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Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease.

British journal of cancer

Traversa D, Simonetti G, Tolomeo D, Visci G, Macchia G, Ghetti M, Martinelli G, Kristensen LS, Storlazzi CT.
PMID: 34754096
Br J Cancer. 2021 Nov 09; doi: 10.1038/s41416-021-01584-7. Epub 2021 Nov 09.

The plasmacytoma variant translocation 1 (PVT1) is a long non-coding RNA gene involved in human disease, mainly in cancer onset/progression. Although widely analysed, its biological roles need to be further clarified. Notably, functional studies on PVT1 are complicated by...

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Traversa D, Simonetti G, Tolomeo D, et al. Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. Br J Cancer. 2021;doi: 10.1038/s41416-021-01584-7.
Traversa, D., Simonetti, G., Tolomeo, D., Visci, G., Macchia, G., Ghetti, M., Martinelli, G., Kristensen, L. S., & Storlazzi, C. T. (2021). Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. British journal of cancer, . https://doi.org/10.1038/s41416-021-01584-7
Traversa, Debora, et al. "Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease." British journal of cancer vol. (2021). doi: https://doi.org/10.1038/s41416-021-01584-7
Traversa D, Simonetti G, Tolomeo D, Visci G, Macchia G, Ghetti M, Martinelli G, Kristensen LS, Storlazzi CT. Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. Br J Cancer. 2021 Nov 09; doi: 10.1038/s41416-021-01584-7. Epub 2021 Nov 09. PMID: 34754096.
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Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials.

Leukemia

Dahl M, Husby S, Eskelund CW, Besenbacher S, Fjelstrup S, Côme C, Ek S, Kolstad A, Räty R, Jerkeman M, Geisler CH, Kjems J, Kristensen LS, Grønbæk K.
PMID: 34244612
Leukemia. 2021 Jul 09; doi: 10.1038/s41375-021-01311-4. Epub 2021 Jul 09.

Mantle cell lymphoma (MCL) is characterized by marked differences in outcome, emphasizing the need for strong prognostic biomarkers. Here, we explore expression patterns and prognostic relevance of circular RNAs (circRNAs), a group of endogenous non-coding RNA molecules, in MCL....

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Dahl M, Husby S, Eskelund CW, et al. Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials. Leukemia. 2021;doi: 10.1038/s41375-021-01311-4.
Dahl, M., Husby, S., Eskelund, C. W., Besenbacher, S., Fjelstrup, S., Côme, C., Ek, S., Kolstad, A., Räty, R., Jerkeman, M., Geisler, C. H., Kjems, J., Kristensen, L. S., & Grønbæk, K. (2021). Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials. Leukemia, . https://doi.org/10.1038/s41375-021-01311-4
Dahl, Mette, et al. "Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials." Leukemia vol. (2021). doi: https://doi.org/10.1038/s41375-021-01311-4
Dahl M, Husby S, Eskelund CW, Besenbacher S, Fjelstrup S, Côme C, Ek S, Kolstad A, Räty R, Jerkeman M, Geisler CH, Kjems J, Kristensen LS, Grønbæk K. Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials. Leukemia. 2021 Jul 09; doi: 10.1038/s41375-021-01311-4. Epub 2021 Jul 09. PMID: 34244612.
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Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma.

Neuropathology and applied neurobiology

Mirian C, Grell K, Juratli TA, Sahm F, Spiegl-Kreinecker S, Peyre M, Biczok A, Tonn JC, Goutagny S, Bertero L, Maier AD, Jensen LR, Schackert G, Broholm H, Scheie D, Cahill DP, Brastianos PK, Skjøth-Rasmussen J, Fugleholm K, Ziebell M, Munch TN, Kristensen BW, Mathiesen T.
PMID: 34799864
Neuropathol Appl Neurobiol. 2021 Nov 19; doi: 10.1111/nan.12773. Epub 2021 Nov 19.

TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from...

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Mirian C, Grell K, Juratli TA, et al. Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma. Neuropathol Appl Neurobiol. 2021;doi: 10.1111/nan.12773.
Mirian, C., Grell, K., Juratli, T. A., Sahm, F., Spiegl-Kreinecker, S., Peyre, M., Biczok, A., Tonn, J. C., Goutagny, S., Bertero, L., Maier, A. D., Jensen, L. R., Schackert, G., Broholm, H., Scheie, D., Cahill, D. P., Brastianos, P. K., Skjøth-Rasmussen, J., Fugleholm, K., Ziebell, M., Munch, T. N., Kristensen, B. W., & Mathiesen, T. (2021). Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma. Neuropathology and applied neurobiology, . https://doi.org/10.1111/nan.12773
Mirian, Christian, et al. "Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma." Neuropathology and applied neurobiology vol. (2021). doi: https://doi.org/10.1111/nan.12773
Mirian C, Grell K, Juratli TA, Sahm F, Spiegl-Kreinecker S, Peyre M, Biczok A, Tonn JC, Goutagny S, Bertero L, Maier AD, Jensen LR, Schackert G, Broholm H, Scheie D, Cahill DP, Brastianos PK, Skjøth-Rasmussen J, Fugleholm K, Ziebell M, Munch TN, Kristensen BW, Mathiesen T. Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma. Neuropathol Appl Neurobiol. 2021 Nov 19; doi: 10.1111/nan.12773. Epub 2021 Nov 19. PMID: 34799864.
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Patient-reported outcome measures after hip fracture in patients with chronic cognitive impairment : results from 34,675 patients in the Norwegian Hip Fracture Register.

Bone & joint open

Kristoffersen MH, Dybvik EH, Steihaug OM, Kristensen TB, Engesæter LB, Ranhoff AH, Gjertsen JE.
PMID: 34233475
Bone Jt Open. 2021 Jul;2(7):454-465. doi: 10.1302/2633-1462.27.BJO-2021-0058.R1.

AIMS: Hip fracture patients have high morbidity and mortality. Patient-reported outcome measures (PROMs) assess the quality of care of patients with hip fracture, including those with chronic cognitive impairment (CCI). Our aim was to compare PROMs from hip fracture...

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Kristoffersen MH, Dybvik EH, Steihaug OM, et al. Patient-reported outcome measures after hip fracture in patients with chronic cognitive impairment : results from 34,675 patients in the Norwegian Hip Fracture Register. Bone Jt Open. 2021;2(7):454-465doi: 10.1302/2633-1462.27.BJO-2021-0058.R1.
Kristoffersen, M. H., Dybvik, E. H., Steihaug, O. M., Kristensen, T. B., Engesæter, L. B., Ranhoff, A. H., & Gjertsen, J. E. (2021). Patient-reported outcome measures after hip fracture in patients with chronic cognitive impairment : results from 34,675 patients in the Norwegian Hip Fracture Register. Bone & joint open, 2(7), 454-465. https://doi.org/10.1302/2633-1462.27.BJO-2021-0058.R1
Kristoffersen, Malfrid H, et al. "Patient-reported outcome measures after hip fracture in patients with chronic cognitive impairment : results from 34,675 patients in the Norwegian Hip Fracture Register." Bone & joint open vol. 2,7 (2021): 454-465. doi: https://doi.org/10.1302/2633-1462.27.BJO-2021-0058.R1
Kristoffersen MH, Dybvik EH, Steihaug OM, Kristensen TB, Engesæter LB, Ranhoff AH, Gjertsen JE. Patient-reported outcome measures after hip fracture in patients with chronic cognitive impairment : results from 34,675 patients in the Norwegian Hip Fracture Register. Bone Jt Open. 2021 Jul;2(7):454-465. doi: 10.1302/2633-1462.27.BJO-2021-0058.R1. PMID: 34233475; PMCID: PMC8325968.
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The Epigenetic Regulator Jumonji Domain-Containing Protein 6 (JMJD6) Is Highly Expressed but Not Prognostic in IDH-Wildtype Glioblastoma Patients.

Journal of neuropathology and experimental neurology

Rosager AM, Dahlrot RH, Sørensen MD, Bangsø JA, Hansen S, Kristensen BW.
PMID: 34875075
J Neuropathol Exp Neurol. 2021 Dec 07; doi: 10.1093/jnen/nlab124. Epub 2021 Dec 07.

Patients with IDH-wildtype glioblastoma (GBM) generally have a poor prognosis. However, there is an increasing need of novel robust biomarkers in the daily clinico-pathological setting to identify and support treatment in patients who become long-time survivors. Jumonji domain-containing protein...

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Rosager AM, Dahlrot RH, Sørensen MD, et al. The Epigenetic Regulator Jumonji Domain-Containing Protein 6 (JMJD6) Is Highly Expressed but Not Prognostic in IDH-Wildtype Glioblastoma Patients. J Neuropathol Exp Neurol. 2021;doi: 10.1093/jnen/nlab124.
Rosager, A. M., Dahlrot, R. H., Sørensen, M. D., Bangsø, J. A., Hansen, S., & Kristensen, B. W. (2021). The Epigenetic Regulator Jumonji Domain-Containing Protein 6 (JMJD6) Is Highly Expressed but Not Prognostic in IDH-Wildtype Glioblastoma Patients. Journal of neuropathology and experimental neurology, . https://doi.org/10.1093/jnen/nlab124
Rosager, Ann Mari, et al. "The Epigenetic Regulator Jumonji Domain-Containing Protein 6 (JMJD6) Is Highly Expressed but Not Prognostic in IDH-Wildtype Glioblastoma Patients." Journal of neuropathology and experimental neurology vol. (2021). doi: https://doi.org/10.1093/jnen/nlab124
Rosager AM, Dahlrot RH, Sørensen MD, Bangsø JA, Hansen S, Kristensen BW. The Epigenetic Regulator Jumonji Domain-Containing Protein 6 (JMJD6) Is Highly Expressed but Not Prognostic in IDH-Wildtype Glioblastoma Patients. J Neuropathol Exp Neurol. 2021 Dec 07; doi: 10.1093/jnen/nlab124. Epub 2021 Dec 07. PMID: 34875075.
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Building the case for the use of gut feelings in cancer referrals: perspectives of patients referred to a non-specific symptoms pathway.

The British journal of general practice : the journal of the Royal College of General Practitioners

Smith CF, Kristensen BM, Andersen RS, Ziebland S, Nicholson BD.
PMID: 34844921
Br J Gen Pract. 2021 Sep 22; doi: 10.3399/BJGP.2021.0275. Epub 2021 Sep 22.

BACKGROUND: Gut feelings may be useful when dealing with uncertainty, which is ubiquitous in primary care. Both patients and GPs experience this uncertainty but patients' views on gut feelings in the consultation have not been explored.AIM: To explore patients'...

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Smith CF, Kristensen BM, Andersen RS, et al. Building the case for the use of gut feelings in cancer referrals: perspectives of patients referred to a non-specific symptoms pathway. Br J Gen Pract. 2021;doi: 10.3399/BJGP.2021.0275.
Smith, C. F., Kristensen, B. M., Andersen, R. S., Ziebland, S., & Nicholson, B. D. (2021). Building the case for the use of gut feelings in cancer referrals: perspectives of patients referred to a non-specific symptoms pathway. The British journal of general practice : the journal of the Royal College of General Practitioners, . https://doi.org/10.3399/BJGP.2021.0275
Smith, Claire Friedemann, et al. "Building the case for the use of gut feelings in cancer referrals: perspectives of patients referred to a non-specific symptoms pathway." The British journal of general practice : the journal of the Royal College of General Practitioners vol. (2021). doi: https://doi.org/10.3399/BJGP.2021.0275
Smith CF, Kristensen BM, Andersen RS, Ziebland S, Nicholson BD. Building the case for the use of gut feelings in cancer referrals: perspectives of patients referred to a non-specific symptoms pathway. Br J Gen Pract. 2021 Sep 22; doi: 10.3399/BJGP.2021.0275. Epub 2021 Sep 22. PMID: 34844921.
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Impacts of Quarterly Sow Mass Vaccination with a Porcine Reproductive and Respiratory Syndrome Virus Type 1 (PRRSV-1) Modified Live Vaccine in Two Herds.

Vaccines

Pedersen K, Kristensen CS, Kvisgaard LK, Larsen LE.
PMID: 34696165
Vaccines (Basel). 2021 Sep 23;9(10). doi: 10.3390/vaccines9101057.

In recent years, there has been a considerable increase in the use of Modified Live PRRSV Vaccines (MLV) for mass vaccination in Denmark. The potential risks and negative impact of this strategy have been sparsely studied. The aim of...

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Pedersen K, Kristensen CS, Kvisgaard LK, et al. Impacts of Quarterly Sow Mass Vaccination with a Porcine Reproductive and Respiratory Syndrome Virus Type 1 (PRRSV-1) Modified Live Vaccine in Two Herds. Vaccines (Basel). 2021;9(10)doi: 10.3390/vaccines9101057.
Pedersen, K., Kristensen, C. S., Kvisgaard, L. K., & Larsen, L. E. (2021). Impacts of Quarterly Sow Mass Vaccination with a Porcine Reproductive and Respiratory Syndrome Virus Type 1 (PRRSV-1) Modified Live Vaccine in Two Herds. Vaccines, 9(10), . https://doi.org/10.3390/vaccines9101057
Pedersen, Kasper, et al. "Impacts of Quarterly Sow Mass Vaccination with a Porcine Reproductive and Respiratory Syndrome Virus Type 1 (PRRSV-1) Modified Live Vaccine in Two Herds." Vaccines vol. 9,10 (2021). doi: https://doi.org/10.3390/vaccines9101057
Pedersen K, Kristensen CS, Kvisgaard LK, Larsen LE. Impacts of Quarterly Sow Mass Vaccination with a Porcine Reproductive and Respiratory Syndrome Virus Type 1 (PRRSV-1) Modified Live Vaccine in Two Herds. Vaccines (Basel). 2021 Sep 23;9(10). doi: 10.3390/vaccines9101057. PMID: 34696165; PMCID: PMC8537578.
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Falls in individuals with type 2 diabetes; a cross-sectional study on the impact of motor dysfunction, postural instability and diabetic polyneuropathy.

Diabetic medicine : a journal of the British Diabetic Association

Khan KS, Pop-Busui R, Devantier L, Kristensen AG, Tankisi H, Dalgas U, Overgaard K, Andersen H.
PMID: 33259675
Diabet Med. 2021 Sep;38(9):e14470. doi: 10.1111/dme.14470. Epub 2020 Dec 12.

AIM: To estimate the incidence of falls in individuals with type 2 diabetes compared to healthy controls and to describe the characteristics of fallers with type 2 diabetes in relation to motor dysfunction, postural instability and diabetic polyneuropathy (DPN).METHODS:...

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Khan KS, Pop-Busui R, Devantier L, et al. Falls in individuals with type 2 diabetes; a cross-sectional study on the impact of motor dysfunction, postural instability and diabetic polyneuropathy. Diabet Med. 2020;38(9):e14470doi: 10.1111/dme.14470.
Khan, K. S., Pop-Busui, R., Devantier, L., Kristensen, A. G., Tankisi, H., Dalgas, U., Overgaard, K., & Andersen, H. (2021). Falls in individuals with type 2 diabetes; a cross-sectional study on the impact of motor dysfunction, postural instability and diabetic polyneuropathy. Diabetic medicine : a journal of the British Diabetic Association, 38(9), e14470. https://doi.org/10.1111/dme.14470
Khan, Karolina S, et al. "Falls in individuals with type 2 diabetes; a cross-sectional study on the impact of motor dysfunction, postural instability and diabetic polyneuropathy." Diabetic medicine : a journal of the British Diabetic Association vol. 38,9 (2021): e14470. doi: https://doi.org/10.1111/dme.14470
Khan KS, Pop-Busui R, Devantier L, Kristensen AG, Tankisi H, Dalgas U, Overgaard K, Andersen H. Falls in individuals with type 2 diabetes; a cross-sectional study on the impact of motor dysfunction, postural instability and diabetic polyneuropathy. Diabet Med. 2021 Sep;38(9):e14470. doi: 10.1111/dme.14470. Epub 2020 Dec 12. PMID: 33259675.
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Exposure to low environmental copper concentrations does not affect survival and development in Atlantic cod (.

Toxicology reports

Farkas J, Svendheim LH, Jager T, Ciesielski TM, Nordtug T, Kvæstad B, Hansen BH, Kristensen T, Altin D, Olsvik PA.
PMID: 34926169
Toxicol Rep. 2021 Nov 24;8:1909-1916. doi: 10.1016/j.toxrep.2021.11.012. eCollection 2021.

In this study we investigated potential impacts of Cu exposure at low, environmentally relevant, concentrations on early live stages of Atlantic cod (

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Farkas J, Svendheim LH, Jager T, et al. Exposure to low environmental copper concentrations does not affect survival and development in Atlantic cod (. Toxicol Rep. 2021;8:1909-1916doi: 10.1016/j.toxrep.2021.11.012.
Farkas, J., Svendheim, L. H., Jager, T., Ciesielski, T. M., Nordtug, T., Kvæstad, B., Hansen, B. H., Kristensen, T., Altin, D., & Olsvik, P. A. (2021). Exposure to low environmental copper concentrations does not affect survival and development in Atlantic cod (. Toxicology reports, 81909-1916. https://doi.org/10.1016/j.toxrep.2021.11.012
Farkas, Julia, et al. "Exposure to low environmental copper concentrations does not affect survival and development in Atlantic cod (." Toxicology reports vol. 8 (2021): 1909-1916. doi: https://doi.org/10.1016/j.toxrep.2021.11.012
Farkas J, Svendheim LH, Jager T, Ciesielski TM, Nordtug T, Kvæstad B, Hansen BH, Kristensen T, Altin D, Olsvik PA. Exposure to low environmental copper concentrations does not affect survival and development in Atlantic cod (. Toxicol Rep. 2021 Nov 24;8:1909-1916. doi: 10.1016/j.toxrep.2021.11.012. eCollection 2021. PMID: 34926169; PMCID: PMC8648920.
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Drivers and barriers for taking account of geological uncertainty in decision making for groundwater protection.

The Science of the total environment

Bjerre E, Kristensen LS, Engesgaard P, Højberg AL.
PMID: 32758986
Sci Total Environ. 2020 Dec 01;746:141045. doi: 10.1016/j.scitotenv.2020.141045. Epub 2020 Jul 22.

The geological conceptual model is considered a major source of uncertainty in groundwater modelling and well capture zone delineation. However, how to account for it in groundwater policy and management remains largely unresolved. We explore the drivers and barriers...

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Bjerre E, Kristensen LS, Engesgaard P, et al. Drivers and barriers for taking account of geological uncertainty in decision making for groundwater protection. Sci Total Environ. 2020;746:141045doi: 10.1016/j.scitotenv.2020.141045.
Bjerre, E., Kristensen, L. S., Engesgaard, P., & Højberg, A. L. (2020). Drivers and barriers for taking account of geological uncertainty in decision making for groundwater protection. The Science of the total environment, 746141045. https://doi.org/10.1016/j.scitotenv.2020.141045
Bjerre, Elisa, et al. "Drivers and barriers for taking account of geological uncertainty in decision making for groundwater protection." The Science of the total environment vol. 746 (2020): 141045. doi: https://doi.org/10.1016/j.scitotenv.2020.141045
Bjerre E, Kristensen LS, Engesgaard P, Højberg AL. Drivers and barriers for taking account of geological uncertainty in decision making for groundwater protection. Sci Total Environ. 2020 Dec 01;746:141045. doi: 10.1016/j.scitotenv.2020.141045. Epub 2020 Jul 22. PMID: 32758986.
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Distinct circular RNA expression profiles in pediatric ependymomas.

Brain pathology (Zurich, Switzerland)

Ahmadov U, Bendikas MM, Ebbesen KK, Sehested AM, Kjems J, Broholm H, Kristensen LS.
PMID: 33247464
Brain Pathol. 2021 Mar;31(2):387-392. doi: 10.1111/bpa.12922. Epub 2021 Jan 29.

Pediatric ependymomas frequently develop in the cerebellum and are currently treated using non-specific therapies, in part, because few somatically mutated driver genes are present, and the underlying pathobiology is poorly described. Circular RNAs (circRNAs) constitute as a large class...

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Ahmadov U, Bendikas MM, Ebbesen KK, et al. Distinct circular RNA expression profiles in pediatric ependymomas. Brain Pathol. 2021;31(2):387-392doi: 10.1111/bpa.12922.
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M., Kjems, J., Broholm, H., & Kristensen, L. S. (2021). Distinct circular RNA expression profiles in pediatric ependymomas. Brain pathology (Zurich, Switzerland), 31(2), 387-392. https://doi.org/10.1111/bpa.12922
Ahmadov, Ulvi, et al. "Distinct circular RNA expression profiles in pediatric ependymomas." Brain pathology (Zurich, Switzerland) vol. 31,2 (2021): 387-392. doi: https://doi.org/10.1111/bpa.12922
Ahmadov U, Bendikas MM, Ebbesen KK, Sehested AM, Kjems J, Broholm H, Kristensen LS. Distinct circular RNA expression profiles in pediatric ependymomas. Brain Pathol. 2021 Mar;31(2):387-392. doi: 10.1111/bpa.12922. Epub 2021 Jan 29. PMID: 33247464; PMCID: PMC8018153.
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Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing.

Porcine health management

Goecke NB, Kobberø M, Kusk TK, Hjulsager CK, Pedersen KS, Kristensen CS, Larsen LE.
PMID: 32922832
Porcine Health Manag. 2020 Sep 08;6:23. doi: 10.1186/s40813-020-00161-3. eCollection 2020.

BACKGROUND: Infectious diseases are of great economic importance in commercial pig production, causing both clinical and subclinical disease, with influence on welfare, productivity, and antibiotic use. The causes of these diseases are often multifactorial and laboratory diagnostics are seldom...

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Goecke NB, Kobberø M, Kusk TK, et al. Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing. Porcine Health Manag. 2020;6:23doi: 10.1186/s40813-020-00161-3.
Goecke, N. B., Kobberø, M., Kusk, T. K., Hjulsager, C. K., Pedersen, K. S., Kristensen, C. S., & Larsen, L. E. (2020). Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing. Porcine health management, 623. https://doi.org/10.1186/s40813-020-00161-3
Goecke, Nicole B, et al. "Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing." Porcine health management vol. 6 (2020): 23. doi: https://doi.org/10.1186/s40813-020-00161-3
Goecke NB, Kobberø M, Kusk TK, Hjulsager CK, Pedersen KS, Kristensen CS, Larsen LE. Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing. Porcine Health Manag. 2020 Sep 08;6:23. doi: 10.1186/s40813-020-00161-3. eCollection 2020. PMID: 32922832; PMCID: PMC7476771.
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