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Impacts of Hydrothermal Treatments on the Morphology, Structural Characteristics, and In Vitro Digestibility of Water Caltrop Starch.

Molecules (Basel, Switzerland)

Liu JL, Tsai PC, Lai LS.
PMID: 34443559
Molecules. 2021 Aug 17;26(16). doi: 10.3390/molecules26164974.

The influence of hydrothermal treatments on the structural properties and digestibility of water caltrop starch was investigated. Scanning electron microscopy (SEM) showed some small dents on the surface of starch granules for samples treated with heat moisture treatment (HMT),...

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Liu JL, Tsai PC, Lai LS. Impacts of Hydrothermal Treatments on the Morphology, Structural Characteristics, and In Vitro Digestibility of Water Caltrop Starch. Molecules. 2021;26(16)doi: 10.3390/molecules26164974.
Liu, J. L., Tsai, P. C., & Lai, L. S. (2021). Impacts of Hydrothermal Treatments on the Morphology, Structural Characteristics, and In Vitro Digestibility of Water Caltrop Starch. Molecules (Basel, Switzerland), 26(16), . https://doi.org/10.3390/molecules26164974
Liu, Jia-Lin, et al. "Impacts of Hydrothermal Treatments on the Morphology, Structural Characteristics, and In Vitro Digestibility of Water Caltrop Starch." Molecules (Basel, Switzerland) vol. 26,16 (2021). doi: https://doi.org/10.3390/molecules26164974
Liu JL, Tsai PC, Lai LS. Impacts of Hydrothermal Treatments on the Morphology, Structural Characteristics, and In Vitro Digestibility of Water Caltrop Starch. Molecules. 2021 Aug 17;26(16). doi: 10.3390/molecules26164974. PMID: 34443559; PMCID: PMC8401936.
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Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus.

Epilepsia

Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T.
PMID: 34418087
Epilepsia. 2021 Nov;62(11):2766-2777. doi: 10.1111/epi.17043. Epub 2021 Aug 21.

OBJECTIVE: This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non-BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE).METHODS: This retrospective multicenter study in the United States and Canada used prospectively...

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Sheehan T, Amengual-Gual M, Vasquez A, et al. Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus. Epilepsia. 2021;62(11):2766-2777doi: 10.1111/epi.17043.
Sheehan, T., Amengual-Gual, M., Vasquez, A., Abend, N. S., Anderson, A., Appavu, B., Arya, R., Barcia Aguilar, C., Brenton, J. N., Carpenter, J. L., Chapman, K. E., Clark, J., Farias-Moeller, R., Gaillard, W. D., Gaínza-Lein, M., Glauser, T. A., Goldstein, J. L., Goodkin, H. P., Guerriero, R. M., Huh, L., Jackson, M., Kapur, K., Kahoud, R., Lai, Y. C., McDonough, T. L., Mikati, M. A., Morgan, L. A., Novotny, E. J., Ostendorf, A. P., Payne, E. T., Peariso, K., Piantino, J., Reece, L., Riviello, J. J., Sands, T. T., Sannagowdara, K., Shellhaas, R., Smith, G., Tasker, R. C., Tchapyjnikov, D., Topjian, A. A., Wainwright, M. S., Wilfong, A., Williams, K., Zhang, B., Loddenkemper, T. (2021). Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus. Epilepsia, 62(11), 2766-2777. https://doi.org/10.1111/epi.17043
Sheehan, Theodore, et al. "Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus." Epilepsia vol. 62,11 (2021): 2766-2777. doi: https://doi.org/10.1111/epi.17043
Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T. Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus. Epilepsia. 2021 Nov;62(11):2766-2777. doi: 10.1111/epi.17043. Epub 2021 Aug 21. PMID: 34418087.
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Germline genome modification through novel political, ethical, and social lenses.

PLoS genetics

Xafis V, Schaefer GO, Labude MK, Zhu Y, Holm S, Foo RS, Lai PS, Chadwick R.
PMID: 34499641
PLoS Genet. 2021 Sep 09;17(9):e1009741. doi: 10.1371/journal.pgen.1009741. eCollection 2021 Sep.

Much has been written about gene modifying technologies (GMTs), with a particularly strong focus on human germline genome editing (HGGE) sparked by its unprecedented clinical research application in 2018, shocking the scientific community. This paper applies political, ethical, and...

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Xafis V, Schaefer GO, Labude MK, et al. Germline genome modification through novel political, ethical, and social lenses. PLoS Genet. 2021;17(9):e1009741doi: 10.1371/journal.pgen.1009741.
Xafis, V., Schaefer, G. O., Labude, M. K., Zhu, Y., Holm, S., Foo, R. S., Lai, P. S., & Chadwick, R. (2021). Germline genome modification through novel political, ethical, and social lenses. PLoS genetics, 17(9), e1009741. https://doi.org/10.1371/journal.pgen.1009741
Xafis, Vicki, et al. "Germline genome modification through novel political, ethical, and social lenses." PLoS genetics vol. 17,9 (2021): e1009741. doi: https://doi.org/10.1371/journal.pgen.1009741
Xafis V, Schaefer GO, Labude MK, Zhu Y, Holm S, Foo RS, Lai PS, Chadwick R. Germline genome modification through novel political, ethical, and social lenses. PLoS Genet. 2021 Sep 09;17(9):e1009741. doi: 10.1371/journal.pgen.1009741. eCollection 2021 Sep. PMID: 34499641; PMCID: PMC8428543.
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Novel Autoantibodies in Idiopathic Small Fiber Neuropathy.

Annals of neurology

Chan ACY, Wong HY, Chong YF, Lai PS, Teoh HL, Ng AYY, Hung JHM, Chan YC, Ng KWP, Vijayan J, Ong JJY, Chandra B, Tan CH, Rutt NH, Tan TM, Ismail NH, Wilder-Smith E, Schwarz H, Choi H, Sharma VK, Mak A.
PMID: 34761434
Ann Neurol. 2022 Jan;91(1):66-77. doi: 10.1002/ana.26268. Epub 2021 Dec 01.

OBJECTIVE: Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel...

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Chan ACY, Wong HY, Chong YF, et al. Novel Autoantibodies in Idiopathic Small Fiber Neuropathy. Ann Neurol. 2021;91(1):66-77doi: 10.1002/ana.26268.
Chan, A. C. Y., Wong, H. Y., Chong, Y. F., Lai, P. S., Teoh, H. L., Ng, A. Y. Y., Hung, J. H. M., Chan, Y. C., Ng, K. W. P., Vijayan, J., Ong, J. J. Y., Chandra, B., Tan, C. H., Rutt, N. H., Tan, T. M., Ismail, N. H., Wilder-Smith, E., Schwarz, H., Choi, H., Sharma, V. K., & Mak, A. (2022). Novel Autoantibodies in Idiopathic Small Fiber Neuropathy. Annals of neurology, 91(1), 66-77. https://doi.org/10.1002/ana.26268
Chan, Amanda C Y, et al. "Novel Autoantibodies in Idiopathic Small Fiber Neuropathy." Annals of neurology vol. 91,1 (2022): 66-77. doi: https://doi.org/10.1002/ana.26268
Chan ACY, Wong HY, Chong YF, Lai PS, Teoh HL, Ng AYY, Hung JHM, Chan YC, Ng KWP, Vijayan J, Ong JJY, Chandra B, Tan CH, Rutt NH, Tan TM, Ismail NH, Wilder-Smith E, Schwarz H, Choi H, Sharma VK, Mak A. Novel Autoantibodies in Idiopathic Small Fiber Neuropathy. Ann Neurol. 2022 Jan;91(1):66-77. doi: 10.1002/ana.26268. Epub 2021 Dec 01. PMID: 34761434.
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Letter to the editor regarding: "The analgesic efficacy of iPACK after knee surgery: A systematic review and meta-analysis with trial sequential analysis".

Journal of clinical anesthesia

Tang XM, Lai YH, Hu R, Ning N.
PMID: 34174639
J Clin Anesth. 2021 Nov;74:110412. doi: 10.1016/j.jclinane.2021.110412. Epub 2021 Jun 23.

No abstract available.

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Tang XM, Lai YH, Hu R, et al. Letter to the editor regarding: "The analgesic efficacy of iPACK after knee surgery: A systematic review and meta-analysis with trial sequential analysis". J Clin Anesth. 2021;74:110412doi: 10.1016/j.jclinane.2021.110412.
Tang, X. M., Lai, Y. H., Hu, R., & Ning, N. (2021). Letter to the editor regarding: "The analgesic efficacy of iPACK after knee surgery: A systematic review and meta-analysis with trial sequential analysis". Journal of clinical anesthesia, 74110412. https://doi.org/10.1016/j.jclinane.2021.110412
Tang, Xiu-Mei, et al. "Letter to the editor regarding: "The analgesic efficacy of iPACK after knee surgery: A systematic review and meta-analysis with trial sequential analysis"." Journal of clinical anesthesia vol. 74 (2021): 110412. doi: https://doi.org/10.1016/j.jclinane.2021.110412
Tang XM, Lai YH, Hu R, Ning N. Letter to the editor regarding: "The analgesic efficacy of iPACK after knee surgery: A systematic review and meta-analysis with trial sequential analysis". J Clin Anesth. 2021 Nov;74:110412. doi: 10.1016/j.jclinane.2021.110412. Epub 2021 Jun 23. PMID: 34174639.
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Optic Neuritis and Immune Thrombocytopenia as the Initial Presentation of Primary Sjögren Syndrome.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

Sun Y, Ieng FC, Lai YH.
PMID: 34924533
J Neuroophthalmol. 2021 Dec 16; doi: 10.1097/WNO.0000000000001436. Epub 2021 Dec 16.

No abstract available.

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Sun Y, Ieng FC, Lai YH. Optic Neuritis and Immune Thrombocytopenia as the Initial Presentation of Primary Sjögren Syndrome. J Neuroophthalmol. 2021;doi: 10.1097/WNO.0000000000001436.
Sun, Y., Ieng, F. C., & Lai, Y. H. (2021). Optic Neuritis and Immune Thrombocytopenia as the Initial Presentation of Primary Sjögren Syndrome. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, . https://doi.org/10.1097/WNO.0000000000001436
Sun, Yng, et al. "Optic Neuritis and Immune Thrombocytopenia as the Initial Presentation of Primary Sjögren Syndrome." Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society vol. (2021). doi: https://doi.org/10.1097/WNO.0000000000001436
Sun Y, Ieng FC, Lai YH. Optic Neuritis and Immune Thrombocytopenia as the Initial Presentation of Primary Sjögren Syndrome. J Neuroophthalmol. 2021 Dec 16; doi: 10.1097/WNO.0000000000001436. Epub 2021 Dec 16. PMID: 34924533.
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Revealing the effects of molecular orientations on the azo-coupling reaction of nitro compounds driven by surface plasmonic resonances.

Physical chemistry chemical physics : PCCP

Shiu YJ, Hayashi M, Lai YH, Jeng US.
PMID: 34549758
Phys Chem Chem Phys. 2021 Oct 06;23(38):21748-21756. doi: 10.1039/d1cp03041h.

A recent report on the azo coupling of 4-nitrobenzo-15-crown-ether (4NB15C) and 4-nitrothiophenol (4NTP) indicated that the reaction barrier could be reduced greatly with surface plasmonic effects on silver dendritic nanostructures in aqueous solution. Accordingly, an azo coupling reaction mechanism...

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Shiu YJ, Hayashi M, Lai YH, et al. Revealing the effects of molecular orientations on the azo-coupling reaction of nitro compounds driven by surface plasmonic resonances. Phys Chem Chem Phys. 2021;23(38):21748-21756doi: 10.1039/d1cp03041h.
Shiu, Y. J., Hayashi, M., Lai, Y. H., & Jeng, U. S. (2021). Revealing the effects of molecular orientations on the azo-coupling reaction of nitro compounds driven by surface plasmonic resonances. Physical chemistry chemical physics : PCCP, 23(38), 21748-21756. https://doi.org/10.1039/d1cp03041h
Shiu, Ying-Jen, et al. "Revealing the effects of molecular orientations on the azo-coupling reaction of nitro compounds driven by surface plasmonic resonances." Physical chemistry chemical physics : PCCP vol. 23,38 (2021): 21748-21756. doi: https://doi.org/10.1039/d1cp03041h
Shiu YJ, Hayashi M, Lai YH, Jeng US. Revealing the effects of molecular orientations on the azo-coupling reaction of nitro compounds driven by surface plasmonic resonances. Phys Chem Chem Phys. 2021 Oct 06;23(38):21748-21756. doi: 10.1039/d1cp03041h. PMID: 34549758.
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A Reconfigurable Differential-to-Single-Ended Autonomous Current Adaptation Buffer Amplifier Suitable for Biomedical Applications.

IEEE transactions on biomedical circuits and systems

Lo ZJ, Wang YC, Huang YJ, Hung RY, Wu YH, Wang TY, Huang YJ, Huang HC, Lu YC, Peng SY, Chang CY, Lai WS, Hsu YJ.
PMID: 34919521
IEEE Trans Biomed Circuits Syst. 2021 Dec 17; doi: 10.1109/TBCAS.2021.3136248. Epub 2021 Dec 17.

A reconfigurable differential-to-single-ended autonomous current adaptation buffer amplifier (ACABA) suitable for biomedical applications is proposed. The ACABA, based on floating-gate technologies, is a capacitive circuit, of which output DC level and bandwidth can be adjusted by programming charges on...

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Lo ZJ, Wang YC, Huang YJ, et al. A Reconfigurable Differential-to-Single-Ended Autonomous Current Adaptation Buffer Amplifier Suitable for Biomedical Applications. IEEE Trans Biomed Circuits Syst. 2021;doi: 10.1109/TBCAS.2021.3136248.
Lo, Z. J., Wang, Y. C., Huang, Y. J., Hung, R. Y., Wu, Y. H., Wang, T. Y., Huang, Y. J., Huang, H. C., Lu, Y. C., Peng, S. Y., Chang, C. Y., Lai, W. S., & Hsu, Y. J. (2021). A Reconfigurable Differential-to-Single-Ended Autonomous Current Adaptation Buffer Amplifier Suitable for Biomedical Applications. IEEE transactions on biomedical circuits and systems, . https://doi.org/10.1109/TBCAS.2021.3136248
Lo, Zu-Jia, et al. "A Reconfigurable Differential-to-Single-Ended Autonomous Current Adaptation Buffer Amplifier Suitable for Biomedical Applications." IEEE transactions on biomedical circuits and systems vol. (2021). doi: https://doi.org/10.1109/TBCAS.2021.3136248
Lo ZJ, Wang YC, Huang YJ, Hung RY, Wu YH, Wang TY, Huang YJ, Huang HC, Lu YC, Peng SY, Chang CY, Lai WS, Hsu YJ. A Reconfigurable Differential-to-Single-Ended Autonomous Current Adaptation Buffer Amplifier Suitable for Biomedical Applications. IEEE Trans Biomed Circuits Syst. 2021 Dec 17; doi: 10.1109/TBCAS.2021.3136248. Epub 2021 Dec 17. PMID: 34919521.
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Natural killer cell-targeted immunotherapy for cancer.

Current stem cell research & therapy

Tang J, Zhu Q, Li Z, Yang J, Lai Y.
PMID: 34994316
Curr Stem Cell Res Ther. 2022 Jan 07; doi: 10.2174/1574888X17666220107101722. Epub 2022 Jan 07.

Natural killer (NK) cells were initially described in the early 1970s as major histocompatibility complex unrestricted killers due to their ability to spontaneously kill certain tumor cells. In the past decade, the field of NK cell-based treatment has been...

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Tang J, Zhu Q, Li Z, et al. Natural killer cell-targeted immunotherapy for cancer. Curr Stem Cell Res Ther. 2022;doi: 10.2174/1574888X17666220107101722.
Tang, J., Zhu, Q., Li, Z., Yang, J., & Lai, Y. (2022). Natural killer cell-targeted immunotherapy for cancer. Current stem cell research & therapy, . https://doi.org/10.2174/1574888X17666220107101722
Tang, Jingyi, et al. "Natural killer cell-targeted immunotherapy for cancer." Current stem cell research & therapy vol. (2022). doi: https://doi.org/10.2174/1574888X17666220107101722
Tang J, Zhu Q, Li Z, Yang J, Lai Y. Natural killer cell-targeted immunotherapy for cancer. Curr Stem Cell Res Ther. 2022 Jan 07; doi: 10.2174/1574888X17666220107101722. Epub 2022 Jan 07. PMID: 34994316.
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MicroRNA-27b-3p downregulates FGF1 and aggravates pathological cardiac remodelling.

Cardiovascular research

Li G, Shao Y, Guo HC, Zhi Y, Qiao B, Ma K, Lai YQ, Du J, Li Y.
PMID: 34358309
Cardiovasc Res. 2021 Aug 06; doi: 10.1093/cvr/cvab248. Epub 2021 Aug 06.

AIMS: The heart undergoes pathological remodelling under increased stress and neuronal imbalance. MicroRNAs (miRNAs) are involved in post-transcriptional regulation of genes in cardiac physiology and pathology. However, the mechanisms underlying miRNA-mediated regulation of pathological cardiac remodelling remain to be...

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Li G, Shao Y, Guo HC, et al. MicroRNA-27b-3p downregulates FGF1 and aggravates pathological cardiac remodelling. Cardiovasc Res. 2021;doi: 10.1093/cvr/cvab248.
Li, G., Shao, Y., Guo, H. C., Zhi, Y., Qiao, B., Ma, K., Lai, Y. Q., Du, J., & Li, Y. (2021). MicroRNA-27b-3p downregulates FGF1 and aggravates pathological cardiac remodelling. Cardiovascular research, . https://doi.org/10.1093/cvr/cvab248
Li, Guoqi, et al. "MicroRNA-27b-3p downregulates FGF1 and aggravates pathological cardiac remodelling." Cardiovascular research vol. (2021). doi: https://doi.org/10.1093/cvr/cvab248
Li G, Shao Y, Guo HC, Zhi Y, Qiao B, Ma K, Lai YQ, Du J, Li Y. MicroRNA-27b-3p downregulates FGF1 and aggravates pathological cardiac remodelling. Cardiovasc Res. 2021 Aug 06; doi: 10.1093/cvr/cvab248. Epub 2021 Aug 06. PMID: 34358309.
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Periodontal conditions in patients with Sjögren's syndrome: A meta-analysis.

Journal of dental sciences

Wu SY, Wu CY, Chen MH, Huang HY, Chen YH, Tsao YP, Lai YL, Lee SY.
PMID: 34484591
J Dent Sci. 2021 Oct;16(4):1222-1232. doi: 10.1016/j.jds.2020.11.015. Epub 2021 Mar 06.

Sjögren's syndrome (SS) is a chronic autoimmune rheumatic disease characterized by a progressive lymphocytic infiltration of salivary glands, resulting in xerostomia and other oral diseases. The pathogenesis and mechanisms of SS on periodontal tissues are not well understood. Furthermore,...

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Wu SY, Wu CY, Chen MH, et al. Periodontal conditions in patients with Sjögren's syndrome: A meta-analysis. J Dent Sci. 2021;16(4):1222-1232doi: 10.1016/j.jds.2020.11.015.
Wu, S. Y., Wu, C. Y., Chen, M. H., Huang, H. Y., Chen, Y. H., Tsao, Y. P., Lai, Y. L., & Lee, S. Y. (2021). Periodontal conditions in patients with Sjögren's syndrome: A meta-analysis. Journal of dental sciences, 16(4), 1222-1232. https://doi.org/10.1016/j.jds.2020.11.015
Wu, Shih-Yun, et al. "Periodontal conditions in patients with Sjögren's syndrome: A meta-analysis." Journal of dental sciences vol. 16,4 (2021): 1222-1232. doi: https://doi.org/10.1016/j.jds.2020.11.015
Wu SY, Wu CY, Chen MH, Huang HY, Chen YH, Tsao YP, Lai YL, Lee SY. Periodontal conditions in patients with Sjögren's syndrome: A meta-analysis. J Dent Sci. 2021 Oct;16(4):1222-1232. doi: 10.1016/j.jds.2020.11.015. Epub 2021 Mar 06. PMID: 34484591; PMCID: PMC8403803.
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Advances in Imaging for HPV-Related Oropharyngeal Cancer: Applications to Radiation Oncology.

Seminars in radiation oncology

Salzillo TC, Taku N, Wahid KA, McDonald BA, Wang J, van Dijk LV, Rigert JM, Mohamed ASR, Wang J, Lai SY, Fuller CD.
PMID: 34455992
Semin Radiat Oncol. 2021 Oct;31(4):371-388. doi: 10.1016/j.semradonc.2021.05.001.

While there has been an overall decline of tobacco and alcohol-related head and neck cancer in recent decades, there has been an increased incidence of HPV-associated oropharyngeal cancer (OPC). Recent research studies and clinical trials have revealed that the...

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Salzillo TC, Taku N, Wahid KA, et al. Advances in Imaging for HPV-Related Oropharyngeal Cancer: Applications to Radiation Oncology. Semin Radiat Oncol. 2021;31(4):371-388doi: 10.1016/j.semradonc.2021.05.001.
Salzillo, T. C., Taku, N., Wahid, K. A., McDonald, B. A., Wang, J., van Dijk, L. V., Rigert, J. M., Mohamed, A. S. R., Wang, J., Lai, S. Y., & Fuller, C. D. (2021). Advances in Imaging for HPV-Related Oropharyngeal Cancer: Applications to Radiation Oncology. Seminars in radiation oncology, 31(4), 371-388. https://doi.org/10.1016/j.semradonc.2021.05.001
Salzillo, Travis C, et al. "Advances in Imaging for HPV-Related Oropharyngeal Cancer: Applications to Radiation Oncology." Seminars in radiation oncology vol. 31,4 (2021): 371-388. doi: https://doi.org/10.1016/j.semradonc.2021.05.001
Salzillo TC, Taku N, Wahid KA, McDonald BA, Wang J, van Dijk LV, Rigert JM, Mohamed ASR, Wang J, Lai SY, Fuller CD. Advances in Imaging for HPV-Related Oropharyngeal Cancer: Applications to Radiation Oncology. Semin Radiat Oncol. 2021 Oct;31(4):371-388. doi: 10.1016/j.semradonc.2021.05.001. PMID: 34455992.
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