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Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans.

G3 (Bethesda, Md.)

Saxton AD, Kraemer BC.
PMID: 33963840
G3 (Bethesda). 2021 Aug 07;11(8). doi: 10.1093/g3journal/jkab158.

Amyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD). These diseases are caused by aberrant activity of a set of...

Cite
Saxton AD, Kraemer BC. Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans. G3 (Bethesda). 2021;11(8)doi: 10.1093/g3journal/jkab158.
Saxton, A. D., & Kraemer, B. C. (2021). Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans. G3 (Bethesda, Md.), 11(8), . https://doi.org/10.1093/g3journal/jkab158
Saxton, Aleen D, and Kraemer, Brian C. "Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans." G3 (Bethesda, Md.) vol. 11,8 (2021). doi: https://doi.org/10.1093/g3journal/jkab158
Saxton AD, Kraemer BC. Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans. G3 (Bethesda). 2021 Aug 07;11(8). doi: 10.1093/g3journal/jkab158. PMID: 33963840; PMCID: PMC8496285.
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Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD).

Biomolecules

Chen CH, Kraemer BR, Lee L, Mochly-Rosen D.
PMID: 34680056
Biomolecules. 2021 Sep 29;11(10). doi: 10.3390/biom11101423.

Human aldehyde dehydrogenase (ALDH) is a multigene family with 19 functional members encoding a class of diverse but important enzymes for detoxification or biotransformation of different endogenous and exogenous aldehyde substrates. Genetic mutations in the ALDH genes can cause...

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Chen CH, Kraemer BR, Lee L, et al. Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD). Biomolecules. 2021;11(10)doi: 10.3390/biom11101423.
Chen, C. H., Kraemer, B. R., Lee, L., & Mochly-Rosen, D. (2021). Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD). Biomolecules, 11(10), . https://doi.org/10.3390/biom11101423
Chen, Che-Hong, et al. "Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD)." Biomolecules vol. 11,10 (2021). doi: https://doi.org/10.3390/biom11101423
Chen CH, Kraemer BR, Lee L, Mochly-Rosen D. Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD). Biomolecules. 2021 Sep 29;11(10). doi: 10.3390/biom11101423. PMID: 34680056; PMCID: PMC8533364.
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TDP-43 promotes pathological tau phosphorylation and selective neurotoxicity in C. elegans.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Latimer CS, Keene CD, Kraemer BC, Liachko NF.
PMID: 34971207
Alzheimers Dement. 2021 Dec;17:e058137. doi: 10.1002/alz.058137.

BACKGROUND: TDP-43-positive inclusions are present in disease-affected neurons in over half of patients with Alzheimer's disease (AD). AD patients with TDP-43 pathology have worsened clinical outcomes and increased neurodegeneration, but the molecular mechanisms underlying this are unknown.METHODS: We have...

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Latimer CS, Keene CD, Kraemer BC, et al. TDP-43 promotes pathological tau phosphorylation and selective neurotoxicity in C. elegans. Alzheimers Dement. 2021;17:e058137doi: 10.1002/alz.058137.
Latimer, C. S., Keene, C. D., Kraemer, B. C., & Liachko, N. F. (2021). TDP-43 promotes pathological tau phosphorylation and selective neurotoxicity in C. elegans. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17e058137. https://doi.org/10.1002/alz.058137
Latimer, Caitlin S, et al. "TDP-43 promotes pathological tau phosphorylation and selective neurotoxicity in C. elegans." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17 (2021): e058137. doi: https://doi.org/10.1002/alz.058137
Latimer CS, Keene CD, Kraemer BC, Liachko NF. TDP-43 promotes pathological tau phosphorylation and selective neurotoxicity in C. elegans. Alzheimers Dement. 2021 Dec;17:e058137. doi: 10.1002/alz.058137. PMID: 34971207.
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Global data set of long-term summertime vertical temperature profiles in 153 lakes.

Scientific data

Pilla RM, Mette EM, Williamson CE, Adamovich BV, Adrian R, Anneville O, Balseiro E, Ban S, Chandra S, Colom-Montero W, Devlin SP, Dix MA, Dokulil MT, Feldsine NA, Feuchtmayr H, Fogarty NK, Gaiser EE, Girdner SF, González MJ, Hambright KD, Hamilton DP, Havens K, Hessen DO, Hetzenauer H, Higgins SN, Huttula TH, Huuskonen H, Isles PDF, Joehnk KD, Keller WB, Klug J, Knoll LB, Korhonen J, Korovchinsky NM, Köster O, Kraemer BM, Leavitt PR, Leoni B, Lepori F, Lepskaya EV, Lottig NR, Luger MS, Maberly SC, MacIntyre S, McBride C, McIntyre P, Melles SJ, Modenutti B, Müller-Navarra DC, Pacholski L, Paterson AM, Pierson DC, Pislegina HV, Plisnier PD, Richardson DC, Rimmer A, Rogora M, Rogozin DY, Rusak JA, Rusanovskaya OO, Sadro S, Salmaso N, Saros JE, Sarvala J, Saulnier-Talbot É, Schindler DE, Shimaraeva SV, Silow EA, Sitoki LM, Sommaruga R, Straile D, Strock KE, Swain H, Tallant JM, Thiery W, Timofeyev MA, Tolomeev AP, Tominaga K, Vanni MJ, Verburg P, Vinebrooke RD, Wanzenböck J, Weathers K, Weyhenmeyer GA, Zadereev ES, Zhukova TV.
PMID: 34349102
Sci Data. 2021 Aug 04;8(1):200. doi: 10.1038/s41597-021-00983-y.

Climate change and other anthropogenic stressors have led to long-term changes in the thermal structure, including surface temperatures, deepwater temperatures, and vertical thermal gradients, in many lakes around the world. Though many studies highlight warming of surface water temperatures...

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Pilla RM, Mette EM, Williamson CE, et al. Global data set of long-term summertime vertical temperature profiles in 153 lakes. Sci Data. 2021;8(1):200doi: 10.1038/s41597-021-00983-y.
Pilla, R. M., Mette, E. M., Williamson, C. E., Adamovich, B. V., Adrian, R., Anneville, O., Balseiro, E., Ban, S., Chandra, S., Colom-Montero, W., Devlin, S. P., Dix, M. A., Dokulil, M. T., Feldsine, N. A., Feuchtmayr, H., Fogarty, N. K., Gaiser, E. E., Girdner, S. F., González, M. J., Hambright, K. D., Hamilton, D. P., Havens, K., Hessen, D. O., Hetzenauer, H., Higgins, S. N., Huttula, T. H., Huuskonen, H., Isles, P. D. F., Joehnk, K. D., Keller, W. B., Klug, J., Knoll, L. B., Korhonen, J., Korovchinsky, N. M., Köster, O., Kraemer, B. M., Leavitt, P. R., Leoni, B., Lepori, F., Lepskaya, E. V., Lottig, N. R., Luger, M. S., Maberly, S. C., MacIntyre, S., McBride, C., McIntyre, P., Melles, S. J., Modenutti, B., Müller-Navarra, D. C., Pacholski, L., Paterson, A. M., Pierson, D. C., Pislegina, H. V., Plisnier, P. D., Richardson, D. C., Rimmer, A., Rogora, M., Rogozin, D. Y., Rusak, J. A., Rusanovskaya, O. O., Sadro, S., Salmaso, N., Saros, J. E., Sarvala, J., Saulnier-Talbot, �. �., Schindler, D. E., Shimaraeva, S. V., Silow, E. A., Sitoki, L. M., Sommaruga, R., Straile, D., Strock, K. E., Swain, H., Tallant, J. M., Thiery, W., Timofeyev, M. A., Tolomeev, A. P., Tominaga, K., Vanni, M. J., Verburg, P., Vinebrooke, R. D., Wanzenböck, J., Weathers, K., Weyhenmeyer, G. A., Zadereev, E. S., & Zhukova, T. V. (2021). Global data set of long-term summertime vertical temperature profiles in 153 lakes. Scientific data, 8(1), 200. https://doi.org/10.1038/s41597-021-00983-y
Pilla, Rachel M, et al. "Global data set of long-term summertime vertical temperature profiles in 153 lakes." Scientific data vol. 8,1 (2021): 200. doi: https://doi.org/10.1038/s41597-021-00983-y
Pilla RM, Mette EM, Williamson CE, Adamovich BV, Adrian R, Anneville O, Balseiro E, Ban S, Chandra S, Colom-Montero W, Devlin SP, Dix MA, Dokulil MT, Feldsine NA, Feuchtmayr H, Fogarty NK, Gaiser EE, Girdner SF, González MJ, Hambright KD, Hamilton DP, Havens K, Hessen DO, Hetzenauer H, Higgins SN, Huttula TH, Huuskonen H, Isles PDF, Joehnk KD, Keller WB, Klug J, Knoll LB, Korhonen J, Korovchinsky NM, Köster O, Kraemer BM, Leavitt PR, Leoni B, Lepori F, Lepskaya EV, Lottig NR, Luger MS, Maberly SC, MacIntyre S, McBride C, McIntyre P, Melles SJ, Modenutti B, Müller-Navarra DC, Pacholski L, Paterson AM, Pierson DC, Pislegina HV, Plisnier PD, Richardson DC, Rimmer A, Rogora M, Rogozin DY, Rusak JA, Rusanovskaya OO, Sadro S, Salmaso N, Saros JE, Sarvala J, Saulnier-Talbot É, Schindler DE, Shimaraeva SV, Silow EA, Sitoki LM, Sommaruga R, Straile D, Strock KE, Swain H, Tallant JM, Thiery W, Timofeyev MA, Tolomeev AP, Tominaga K, Vanni MJ, Verburg P, Vinebrooke RD, Wanzenböck J, Weathers K, Weyhenmeyer GA, Zadereev ES, Zhukova TV. Global data set of long-term summertime vertical temperature profiles in 153 lakes. Sci Data. 2021 Aug 04;8(1):200. doi: 10.1038/s41597-021-00983-y. PMID: 34349102; PMCID: PMC8339007.
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Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China.

BMJ open

Yang Y, Zeng Y, Yuan S, Xie M, Dong Y, Li J, He Q, Ye X, Lv Y, Hocher CF, Kraemer BK, Hong X, Hocher B.
PMID: 34872994
BMJ Open. 2021 Dec 06;11(12):e048575. doi: 10.1136/bmjopen-2020-048575.

OBJECTIVES: Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and risk factors for hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour and dietary factors.DESIGN: Population-based cross-sectional study.SETTING: Hunan Province, China PARTICIPANTS:...

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Yang Y, Zeng Y, Yuan S, et al. Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China. BMJ Open. 2021;11(12):e048575doi: 10.1136/bmjopen-2020-048575.
Yang, Y., Zeng, Y., Yuan, S., Xie, M., Dong, Y., Li, J., He, Q., Ye, X., Lv, Y., Hocher, C. F., Kraemer, B. K., Hong, X., & Hocher, B. (2021). Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China. BMJ open, 11(12), e048575. https://doi.org/10.1136/bmjopen-2020-048575
Yang, Yide, et al. "Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China." BMJ open vol. 11,12 (2021): e048575. doi: https://doi.org/10.1136/bmjopen-2020-048575
Yang Y, Zeng Y, Yuan S, Xie M, Dong Y, Li J, He Q, Ye X, Lv Y, Hocher CF, Kraemer BK, Hong X, Hocher B. Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China. BMJ Open. 2021 Dec 06;11(12):e048575. doi: 10.1136/bmjopen-2020-048575. PMID: 34872994; PMCID: PMC8650492.
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Sex and Racial Differences in High-Density Lipoprotein Levels in Acute Coronary Syndromes.

The American journal of the medical sciences

Ozaki A, Bravo-Jaimes K, Smotherman C, Kraemer DF, Samura A, Velarde GP.
PMID: 33961844
Am J Med Sci. 2021 Nov;362(5):435-441. doi: 10.1016/j.amjms.2021.04.013. Epub 2021 May 04.

BACKGROUND: This study aimed to assess sex and racial differences related to high-density lipoprotein cholesterol (HDL-C) levels in those presenting with acute coronary syndromes (ACS).METHODS: Records from patients with ACS presenting to the Emergency Department of University of Florida...

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Ozaki A, Bravo-Jaimes K, Smotherman C, et al. Sex and Racial Differences in High-Density Lipoprotein Levels in Acute Coronary Syndromes. Am J Med Sci. 2021;362(5):435-441doi: 10.1016/j.amjms.2021.04.013.
Ozaki, A., Bravo-Jaimes, K., Smotherman, C., Kraemer, D. F., Samura, A., & Velarde, G. P. (2021). Sex and Racial Differences in High-Density Lipoprotein Levels in Acute Coronary Syndromes. The American journal of the medical sciences, 362(5), 435-441. https://doi.org/10.1016/j.amjms.2021.04.013
Ozaki, Asuka, et al. "Sex and Racial Differences in High-Density Lipoprotein Levels in Acute Coronary Syndromes." The American journal of the medical sciences vol. 362,5 (2021): 435-441. doi: https://doi.org/10.1016/j.amjms.2021.04.013
Ozaki A, Bravo-Jaimes K, Smotherman C, Kraemer DF, Samura A, Velarde GP. Sex and Racial Differences in High-Density Lipoprotein Levels in Acute Coronary Syndromes. Am J Med Sci. 2021 Nov;362(5):435-441. doi: 10.1016/j.amjms.2021.04.013. Epub 2021 May 04. PMID: 33961844.
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SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior.

Biochimica et biophysica acta. Molecular basis of disease

Hao X, Zhu B, Yang P, Dong D, Sahbaie P, Oliver PL, Shen WJ, Azhar S, Kraemer FB.
PMID: 34826585
Biochim Biophys Acta Mol Basis Dis. 2021 Nov 24;1868(2):166304. doi: 10.1016/j.bbadis.2021.166304. Epub 2021 Nov 24.

OBJECTIVE: SNAP-25 is one of the key proteins involved in formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes that are at the core of hormonal secretion and synaptic transmission. Altered expression or function of SNAP-25 can contribute...

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Hao X, Zhu B, Yang P, et al. SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior. Biochim Biophys Acta Mol Basis Dis. 2021;1868(2):166304doi: 10.1016/j.bbadis.2021.166304.
Hao, X., Zhu, B., Yang, P., Dong, D., Sahbaie, P., Oliver, P. L., Shen, W. J., Azhar, S., & Kraemer, F. B. (2021). SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior. Biochimica et biophysica acta. Molecular basis of disease, 1868(2), 166304. https://doi.org/10.1016/j.bbadis.2021.166304
Hao, Xiao, et al. "SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior." Biochimica et biophysica acta. Molecular basis of disease vol. 1868,2 (2021): 166304. doi: https://doi.org/10.1016/j.bbadis.2021.166304
Hao X, Zhu B, Yang P, Dong D, Sahbaie P, Oliver PL, Shen WJ, Azhar S, Kraemer FB. SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior. Biochim Biophys Acta Mol Basis Dis. 2021 Nov 24;1868(2):166304. doi: 10.1016/j.bbadis.2021.166304. Epub 2021 Nov 24. PMID: 34826585.
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Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans.

G3 (Bethesda, Md.)

Saxton AD, Kraemer BC.
PMID: 33963840
G3 (Bethesda). 2021 Aug 07;11(8). doi: 10.1093/g3journal/jkab158.

Amyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD). These diseases are caused by aberrant activity of a set of...

Cite
Saxton AD, Kraemer BC. Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans. G3 (Bethesda). 2021;11(8)doi: 10.1093/g3journal/jkab158.
Saxton, A. D., & Kraemer, B. C. (2021). Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans. G3 (Bethesda, Md.), 11(8), . https://doi.org/10.1093/g3journal/jkab158
Saxton, Aleen D, and Kraemer, Brian C. "Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans." G3 (Bethesda, Md.) vol. 11,8 (2021). doi: https://doi.org/10.1093/g3journal/jkab158
Saxton AD, Kraemer BC. Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans. G3 (Bethesda). 2021 Aug 07;11(8). doi: 10.1093/g3journal/jkab158. PMID: 33963840; PMCID: PMC8496285.
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Showing 373 to 128 of 128 entries