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Showing 109 to 120 of 136 entries
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Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.

Nature communications

Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A.
PMID: 34911951
Nat Commun. 2021 Dec 15;12(1):7310. doi: 10.1038/s41467-021-27597-7.

Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates the transcription factor XBP1s by intron excision between similar...

CONTROLLING PHYSICAL INTERACTIONS: HUMANS DO NOT MINIMIZE MUSCLE EFFORT.

Proceedings of the ASME Dynamic Systems and Control Conference. ASME Dynamic Systems and Control Conference

Koeppen R, Sternad D, Huber ME, Hogan N.
PMID: 32494367
Proc ASME Dyn Syst Control Conf. 2017 Oct;2017. doi: 10.1115/DSCC2017-5202.

Physical interaction with tools is ubiquitous in functional activities of daily living. While tool use is considered a hallmark of human behavior, how humans control such physical interactions is still poorly understood. When humans perform a motor task, it...

Case report: Urogenital myiasis in an adult male.

Urology case reports

Koeppen RL, Tadros NN.
PMID: 33102006
Urol Case Rep. 2020 Jun 17;33:101303. doi: 10.1016/j.eucr.2020.101303. eCollection 2020 Nov.

Urogenital Myiasis is rarely documented in developed countries, so epidemiological data are limited and often associated with travel to endemic regions. We report a Case of urogenital myiasis, unassociated with travel, in a 31 year old male. The patient...

A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).

Cancer

Makker V, Recio FO, Ma L, Matulonis UA, Lauchle JO, Parmar H, Gilbert HN, Ware JA, Zhu R, Lu S, Huw LY, Wang Y, Koeppen H, Spoerke JM, Lackner MR, Aghajanian CA.
PMID: 27603005
Cancer. 2016 Nov 15;122(22):3519-3528. doi: 10.1002/cncr.30286. Epub 2016 Sep 07.

BACKGROUND: The current single-arm, open-label trial was designed to evaluate the activity of apitolisib (GDC-0980), a dual phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibitor, in patients with advanced endometrial cancer (EC).METHODS: Patients with recurrent or persistent EC who were...

Photovoice as a tool to improve patient-Provider communication in inflammatory bowel disease clinic: A feasibility study.

Journal of evaluation in clinical practice

Gorbenko KO, Riggs AR, Koeppel B, Phlegar S, Dubinsky MC, Ungaro R, Keefer L.
PMID: 34382292
J Eval Clin Pract. 2022 Feb;28(1):159-168. doi: 10.1111/jep.13609. Epub 2021 Aug 11.

BACKGROUND: The emotional health of patients with inflammatory bowel disease (IBD) is critical to self-management, but has been difficult to elucidate in routine care. Patients are often unsure how to communicate their preferences and concerns to their providers in...

Search for effects beyond the born approximation in polarization transfer observables in e(over→)p elastic scattering.

Physical review letters

Meziane M, Brash EJ, Gilman R, Jones MK, Luo W, Pentchev L, Perdrisat CF, Puckett AJ, Punjabi V, Wesselmann FR, Ahmidouch A, Albayrak I, Aniol KA, Arrington J, Asaturyan A, Ates O, Baghdasaryan H, Benmokhtar F, Bertozzi W, Bimbot L, Bosted P, Boeglin W, Butuceanu C, Carter P, Chernenko S, Christy E, Commisso M, Cornejo JC, Covrig S, Danagoulian S, Daniel A, Davidenko A, Day D, Dhamija S, Dutta D, Ent R, Frullani S, Fenker H, Frlez E, Garibaldi F, Gaskell D, Gilad S, Goncharenko Y, Hafidi K, Hamilton D, Higinbotham DW, Hinton W, Horn T, Hu B, Huang J, Huber GM, Jensen E, Kang H, Keppel C, Khandaker M, King P, Kirillov D, Kohl M, Kravtsov V, Kumbartzki G, Li Y, Mamyan V, Margaziotis DJ, Markowitz P, Marsh A, Matulenko Y, Maxwell J, Mbianda G, Meekins D, Melnik Y, Miller J, Mkrtchyan A, Mkrtchyan H, Moffit B, Moreno O, Mulholland J, Narayan A, Nuruzzaman, Nedev S, Piasetzky E, Pierce W, Piskunov NM, Prok Y, Ransome RD, Razin DS, Reimer PE, Reinhold J, Rondon O, Shabestari M, Shahinyan A, Shestermanov K, Širca S, Sitnik I, Smykov L, Smith G, Solovyev L, Solvignon P, Subedi R, Suleiman R, Tomasi-Gustafsson E, Vasiliev A, Vanderhaeghen M, Veilleux M, Wojtsekhowski BB, Wood S, Ye Z, Zanevsky Y, Zhang X, Zhang Y, Zheng X, Zhu L.
PMID: 21520982
Phys Rev Lett. 2011 Apr 01;106(13):132501. doi: 10.1103/PhysRevLett.106.132501. Epub 2011 Mar 29.

Intensive theoretical and experimental efforts over the past decade have aimed at explaining the discrepancy between data for the proton electric to magnetic form factor ratio, G(E)/G(M), obtained separately from cross section and polarization transfer measurements. One possible explanation...

Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.

Nature biotechnology

Davies CW, Oh AJ, Mroue R, Steffek M, Bruning JM, Xiao Y, Feng S, Jayakar S, Chan E, Arumugam V, Uribe SC, Drummond J, Frommlet A, Lu C, Franke Y, Merchant M, Koeppen H, Quinn JG, Malhotra S, Do S, Gazzard L, Purkey HE, Rudolph J, Mulvihill MM, Koerber JT, Wang W, Evangelista M.
PMID: 34992247
Nat Biotechnol. 2022 Jan 06; doi: 10.1038/s41587-021-01126-9. Epub 2022 Jan 06.

Small molecules that stabilize inactive protein conformations are an underutilized strategy for drugging dynamic or otherwise intractable proteins. To facilitate the discovery and characterization of such inhibitors, we created a screening platform to identify conformation-locking antibodies for molecular probes...

Measurement of the charged pion electromagnetic form factor.

Physical review letters

Volmer J, Abbott D, Anklin H, Armstrong C, Arrington J, Assamagan K, Avery S, Baker OK, Blok HP, Bochna C, Brash EJ, Breuer H, Chant N, Dunne J, Eden T, Ent R, Gaskell D, Gilman R, Gustafsson K, Hinton W, Huber GM, Jackson H, Jones MK, Keppel C, Kim PH, Kim W, Klein A, Koltenuk D, Liang M, Lolos GJ, Lung A, Mack DJ, McKee D, Meekins D, Mitchell J, Mkrtchyan H, Mueller B, Niculescu G, Niculescu I, Pitz D, Potterveld D, Qin LM, Reinhold J, Shin IK, Stepanyan S, Tadevosyan V, Tang LG, van der Meer RL, Vansyoc K, Van Westrum D, Vulcan W, Wood S, Yan C, Zhao WX, Zihlmann B.
PMID: 11290230
Phys Rev Lett. 2001 Feb 26;86(9):1713-6. doi: 10.1103/PhysRevLett.86.1713.

Separated longitudinal and transverse structure functions for the reaction 1H(e,e(')pi(+))n were measured in the momentum transfer region Q2 = 0.6--1.6 (GeV/c)(2) at a value of the invariant mass W = 1.95 GeV. New values for the pion charge form...

The quality of in-house medical school examinations.

Academic medicine : journal of the Association of American Medical Colleges

Jozefowicz RF, Koeppen BM, Case S, Galbraith R, Swanson D, Glew RH.
PMID: 11841981
Acad Med. 2002 Feb;77(2):156-61. doi: 10.1097/00001888-200202000-00016.

PURPOSE: Most medical schools test their students throughout the curriculum using in-house examinations written by the faculty who teach the courses. The authors assessed the quality of in-house examinations used in three U.S. medical schools.METHOD: In 1998, nine basic...

Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration.

Stem cells international

Behaegel J, Ní Dhubhghaill S, Koppen C, Zakaria N.
PMID: 28465692
Stem Cells Int. 2017;2017:6978253. doi: 10.1155/2017/6978253. Epub 2017 Mar 30.

Ex vivo cultivated limbal stem cell transplantation is a promising technique for the treatment of limbal stem cell deficiency. While the results of the clinical trials have been extensively reported since the introduction of the technique in 1997, little...

Effects of chromophore dissociation on the optical properties of rare-Earth-doped polymers.

Applied optics

Gao R, Koeppen C, Zheng G, Garito AF.
PMID: 18301532
Appl Opt. 1998 Oct 20;37(30):7100-6. doi: 10.1364/ao.37.007100.

The observed dissociation of tetrakis rare-earth chromophores in rare-earth-doped organic polymers is reported, and a time-resolved spectroscopic technique is presented to determine quantitatively the fractional concentrations of different chromophore species in various solvents. Based on this technique, the equilibrium...

Rehabilitation of children with brain tumors.

NeuroRehabilitation

Michaud LJ, Ried SR, Radcliffe J, Lazar MF, King LA, Manitta P, Koeppel C, Domers HS, Middaugh PA.
PMID: 24526071
NeuroRehabilitation. 1993;3(3):53-65. doi: 10.3233/NRE-1993-3307.

Brain tumors are the most common type of solid tumors in childhood. It has only been over the past 20 years that the majority of children with intracranial tumors are surviving. Children who survive their tumors may do so...

Showing 109 to 120 of 136 entries