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Showing 661 to 672 of 672 entries
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Assessment of bias in carbon isotope composition of organic leaf matter due to pre-analysis milling methods.

Rapid communications in mass spectrometry : RCM

Worne S, Lacey JH, Barr C, Schulz C, Leng MJ.
PMID: 34087023
Rapid Commun Mass Spectrom. 2021 Jun 04;e9134. doi: 10.1002/rcm.9134. Epub 2021 Jun 04.

RATIONALE: Stable isotope analysis of leaf material has many applications including assessment of plant water-use efficiency and palaeoclimatology. To facilitate interpretations of small shifts in the carbon isotope composition (δMETHODS: We investigate how different grinding methods (freezer-milling and ball-milling)...

Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis.

FEBS letters

Cai C, Bi D, Bick G, Wei Q, Liu H, Lu L, Zhang X, Qin H.
PMID: 34719039
FEBS Lett. 2021 Dec;595(24):3056-3071. doi: 10.1002/1873-3468.14219. Epub 2021 Nov 22.

Super-enhancers (SEs) play essential roles in colorectal cancer (CRC) progression. However, how the SE landscape is orchestrated by transcriptional regulators and evolves is not clear. Using de novo motif analysis, we show that the hepatocyte nuclear factor 1 (HNF1)-binding...

Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma.

Cancers

Henderson JM, Xiang MSW, Huang JC, Wetzel S, Jiang L, Lai JH, Wu W, Kench JG, Bachovchin WW, Roediger B, McCaughan GW, Zhang HE, Gorrell MD.
PMID: 34771657
Cancers (Basel). 2021 Nov 01;13(21). doi: 10.3390/cancers13215495.

The mRNA expression of the dipeptidyl peptidase 4 (DPP4) gene family is highly upregulated in human hepatocellular carcinoma (HCC) and is associated with poor survival in HCC patients. Compounds that inhibit the DPP4 enzyme family, such as talabostat and...

The Risk of Venous Thromboembolism (VTE) in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors (5ARIs).

Clinical epidemiology

Ayodele O, Cabral HJ, McManus D, Jick S.
PMID: 34377032
Clin Epidemiol. 2021 Aug 03;13:661-673. doi: 10.2147/CLEP.S317019. eCollection 2021.

BACKGROUND: Many men receive 5-alpha reductase inhibitors (5ARIs) for ongoing treatment of benign prostatic hyperplasia (BPH). The increased risk of cardiovascular complications with 5ARIs has been documented in BPH studies and the occurrence of cerebral venous thrombosis, presumably due...

Assessing the feasibility and value of employing an ecosystem services approach in chemical environmental risk assessment under the Water Framework Directive.

The Science of the total environment

Brown AR, Marshall S, Cooper C, Whitehouse P, Van den Brink PJ, Faber JH, Maltby L.
PMID: 34323835
Sci Total Environ. 2021 May 24;789:147857. doi: 10.1016/j.scitotenv.2021.147857. Epub 2021 May 24.

The feasibility and added value of an ecosystem services approach in retrospective environmental risk assessment were evaluated using a site-specific case study in a lowland UK river. The studied water body failed to achieve good ecological status temporarily in...

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.

The Journal of experimental medicine

Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL.
PMID: 34698806
J Exp Med. 2021 Dec 06;218(12). doi: 10.1084/jem.20211872. Epub 2021 Oct 26.

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of...

Navigating Still Waters of Infertility: Role of Goal Features in Coping with a Thwarted Goal.

International journal of behavioral medicine

Andrade FC, Davisson EK, Kwiatek S, Hoyle RH.
PMID: 34268707
Int J Behav Med. 2021 Jul 15; doi: 10.1007/s12529-021-10006-0. Epub 2021 Jul 15.

BACKGROUND: The infertility experience is often surrounded by frustration and discouragement associated with the thwarted goal to have a child. Though research has identified commonly used strategies to cope with infertility, this study is the first to examine how...

Ecosystem approach to harvesting in the Arctic: Walking the tightrope between exploitation and conservation in the Barents Sea.

Ambio

Heath MR, Benkort D, Brierley AS, Daewel U, Laverick JH, Proud R, Speirs DC.
PMID: 34478036
Ambio. 2021 Sep 03; doi: 10.1007/s13280-021-01616-9. Epub 2021 Sep 03.

Projecting the consequences of warming and sea-ice loss for Arctic marine food web and fisheries is challenging due to the intricate relationships between biology and ice. We used StrathE2EPolar, an end-to-end (microbes-to-megafauna) food web model incorporating ice-dependencies to simulate...

Links between socioeconomic disadvantage, neural function, and working memory in early childhood.

Developmental psychobiology

Li X, Lipschutz R, Hernandez SM, Biekman B, Shen S, Montgomery DA, Perlman SB, Pollonini L, Bick J.
PMID: 34423434
Dev Psychobiol. 2021 Sep;63(6):e22181. doi: 10.1002/dev.22181. Epub 2021 Aug 22.

Children reared in socioeconomically disadvantaged environments are at risk for academic, cognitive, and behavioral problems. Mounting evidence suggests that childhood adversities, encountered at disproportionate rates in contexts of socioeconomic risk, shape the developing brain in ways that explain disparities....

Nematic Triphenyltriazine Triesters and the Induction of the Columnar Mesophase by Fluorine Substitution.

Chemistry (Weinheim an der Bergstrasse, Germany)

Vieira AA, Farias G, Costa WC, Eccher J, Bechtold IH, Durola F, Bock H.
PMID: 33871125
Chemistry. 2021 Jun 21;27(35):9003-9010. doi: 10.1002/chem.202005456. Epub 2021 May 21.

Whereas their para homologs are not mesogenic, the disk-shaped triphenyltriazine meta-trialkylesters obtained via trimerization of 3-cyanobenzoic alkylester, which are configurationally more flexible, exhibit a monotropic nematic mesophase. Introduction of fluorine atoms into the alkyl chains or into the phenyl...

Psychosocial Moderators and Mediators of Sensorimotor Exercise in Low Back Pain: A Randomized Multicenter Controlled Trial.

Frontiers in psychiatry

Wippert PM, Niederer D, Drießlein D, Beck H, Banzer W, Schneider C, Schiltenwolf M, Mayer F.
PMID: 34393840
Front Psychiatry. 2021 Jul 29;12:629474. doi: 10.3389/fpsyt.2021.629474. eCollection 2021.

The effects of exercise interventions on unspecific chronic low back pain (CLBP) have been investigated in many studies, but the results are inconclusive regarding exercise types, efficiency, and sustainability. This may be because the influence of psychosocial factors on...

Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease.

Journal of molecular and cellular cardiology

Marnell CS, Bick A, Natarajan P.
PMID: 34298011
J Mol Cell Cardiol. 2021 Dec;161:98-105. doi: 10.1016/j.yjmcc.2021.07.004. Epub 2021 Jul 21.

Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals without evidence of hematologic malignancy, dysplasia, or cytopenia. CHIP is associated with a 0.5-1.0% risk per...

Showing 661 to 672 of 672 entries