doi.org/10.1093/tbm/ibab099
Hayes JF, Tate DF, Espeland MA, LaRose JG, Gorin AA, Lewis CE, Jelalian E, Bahnson J, Dunsiger SI, Wing RR. Making large changes or small changes to prevent weight gain in young adulthood: which is preferred and by whom?. Transl Behav Med. 2021 Dec 14;11(12):2081-2090. doi: 10.1093/tbm/ibab099. PMID: 34293164.
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Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment.

ILAR journal

Lewis CE, Pickering B.
PMID: 34864994
ILAR J. 2022 Jan 07;61(1):86-102. doi: 10.1093/ilar/ilab029.

Maximum-containment laboratories are a unique and essential component of the bioeconomy of the United States. These facilities play a critical role in the national infrastructure, supporting research on a select set of especially dangerous pathogens, as well as novel,...

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Lewis CE, Pickering B. Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment. ILAR J. 2022;61(1):86-102doi: 10.1093/ilar/ilab029.
Lewis, C. E., & Pickering, B. (2022). Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment. ILAR journal, 61(1), 86-102. https://doi.org/10.1093/ilar/ilab029
Lewis, Charles E, and Pickering, Bradley. "Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment." ILAR journal vol. 61,1 (2022): 86-102. doi: https://doi.org/10.1093/ilar/ilab029
Lewis CE, Pickering B. Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment. ILAR J. 2022 Jan 07;61(1):86-102. doi: 10.1093/ilar/ilab029. PMID: 34864994.
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Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease.

Alzheimer's research & therapy

Fang J, Zhang P, Wang Q, Chiang CW, Zhou Y, Hou Y, Xu J, Chen R, Zhang B, Lewis SJ, Leverenz JB, Pieper AA, Li B, Li L, Cummings J, Cheng F.
PMID: 35012639
Alzheimers Res Ther. 2022 Jan 10;14(1):7. doi: 10.1186/s13195-021-00951-z.

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous susceptibility loci for Alzheimer's disease (AD). However, utilizing GWAS and multi-omics data to identify high-confidence AD risk genes (ARGs) and druggable targets that can guide development of new therapeutics for patients...

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Fang J, Zhang P, Wang Q, et al. Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. Alzheimers Res Ther. 2022;14(1):7doi: 10.1186/s13195-021-00951-z.
Fang, J., Zhang, P., Wang, Q., Chiang, C. W., Zhou, Y., Hou, Y., Xu, J., Chen, R., Zhang, B., Lewis, S. J., Leverenz, J. B., Pieper, A. A., Li, B., Li, L., Cummings, J., & Cheng, F. (2022). Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. Alzheimer's research & therapy, 14(1), 7. https://doi.org/10.1186/s13195-021-00951-z
Fang, Jiansong, et al. "Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease." Alzheimer's research & therapy vol. 14,1 (2022): 7. doi: https://doi.org/10.1186/s13195-021-00951-z
Fang J, Zhang P, Wang Q, Chiang CW, Zhou Y, Hou Y, Xu J, Chen R, Zhang B, Lewis SJ, Leverenz JB, Pieper AA, Li B, Li L, Cummings J, Cheng F. Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. Alzheimers Res Ther. 2022 Jan 10;14(1):7. doi: 10.1186/s13195-021-00951-z. PMID: 35012639; PMCID: PMC8751379.
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Showing 1921 to 1927 of 1927 entries