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Showing 13 to 24 of 176 entries
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Pneumocystis jirovecii pneumonia in liver transplant recipients in an era of routine prophylaxis.

Immunity, inflammation and disease

Andreasen PB, Rezahosseini O, Møller DL, Wareham NE, Thomsen MT, Houmami R, Knudsen AD, Knudsen J, Kurtzhals JAL, Rostved AA, Pedersen CR, Rasmussen A, Nielsen SD.
PMID: 34713963
Immun Inflamm Dis. 2022 Jan;10(1):93-100. doi: 10.1002/iid3.546. Epub 2021 Oct 29.

BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in organ transplant recipients that may be prevented by antibiotic prophylaxis. We aimed to investigate the incidence rate (IR) of PCP and the related hospitalization and mortality rates in liver...

Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.

Bioorganic & medicinal chemistry letters

Fuertes M, Selas A, Trejo A, Knudsen BR, Palacios F, Alonso C.
PMID: 34952177
Bioorg Med Chem Lett. 2021 Dec 21;57:128517. doi: 10.1016/j.bmcl.2021.128517. Epub 2021 Dec 21.

This work describes the first synthesis of diethyl 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolinylphosphonates 5, diethyl 7H-indeno[2,1-c]quinolinylphosphonates 6 and diethyl 7-oxo-7H-indeno[2,1-c]quinolinylphosphonates 7, which were prepared in good to high overall yields. The synthetic route involves a multicomponent reaction of 2-phosphonateaniline, aldehydes and indene as...

Phase Ib/II Study of Cetuximab plus Pembrolizumab in Patients with Advanced RAS Wild-Type Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Fountzilas C, Bajor DL, Mukherjee S, Saltzman J, Witkiewicz AK, Maguire O, Minderman H, Nambiar R, Rosenheck HR, Knudsen ES, Muhitch JB, Abrams SI, Wang C, Hutson AD, Attwood K, Hicks KA, Jurcevic JA, Kalinski P, Iyer R, Boland PM.
PMID: 34645646
Clin Cancer Res. 2021 Dec 15;27(24):6726-6736. doi: 10.1158/1078-0432.CCR-21-1650. Epub 2021 Oct 13.

PURPOSE: We evaluated the antitumor efficacy of cetuximab in combination with pembrolizumab in patients with PATIENTS AND METHODS: In this phase Ib/II study, cetuximab was combined with pembrolizumab in patients with RASwt mCRC with ≥ one prior line of...

Switch to INSTIs, but Not Long-Term Stable INSTIs, Is Associated With Excess Weight Gain in People Living With HIV.

Journal of acquired immune deficiency syndromes (1999)

Sørensen EW, Gelpi M, Knudsen AD, Benfield T, Mocroft A, Nielsen SD.
PMID: 34520441
J Acquir Immune Defic Syndr. 2021 Dec 15;88(5):e36-e38. doi: 10.1097/QAI.0000000000002802.

No abstract available.

TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.

Lung cancer (Amsterdam, Netherlands)

Jakobsen AK, Yuusufi S, Madsen LB, Meldgaard P, Knudsen BR, Stougaard M.
PMID: 34974222
Lung Cancer. 2021 Dec 22;164:23-32. doi: 10.1016/j.lungcan.2021.12.010. Epub 2021 Dec 22.

OBJECTIVES: Topoisomerase 1 (TOP1) is a drug target used in anticancer treatment of various cancer types. The effect of the TOP1 drugs can be counteracted by the enzymatic activity of tyrosyl-DNA phosphodiesterase 1 (TDP1). Thus, to elucidate the relevance...

Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum.

Molecular biology international

Roy A, D'Annessa I, Nielsen CJ, Tordrup D, Laursen RR, Knudsen BR, Desideri A, Andersen FF.
PMID: 22091414
Mol Biol Int. 2011;2011:854626. doi: 10.4061/2011/854626. Epub 2011 May 04.

Control of diseases inflicted by protozoan parasites such as Leishmania, Trypanosoma, and Plasmodium, which pose a serious threat to human health worldwide, depends on a rather small number of antiparasite drugs, of which many are toxic and/or inefficient. Moreover,...

Corrigendum: Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation (2020.

Journal of neural engineering

Settell ML, Pelot NA, Knudsen BE, Dingle AM, McConico AL, Nicolai EN, Trevathan JK, Ezzell JA, Ross EK, Gustafson KJ, Shoffstall AJ, Williams JC, Zeng W, Poore SO, Populin LC, Suminski AJ, Grill WM, Ludwig KA.
PMID: 34096889
J Neural Eng. 2021 Jun 01;18(4). doi: 10.1088/1741-2552/ac01ff.

No abstract available.

Phase Ib/II Study of Cetuximab plus Pembrolizumab in Patients with Advanced RAS Wild-Type Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Fountzilas C, Bajor DL, Mukherjee S, Saltzman J, Witkiewicz AK, Maguire O, Minderman H, Nambiar R, Rosenheck HR, Knudsen ES, Muhitch JB, Abrams SI, Wang C, Hutson AD, Attwood K, Hicks KA, Jurcevic JA, Kalinski P, Iyer R, Boland PM.
PMID: 34645646
Clin Cancer Res. 2021 Oct 13; doi: 10.1158/1078-0432.CCR-21-1650. Epub 2021 Oct 13.

PURPOSE: We evaluated the antitumor efficacy of cetuximab in combination with pembrolizumab in patients with PATIENTS AND METHODS: In this phase Ib/II study, cetuximab was combined with pembrolizumab in patients with RASwt mCRC with ≥ one prior line of...

Level of MFAP4 in ascites independently predicts 1-year transplant-free survival in patients with cirrhosis.

JHEP reports : innovation in hepatology

Torp N, Israelsen M, Madsen B, Lutz P, Jansen C, Strassburg C, Mortensen C, Knudsen AW, Sorensen GL, Holmskov U, Schlosser A, Thiele M, Trebicka J, Krag A.
PMID: 34041469
JHEP Rep. 2021 Mar 29;3(3):100287. doi: 10.1016/j.jhepr.2021.100287. eCollection 2021 Jun.

BACKGROUND & AIMS: Prognostic models of cirrhosis underestimate disease severity for patients with cirrhosis and ascites. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein linked to hepatic neoangiogenesis and fibrogenesis. We investigated ascites MFAP4 as a predictor of...

The central role of the glutamate metabolism in long-term antiretroviral treated HIV-infected individuals with metabolic syndrome.

Aging

Gelpi M, Mikaeloff F, Knudsen AD, Benfeitas R, Krishnan S, Svenssson Akusjärvi S, Høgh J, Murray DD, Ullum H, Neogi U, Nielsen SD.
PMID: 34635603
Aging (Albany NY). 2021 Oct 11;13(19):22732-22751. doi: 10.18632/aging.203622. Epub 2021 Oct 11.

Metabolic syndrome (MetS) is a significant factor for cardiometabolic comorbidities in people living with HIV (PLWH) and a barrier to healthy aging. The long-term consequences of HIV-infection and combination antiretroviral therapy (cART) in metabolic reprogramming are unknown. In this...

Pneumocystis jirovecii pneumonia in liver transplant recipients in an era of routine prophylaxis.

Immunity, inflammation and disease

Andreasen PB, Rezahosseini O, Møller DL, Wareham NE, Thomsen MT, Houmami R, Knudsen AD, Knudsen J, Kurtzhals JAL, Rostved AA, Pedersen CR, Rasmussen A, Nielsen SD.
PMID: 34713963
Immun Inflamm Dis. 2021 Oct 29; doi: 10.1002/iid3.546. Epub 2021 Oct 29.

BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in organ transplant recipients that may be prevented by antibiotic prophylaxis. We aimed to investigate the incidence rate (IR) of PCP and the related hospitalization and mortality rates in liver...

Reference intervals for plasma vitamin B12 and plasma/serum methylmalonic acid in Danish children, adults and elderly.

Clinica chimica acta; international journal of clinical chemistry

Abildgaard A, Knudsen CS, Hoejskov CS, Greibe E, Parkner T.
PMID: 34942168
Clin Chim Acta. 2021 Dec 21;525:62-68. doi: 10.1016/j.cca.2021.12.015. Epub 2021 Dec 21.

BACKGROUND: Plasma/serum vitamin B12 (B12) is often used to screen for B12 deficiency complemented with analysis of methylmalonic acid (MMA) in case of low B12. The concentration of both analytes likely depends on age, and we, therefore, aimed at...

Showing 13 to 24 of 176 entries