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Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology.

Molecular informatics

Villoutreix BO, Kuenemann MA, Poyet JL, Bruzzoni-Giovanelli H, Labbé C, Lagorce D, Sperandio O, Miteva MA.
PMID: 25254076
Mol Inform. 2014 Jun;33(6):414-437. doi: 10.1002/minf.201400040. Epub 2014 Jun 02.

[Formula: see text] Fundamental processes in living cells are largely controlled by macromolecular interactions and among them, protein-protein interactions (PPIs) have a critical role while their dysregulations can contribute to the pathogenesis of numerous diseases. Although PPIs were considered...

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Villoutreix BO, Kuenemann MA, Poyet JL, et al. Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology. Mol Inform. 2014;33(6):414-437doi: 10.1002/minf.201400040.
Villoutreix, B. O., Kuenemann, M. A., Poyet, J. L., Bruzzoni-Giovanelli, H., Labbé, C., Lagorce, D., Sperandio, O., & Miteva, M. A. (2014). Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology. Molecular informatics, 33(6), 414-437. https://doi.org/10.1002/minf.201400040
Villoutreix, Bruno O, et al. "Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology." Molecular informatics vol. 33,6 (2014): 414-437. doi: https://doi.org/10.1002/minf.201400040
Villoutreix BO, Kuenemann MA, Poyet JL, Bruzzoni-Giovanelli H, Labbé C, Lagorce D, Sperandio O, Miteva MA. Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology. Mol Inform. 2014 Jun;33(6):414-437. doi: 10.1002/minf.201400040. Epub 2014 Jun 02. PMID: 25254076; PMCID: PMC4160817.
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Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease.

Journal of medical biochemistry

Ghaffarzadeh M, Ghaedi H, Alipoor B, Omrani MD, Kazerouni F, Shanaki M, Labbaf A, Pashaiefar H, Rahimipour A.
PMID: 30568542
J Med Biochem. 2017 Jul 14;36(3):251-258. doi: 10.1515/jomb-2017-0005. eCollection 2017 Sep.

BACKGROUND: Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been...

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Ghaffarzadeh M, Ghaedi H, Alipoor B, et al. Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease. J Med Biochem. 2017;36(3):251-258doi: 10.1515/jomb-2017-0005.
Ghaffarzadeh, M., Ghaedi, H., Alipoor, B., Omrani, M. D., Kazerouni, F., Shanaki, M., Labbaf, A., Pashaiefar, H., & Rahimipour, A. (2017). Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease. Journal of medical biochemistry, 36(3), 251-258. https://doi.org/10.1515/jomb-2017-0005
Ghaffarzadeh, Maryam, et al. "Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease." Journal of medical biochemistry vol. 36,3 (2017): 251-258. doi: https://doi.org/10.1515/jomb-2017-0005
Ghaffarzadeh M, Ghaedi H, Alipoor B, Omrani MD, Kazerouni F, Shanaki M, Labbaf A, Pashaiefar H, Rahimipour A. Association of MiR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease. J Med Biochem. 2017 Jul 14;36(3):251-258. doi: 10.1515/jomb-2017-0005. eCollection 2017 Sep. PMID: 30568542; PMCID: PMC6287219.
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Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study .

NPJ microgravity

Barrila J, Yang J, Crabbé A, Sarker SF, Liu Y, Ott CM, Nelman-Gonzalez MA, Clemett SJ, Nydam SD, Forsyth RJ, Davis RR, Crucian BE, Quiriarte H, Roland KL, Brenneman K, Sams C, Loscher C, Nickerson CA.
PMID: 28649632
NPJ Microgravity. 2017 Feb 28;3:10. doi: 10.1038/s41526-017-0011-2. eCollection 2017.

Three-dimensional models of human intestinal epithelium mimic the differentiated form and function of parental tissues often not exhibited by two-dimensional monolayers and respond to

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Barrila J, Yang J, Crabbé A, et al. Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study . NPJ Microgravity. 2017;3:10doi: 10.1038/s41526-017-0011-2.
Barrila, J., Yang, J., Crabbé, A., Sarker, S. F., Liu, Y., Ott, C. M., Nelman-Gonzalez, M. A., Clemett, S. J., Nydam, S. D., Forsyth, R. J., Davis, R. R., Crucian, B. E., Quiriarte, H., Roland, K. L., Brenneman, K., Sams, C., Loscher, C., & Nickerson, C. A. (2017). Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study . NPJ microgravity, 310. https://doi.org/10.1038/s41526-017-0011-2
Barrila, Jennifer, et al. "Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study ." NPJ microgravity vol. 3 (2017): 10. doi: https://doi.org/10.1038/s41526-017-0011-2
Barrila J, Yang J, Crabbé A, Sarker SF, Liu Y, Ott CM, Nelman-Gonzalez MA, Clemett SJ, Nydam SD, Forsyth RJ, Davis RR, Crucian BE, Quiriarte H, Roland KL, Brenneman K, Sams C, Loscher C, Nickerson CA. Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study . NPJ Microgravity. 2017 Feb 28;3:10. doi: 10.1038/s41526-017-0011-2. eCollection 2017. PMID: 28649632; PMCID: PMC5460263.
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Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines.

Organic letters

Cabré A, Sciortino G, Ujaque G, Verdaguer X, Lledós A, Riera A.
PMID: 30188732
Org Lett. 2018 Sep 21;20(18):5747-5751. doi: 10.1021/acs.orglett.8b02450. Epub 2018 Sep 06.

The Crabtree's reagent catalyzes the isomerization of N-sulfonyl 2,2-disubstituted aziridines to allyl amines. The selectivity of allyl amine vs imine is very high (up to 99/1). The unprecedented isomerization takes place in mild conditions without activation of the catalyst...

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Cabré A, Sciortino G, Ujaque G, et al. Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines. Org Lett. 2018;20(18):5747-5751doi: 10.1021/acs.orglett.8b02450.
Cabré, A., Sciortino, G., Ujaque, G., Verdaguer, X., Lledós, A., & Riera, A. (2018). Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines. Organic letters, 20(18), 5747-5751. https://doi.org/10.1021/acs.orglett.8b02450
Cabré, Albert, et al. "Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines." Organic letters vol. 20,18 (2018): 5747-5751. doi: https://doi.org/10.1021/acs.orglett.8b02450
Cabré A, Sciortino G, Ujaque G, Verdaguer X, Lledós A, Riera A. Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines. Org Lett. 2018 Sep 21;20(18):5747-5751. doi: 10.1021/acs.orglett.8b02450. Epub 2018 Sep 06. PMID: 30188732.
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The Effect of Language Barrier and Non-professional Interpreters on the Accuracy of Patient-physician Communication in Emergency Department.

Advanced journal of emergency medicine

Labaf A, Shahvaraninasab A, Baradaran H, Seyedhosseini J, Jahanshir A.
PMID: 31633093
Adv J Emerg Med. 2019 Jun 02;3(4):e38. doi: 10.22114/ajem.v0i0.123. eCollection 2019.

INTRODUCTION: Patients' relatives commonly play the role of interpreters in medical interviews. These non-professional interpreters are prone to potentially-dangerous translation errors.OBJECTIVE: The present study was conducted to evaluate these errors in the emergency department (ED).METHOD: Twenty interviews with Azeri...

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Labaf A, Shahvaraninasab A, Baradaran H, et al. The Effect of Language Barrier and Non-professional Interpreters on the Accuracy of Patient-physician Communication in Emergency Department. Adv J Emerg Med. 2019;3(4):e38doi: 10.22114/ajem.v0i0.123.
Labaf, A., Shahvaraninasab, A., Baradaran, H., Seyedhosseini, J., & Jahanshir, A. (2019). The Effect of Language Barrier and Non-professional Interpreters on the Accuracy of Patient-physician Communication in Emergency Department. Advanced journal of emergency medicine, 3(4), e38. https://doi.org/10.22114/ajem.v0i0.123
Labaf, Ali, et al. "The Effect of Language Barrier and Non-professional Interpreters on the Accuracy of Patient-physician Communication in Emergency Department." Advanced journal of emergency medicine vol. 3,4 (2019): e38. doi: https://doi.org/10.22114/ajem.v0i0.123
Labaf A, Shahvaraninasab A, Baradaran H, Seyedhosseini J, Jahanshir A. The Effect of Language Barrier and Non-professional Interpreters on the Accuracy of Patient-physician Communication in Emergency Department. Adv J Emerg Med. 2019 Jun 02;3(4):e38. doi: 10.22114/ajem.v0i0.123. eCollection 2019. PMID: 31633093; PMCID: PMC6789075.
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Antibiotic therapy for snakebite envenoming.

The journal of venomous animals and toxins including tropical diseases

Resiere D, Gutiérrez JM, Névière R, Cabié A, Hossein M, Kallel H.
PMID: 32095137
J Venom Anim Toxins Incl Trop Dis. 2020 Feb 03;26:e20190098. doi: 10.1590/1678-9199-JVATITD-2019-0098. eCollection 2020.

There are numerous conflicting recommendations available on the use of antibiotics following snakebite. The present letter to the editor presents some recommendations based on recent studies, and aims to stimulate debate on this topic.

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Resiere D, Gutiérrez JM, Névière R, et al. Antibiotic therapy for snakebite envenoming. J Venom Anim Toxins Incl Trop Dis. 2020;26:e20190098doi: 10.1590/1678-9199-JVATITD-2019-0098.
Resiere, D., Gutiérrez, J. M., Névière, R., Cabié, A., Hossein, M., & Kallel, H. (2020). Antibiotic therapy for snakebite envenoming. The journal of venomous animals and toxins including tropical diseases, 26e20190098. https://doi.org/10.1590/1678-9199-JVATITD-2019-0098
Resiere, Dabor, et al. "Antibiotic therapy for snakebite envenoming." The journal of venomous animals and toxins including tropical diseases vol. 26 (2020): e20190098. doi: https://doi.org/10.1590/1678-9199-JVATITD-2019-0098
Resiere D, Gutiérrez JM, Névière R, Cabié A, Hossein M, Kallel H. Antibiotic therapy for snakebite envenoming. J Venom Anim Toxins Incl Trop Dis. 2020 Feb 03;26:e20190098. doi: 10.1590/1678-9199-JVATITD-2019-0098. eCollection 2020. PMID: 32095137; PMCID: PMC7011479.
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Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D.

Journal of materials chemistry. B

Sandrin L, Thakar D, Goyer C, Labbé P, Boturyn D, Coche-Guérente L.
PMID: 32262527
J Mater Chem B. 2015 Jul 21;3(27):5577-5587. doi: 10.1039/c5tb00420a. Epub 2015 Jun 17.

RGD peptides (Arg-Gly-Asp) are known to promote cell adhesion. As a consequence, numerous materials have been functionalized using these peptides for several medical applications. We report herein the controlled functionalization of surfaces to study the influence of RGD density...

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Sandrin L, Thakar D, Goyer C, et al. Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D. J Mater Chem B. 2015;3(27):5577-5587doi: 10.1039/c5tb00420a.
Sandrin, L., Thakar, D., Goyer, C., Labbé, P., Boturyn, D., & Coche-Guérente, L. (2015). Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D. Journal of materials chemistry. B, 3(27), 5577-5587. https://doi.org/10.1039/c5tb00420a
Sandrin, L, et al. "Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D." Journal of materials chemistry. B vol. 3,27 (2015): 5577-5587. doi: https://doi.org/10.1039/c5tb00420a
Sandrin L, Thakar D, Goyer C, Labbé P, Boturyn D, Coche-Guérente L. Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D. J Mater Chem B. 2015 Jul 21;3(27):5577-5587. doi: 10.1039/c5tb00420a. Epub 2015 Jun 17. PMID: 32262527.
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An optimised CRISPR/Cas9 protocol to create targeted mutations in homoeologous genes and an efficient genotyping protocol to identify edited events in wheat.

Plant methods

Cui X, Balcerzak M, Schernthaner J, Babic V, Datla R, Brauer EK, Labbé N, Subramaniam R, Ouellet T.
PMID: 31673276
Plant Methods. 2019 Oct 24;15:119. doi: 10.1186/s13007-019-0500-2. eCollection 2019.

BACKGROUND: Targeted genome editing using the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system has been applied in a large number of plant species. Using a gene-specific single guide RNA (sgRNA) and the CRISPR/Cas9 system, small editing events such...

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Cui X, Balcerzak M, Schernthaner J, et al. An optimised CRISPR/Cas9 protocol to create targeted mutations in homoeologous genes and an efficient genotyping protocol to identify edited events in wheat. Plant Methods. 2019;15:119doi: 10.1186/s13007-019-0500-2.
Cui, X., Balcerzak, M., Schernthaner, J., Babic, V., Datla, R., Brauer, E. K., Labbé, N., Subramaniam, R., & Ouellet, T. (2019). An optimised CRISPR/Cas9 protocol to create targeted mutations in homoeologous genes and an efficient genotyping protocol to identify edited events in wheat. Plant methods, 15119. https://doi.org/10.1186/s13007-019-0500-2
Cui, Xiucheng, et al. "An optimised CRISPR/Cas9 protocol to create targeted mutations in homoeologous genes and an efficient genotyping protocol to identify edited events in wheat." Plant methods vol. 15 (2019): 119. doi: https://doi.org/10.1186/s13007-019-0500-2
Cui X, Balcerzak M, Schernthaner J, Babic V, Datla R, Brauer EK, Labbé N, Subramaniam R, Ouellet T. An optimised CRISPR/Cas9 protocol to create targeted mutations in homoeologous genes and an efficient genotyping protocol to identify edited events in wheat. Plant Methods. 2019 Oct 24;15:119. doi: 10.1186/s13007-019-0500-2. eCollection 2019. PMID: 31673276; PMCID: PMC6814032.
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Rationale, Design, and Methodology of a Prospective Cohort Study for Coping with Behavioral and Psychological Symptoms of Dementia: The RECage Project.

Journal of Alzheimer's disease : JAD

Poptsi E, Tsolaki M, Bergh S, Cesana BM, Ciceone A, Fabbo A, Frisoni GB, Frölich L, Guazzarini AG, Hugon J, Fascendini S, Lavolpe S, Mecocci P, Peters O, Defanti CA.
PMID: 34366360
J Alzheimers Dis. 2021;82(4):1861-1862. doi: 10.3233/JAD-219008.

No abstract available.

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Poptsi E, Tsolaki M, Bergh S, et al. Rationale, Design, and Methodology of a Prospective Cohort Study for Coping with Behavioral and Psychological Symptoms of Dementia: The RECage Project. J Alzheimers Dis. 2021;82(4):1861-1862doi: 10.3233/JAD-219008.
Poptsi, E., Tsolaki, M., Bergh, S., Cesana, B. M., Ciceone, A., Fabbo, A., Frisoni, G. B., Frölich, L., Guazzarini, A. G., Hugon, J., Fascendini, S., Lavolpe, S., Mecocci, P., Peters, O., & Defanti, C. A. (2021). Rationale, Design, and Methodology of a Prospective Cohort Study for Coping with Behavioral and Psychological Symptoms of Dementia: The RECage Project. Journal of Alzheimer's disease : JAD, 82(4), 1861-1862. https://doi.org/10.3233/JAD-219008
Poptsi, Eleni, et al. "Rationale, Design, and Methodology of a Prospective Cohort Study for Coping with Behavioral and Psychological Symptoms of Dementia: The RECage Project." Journal of Alzheimer's disease : JAD vol. 82,4 (2021): 1861-1862. doi: https://doi.org/10.3233/JAD-219008
Poptsi E, Tsolaki M, Bergh S, Cesana BM, Ciceone A, Fabbo A, Frisoni GB, Frölich L, Guazzarini AG, Hugon J, Fascendini S, Lavolpe S, Mecocci P, Peters O, Defanti CA. Rationale, Design, and Methodology of a Prospective Cohort Study for Coping with Behavioral and Psychological Symptoms of Dementia: The RECage Project. J Alzheimers Dis. 2021;82(4):1861-1862. doi: 10.3233/JAD-219008. PMID: 34366360; PMCID: PMC8485736.
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Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.

Chemical reviews

Cabré A, Verdaguer X, Riera A.
PMID: 34677059
Chem Rev. 2022 Jan 12;122(1):269-339. doi: 10.1021/acs.chemrev.1c00496. Epub 2021 Oct 22.

Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the past decade, significant advances have been made with respect to the enantioselective synthesis of chiral amines, many...

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Cabré A, Verdaguer X, Riera A. Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation. Chem Rev. 2021;122(1):269-339doi: 10.1021/acs.chemrev.1c00496.
Cabré, A., Verdaguer, X., & Riera, A. (2022). Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation. Chemical reviews, 122(1), 269-339. https://doi.org/10.1021/acs.chemrev.1c00496
Cabré, Albert, et al. "Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation." Chemical reviews vol. 122,1 (2022): 269-339. doi: https://doi.org/10.1021/acs.chemrev.1c00496
Cabré A, Verdaguer X, Riera A. Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation. Chem Rev. 2022 Jan 12;122(1):269-339. doi: 10.1021/acs.chemrev.1c00496. Epub 2021 Oct 22. PMID: 34677059.
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"What If We Get Sick?": Spanish Adaptation and Validation of the Fear of Illness and Virus Evaluation Scale in a Non-clinical Sample Exposed to the COVID-19 Pandemic.

Frontiers in psychology

Cottin M, Hernández C, Núñez C, Labbé N, Quevedo Y, Davanzo A, Behn A.
PMID: 33776833
Front Psychol. 2021 Mar 11;12:590283. doi: 10.3389/fpsyg.2021.590283. eCollection 2021.

Distinct sources of stress have emerged during the COVID-19 pandemic. Particularly, fear is expected to generate significant psychological burden on individuals and influence on either unsafe behavior that may hinder recovery efforts or virus-mitigating behaviors. However, little is known...

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Cottin M, Hernández C, Núñez C, et al. "What If We Get Sick?": Spanish Adaptation and Validation of the Fear of Illness and Virus Evaluation Scale in a Non-clinical Sample Exposed to the COVID-19 Pandemic. Front Psychol. 2021;12:590283doi: 10.3389/fpsyg.2021.590283.
Cottin, M., Hernández, C., Núñez, C., Labbé, N., Quevedo, Y., Davanzo, A., & Behn, A. (2021). "What If We Get Sick?": Spanish Adaptation and Validation of the Fear of Illness and Virus Evaluation Scale in a Non-clinical Sample Exposed to the COVID-19 Pandemic. Frontiers in psychology, 12590283. https://doi.org/10.3389/fpsyg.2021.590283
Cottin, Marianne, et al. ""What If We Get Sick?": Spanish Adaptation and Validation of the Fear of Illness and Virus Evaluation Scale in a Non-clinical Sample Exposed to the COVID-19 Pandemic." Frontiers in psychology vol. 12 (2021): 590283. doi: https://doi.org/10.3389/fpsyg.2021.590283
Cottin M, Hernández C, Núñez C, Labbé N, Quevedo Y, Davanzo A, Behn A. "What If We Get Sick?": Spanish Adaptation and Validation of the Fear of Illness and Virus Evaluation Scale in a Non-clinical Sample Exposed to the COVID-19 Pandemic. Front Psychol. 2021 Mar 11;12:590283. doi: 10.3389/fpsyg.2021.590283. eCollection 2021. PMID: 33776833; PMCID: PMC7990903.
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Identification of (Tb,Eu).

Inorganic chemistry

Leroux C, Guillaume C, Labbé C, Portier X, Pelloquin D.
PMID: 33705658
Inorg Chem. 2021 Apr 05;60(7):4508-4516. doi: 10.1021/acs.inorgchem.0c03361. Epub 2021 Mar 11.

(Tb,Eu)-doped ZnO-annealed films at 1100 °C showed intense photoluminescense (PL) emission from Eu and Tb ions. The high-temperature annealing led to a chemical segregation and a secondary Zn-free phase formation that is suspected to be responsible for the high...

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Leroux C, Guillaume C, Labbé C, et al. Identification of (Tb,Eu). Inorg Chem. 2021;60(7):4508-4516doi: 10.1021/acs.inorgchem.0c03361.
Leroux, C., Guillaume, C., Labbé, C., Portier, X., & Pelloquin, D. (2021). Identification of (Tb,Eu). Inorganic chemistry, 60(7), 4508-4516. https://doi.org/10.1021/acs.inorgchem.0c03361
Leroux, Chris, et al. "Identification of (Tb,Eu)." Inorganic chemistry vol. 60,7 (2021): 4508-4516. doi: https://doi.org/10.1021/acs.inorgchem.0c03361
Leroux C, Guillaume C, Labbé C, Portier X, Pelloquin D. Identification of (Tb,Eu). Inorg Chem. 2021 Apr 05;60(7):4508-4516. doi: 10.1021/acs.inorgchem.0c03361. Epub 2021 Mar 11. PMID: 33705658.
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