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Showing 37 to 48 of 743 entries
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Mutations in the nuclear localization sequence of the Aristaless related homeobox; sequestration of mutant ARX with IPO13 disrupts normal subcellular distribution of the transcription factor and retards cell division.

PathoGenetics

Shoubridge C, Tan MH, Fullston T, Cloosterman D, Coman D, McGillivray G, Mancini GM, Kleefstra T, Gécz J.
PMID: 20148114
Pathogenetics. 2010 Jan 05;3:1. doi: 10.1186/1755-8417-3-1.

BACKGROUND: Aristaless related homeobox (ARX) is a paired-type homeobox gene. ARX function is frequently affected by naturally occurring mutations. Nonsense mutations, polyalanine tract expansions and missense mutations in ARX cause a range of intellectual disability and epilepsy phenotypes with...

14-3-3-β and -{varepsilon} contribute to activation of the osmoprotective transcription factor NFAT5 by increasing its protein abundance and its transactivating activity.

Physiological reports

Izumi Y, Burg MB, Ferraris JD.
PMID: 24771694
Physiol Rep. 2014 Apr 22;2(4):e12000. doi: 10.14814/phy2.12000. Print 2014.

Abstract Having previously found that high NaCl causes rapid exit of 14-3-3 isoforms from the nucleus, we used siRNA-mediated knockdown to test whether 14-3-3s contribute to the high NaCl-induced increase in the activity of the osmoprotective transcription factor NFAT5....

Amyloid-β induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse.

Frontiers in cellular neuroscience

Nava-Mesa MO, Jiménez-Díaz L, Yajeya J, Navarro-Lopez JD.
PMID: 23898239
Front Cell Neurosci. 2013 Jul 25;7:117. doi: 10.3389/fncel.2013.00117. eCollection 2013.

Last evidences suggest that, in Alzheimer's disease (AD) early stage, Amyloid-β (Aβ) peptide induces an imbalance between excitatory and inhibitory neurotransmission systems resulting in the functional impairment of neural networks. Such alterations are particularly important in the septohippocampal system...

[Not Available].

Reumatologia clinica

Cañete Crespillo JD.
PMID: 21794460
Reumatol Clin. 2007 Jul;3:S19-23. doi: 10.1016/S1699-258X(07)73635-5. Epub 2008 Dec 29.

No abstract available.

Transcriptional dissection of pancreatic tumors engrafted in mice.

Genome medicine

Martinez-Garcia R, Juan D, Rausell A, Muñoz M, Baños N, Menéndez C, Lopez-Casas PP, Rico D, Valencia A, Hidalgo M.
PMID: 24739241
Genome Med. 2014 Apr 16;6(4):27. doi: 10.1186/gm544. eCollection 2014.

BACKGROUND: Engraftment of primary pancreas ductal adenocarcinomas (PDAC) in mice to generate patient-derived xenograft (PDX) models is a promising platform for biological and therapeutic studies in this disease. However, these models are still incompletely characterized. Here, we measured the...

Clinics and practice

Swan L, Cardinal J, Coman D.
PMID: 30275942
Clin Pract. 2018 Aug 27;8(3):1071. doi: 10.4081/cp.2018.1071. eCollection 2018 Jul 10.

The spectrin repeat-containing nuclear envelope protein 1 (

mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells.

Pharmaceutics

Mayati A, Moreau A, Jouan E, Febvre-James M, Denizot C, Parmentier Y, Fardel O.
PMID: 30469356
Pharmaceutics. 2018 Nov 21;10(4). doi: 10.3390/pharmaceutics10040246.

The HepaRG cell line is a highly differentiated human hepatoma cell line, displaying the expression of various drug transporters. However, functional expression of nucleoside transporters remains poorly characterized in HepaRG cells, although these transporters play a key role in...

Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients.

Pain reports

Sieberg CB, Taras C, Gomaa A, Nickerson C, Wong C, Ward C, Baskozos G, Bennett DLH, Ramirez JD, Themistocleous AC, Rice ASC, Shillo PR, Tesfaye S, Edwards RR, Andrews NA, Berde C, Costigan M.
PMID: 29922743
Pain Rep. 2018 May 24;3(3):e651. doi: 10.1097/PR9.0000000000000651. eCollection 2018 May.

BACKGROUND: Epidemiological studies in patients with neuropathic pain demonstrate a strong association with psychiatric conditions such as anxiety; however, the precipitating pathology between these symptoms remains unclear. To investigate this, we studied the effects of lifelong stress on levels...

Wild Origins of Macadamia Domestication Identified Through Intraspecific Chloroplast Genome Sequencing.

Frontiers in plant science

Nock CJ, Hardner CM, Montenegro JD, Ahmad Termizi AA, Hayashi S, Playford J, Edwards D, Batley J.
PMID: 30949191
Front Plant Sci. 2019 Mar 21;10:334. doi: 10.3389/fpls.2019.00334. eCollection 2019.

Identifying the geographic origins of crops is important for the conservation and utilization of novel genetic variation. Even so, the origins of many food crops remain elusive. The tree nut crop macadamia has a remarkable domestication history, from subtropical...

The effect of surface coverage on N.

Physical chemistry chemical physics : PCCP

Gonzalez JD, Shojaee K, Haynes BS, Montoya A.
PMID: 30255883
Phys Chem Chem Phys. 2018 Oct 10;20(39):25314-25323. doi: 10.1039/c8cp04066d.

The effect of surface coverage of species, θ, on the kinetic parameters of N2, NO and N2O formation in a system simulating ammonia oxidation over Pt(111) has been studied by using periodic density functional theory (DFT). The energy barriers...

Soybean meal substitution by dehulled lupine (Lupinus angustifolius) with enzymes in broiler diets.

Asian-Australasian journal of animal sciences

Mera-Zúñiga F, Pro-Martínez A, Zamora-Natera JF, Sosa-Montes E, Guerrero-Rodríguez JD, Mendoza-Pedroza SI, Cuca-García JM, López-Romero RM, Chan-Díaz D, Becerril-Pérez CM, Vargas-Galicia AJ, Bautista-Ortega J.
PMID: 30208697
Asian-Australas J Anim Sci. 2019 Apr;32(4):564-573. doi: 10.5713/ajas.18.0340. Epub 2018 Sep 13.

OBJECTIVE: Evaluate the effects of i) dehulling of lupine seed on chemical composition and apparent metabolizable energy (AME) and ii) soybean meal substitution by dehulled lupine seed in broiler diets with enzymes on productive performance, size of digestive organs...

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.

Frontiers in immunology

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH, Trottein F, Paget C, Lang KS, Futerman AH.
PMID: 29163475
Front Immunol. 2017 Nov 01;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.

The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length of SLs...

Showing 37 to 48 of 743 entries