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Showing 25 to 36 of 36 entries
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Rare Variants in Genes Associated With Cardiomyopathy Are Not Common in Hypoplastic Left Heart Syndrome Patients With Myocardial Dysfunction.

Frontiers in pediatrics

Helle E, Pihkala J, Turunen R, Ruotsalainen H, Tuupanen S, Koskenvuo J, Ojala T.
PMID: 33194928
Front Pediatr. 2020 Oct 30;8:596840. doi: 10.3389/fped.2020.596840. eCollection 2020.

Myocardial dysfunction is a known risk factor for morbidity and mortality in hypoplastic left heart syndrome (HLHS). Variants in some transcription factor and contractility genes, which are known to cause cardiomyopathy, have previously been associated with impaired right ventricular...

Prolonged survival in a patient with a novel pyrroline-5-carboxylase reductase 2 genetic variant.

European journal of neurology

Spagnoli C, Pavlidis E, Salerno GG, Koskinen L, Kääriäinen H, Frattini D, Koskenvuo JW, Fusco C.
PMID: 30829456
Eur J Neurol. 2019 Apr;26(4):e45-e46. doi: 10.1111/ene.13817.

No abstract available.

GRINL1A Complex Transcription Unit Containing GCOM1, MYZAP, and POLR2M Genes Associates with Fully Penetrant Recessive Dilated Cardiomyopathy.

Frontiers in genetics

Heliö K, Mäyränpää MI, Saarinen I, Ahonen S, Junnila H, Tommiska J, Weckström S, Holmström M, Toivonen M, Nikus K, Hathaway J, Siivonen P, Muona M, Sistonen J, Salmenperä P, Gentile M, Paananen J, Myllykangas S, Alastalo TP, Heliö T, Koskenvuo J.
PMID: 34899865
Front Genet. 2021 Nov 25;12:786705. doi: 10.3389/fgene.2021.786705. eCollection 2021.

No abstract available.

Middle age self-report risk score predicts cognitive functioning and dementia in 20-40 years.

Alzheimer's & dementia (Amsterdam, Netherlands)

Vuoksimaa E, Rinne JO, Lindgren N, Heikkilä K, Koskenvuo M, Kaprio J.
PMID: 27752535
Alzheimers Dement (Amst). 2016 Sep 14;4:118-125. doi: 10.1016/j.dadm.2016.08.003. eCollection 2016.

INTRODUCTION: On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia.METHODS: We used a longitudinal population-based study of 2602 individuals with a replication sample (N =...

The critical view of safety and bile duct injuries in laparoscopic cholecystectomy: a photo evaluation study on 1532 patients.

HPB : the official journal of the International Hepato Pancreato Biliary Association

Terho P, Sallinen V, Lampela H, Harju J, Koskenvuo L, Mentula P.
PMID: 33975802
HPB (Oxford). 2021 Dec;23(12):1824-1829. doi: 10.1016/j.hpb.2021.04.017. Epub 2021 Apr 27.

BACKGROUND: Laparoscopic cholecystectomy (LCC) carries a 0.3-1.8% risk of bile duct injury (BDI). This study investigated if intraoperative photo documentation of the critical view of safety (CVS) is related to lower rates of BDIs and postoperative complications in LCC.METHODS:...

Pravastatin-induced improvement in coronary reactivity and circulating ATP and ADP levels in young adults with type 1 diabetes.

Frontiers in physiology

Kiviniemi TO, Yegutkin GG, Toikka JO, Paul S, Aittokallio T, Janatuinen T, Knuuti J, Rönnemaa T, Koskenvuo JW, Hartiala JJ, Jalkanen S, Raitakari OT.
PMID: 22934084
Front Physiol. 2012 Aug 23;3:338. doi: 10.3389/fphys.2012.00338. eCollection 2012.

AIMS: Extracellular ATP and ADP regulate diverse inflammatory, prothrombotic and vasoactive responses in the vasculature. Statins have been shown to modulate their signaling pathways in vitro. We hypothesized that altered intravascular nucleotide turnover modulates vasodilation in patients with type...

Non-response in a nationwide follow-up postal survey in Finland: a register-based mortality analysis of respondents and non-respondents of the Health and Social Support (HeSSup) Study.

BMJ open

Suominen S, Koskenvuo K, Sillanmäki L, Vahtera J, Korkeila K, Kivimäki M, Mattila KJ, Virtanen P, Sumanen M, Rautava P, Koskenvuo M.
PMID: 22422917
BMJ Open. 2012 Mar 15;2(2):e000657. doi: 10.1136/bmjopen-2011-000657. Print 2012.

OBJECTIVE: To examine difference in mortality between postal survey non-respondents and respondents.DESIGN: A prospective cohort study with baseline survey in 1998 and comprehensive linkage to national mortality registers until 2005, the Health and Social Support study.SETTING: A population-based postal...

STRN-ALK rearranged pediatric malignant peritoneal mesothelioma - Functional testing of 527 cancer drugs in patient-derived cancer cells.

Translational oncology

Murumägi A, Ungureanu D, Arjama M, Bützow R, Lohi J, Sariola H, Kanerva J, Koskenvuo M, Kallioniemi O.
PMID: 33530027
Transl Oncol. 2021 Apr;14(4):101027. doi: 10.1016/j.tranon.2021.101027. Epub 2021 Jan 30.

Genetic rearrangements involving the anaplastic lymphoma kinase (ALK) gene create oncogenic drivers for several cancers, including malignant peritoneal mesothelioma (MPeM). Here, we report genomic and functional precision oncology profiling on a rare case of a 5-year old patient diagnosed...

SPG6 (NIPA1 variant): A report of a case with early-onset complex hereditary spastic paraplegia and brief literature review.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Spagnoli C, Schiavoni S, Rizzi S, Salerno GG, Frattini D, Koskenvuo J, Fusco C.
PMID: 34863451
J Clin Neurosci. 2021 Dec;94:281-285. doi: 10.1016/j.jocn.2021.10.026. Epub 2021 Nov 09.

SPG6, caused by NIPA1 (nonimprinted in Prader-Willi/Angelman syndrome) gene pathogenic variants, is mainly considered as a pure autosomal dominant hereditary spastic paraplegia (AD-HSP), even if descriptions of complex cases have also been reported. We detected the common c.316G >...

Childhood adversities and adult-onset asthma: a cohort study.

BMJ open

Korkeila J, Lietzen R, Sillanmäki LH, Rautava P, Korkeila K, Kivimäki M, Koskenvuo M, Vahtera J.
PMID: 23069774
BMJ Open. 2012 Oct 14;2(5). doi: 10.1136/bmjopen-2012-001625. Print 2012.

OBJECTIVES: Childhood adversities may be important determinants of later illnesses and poor health behaviour. However, large-scale prospective studies on the associations between childhood adversities and the onset of asthma in adulthood are lacking.DESIGN: Prospective cohort study with 7-year follow-up.SETTING:...

Prevalent migraine as a predictor of incident hypertension.

European journal of public health

Entonen AH, Suominen SB, Sillanmäki LH, Rautava PT, Kauniskangas K, Mäntyselkä PT, Sumanen M, Koskenvuo MJ.
PMID: 35021188
Eur J Public Health. 2022 Jan 11; doi: 10.1093/eurpub/ckab219. Epub 2022 Jan 11.

BACKGROUND: Migraine has been associated with several diseases. This population-based prospective Finnish postal survey Health and Social Support Study explored whether self-reported migraine predicted incident hypertension independently in a working-age population by utilising two data sources: the baseline survey...

The critical view of safety and bile duct injuries in laparoscopic cholecystectomy: a photo evaluation study on 1532 patients.

HPB : the official journal of the International Hepato Pancreato Biliary Association

Terho P, Sallinen V, Lampela H, Harju J, Koskenvuo L, Mentula P.
PMID: 33975802
HPB (Oxford). 2021 Apr 27; doi: 10.1016/j.hpb.2021.04.017. Epub 2021 Apr 27.

BACKGROUND: Laparoscopic cholecystectomy (LCC) carries a 0.3-1.8% risk of bile duct injury (BDI). This study investigated if intraoperative photo documentation of the critical view of safety (CVS) is related to lower rates of BDIs and postoperative complications in LCC.METHODS:...

Showing 25 to 36 of 36 entries