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Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.

Science immunology

Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ.
PMID: 34215680
Sci Immunol. 2021 Jul 02;6(61). doi: 10.1126/sciimmunol.abi7083.

Immunotherapy is revolutionizing cancer treatment but is often restricted by toxicities. What distinguishes adverse events from concomitant antitumor reactions is poorly understood. Here, using anti-CD40 treatment in mice as a model of T

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Siwicki M, Gort-Freitas NA, Messemaker M, et al. Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Sci Immunol. 2021;6(61)doi: 10.1126/sciimmunol.abi7083.
Siwicki, M., Gort-Freitas, N. A., Messemaker, M., Bill, R., Gungabeesoon, J., Engblom, C., Zilionis, R., Garris, C., Gerhard, G. M., Kohl, A., Lin, Y., Zou, A. E., Cianciaruso, C., Bolli, E., Pfirschke, C., Lin, Y. J., Piot, C., Mindur, J. E., Talele, N., Kohler, R. H., Iwamoto, Y., Mino-Kenudson, M., Pai, S. I., deVito, C., Koessler, T., Merkler, D., Coukos, A., Wicky, A., Fraga, M., Sempoux, C., Jain, R. K., Dietrich, P. Y., Michielin, O., Weissleder, R., Klein, A. M., & Pittet, M. J. (2021). Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Science immunology, 6(61), . https://doi.org/10.1126/sciimmunol.abi7083
Siwicki, Marie, et al. "Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy." Science immunology vol. 6,61 (2021). doi: https://doi.org/10.1126/sciimmunol.abi7083
Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ. Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Sci Immunol. 2021 Jul 02;6(61). doi: 10.1126/sciimmunol.abi7083. PMID: 34215680.
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ASO Visual Abstract: The Impact of Radiotherapy Delay in Breast-Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures.

Annals of surgical oncology

Bleicher RJ, Moran MS, Ruth K, Edge SB, Dietz JM, Wilke LG, Stearns V, Kurtzman SH, Klein J, Yao KA.
PMID: 34346019
Ann Surg Oncol. 2021 Dec;28:572-573. doi: 10.1245/s10434-021-10535-8.

No abstract available.

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Bleicher RJ, Moran MS, Ruth K, et al. ASO Visual Abstract: The Impact of Radiotherapy Delay in Breast-Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures. Ann Surg Oncol. 2021;28:572-573doi: 10.1245/s10434-021-10535-8.
Bleicher, R. J., Moran, M. S., Ruth, K., Edge, S. B., Dietz, J. M., Wilke, L. G., Stearns, V., Kurtzman, S. H., Klein, J., & Yao, K. A. (2021). ASO Visual Abstract: The Impact of Radiotherapy Delay in Breast-Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures. Annals of surgical oncology, 28572-573. https://doi.org/10.1245/s10434-021-10535-8
Bleicher, Richard J, et al. "ASO Visual Abstract: The Impact of Radiotherapy Delay in Breast-Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures." Annals of surgical oncology vol. 28 (2021): 572-573. doi: https://doi.org/10.1245/s10434-021-10535-8
Bleicher RJ, Moran MS, Ruth K, Edge SB, Dietz JM, Wilke LG, Stearns V, Kurtzman SH, Klein J, Yao KA. ASO Visual Abstract: The Impact of Radiotherapy Delay in Breast-Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures. Ann Surg Oncol. 2021 Dec;28:572-573. doi: 10.1245/s10434-021-10535-8. PMID: 34346019.
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Examining the impact of the COVID-19 pandemic through the lens of the network approach to psychopathology: Analysis of the Brazilian Longitudinal Study of Health (ELSA-Brasil) cohort over a 12-year timespan.

Journal of anxiety disorders

Suen PJC, Bacchi PS, Razza L, Dos Santos LA, Fatori D, Klein I, Passos IC, Smoller JW, Bauermeister S, Goulart AC, de Souza Santos I, Bensenor IM, Lotufo PA, Heeren A, Brunoni AR.
PMID: 34911001
J Anxiety Disord. 2022 Jan;85:102512. doi: 10.1016/j.janxdis.2021.102512. Epub 2021 Dec 08.

Cohort studies have displayed mixed findings on changes in mental symptoms severity in 2020, when the COVID-19 pandemic outbreak started. Network approaches can provide additional insights by analyzing the connectivity of such symptoms. We assessed the network structure of...

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Suen PJC, Bacchi PS, Razza L, et al. Examining the impact of the COVID-19 pandemic through the lens of the network approach to psychopathology: Analysis of the Brazilian Longitudinal Study of Health (ELSA-Brasil) cohort over a 12-year timespan. J Anxiety Disord. 2021;85:102512doi: 10.1016/j.janxdis.2021.102512.
Suen, P. J. C., Bacchi, P. S., Razza, L., Dos Santos, L. A., Fatori, D., Klein, I., Passos, I. C., Smoller, J. W., Bauermeister, S., Goulart, A. C., de Souza Santos, I., Bensenor, I. M., Lotufo, P. A., Heeren, A., & Brunoni, A. R. (2022). Examining the impact of the COVID-19 pandemic through the lens of the network approach to psychopathology: Analysis of the Brazilian Longitudinal Study of Health (ELSA-Brasil) cohort over a 12-year timespan. Journal of anxiety disorders, 85102512. https://doi.org/10.1016/j.janxdis.2021.102512
Suen, Paulo Jeng Chian, et al. "Examining the impact of the COVID-19 pandemic through the lens of the network approach to psychopathology: Analysis of the Brazilian Longitudinal Study of Health (ELSA-Brasil) cohort over a 12-year timespan." Journal of anxiety disorders vol. 85 (2022): 102512. doi: https://doi.org/10.1016/j.janxdis.2021.102512
Suen PJC, Bacchi PS, Razza L, Dos Santos LA, Fatori D, Klein I, Passos IC, Smoller JW, Bauermeister S, Goulart AC, de Souza Santos I, Bensenor IM, Lotufo PA, Heeren A, Brunoni AR. Examining the impact of the COVID-19 pandemic through the lens of the network approach to psychopathology: Analysis of the Brazilian Longitudinal Study of Health (ELSA-Brasil) cohort over a 12-year timespan. J Anxiety Disord. 2022 Jan;85:102512. doi: 10.1016/j.janxdis.2021.102512. Epub 2021 Dec 08. PMID: 34911001; PMCID: PMC8653404.
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A pragmatic regulatory approach for complex generics through the U.S. FDA 505(j) or 505(b)(2) approval pathways.

Annals of the New York Academy of Sciences

Klein K, Borchard G, Shah VP, Flühmann B, McNeil SE, de Vlieger JSB.
PMID: 34296458
Ann N Y Acad Sci. 2021 Oct;1502(1):5-13. doi: 10.1111/nyas.14662. Epub 2021 Jul 22.

The diverse nature of complex drug products poses challenges for the development of regulatory guidelines for generic versions. While complexity is not new in medicines, the technical capacity to measure and analyze data has increased. This requires a determination...

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Klein K, Borchard G, Shah VP, et al. A pragmatic regulatory approach for complex generics through the U.S. FDA 505(j) or 505(b)(2) approval pathways. Ann N Y Acad Sci. 2021;1502(1):5-13doi: 10.1111/nyas.14662.
Klein, K., Borchard, G., Shah, V. P., Flühmann, B., McNeil, S. E., & de Vlieger, J. S. B. (2021). A pragmatic regulatory approach for complex generics through the U.S. FDA 505(j) or 505(b)(2) approval pathways. Annals of the New York Academy of Sciences, 1502(1), 5-13. https://doi.org/10.1111/nyas.14662
Klein, Kevin, et al. "A pragmatic regulatory approach for complex generics through the U.S. FDA 505(j) or 505(b)(2) approval pathways." Annals of the New York Academy of Sciences vol. 1502,1 (2021): 5-13. doi: https://doi.org/10.1111/nyas.14662
Klein K, Borchard G, Shah VP, Flühmann B, McNeil SE, de Vlieger JSB. A pragmatic regulatory approach for complex generics through the U.S. FDA 505(j) or 505(b)(2) approval pathways. Ann N Y Acad Sci. 2021 Oct;1502(1):5-13. doi: 10.1111/nyas.14662. Epub 2021 Jul 22. PMID: 34296458; PMCID: PMC8597169.
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Head injuries in professional football (soccer): Results of video analysis verified by an accident insurance registry.

PloS one

Krutsch V, Krutsch W, Härtl J, Bloch H, Alt V, Klein C, Reinsberger C, Seiffert R, Huber L, Weber J.
PMID: 34379643
PLoS One. 2021 Aug 11;16(8):e0255695. doi: 10.1371/journal.pone.0255695. eCollection 2021.

BACKGROUND: Video analysis is one of the most commonly applied methods for analysing football injuries.PURPOSE: The objective of this study was to assess the accuracy of video analysis for recording head injuries in professional football from official matches in...

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Krutsch V, Krutsch W, Härtl J, et al. Head injuries in professional football (soccer): Results of video analysis verified by an accident insurance registry. PLoS One. 2021;16(8):e0255695doi: 10.1371/journal.pone.0255695.
Krutsch, V., Krutsch, W., Härtl, J., Bloch, H., Alt, V., Klein, C., Reinsberger, C., Seiffert, R., Huber, L., & Weber, J. (2021). Head injuries in professional football (soccer): Results of video analysis verified by an accident insurance registry. PloS one, 16(8), e0255695. https://doi.org/10.1371/journal.pone.0255695
Krutsch, Volker, et al. "Head injuries in professional football (soccer): Results of video analysis verified by an accident insurance registry." PloS one vol. 16,8 (2021): e0255695. doi: https://doi.org/10.1371/journal.pone.0255695
Krutsch V, Krutsch W, Härtl J, Bloch H, Alt V, Klein C, Reinsberger C, Seiffert R, Huber L, Weber J. Head injuries in professional football (soccer): Results of video analysis verified by an accident insurance registry. PLoS One. 2021 Aug 11;16(8):e0255695. doi: 10.1371/journal.pone.0255695. eCollection 2021. PMID: 34379643; PMCID: PMC8357092.
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Warming has a minor effect on surface soil organic carbon in alpine meadow ecosystems on the Qinghai-Tibetan Plateau.

Global change biology

Chen Y, Han M, Yuan X, Hou Y, Qin W, Zhou H, Zhao X, Klein JA, Zhu B.
PMID: 34755425
Glob Chang Biol. 2022 Feb;28(4):1618-1629. doi: 10.1111/gcb.15984. Epub 2021 Nov 17.

The alpine meadow ecosystem on the Qinghai-Tibetan Plateau (QTP) is very sensitive to warming and plays a key role in regulating global carbon (C) cycling. However, how warming affects the soil organic carbon (SOC) pool and related C inputs...

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Chen Y, Han M, Yuan X, et al. Warming has a minor effect on surface soil organic carbon in alpine meadow ecosystems on the Qinghai-Tibetan Plateau. Glob Chang Biol. 2021;28(4):1618-1629doi: 10.1111/gcb.15984.
Chen, Y., Han, M., Yuan, X., Hou, Y., Qin, W., Zhou, H., Zhao, X., Klein, J. A., & Zhu, B. (2022). Warming has a minor effect on surface soil organic carbon in alpine meadow ecosystems on the Qinghai-Tibetan Plateau. Global change biology, 28(4), 1618-1629. https://doi.org/10.1111/gcb.15984
Chen, Ying, et al. "Warming has a minor effect on surface soil organic carbon in alpine meadow ecosystems on the Qinghai-Tibetan Plateau." Global change biology vol. 28,4 (2022): 1618-1629. doi: https://doi.org/10.1111/gcb.15984
Chen Y, Han M, Yuan X, Hou Y, Qin W, Zhou H, Zhao X, Klein JA, Zhu B. Warming has a minor effect on surface soil organic carbon in alpine meadow ecosystems on the Qinghai-Tibetan Plateau. Glob Chang Biol. 2022 Feb;28(4):1618-1629. doi: 10.1111/gcb.15984. Epub 2021 Nov 17. PMID: 34755425.
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Showing 3481 to 3486 of 3486 entries