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An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals.

Drug metabolism and pharmacokinetics

Uehara S, Higuchi Y, Yoneda N, Kawai K, Yamamoto M, Kamimura H, Iida Y, Oshimura M, Kazuki Y, Yamazaki H, Hikita H, Takehara T, Suemizu H.
PMID: 34839181
Drug Metab Pharmacokinet. 2021 Jun 12;42:100410. doi: 10.1016/j.dmpk.2021.100410. Epub 2021 Jun 12.

We developed a novel immunodeficient NOG mouse expressing HSVtk mutant clone 30 cDNA under the control of mouse transthyretin gene enhancer/promoter (NOG-TKm30) to acquire fertility in males and high inducibility of liver injury in females. Maximum human albumin levels...

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Uehara S, Higuchi Y, Yoneda N, et al. An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals. Drug Metab Pharmacokinet. 2021;42:100410doi: 10.1016/j.dmpk.2021.100410.
Uehara, S., Higuchi, Y., Yoneda, N., Kawai, K., Yamamoto, M., Kamimura, H., Iida, Y., Oshimura, M., Kazuki, Y., Yamazaki, H., Hikita, H., Takehara, T., & Suemizu, H. (2021). An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals. Drug metabolism and pharmacokinetics, 42100410. https://doi.org/10.1016/j.dmpk.2021.100410
Uehara, Shotaro, et al. "An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals." Drug metabolism and pharmacokinetics vol. 42 (2021): 100410. doi: https://doi.org/10.1016/j.dmpk.2021.100410
Uehara S, Higuchi Y, Yoneda N, Kawai K, Yamamoto M, Kamimura H, Iida Y, Oshimura M, Kazuki Y, Yamazaki H, Hikita H, Takehara T, Suemizu H. An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals. Drug Metab Pharmacokinet. 2021 Jun 12;42:100410. doi: 10.1016/j.dmpk.2021.100410. Epub 2021 Jun 12. PMID: 34839181.
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LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors.

Molecular informatics

Kawai K, Asanuma Y, Kato T, Karuo Y, Tarui A, Sato K, Omote M.
PMID: 34843171
Mol Inform. 2021 Nov 29;e2100245. doi: 10.1002/minf.202100245. Epub 2021 Nov 29.

In this paper, we propose a simple descriptor called the ligand coordinate profile (LCP) for describing docking poses. The LCP descriptor is generated from the coordinates of the polar hydrogen and heavy atoms of the docked ligand. We hypothesize...

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Kawai K, Asanuma Y, Kato T, et al. LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors. Mol Inform. 2021;e2100245doi: 10.1002/minf.202100245.
Kawai, K., Asanuma, Y., Kato, T., Karuo, Y., Tarui, A., Sato, K., & Omote, M. (2021). LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors. Molecular informatics, e2100245. https://doi.org/10.1002/minf.202100245
Kawai, Kentaro, et al. "LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors." Molecular informatics vol. (2021): e2100245. doi: https://doi.org/10.1002/minf.202100245
Kawai K, Asanuma Y, Kato T, Karuo Y, Tarui A, Sato K, Omote M. LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors. Mol Inform. 2021 Nov 29;e2100245. doi: 10.1002/minf.202100245. Epub 2021 Nov 29. PMID: 34843171.
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Assessment of Triage DOA®, Status DS10, and DRIVEN-FLOW® M8-Z on-site drug screening kits for postmortem urine.

Legal medicine (Tokyo, Japan)

Tanaka T, Yoshida K, Kasai K, Yoshizumi S, Sato H.
PMID: 34808562
Leg Med (Tokyo). 2021 Nov 16;54:101993. doi: 10.1016/j.legalmed.2021.101993. Epub 2021 Nov 16.

Based on the screening results of mass analyses using gas chromatography- mass spectrometry (GC-MS) and liquid chromatograph-tandem mass spectrometry (LC-MS/MS), we assessed the performance of Status DS10 (Status) and DRIVEN-FLOW® M8-Z (DF8), and compared the results with those of...

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Tanaka T, Yoshida K, Kasai K, et al. Assessment of Triage DOA®, Status DS10, and DRIVEN-FLOW® M8-Z on-site drug screening kits for postmortem urine. Leg Med (Tokyo). 2021;54:101993doi: 10.1016/j.legalmed.2021.101993.
Tanaka, T., Yoshida, K., Kasai, K., Yoshizumi, S., & Sato, H. (2021). Assessment of Triage DOA®, Status DS10, and DRIVEN-FLOW® M8-Z on-site drug screening kits for postmortem urine. Legal medicine (Tokyo, Japan), 54101993. https://doi.org/10.1016/j.legalmed.2021.101993
Tanaka, Toshiko, et al. "Assessment of Triage DOA®, Status DS10, and DRIVEN-FLOW® M8-Z on-site drug screening kits for postmortem urine." Legal medicine (Tokyo, Japan) vol. 54 (2021): 101993. doi: https://doi.org/10.1016/j.legalmed.2021.101993
Tanaka T, Yoshida K, Kasai K, Yoshizumi S, Sato H. Assessment of Triage DOA®, Status DS10, and DRIVEN-FLOW® M8-Z on-site drug screening kits for postmortem urine. Leg Med (Tokyo). 2021 Nov 16;54:101993. doi: 10.1016/j.legalmed.2021.101993. Epub 2021 Nov 16. PMID: 34808562.
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A case of fetal-onset type 3 familial hemophagocytic lymphohistiocytosis surviving without severe complications after early diagnosis and treatment.

Pediatric blood & cancer

Matsumoto T, Fukushima H, Fujiyama S, Nagatomo K, Hosaka S, Suzuki R, Yamaki Y, Kanai Y, Shibata H, Yasumi T, Isshiki K, Kato M, Miyazono Y, Takada H.
PMID: 33769695
Pediatr Blood Cancer. 2021 Jul;68(7):e29016. doi: 10.1002/pbc.29016. Epub 2021 Mar 26.

No abstract available.

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Matsumoto T, Fukushima H, Fujiyama S, et al. A case of fetal-onset type 3 familial hemophagocytic lymphohistiocytosis surviving without severe complications after early diagnosis and treatment. Pediatr Blood Cancer. 2021;68(7):e29016doi: 10.1002/pbc.29016.
Matsumoto, T., Fukushima, H., Fujiyama, S., Nagatomo, K., Hosaka, S., Suzuki, R., Yamaki, Y., Kanai, Y., Shibata, H., Yasumi, T., Isshiki, K., Kato, M., Miyazono, Y., & Takada, H. (2021). A case of fetal-onset type 3 familial hemophagocytic lymphohistiocytosis surviving without severe complications after early diagnosis and treatment. Pediatric blood & cancer, 68(7), e29016. https://doi.org/10.1002/pbc.29016
Matsumoto, Takashi, et al. "A case of fetal-onset type 3 familial hemophagocytic lymphohistiocytosis surviving without severe complications after early diagnosis and treatment." Pediatric blood & cancer vol. 68,7 (2021): e29016. doi: https://doi.org/10.1002/pbc.29016
Matsumoto T, Fukushima H, Fujiyama S, Nagatomo K, Hosaka S, Suzuki R, Yamaki Y, Kanai Y, Shibata H, Yasumi T, Isshiki K, Kato M, Miyazono Y, Takada H. A case of fetal-onset type 3 familial hemophagocytic lymphohistiocytosis surviving without severe complications after early diagnosis and treatment. Pediatr Blood Cancer. 2021 Jul;68(7):e29016. doi: 10.1002/pbc.29016. Epub 2021 Mar 26. PMID: 33769695.
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Update of pediatric soft tissue tumors with review of conventional MRI appearance-part 2: vascular lesions, fibrohistiocytic tumors, muscle tumors, peripheral nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated small round cell sarcomas.

Skeletal radiology

Maloney E, Al-Dasuqi K, Irshaid L, Wang A, Kani K, Haims A, Porrino J.
PMID: 34297167
Skeletal Radiol. 2021 Jul 23; doi: 10.1007/s00256-021-03837-1. Epub 2021 Jul 23.

There are numerous soft tissue tumors and tumor-like conditions in the pediatric population. Magnetic resonance imaging is the most useful modality for imaging these lesions. Although certain soft tissue lesions exhibit magnetic resonance features characteristic of a specific diagnosis,...

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Maloney E, Al-Dasuqi K, Irshaid L, et al. Update of pediatric soft tissue tumors with review of conventional MRI appearance-part 2: vascular lesions, fibrohistiocytic tumors, muscle tumors, peripheral nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated small round cell sarcomas. Skeletal Radiol. 2021;doi: 10.1007/s00256-021-03837-1.
Maloney, E., Al-Dasuqi, K., Irshaid, L., Wang, A., Kani, K., Haims, A., & Porrino, J. (2021). Update of pediatric soft tissue tumors with review of conventional MRI appearance-part 2: vascular lesions, fibrohistiocytic tumors, muscle tumors, peripheral nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated small round cell sarcomas. Skeletal radiology, . https://doi.org/10.1007/s00256-021-03837-1
Maloney, Ezekiel, et al. "Update of pediatric soft tissue tumors with review of conventional MRI appearance-part 2: vascular lesions, fibrohistiocytic tumors, muscle tumors, peripheral nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated small round cell sarcomas." Skeletal radiology vol. (2021). doi: https://doi.org/10.1007/s00256-021-03837-1
Maloney E, Al-Dasuqi K, Irshaid L, Wang A, Kani K, Haims A, Porrino J. Update of pediatric soft tissue tumors with review of conventional MRI appearance-part 2: vascular lesions, fibrohistiocytic tumors, muscle tumors, peripheral nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated small round cell sarcomas. Skeletal Radiol. 2021 Jul 23; doi: 10.1007/s00256-021-03837-1. Epub 2021 Jul 23. PMID: 34297167.
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Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype.

Life sciences

Singh N, Zabbarova I, Ikeda Y, Kanai A, Chermansky C, Yoshimura N, Tyagi P.
PMID: 34875252
Life Sci. 2021 Dec 04;289:120203. doi: 10.1016/j.lfs.2021.120203. Epub 2021 Dec 04.

OBJECTIVE: To assess the functional role of Hyperpolarization-activated cyclic nucleotide-gated gated channel (HCN) subtypes in the aging bladder phenotype characterized by diminished bladder volume sensation (BVS) with or without the detrusor instability (DI).METHODS: Expression of HCN subtypes was examined...

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Singh N, Zabbarova I, Ikeda Y, et al. Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype. Life Sci. 2021;289:120203doi: 10.1016/j.lfs.2021.120203.
Singh, N., Zabbarova, I., Ikeda, Y., Kanai, A., Chermansky, C., Yoshimura, N., & Tyagi, P. (2021). Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype. Life sciences, 289120203. https://doi.org/10.1016/j.lfs.2021.120203
Singh, Nishant, et al. "Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype." Life sciences vol. 289 (2021): 120203. doi: https://doi.org/10.1016/j.lfs.2021.120203
Singh N, Zabbarova I, Ikeda Y, Kanai A, Chermansky C, Yoshimura N, Tyagi P. Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype. Life Sci. 2021 Dec 04;289:120203. doi: 10.1016/j.lfs.2021.120203. Epub 2021 Dec 04. PMID: 34875252.
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Showing 1837 to 1842 of 1842 entries