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Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies.

Emerging topics in life sciences

Maya JD, Lapier M, Castillo C, Kemmerling U, Campos-Estrada C, López-Muñoz R.
PMID: 33525838
Emerg Top Life Sci. 2017 Dec 22;1(6):579-584. doi: 10.1042/ETLS20170109.

Infectious diseases are the main cause of acquired dilated cardiomyopathy. This group of disorders shares in common inflammatory cell infiltrate and myocardial remodeling. As part of its pathophysiology, there is coronary microvascular dysfunction, distinct from that observed in coronary...

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Maya JD, Lapier M, Castillo C, et al. Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies. Emerg Top Life Sci. 2017;1(6):579-584doi: 10.1042/ETLS20170109.
Maya, J. D., Lapier, M., Castillo, C., Kemmerling, U., Campos-Estrada, C., & López-Muñoz, R. (2017). Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies. Emerging topics in life sciences, 1(6), 579-584. https://doi.org/10.1042/ETLS20170109
Maya, Juan D, et al. "Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies." Emerging topics in life sciences vol. 1,6 (2017): 579-584. doi: https://doi.org/10.1042/ETLS20170109
Maya JD, Lapier M, Castillo C, Kemmerling U, Campos-Estrada C, López-Muñoz R. Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies. Emerg Top Life Sci. 2017 Dec 22;1(6):579-584. doi: 10.1042/ETLS20170109. PMID: 33525838.
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Enhancing electrocardiographic analysis by combining a high-resolution 12-lead ECG with novel software tools.

Journal of electrocardiology

Barcos JC, Humphreys JD, Tello Santacruz IA, Guzman JP, Fernández Recalde ML, Avaca HA, Cáceres Monié CR.
PMID: 34929607
J Electrocardiol. 2021 Dec 11;70:70-74. doi: 10.1016/j.jelectrocard.2021.12.001. Epub 2021 Dec 11.

INTRODUCTION: Signal-averaged electrocardiography is a non-invasive, computerized technique that amplifies, filters, and averages cardiac electrical signals reducing contaminating noise to obtain a high-resolution record. The most widely used signal averaging (SA) method involves a bipolar X, Y, and Z...

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Barcos JC, Humphreys JD, Tello Santacruz IA, et al. Enhancing electrocardiographic analysis by combining a high-resolution 12-lead ECG with novel software tools. J Electrocardiol. 2021;70:70-74doi: 10.1016/j.jelectrocard.2021.12.001.
Barcos, J. C., Humphreys, J. D., Tello Santacruz, I. A., Guzman, J. P., Fernández Recalde, M. L., Avaca, H. A., & Cáceres Monié, C. R. (2021). Enhancing electrocardiographic analysis by combining a high-resolution 12-lead ECG with novel software tools. Journal of electrocardiology, 7070-74. https://doi.org/10.1016/j.jelectrocard.2021.12.001
Barcos, Javier C, et al. "Enhancing electrocardiographic analysis by combining a high-resolution 12-lead ECG with novel software tools." Journal of electrocardiology vol. 70 (2021): 70-74. doi: https://doi.org/10.1016/j.jelectrocard.2021.12.001
Barcos JC, Humphreys JD, Tello Santacruz IA, Guzman JP, Fernández Recalde ML, Avaca HA, Cáceres Monié CR. Enhancing electrocardiographic analysis by combining a high-resolution 12-lead ECG with novel software tools. J Electrocardiol. 2021 Dec 11;70:70-74. doi: 10.1016/j.jelectrocard.2021.12.001. Epub 2021 Dec 11. PMID: 34929607.
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Renal plasticity revealed through reversal of polycystic kidney disease in mice.

Nature genetics

Dong K, Zhang C, Tian X, Coman D, Hyder F, Ma M, Somlo S.
PMID: 34635846
Nat Genet. 2021 Dec;53(12):1649-1663. doi: 10.1038/s41588-021-00946-4. Epub 2021 Oct 11.

Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic 'second hit' mutations. Subsequent cyst progression remodels the organ through changes in tubule...

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Dong K, Zhang C, Tian X, et al. Renal plasticity revealed through reversal of polycystic kidney disease in mice. Nat Genet. 2021;53(12):1649-1663doi: 10.1038/s41588-021-00946-4.
Dong, K., Zhang, C., Tian, X., Coman, D., Hyder, F., Ma, M., & Somlo, S. (2021). Renal plasticity revealed through reversal of polycystic kidney disease in mice. Nature genetics, 53(12), 1649-1663. https://doi.org/10.1038/s41588-021-00946-4
Dong, Ke, et al. "Renal plasticity revealed through reversal of polycystic kidney disease in mice." Nature genetics vol. 53,12 (2021): 1649-1663. doi: https://doi.org/10.1038/s41588-021-00946-4
Dong K, Zhang C, Tian X, Coman D, Hyder F, Ma M, Somlo S. Renal plasticity revealed through reversal of polycystic kidney disease in mice. Nat Genet. 2021 Dec;53(12):1649-1663. doi: 10.1038/s41588-021-00946-4. Epub 2021 Oct 11. PMID: 34635846.
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New insights into carnitine-acylcarnitine translocase deficiency from 23 cases: Management challenges and potential therapeutic approaches.

Journal of inherited metabolic disease

Ryder B, Inbar-Feigenberg M, Glamuzina E, Halligan R, Vara R, Elliot A, Coman D, Minto T, Lewis K, Schiff M, Vijay S, Akroyd R, Thompson S, MacDonald A, Woodward AJM, Gribben JEL, Grunewald S, Belaramani K, Hall M, van der Haak N, Devanapalli B, Tolun AA, Wilson C, Bhattacharya K.
PMID: 33634872
J Inherit Metab Dis. 2021 Jul;44(4):903-915. doi: 10.1002/jimd.12371. Epub 2021 Mar 29.

Carnitine acyl-carnitine translocase deficiency (CACTD) is a rare autosomal recessive disorder of mitochondrial long-chain fatty-acid transport. Most patients present in the first 2 days of life, with hypoketotic hypoglycaemia, hyperammonaemia, cardiomyopathy or arrhythmia, hepatomegaly and elevated liver enzymes. Multi-centre...

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Ryder B, Inbar-Feigenberg M, Glamuzina E, et al. New insights into carnitine-acylcarnitine translocase deficiency from 23 cases: Management challenges and potential therapeutic approaches. J Inherit Metab Dis. 2021;44(4):903-915doi: 10.1002/jimd.12371.
Ryder, B., Inbar-Feigenberg, M., Glamuzina, E., Halligan, R., Vara, R., Elliot, A., Coman, D., Minto, T., Lewis, K., Schiff, M., Vijay, S., Akroyd, R., Thompson, S., MacDonald, A., Woodward, A. J. M., Gribben, J. E. L., Grunewald, S., Belaramani, K., Hall, M., van der Haak, N., Devanapalli, B., Tolun, A. A., Wilson, C., & Bhattacharya, K. (2021). New insights into carnitine-acylcarnitine translocase deficiency from 23 cases: Management challenges and potential therapeutic approaches. Journal of inherited metabolic disease, 44(4), 903-915. https://doi.org/10.1002/jimd.12371
Ryder, Bryony, et al. "New insights into carnitine-acylcarnitine translocase deficiency from 23 cases: Management challenges and potential therapeutic approaches." Journal of inherited metabolic disease vol. 44,4 (2021): 903-915. doi: https://doi.org/10.1002/jimd.12371
Ryder B, Inbar-Feigenberg M, Glamuzina E, Halligan R, Vara R, Elliot A, Coman D, Minto T, Lewis K, Schiff M, Vijay S, Akroyd R, Thompson S, MacDonald A, Woodward AJM, Gribben JEL, Grunewald S, Belaramani K, Hall M, van der Haak N, Devanapalli B, Tolun AA, Wilson C, Bhattacharya K. New insights into carnitine-acylcarnitine translocase deficiency from 23 cases: Management challenges and potential therapeutic approaches. J Inherit Metab Dis. 2021 Jul;44(4):903-915. doi: 10.1002/jimd.12371. Epub 2021 Mar 29. PMID: 33634872.
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Physicochemical characterization of a DMPC-based nanoemulsion for dry eye and compatibility test with soft contact lenses in vitro.

Contact lens & anterior eye : the journal of the British Contact Lens Association

Chávez-Hurtado P, Pesqueda-Pinedo L, Ceballos-Delgadillo HA, Liñán-Segura A, Figueroa-Ponce H, Quintana-Hau JD.
PMID: 33622607
Cont Lens Anterior Eye. 2021 Feb 20;101428. doi: 10.1016/j.clae.2021.02.014. Epub 2021 Feb 20.

INTRODUCTION: The use of contact lenses (CL) is often associated with hallmark symptoms of dry eye disease (DED) such as red eye and dryness. Even though lipid-based artificial tears are already marketed for DED, there is little evidence that...

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Chávez-Hurtado P, Pesqueda-Pinedo L, Ceballos-Delgadillo HA, et al. Physicochemical characterization of a DMPC-based nanoemulsion for dry eye and compatibility test with soft contact lenses in vitro. Cont Lens Anterior Eye. 2021;101428doi: 10.1016/j.clae.2021.02.014.
Chávez-Hurtado, P., Pesqueda-Pinedo, L., Ceballos-Delgadillo, H. A., Liñán-Segura, A., Figueroa-Ponce, H., & Quintana-Hau, J. D. (2021). Physicochemical characterization of a DMPC-based nanoemulsion for dry eye and compatibility test with soft contact lenses in vitro. Contact lens & anterior eye : the journal of the British Contact Lens Association, 101428. https://doi.org/10.1016/j.clae.2021.02.014
Chávez-Hurtado, Paulina, et al. "Physicochemical characterization of a DMPC-based nanoemulsion for dry eye and compatibility test with soft contact lenses in vitro." Contact lens & anterior eye : the journal of the British Contact Lens Association vol. (2021): 101428. doi: https://doi.org/10.1016/j.clae.2021.02.014
Chávez-Hurtado P, Pesqueda-Pinedo L, Ceballos-Delgadillo HA, Liñán-Segura A, Figueroa-Ponce H, Quintana-Hau JD. Physicochemical characterization of a DMPC-based nanoemulsion for dry eye and compatibility test with soft contact lenses in vitro. Cont Lens Anterior Eye. 2021 Feb 20;101428. doi: 10.1016/j.clae.2021.02.014. Epub 2021 Feb 20. PMID: 33622607.
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The herpetological contributions of Richard Thomas.

Anatomical record (Hoboken, N.J. : 2007)

Bauer AM, Daza JD, Herrera-Martínez A, Ospina OE.
PMID: 34173714
Anat Rec (Hoboken). 2021 Oct;304(10):2095-2109. doi: 10.1002/ar.24687. Epub 2021 Jun 26.

John Paul Richard Thomas is among the living herpetologists to have described the greatest number of new species of amphibians and reptiles, and his contributions to the herpetology of the West Indies, particularly the Greater Antilles, have been exceptional....

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Bauer AM, Daza JD, Herrera-Martínez A, et al. The herpetological contributions of Richard Thomas. Anat Rec (Hoboken). 2021;304(10):2095-2109doi: 10.1002/ar.24687.
Bauer, A. M., Daza, J. D., Herrera-Martínez, A., & Ospina, O. E. (2021). The herpetological contributions of Richard Thomas. Anatomical record (Hoboken, N.J. : 2007), 304(10), 2095-2109. https://doi.org/10.1002/ar.24687
Bauer, Aaron M, et al. "The herpetological contributions of Richard Thomas." Anatomical record (Hoboken, N.J. : 2007) vol. 304,10 (2021): 2095-2109. doi: https://doi.org/10.1002/ar.24687
Bauer AM, Daza JD, Herrera-Martínez A, Ospina OE. The herpetological contributions of Richard Thomas. Anat Rec (Hoboken). 2021 Oct;304(10):2095-2109. doi: 10.1002/ar.24687. Epub 2021 Jun 26. PMID: 34173714.
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Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis.

Cancer research

Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, Rojas JD, Dayton PA, Huang L, Wang AZ.
PMID: 34753773
Cancer Res. 2022 Jan 01;82(1):105-113. doi: 10.1158/0008-5472.CAN-21-2269. Epub 2021 Nov 09.

Liver metastasis is a leading cause of cancer morbidity and mortality. Thus, there has been strong interest in the development of therapeutics that can effectively prevent liver metastasis. One potential strategy is to utilize molecules that have broad effects...

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Sendi H, Yazdimamaghani M, Hu M, et al. Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis. Cancer Res. 2021;82(1):105-113doi: 10.1158/0008-5472.CAN-21-2269.
Sendi, H., Yazdimamaghani, M., Hu, M., Sultanpuram, N., Wang, J., Moody, A. S., McCabe, E., Zhang, J., Graboski, A., Li, L., Rojas, J. D., Dayton, P. A., Huang, L., & Wang, A. Z. (2022). Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis. Cancer research, 82(1), 105-113. https://doi.org/10.1158/0008-5472.CAN-21-2269
Sendi, Hossein, et al. "Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis." Cancer research vol. 82,1 (2022): 105-113. doi: https://doi.org/10.1158/0008-5472.CAN-21-2269
Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, Rojas JD, Dayton PA, Huang L, Wang AZ. Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis. Cancer Res. 2022 Jan 01;82(1):105-113. doi: 10.1158/0008-5472.CAN-21-2269. Epub 2021 Nov 09. PMID: 34753773; PMCID: PMC8732321.
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Academic paediatric surgery and work-life balance: Insights from Mexico.

Seminars in pediatric surgery

Shalkow-Klincovstein J, Porras-Hernandez JD, Villalpando R, Olaya-Vargas A, Esparza-Aguilar M.
PMID: 33648707
Semin Pediatr Surg. 2021 Feb;30(1):151023. doi: 10.1016/j.sempedsurg.2021.151023. Epub 2021 Jan 30.

Academic pediatric surgery in Mexico has many challenges and opportunities. Work life balance, health service delivery and committements to our many students and residents must be tailored to goals and aspirations respecting talent at every opportunity when we encounter...

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Shalkow-Klincovstein J, Porras-Hernandez JD, Villalpando R, et al. Academic paediatric surgery and work-life balance: Insights from Mexico. Semin Pediatr Surg. 2021;30(1):151023doi: 10.1016/j.sempedsurg.2021.151023.
Shalkow-Klincovstein, J., Porras-Hernandez, J. D., Villalpando, R., Olaya-Vargas, A., & Esparza-Aguilar, M. (2021). Academic paediatric surgery and work-life balance: Insights from Mexico. Seminars in pediatric surgery, 30(1), 151023. https://doi.org/10.1016/j.sempedsurg.2021.151023
Shalkow-Klincovstein, Jaime, et al. "Academic paediatric surgery and work-life balance: Insights from Mexico." Seminars in pediatric surgery vol. 30,1 (2021): 151023. doi: https://doi.org/10.1016/j.sempedsurg.2021.151023
Shalkow-Klincovstein J, Porras-Hernandez JD, Villalpando R, Olaya-Vargas A, Esparza-Aguilar M. Academic paediatric surgery and work-life balance: Insights from Mexico. Semin Pediatr Surg. 2021 Feb;30(1):151023. doi: 10.1016/j.sempedsurg.2021.151023. Epub 2021 Jan 30. PMID: 33648707.
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High-resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA-tetraglycinate agents.

NMR in biomedicine

Mihailovic JM, Huang Y, Walsh JJ, Khan MH, Mishra SK, Samuels S, Hyder F, Coman D.
PMID: 34837412
NMR Biomed. 2021 Nov 27;e4658. doi: 10.1002/nbm.4658. Epub 2021 Nov 27.

Chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS) methods differ respectively by detecting exchangeable and nonexchangeable proton signals by magnetic resonance. Because CEST contrast depends on both temperature and pH, simultaneous CEST and...

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Mihailovic JM, Huang Y, Walsh JJ, et al. High-resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA-tetraglycinate agents. NMR Biomed. 2021;e4658doi: 10.1002/nbm.4658.
Mihailovic, J. M., Huang, Y., Walsh, J. J., Khan, M. H., Mishra, S. K., Samuels, S., Hyder, F., & Coman, D. (2021). High-resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA-tetraglycinate agents. NMR in biomedicine, e4658. https://doi.org/10.1002/nbm.4658
Mihailovic, Jelena M, et al. "High-resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA-tetraglycinate agents." NMR in biomedicine vol. (2021): e4658. doi: https://doi.org/10.1002/nbm.4658
Mihailovic JM, Huang Y, Walsh JJ, Khan MH, Mishra SK, Samuels S, Hyder F, Coman D. High-resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA-tetraglycinate agents. NMR Biomed. 2021 Nov 27;e4658. doi: 10.1002/nbm.4658. Epub 2021 Nov 27. PMID: 34837412.
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Management of a Complex Supracondylar Periprosthetic Femur Fracture with Intramedullary Strut Allograft and Bilateral Locking Plates.

Case reports in orthopedics

Moukarzel R, Aouad D, Daher M, Ghanem W, Ezzeddine H, El Rassi G.
PMID: 34840840
Case Rep Orthop. 2021 Nov 17;2021:4882382. doi: 10.1155/2021/4882382. eCollection 2021.

Supracondylar periprosthetic femoral fractures occurring above total knee replacements have been considered a rare entity. However, they continue to increase in frequency with the increasing number of arthroplasties and the improvement in morbidity and mortality in the concerned patient...

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Moukarzel R, Aouad D, Daher M, et al. Management of a Complex Supracondylar Periprosthetic Femur Fracture with Intramedullary Strut Allograft and Bilateral Locking Plates. Case Rep Orthop. 2021;2021:4882382doi: 10.1155/2021/4882382.
Moukarzel, R., Aouad, D., Daher, M., Ghanem, W., Ezzeddine, H., & El Rassi, G. (2021). Management of a Complex Supracondylar Periprosthetic Femur Fracture with Intramedullary Strut Allograft and Bilateral Locking Plates. Case reports in orthopedics, 20214882382. https://doi.org/10.1155/2021/4882382
Moukarzel, Rita, et al. "Management of a Complex Supracondylar Periprosthetic Femur Fracture with Intramedullary Strut Allograft and Bilateral Locking Plates." Case reports in orthopedics vol. 2021 (2021): 4882382. doi: https://doi.org/10.1155/2021/4882382
Moukarzel R, Aouad D, Daher M, Ghanem W, Ezzeddine H, El Rassi G. Management of a Complex Supracondylar Periprosthetic Femur Fracture with Intramedullary Strut Allograft and Bilateral Locking Plates. Case Rep Orthop. 2021 Nov 17;2021:4882382. doi: 10.1155/2021/4882382. eCollection 2021. PMID: 34840840; PMCID: PMC8612792.
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The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs.

Cancer gene therapy

Sami E, Bogan D, Molinolo A, Koziol J, ElShamy WM.
PMID: 33723406
Cancer Gene Ther. 2021 Mar 15; doi: 10.1038/s41417-021-00311-x. Epub 2021 Mar 15.

Triple-negative breast cancer (TNBCs) display lung metastasis tropism. However, the mechanisms underlying this organ-specific pattern remains to be elucidated. We sought to evaluate the utility of blocking extravasation to prevent lung metastasis. To identify potential geminin overexpression-controlled genetic drivers...

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Sami E, Bogan D, Molinolo A, et al. The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs. Cancer Gene Ther. 2021;doi: 10.1038/s41417-021-00311-x.
Sami, E., Bogan, D., Molinolo, A., Koziol, J., & ElShamy, W. M. (2021). The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs. Cancer gene therapy, . https://doi.org/10.1038/s41417-021-00311-x
Sami, Eman, et al. "The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs." Cancer gene therapy vol. (2021). doi: https://doi.org/10.1038/s41417-021-00311-x
Sami E, Bogan D, Molinolo A, Koziol J, ElShamy WM. The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs. Cancer Gene Ther. 2021 Mar 15; doi: 10.1038/s41417-021-00311-x. Epub 2021 Mar 15. PMID: 33723406.
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Class I Myosins, molecular motors involved in cell migration and cancer.

Cell adhesion & migration

Diaz-Valencia JD, Estrada-Abreo LA, Rodríguez-Cruz L, Salgado-Aguayo AR, Patiño-López G.
PMID: 34974807
Cell Adh Migr. 2022 Dec;16(1):1-12. doi: 10.1080/19336918.2021.2020705.

Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these...

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Diaz-Valencia JD, Estrada-Abreo LA, Rodríguez-Cruz L, et al. Class I Myosins, molecular motors involved in cell migration and cancer. Cell Adh Migr. 2022;16(1):1-12doi: 10.1080/19336918.2021.2020705.
Diaz-Valencia, J. D., Estrada-Abreo, L. A., Rodríguez-Cruz, L., Salgado-Aguayo, A. R., & Patiño-López, G. (2022). Class I Myosins, molecular motors involved in cell migration and cancer. Cell adhesion & migration, 16(1), 1-12. https://doi.org/10.1080/19336918.2021.2020705
Diaz-Valencia, Juan D, et al. "Class I Myosins, molecular motors involved in cell migration and cancer." Cell adhesion & migration vol. 16,1 (2022): 1-12. doi: https://doi.org/10.1080/19336918.2021.2020705
Diaz-Valencia JD, Estrada-Abreo LA, Rodríguez-Cruz L, Salgado-Aguayo AR, Patiño-López G. Class I Myosins, molecular motors involved in cell migration and cancer. Cell Adh Migr. 2022 Dec;16(1):1-12. doi: 10.1080/19336918.2021.2020705. PMID: 34974807.
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