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Showing 25 to 36 of 69 entries
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Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies.

Brain : a journal of neurology

Xhima K, Markham-Coultes K, Kofoed RH, Saragovi HU, Hynynen K, Aubert I.
PMID: 34919633
Brain. 2021 Dec 17; doi: 10.1093/brain/awab460. Epub 2021 Dec 17.

Early degeneration of basal forebrain cholinergic neurons (BFCNs) contributes substantially to cognitive decline in Alzheimer's disease (AD). Evidence from preclinical models of neuronal injury and aging support a pivotal role for nerve growth factor (NGF) in neuroprotection, resilience, and...

Lung function decline in relation to COVID-19 in the general population: a matched cohort study with pre-pandemic assessment of lung function.

The Journal of infectious diseases

Iversen KK, Afzal S, Ahlström MG, Nordestgaard BG, Schneider UV, Nielsen L, Kofoed K, Benfield T, Ronit A.
PMID: 34979029
J Infect Dis. 2022 Jan 03; doi: 10.1093/infdis/jiab636. Epub 2022 Jan 03.

OBJECTIVE: To quantify the potential decline in dynamic lung volumes following coronavirus disease 2019 (COVID-19) in the general population.METHODS: A prospective matched cohort study of adult Copenhagen General Population Study (CGPS) participants with a pre-pandemic spirometry available. CGPS individuals...

Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification.

PloS one

Bjergfelt SS, Sørensen IMH, Hjortkjær HØ, Landler N, Ballegaard ELF, Biering-Sørensen T, Kofoed KF, Lange T, Feldt-Rasmussen B, Sillesen H, Christoffersen C, Bro S.
PMID: 34813630
PLoS One. 2021 Nov 23;16(11):e0260417. doi: 10.1371/journal.pone.0260417. eCollection 2021.

BACKGROUND: Chronic kidney disease accelerates both atherosclerosis and arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPTmax) was increased in patients with chronic kidney disease compared to controls and associated with...

The Flipped Classroom: An Innovative Approach to Medical Education in Ophthalmology.

Journal of academic ophthalmology (2017)

Alabiad CR, Moore KJ, Green DP, Kofoed M, Mechaber AJ, Karp CL.
PMID: 33564741
J Acad Ophthalmol. 2020 Jul;12(2):e96-e103. doi: 10.1055/s-0040-1713681.

OBJECTIVE: The aim of the study is to report the creation of a flipped ophthalmology course and preclinical medical student perceptions and knowledge gains before and after a flipped ophthalmology course.DESIGN: The form of the study discussed is an...

[Patient evaluation of nursing care examined by way of 105 questions of 100 patients].

Tidsskrift for sygeplejersker

Kofoed E, Munck L, Martiny K, Martiny P.
PMID: 5211887
Tidsskr Sygepl. 1971 Jun;71(6):235-6.

No abstract available.

De novo electrocardiographic abnormalities in persons living with HIV.

Scientific reports

Knudsen AD, Graff C, Nielsen JB, Thomsen MT, Høgh J, Benfield T, Gerstoft J, Køber L, Kofoed KF, Nielsen SD.
PMID: 34675281
Sci Rep. 2021 Oct 21;11(1):20750. doi: 10.1038/s41598-021-00290-x.

Persons living with HIV (PLWH) may have increased incidence of cardiovascular events and longer QTc intervals than uninfected persons. We aimed to investigate the incidence and risk factors of de novo major electrocardiogram (ECG) abnormalities and QTc prolongation in...

Aortic enlargement and coronary artery calcification in a general population cohort.

European heart journal. Cardiovascular Imaging

Ballegaard CR, Pham MHC, Sigvardsen PE, Kühl JT, Sørgaard M, Taudorf M, Fuchs A, Nordestgaard BG, Køber LV, Kofoed KF.
PMID: 34166489
Eur Heart J Cardiovasc Imaging. 2021 Jun 24; doi: 10.1093/ehjci/jeab122. Epub 2021 Jun 24.

AIMS: The role of atherosclerosis in the pathogenesis of aortic enlargement is uncertain. We aimed to evaluate the relationship between the diameters of the ascending, descending and abdominal aorta, and coronary artery calcification.METHODS AND RESULTS: Individuals in the Copenhagen...

Lung function decline in relation to COVID-19 in the general population: a matched cohort study with pre-pandemic assessment of lung function.

The Journal of infectious diseases

Iversen KK, Afzal S, Ahlström MG, Nordestgaard BG, Schneider UV, Nielsen L, Kofoed K, Benfield T, Ronit A.
PMID: 34979029
J Infect Dis. 2022 Jan 03; doi: 10.1093/infdis/jiab636. Epub 2022 Jan 03.

OBJECTIVE: To quantify the potential decline in dynamic lung volumes following coronavirus disease 2019 (COVID-19) in the general population.METHODS: A prospective matched cohort study of adult Copenhagen General Population Study (CGPS) participants with a pre-pandemic spirometry available. CGPS individuals...

Fluorescein-guided resection of cerebral metastases is associated with greater tumor resection.

Acta neurochirurgica

Kofoed MS, Pedersen CB, Schulz MK, Kristensen BW, Hansen RW, Markovic L, Halle B, Poulsen FR.
PMID: 33721109
Acta Neurochir (Wien). 2021 Mar 15; doi: 10.1007/s00701-021-04796-1. Epub 2021 Mar 15.

BACKGROUND: Sodium fluorescein (fluorescein) crosses a disrupted blood-brain barrier similarly to gadolinium contrast in contrast-enhancing cerebral tumors. When exposed to light with 560 nm wavelength during surgery, fluorescein emits a yellow-green fluorescent light that can be visualized through an...

Monitoring process-related impurities in biologics-host cell protein analysis.

Analytical and bioanalytical chemistry

Pilely K, Johansen MR, Lund RR, Kofoed T, Jørgensen TK, Skriver L, Mørtz E.
PMID: 34595561
Anal Bioanal Chem. 2022 Jan;414(2):747-758. doi: 10.1007/s00216-021-03648-2. Epub 2021 Oct 01.

During biologics development, manufacturers must demonstrate clearance of host cell impurities and contaminants to ensure drug purity, manufacturing process consistency, and patient safety. Host cell proteins (HCPs) are a major class of process-related impurities and require monitoring and documentation...

Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification.

PloS one

Bjergfelt SS, Sørensen IMH, Hjortkjær HØ, Landler N, Ballegaard ELF, Biering-Sørensen T, Kofoed KF, Lange T, Feldt-Rasmussen B, Sillesen H, Christoffersen C, Bro S.
PMID: 34813630
PLoS One. 2021 Nov 23;16(11):e0260417. doi: 10.1371/journal.pone.0260417. eCollection 2021.

BACKGROUND: Chronic kidney disease accelerates both atherosclerosis and arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPTmax) was increased in patients with chronic kidney disease compared to controls and associated with...

Increased Prevalence of Liver Fibrosis in People Living With Human Immunodeficiency Virus Without Viral Hepatitis Compared to Population Controls.

The Journal of infectious diseases

Kirkegaard-Klitbo DM, Bendtsen F, Lundgren J, de Knegt RJ, Kofoed KF, Nielsen SD, Benfield T.
PMID: 33320268
J Infect Dis. 2021 Aug 02;224(3):443-452. doi: 10.1093/infdis/jiaa763.

BACKGROUND: Liver fibrosis is associated with poor liver-related outcomes and mortality. People with human immunodeficiency virus (PWH) may be at increased risk. We aimed to estimate the prevalence and factors associated with liver fibrosis in PWH compared to population...

Showing 25 to 36 of 69 entries