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Showing 2989 to 2999 of 2999 entries
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Comparison of Weight-Based Dosing versus Fixed Dosing of 23.4% Hypertonic Saline for Intracranial Pressure Reduction in Patients with Severe Traumatic Brain Injury.

Journal of emergencies, trauma, and shock

Busey K, Ferreira J, Aldridge P, Crandall M, Johnson D.
PMID: 33897140
J Emerg Trauma Shock. 2020 Oct-Dec;13(4):252-256. doi: 10.4103/JETS.JETS_66_19. Epub 2020 Dec 07.

CONTEXT: Hypertonic saline (HTS) is a pharmacologic therapy used in patients with severe traumatic brain injuries to decrease intracranial pressure (ICP) associated with cerebral edema.AIMS: The purpose of this study was to compare ICP reduction between fixed doses of...

Phase 2 Study of Dabrafenib Plus Trametinib in Patients With BRAF V600E-Mutant Metastatic NSCLC: Updated 5-Year Survival Rates and Genomic Analysis.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Planchard D, Besse B, Groen HJM, Hashemi SMS, Mazieres J, Kim TM, Quoix E, Souquet PJ, Barlesi F, Baik C, Villaruz LC, Kelly RJ, Zhang S, Tan M, Gasal E, Santarpia L, Johnson BE.
PMID: 34455067
J Thorac Oncol. 2022 Jan;17(1):103-115. doi: 10.1016/j.jtho.2021.08.011. Epub 2021 Aug 26.

INTRODUCTION: Dabrafenib plus trametinib was found to have robust antitumor activity in patients with BRAF V600E-mutant metastatic NSCLC (mNSCLC). We report updated survival analysis of a phase 2 study (NCT01336634) with a minimum of 5-year follow-up and updated genomic...

Development and Validation of StrataNGS, a Multiplex PCR, Semiconductor Sequencing-Based Comprehensive Genomic Profiling Test.

The Journal of molecular diagnostics : JMD

Tomlins SA, Hovelson DH, Harms P, Drewery S, Falkner J, Fischer A, Hipp J, Kwiatkowski K, Lazo de la Vega L, Mitchell K, Reeder T, Siddiqui J, Vakil H, Johnson DB, Rhodes DR.
PMID: 34454112
J Mol Diagn. 2021 Nov;23(11):1515-1533. doi: 10.1016/j.jmoldx.2021.08.005. Epub 2021 Aug 25.

Despite widespread use in targeted tumor testing, multiplex PCR/semiconductor (Ion Torrent) sequencing-based assessment of all comprehensive genomic profiling (CGP) variant classes has been limited. Herein, we describe the development and validation of StrataNGS, a 429-gene, multiplex PCR/semiconductor sequencing-based CGP...

Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.

Neoplasia (New York, N.Y.)

Chen T, Zeineldin M, Johnson BA, Dong Y, Narkar A, Li T, Zhu J, Li R, Larman TC.
PMID: 33906087
Neoplasia. 2021 May;23(5):488-501. doi: 10.1016/j.neo.2021.03.010. Epub 2021 Apr 24.

Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of intestinal stem cell niche morphogens alone can...

Predicting treatment efficacy via quantitative magnetic resonance imaging: a Bayesian joint model.

Journal of the Royal Statistical Society. Series C, Applied statistics

Wu J, Johnson TD, Galbán CJ, Chenevert TL, Meyer CR, Rehemtulla A, Hamstra DA, Ross BD.
PMID: 22577240
J R Stat Soc Ser C Appl Stat. 2012 Jan 01;61(1):83-98. doi: 10.1111/j.1467-9876.2011.01015.x. Epub 2011 Oct 10.

The prognosis for patients with high grade gliomas is poor, with a median survival of 1 year. Treatment efficacy assessment is typically unavailable until 5-6 months post diagnosis. Investigators hypothesize that quantitative magnetic resonance imaging can assess treatment efficacy...

The Use of Automated Traps to Assess the Efficacy of Insecticide Barrier Treatments Against Abundant Mosquitoes in Remote Environments.

Journal of medical entomology

Johnson BJ, Manby R, Devine GJ.
PMID: 34748002
J Med Entomol. 2022 Jan 12;59(1):384-389. doi: 10.1093/jme/tjab178.

Commercially available 'smart' trap technology has not yet been widely used to evaluate interventions against mosquitoes despite potential benefits. These benefits include the ability to capture data continuously at fine temporal scales without the human resources usually required for...

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

bioRxiv : the preprint server for biology

Liu Y, Liu J, Johnson BA, Xia H, Ku Z, Schindewolf C, Widen SG, An Z, Weaver SC, Menachery VD, Xie X, Shi PY.
PMID: 34462752
bioRxiv. 2021 Sep 05; doi: 10.1101/2021.08.12.456173.

SARS-CoV-2 Delta variant has rapidly replaced the Alpha variant around the world. The mechanism that drives this global replacement has not been defined. Here we report that Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant...

Shock Pressure Dependence of Hot Spots in a Model Plastic-Bonded Explosive.

The journal of physical chemistry. A

Johnson BP, Zhou X, Dlott DD.
PMID: 34982934
J Phys Chem A. 2022 Jan 13;126(1):145-154. doi: 10.1021/acs.jpca.1c08323. Epub 2022 Jan 04.

Shock initiation of plastic-bonded explosives (PBX) begins with the formation of so-called "hot spots", which are energetic reactions localized in regions where the PBX microstructure concentrates the input shock wave energy. We developed a model PBX system to study...

Chaos during the COVID-19 outbreak: Predictors of household chaos among low-income families during a pandemic.

Family relations

Johnson AD, Martin A, Partika A, Phillips DA, Castle S.
PMID: 34898781
Fam Relat. 2021 Sep 24; doi: 10.1111/fare.12597. Epub 2021 Sep 24.

OBJECTIVE: The objective of this study was to explore whether household chaos measured during the COVID-19 pandemic is predicted by prepandemic parental and household characteristics.BACKGROUND: The COVID-19 pandemic has dramatically altered children's home environments and routines due to stay-at-home...

Promoting Student Learning in Criminal Justice, STEM, and Forensic Science: Aggie Sleuth Initiative (AggieSI)-Guided Inquiry Learning Experience.

Johnson D, Fakayode SO, Mayes JP, Kanipes MI, Cuthbertson EL.
UIID-AD: 3635
2016;1-15. doi: 10.1080/10511253.2016.1199720.

This study reported the first interdisciplinary Aggie Sleuth Initiative (AggieSI) conducted between the Departments of Political Science and Criminal Justice, Sociology and Social Work and Chemistry in order to interest underrepresented minority students in the field of forensic science...

Remote Sensing of Ice Sheets for underrepresented and handicapped middle school students.

Ieee, Hayden L, Hughes T, Johnson D.
UIID-AD: 706
2007;2181-2184.

The NSF Science and Technology Center for the Remote Sensing of Ice Sheets (CReSIS) combines the expertise of researchers from 6 universities, several industries, and federal laboratories to study and conduct research to achieve a better understanding of the...

Showing 2989 to 2999 of 2999 entries