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Showing 3505 to 3516 of 3523 entries
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Resilient structure of nature-based extension programs facilitates transition to online delivery and maintains participant satisfaction.

Ecology and evolution

Main MB, Ober HK, Johnson SA.
PMID: 33250989
Ecol Evol. 2020 Oct 27;10(22):12508-12514. doi: 10.1002/ece3.6860. eCollection 2020 Nov.

Restrictions on public gatherings in early 2020 due to the COVID-19 pandemic resulted in cancelation of in-person outreach programs offered by the Florida Master Naturalist Program and Natural Areas Training Academy, two successful University of Florida extension programs that...

Novel Antimuscarinic Antidepressant-like Compounds with Reduced Effects on Cognition.

The Journal of pharmacology and experimental therapeutics

Johnson CR, Kangas BD, Jutkiewicz EM, Winger G, Bergman J, Coop A, Woods JH.
PMID: 33712507
J Pharmacol Exp Ther. 2021 Jun;377(3):336-345. doi: 10.1124/jpet.120.000337. Epub 2021 Mar 12.

The cholinergic nervous system has been implicated in mood disorders, evident in the fast-onset antidepressant effects of scopolamine, a potent muscarinic antagonist, in clinical studies. One prominent disadvantage of the use of scopolamine in the treatment of depression is...

Exploring The Obesity Paradox In A Murine Model of Sepsis: Improved Survival Despite Increased Organ Injury In Obese Mice.

Shock (Augusta, Ga.)

Lewis ED, Williams HC, Bruno MEC, Stromberg AJ, Saito H, Johnson LA, Starr ME.
PMID: 34482320
Shock. 2021 Sep 03; doi: 10.1097/SHK.0000000000001856. Epub 2021 Sep 03.

ABSTRACT: Despite the known deleterious effects of obesity, clinical data indicate that overweight or obese patients experience higher rates of sepsis survival compared to normal and underweight patients; a phenomenon called the obesity paradox. Results from preclinical sepsis studies...

Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease.

Nature human behaviour

Siddiqi SH, Schaper FLWVJ, Horn A, Hsu J, Padmanabhan JL, Brodtmann A, Cash RFH, Corbetta M, Choi KS, Dougherty DD, Egorova N, Fitzgerald PB, George MS, Gozzi SA, Irmen F, Kuhn AA, Johnson KA, Naidech AM, Pascual-Leone A, Phan TG, Rouhl RPW, Taylor SF, Voss JL, Zalesky A, Grafman JH, Mayberg HS, Fox MD.
PMID: 34239076
Nat Hum Behav. 2021 Dec;5(12):1707-1716. doi: 10.1038/s41562-021-01161-1. Epub 2021 Jul 08.

Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial...

Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.

Neoplasia (New York, N.Y.)

Chen T, Zeineldin M, Johnson BA, Dong Y, Narkar A, Li T, Zhu J, Li R, Larman TC.
PMID: 33906087
Neoplasia. 2021 May;23(5):488-501. doi: 10.1016/j.neo.2021.03.010. Epub 2021 Apr 24.

Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of intestinal stem cell niche morphogens alone can...

Chemical Reduction of Ni.

The journal of physical chemistry. A

Edington SC, Perez EH, Charboneau DJ, Menges FS, Hazari N, Johnson MA.
PMID: 34324319
J Phys Chem A. 2021 Aug 12;125(31):6715-6721. doi: 10.1021/acs.jpca.1c05016. Epub 2021 Jul 29.

Ni

Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial.

Cancer

Chudy-Onwugaje K, Huang WY, Su LJ, Purdue MP, Johnson CC, Wang L, Katki HA, Barry KH, Berndt SI.
PMID: 33974712
Cancer. 2021 Sep 01;127(17):3145-3155. doi: 10.1002/cncr.33623. Epub 2021 May 11.

BACKGROUND: Studying the differential impact of aspirin and other nonsteroidal anti-inflammatory drugs across the stages of colorectal neoplasia from early adenoma to cancer is critical for understanding the benefits of these widely used drugs.METHODS: With 13 years of follow-up,...

A Nearly Packaging-Free Design Paradigm for Light, Powerful, and Energy-Dense Primary Microbatteries.

Advanced materials (Deerfield Beach, Fla.)

Yue X, Johnson AC, Kim S, Kohlmeyer RR, Patra A, Grzyb J, Padmanabha A, Wang M, Jiang Z, Sun P, Kiggins CT, Ates MN, Singh SV, Beale EM, Daroux M, Blake AJ, Cook JB, Braun PV, Pikul JH.
PMID: 34278621
Adv Mater. 2021 Sep;33(35):e2101760. doi: 10.1002/adma.202101760. Epub 2021 Jul 19.

Billions of internet connected devices used for medicine, wearables, and robotics require microbattery power sources, but the conflicting scaling laws between electronics and energy storage have led to inadequate power sources that severely limit the performance of these physically...

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.

Cell host & microbe

Liu C, Zhou D, Nutalai R, Duyvesteyn HME, Tuekprakhon A, Ginn HM, Dejnirattisai W, Supasa P, Mentzer AJ, Wang B, Case JB, Zhao Y, Skelly DT, Chen RE, Johnson SA, Ritter TG, Mason C, Malik T, Temperton N, Paterson NG, Williams MA, Hall DR, Clare DK, Howe A, Goulder PJR, Fry EE, Diamond MS, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR.
PMID: 34921776
Cell Host Microbe. 2022 Jan 12;30(1):53-68.e12. doi: 10.1016/j.chom.2021.11.013. Epub 2021 Nov 27.

Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the antigenic structure of S, causing escape from natural or vaccine-induced immunity. Beta is particularly difficult to neutralize using serum...

Sequence variation in the β7-β8 loop of bacterial class A sortase enzymes alters substrate selectivity.

The Journal of biological chemistry

Piper IM, Struyvenberg SA, Valgardson JD, Johnson DA, Gao M, Johnston K, Svendsen JE, Kodama HM, Hvorecny KL, Antos JM, Amacher JF.
PMID: 34302812
J Biol Chem. 2021 Aug;297(2):100981. doi: 10.1016/j.jbc.2021.100981. Epub 2021 Jul 22.

Gram-positive bacteria contain sortase enzymes on their cell surfaces that catalyze transpeptidation reactions critical for proper cellular function. In vitro, sortases are used in sortase-mediated ligation (SML) reactions for a variety of protein engineering applications. Historically, sortase A from...

Latissimus dorsi tendon transfer in reverse shoulder arthroplasty: transfer location affects strength.

JSES international

Chan K, Langohr GDG, Welsh M, Johnson JA, Athwal GS.
PMID: 33681849
JSES Int. 2020 Dec 11;5(2):277-281. doi: 10.1016/j.jseint.2020.10.013. eCollection 2021 Mar.

BACKGROUND: The optimal insertion location of a latissimus dorsi tendon transfer to restore external rotation after reverse shoulder arthroplasty (RSA) is not well established. The aim of this biomechanical study was to determine the effect of tendon transfer location...

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

bioRxiv : the preprint server for biology

Liu Y, Liu J, Johnson BA, Xia H, Ku Z, Schindewolf C, Widen SG, An Z, Weaver SC, Menachery VD, Xie X, Shi PY.
PMID: 34462752
bioRxiv. 2021 Sep 05; doi: 10.1101/2021.08.12.456173.

SARS-CoV-2 Delta variant has rapidly replaced the Alpha variant around the world. The mechanism that drives this global replacement has not been defined. Here we report that Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant...

Showing 3505 to 3516 of 3523 entries