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MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design.

Neurodegenerative disease management

Oskarsson B, Maragakis N, Bedlack RS, Goyal N, Meyer JA, Genge A, Bodkin C, Maiser S, Staff N, Zinman L, Olney N, Turnbull J, Brooks BR, Klonowski E, Makhay M, Yasui S, Matsuda K.
PMID: 34816762
Neurodegener Dis Manag. 2021 Dec;11(6):431-443. doi: 10.2217/nmt-2021-0042. Epub 2021 Nov 24.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with motor neuron loss as a defining feature. Despite significant effort, therapeutic breakthroughs have been modest. MN-166 (ibudilast) has demonstrated neuroprotective action by various mechanisms: inhibition of proinflammatory cytokines and macrophage...

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Oskarsson B, Maragakis N, Bedlack RS, et al. MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design. Neurodegener Dis Manag. 2021;11(6):431-443doi: 10.2217/nmt-2021-0042.
Oskarsson, B., Maragakis, N., Bedlack, R. S., Goyal, N., Meyer, J. A., Genge, A., Bodkin, C., Maiser, S., Staff, N., Zinman, L., Olney, N., Turnbull, J., Brooks, B. R., Klonowski, E., Makhay, M., Yasui, S., & Matsuda, K. (2021). MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design. Neurodegenerative disease management, 11(6), 431-443. https://doi.org/10.2217/nmt-2021-0042
Oskarsson, Björn, et al. "MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design." Neurodegenerative disease management vol. 11,6 (2021): 431-443. doi: https://doi.org/10.2217/nmt-2021-0042
Oskarsson B, Maragakis N, Bedlack RS, Goyal N, Meyer JA, Genge A, Bodkin C, Maiser S, Staff N, Zinman L, Olney N, Turnbull J, Brooks BR, Klonowski E, Makhay M, Yasui S, Matsuda K. MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design. Neurodegener Dis Manag. 2021 Dec;11(6):431-443. doi: 10.2217/nmt-2021-0042. Epub 2021 Nov 24. PMID: 34816762.
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Population Attributable Fraction of Anemia Associated with .

The American journal of tropical medicine and hygiene

Yimgang DP, Buchwald AG, Coalson JE, Walldorf JA, Bauleni A, Kapito-Tembo A, Mathanga DP, Taylor TE, Laufer MK, Cohee LM.
PMID: 33399043
Am J Trop Med Hyg. 2021 Jan 04; doi: 10.4269/ajtmh.20-1120. Epub 2021 Jan 04.

Anemia is a leading cause of morbidity in sub-Saharan Africa. The etiologies of anemia are multifactorial, and it is unclear what proportion of anemia is attributable to malaria in children of different ages in Malawi. We evaluated the population...

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Yimgang DP, Buchwald AG, Coalson JE, et al. Population Attributable Fraction of Anemia Associated with . Am J Trop Med Hyg. 2021;doi: 10.4269/ajtmh.20-1120.
Yimgang, D. P., Buchwald, A. G., Coalson, J. E., Walldorf, J. A., Bauleni, A., Kapito-Tembo, A., Mathanga, D. P., Taylor, T. E., Laufer, M. K., & Cohee, L. M. (2021). Population Attributable Fraction of Anemia Associated with . The American journal of tropical medicine and hygiene, . https://doi.org/10.4269/ajtmh.20-1120
Yimgang, Doris P, et al. "Population Attributable Fraction of Anemia Associated with ." The American journal of tropical medicine and hygiene vol. (2021). doi: https://doi.org/10.4269/ajtmh.20-1120
Yimgang DP, Buchwald AG, Coalson JE, Walldorf JA, Bauleni A, Kapito-Tembo A, Mathanga DP, Taylor TE, Laufer MK, Cohee LM. Population Attributable Fraction of Anemia Associated with . Am J Trop Med Hyg. 2021 Jan 04; doi: 10.4269/ajtmh.20-1120. Epub 2021 Jan 04. PMID: 33399043; PMCID: PMC7941802.
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Evaluation of immune stimulatory products for whiteleg shrimp (Penaeus vannamei) by a metabolomics approach.

Fish & shellfish immunology

Alfaro AC, Nguyen TV, Rodríguez JA, Bayot B, Domínguez-Borbor C, Sonnenholzner S, Azizan A, Venter L.
PMID: 34896292
Fish Shellfish Immunol. 2021 Dec 09;120:421-428. doi: 10.1016/j.fsi.2021.12.007. Epub 2021 Dec 09.

The use of probiotics, prebiotics and dietary fiber has become a common practice in shrimp aquaculture as alternatives to antibiotic treatment. However, not much is known about the metabolic mechanisms underlying the effects of probiotics and immunostimulant used in...

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Alfaro AC, Nguyen TV, Rodríguez JA, et al. Evaluation of immune stimulatory products for whiteleg shrimp (Penaeus vannamei) by a metabolomics approach. Fish Shellfish Immunol. 2021;120:421-428doi: 10.1016/j.fsi.2021.12.007.
Alfaro, A. C., Nguyen, T. V., Rodríguez, J. A., Bayot, B., Domínguez-Borbor, C., Sonnenholzner, S., Azizan, A., & Venter, L. (2021). Evaluation of immune stimulatory products for whiteleg shrimp (Penaeus vannamei) by a metabolomics approach. Fish & shellfish immunology, 120421-428. https://doi.org/10.1016/j.fsi.2021.12.007
Alfaro, Andrea C, et al. "Evaluation of immune stimulatory products for whiteleg shrimp (Penaeus vannamei) by a metabolomics approach." Fish & shellfish immunology vol. 120 (2021): 421-428. doi: https://doi.org/10.1016/j.fsi.2021.12.007
Alfaro AC, Nguyen TV, Rodríguez JA, Bayot B, Domínguez-Borbor C, Sonnenholzner S, Azizan A, Venter L. Evaluation of immune stimulatory products for whiteleg shrimp (Penaeus vannamei) by a metabolomics approach. Fish Shellfish Immunol. 2021 Dec 09;120:421-428. doi: 10.1016/j.fsi.2021.12.007. Epub 2021 Dec 09. PMID: 34896292.
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11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration.

JCI insight

Snaterse G, van Dessel LF, van Riet J, Taylor AE, van der Vlugt-Daane M, Hamberg P, de Wit R, Visser JA, Arlt W, Lolkema MP, Hofland J.
PMID: 33974560
JCI Insight. 2021 Jun 08;6(11). doi: 10.1172/jci.insight.148507.

BACKGROUNDContinued androgen receptor (AR) signaling constitutes a key target for treatment in metastatic castration-resistant prostate cancer (CRPC). Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically relevant concentrations...

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Snaterse G, van Dessel LF, van Riet J, et al. 11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration. JCI Insight. 2021;6(11)doi: 10.1172/jci.insight.148507.
Snaterse, G., van Dessel, L. F., van Riet, J., Taylor, A. E., van der Vlugt-Daane, M., Hamberg, P., de Wit, R., Visser, J. A., Arlt, W., Lolkema, M. P., & Hofland, J. (2021). 11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration. JCI insight, 6(11), . https://doi.org/10.1172/jci.insight.148507
Snaterse, Gido, et al. "11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration." JCI insight vol. 6,11 (2021). doi: https://doi.org/10.1172/jci.insight.148507
Snaterse G, van Dessel LF, van Riet J, Taylor AE, van der Vlugt-Daane M, Hamberg P, de Wit R, Visser JA, Arlt W, Lolkema MP, Hofland J. 11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration. JCI Insight. 2021 Jun 08;6(11). doi: 10.1172/jci.insight.148507. PMID: 33974560; PMCID: PMC8262344.
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Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.

Genes & development

Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J.
PMID: 34168038
Genes Dev. 2021 Jul 01;35(13):963-975. doi: 10.1101/gad.345629.120. Epub 2021 Jun 24.

Autophagy inhibitors are currently being evaluated in clinical trials for the treatment of diverse cancers, largely due to their ability to impede tumor cell survival and metabolic adaptation. More recently, there is growing interest in whether and how modulating...

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Rudnick JA, Monkkonen T, Mar FA, et al. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis. Genes Dev. 2021;35(13):963-975doi: 10.1101/gad.345629.120.
Rudnick, J. A., Monkkonen, T., Mar, F. A., Barnes, J. M., Starobinets, H., Goldsmith, J., Roy, S., Bustamante Eguiguren, S., Weaver, V. M., & Debnath, J. (2021). Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis. Genes & development, 35(13), 963-975. https://doi.org/10.1101/gad.345629.120
Rudnick, Jenny A, et al. "Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis." Genes & development vol. 35,13 (2021): 963-975. doi: https://doi.org/10.1101/gad.345629.120
Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis. Genes Dev. 2021 Jul 01;35(13):963-975. doi: 10.1101/gad.345629.120. Epub 2021 Jun 24. PMID: 34168038; PMCID: PMC8247603.
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Renaissance for Phage-Based Bacterial Control.

Environmental science & technology

Schwarz C, Mathieu J, Laverde Gomez JA, Yu P, Alvarez PJJ.
PMID: 34793127
Environ Sci Technol. 2021 Nov 18; doi: 10.1021/acs.est.1c06232. Epub 2021 Nov 18.

Bacteriophages (phages) are an underutilized biological resource with vast potential for pathogen control and microbiome editing. Phage research and commercialization have increased rapidly in biomedical and agricultural industries, but adoption has been limited elsewhere. Nevertheless, converging advances in DNA...

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Schwarz C, Mathieu J, Laverde Gomez JA, et al. Renaissance for Phage-Based Bacterial Control. Environ Sci Technol. 2021;doi: 10.1021/acs.est.1c06232.
Schwarz, C., Mathieu, J., Laverde Gomez, J. A., Yu, P., & Alvarez, P. J. J. (2021). Renaissance for Phage-Based Bacterial Control. Environmental science & technology, . https://doi.org/10.1021/acs.est.1c06232
Schwarz, Cory, et al. "Renaissance for Phage-Based Bacterial Control." Environmental science & technology vol. (2021). doi: https://doi.org/10.1021/acs.est.1c06232
Schwarz C, Mathieu J, Laverde Gomez JA, Yu P, Alvarez PJJ. Renaissance for Phage-Based Bacterial Control. Environ Sci Technol. 2021 Nov 18; doi: 10.1021/acs.est.1c06232. Epub 2021 Nov 18. PMID: 34793127.
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Raman Spectral Signatures of Serum-Derived Extracellular Vesicle-Enriched Isolates May Support the Diagnosis of CNS Tumors.

Cancers

Bukva M, Dobra G, Gomez-Perez J, Koos K, Harmati M, Gyukity-Sebestyen E, Biro T, Jenei A, Kormondi S, Horvath P, Konya Z, Klekner A, Buzas K.
PMID: 33808766
Cancers (Basel). 2021 Mar 19;13(6). doi: 10.3390/cancers13061407.

Investigating the molecular composition of small extracellular vesicles (sEVs) for tumor diagnostic purposes is becoming increasingly popular, especially for diseases for which diagnosis is challenging, such as central nervous system (CNS) malignancies. Thorough examination of the molecular content of...

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Bukva M, Dobra G, Gomez-Perez J, et al. Raman Spectral Signatures of Serum-Derived Extracellular Vesicle-Enriched Isolates May Support the Diagnosis of CNS Tumors. Cancers (Basel). 2021;13(6)doi: 10.3390/cancers13061407.
Bukva, M., Dobra, G., Gomez-Perez, J., Koos, K., Harmati, M., Gyukity-Sebestyen, E., Biro, T., Jenei, A., Kormondi, S., Horvath, P., Konya, Z., Klekner, A., & Buzas, K. (2021). Raman Spectral Signatures of Serum-Derived Extracellular Vesicle-Enriched Isolates May Support the Diagnosis of CNS Tumors. Cancers, 13(6), . https://doi.org/10.3390/cancers13061407
Bukva, Matyas, et al. "Raman Spectral Signatures of Serum-Derived Extracellular Vesicle-Enriched Isolates May Support the Diagnosis of CNS Tumors." Cancers vol. 13,6 (2021). doi: https://doi.org/10.3390/cancers13061407
Bukva M, Dobra G, Gomez-Perez J, Koos K, Harmati M, Gyukity-Sebestyen E, Biro T, Jenei A, Kormondi S, Horvath P, Konya Z, Klekner A, Buzas K. Raman Spectral Signatures of Serum-Derived Extracellular Vesicle-Enriched Isolates May Support the Diagnosis of CNS Tumors. Cancers (Basel). 2021 Mar 19;13(6). doi: 10.3390/cancers13061407. PMID: 33808766; PMCID: PMC8003579.
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Association Between Patients' Perceptions of the Sexual Acceptability of Contraceptive Methods and Continued Use Over Time.

JAMA internal medicine

Higgins JA, Kramer RD, Everett B, Wright KQ, Turok DK, Sanders JN.
PMID: 33900361
JAMA Intern Med. 2021 Jun 01;181(6):874-876. doi: 10.1001/jamainternmed.2021.1439.

No abstract available.

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Higgins JA, Kramer RD, Everett B, et al. Association Between Patients' Perceptions of the Sexual Acceptability of Contraceptive Methods and Continued Use Over Time. JAMA Intern Med. 2021;181(6):874-876doi: 10.1001/jamainternmed.2021.1439.
Higgins, J. A., Kramer, R. D., Everett, B., Wright, K. Q., Turok, D. K., & Sanders, J. N. (2021). Association Between Patients' Perceptions of the Sexual Acceptability of Contraceptive Methods and Continued Use Over Time. JAMA internal medicine, 181(6), 874-876. https://doi.org/10.1001/jamainternmed.2021.1439
Higgins, Jenny A, et al. "Association Between Patients' Perceptions of the Sexual Acceptability of Contraceptive Methods and Continued Use Over Time." JAMA internal medicine vol. 181,6 (2021): 874-876. doi: https://doi.org/10.1001/jamainternmed.2021.1439
Higgins JA, Kramer RD, Everett B, Wright KQ, Turok DK, Sanders JN. Association Between Patients' Perceptions of the Sexual Acceptability of Contraceptive Methods and Continued Use Over Time. JAMA Intern Med. 2021 Jun 01;181(6):874-876. doi: 10.1001/jamainternmed.2021.1439. PMID: 33900361; PMCID: PMC8077038.
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Personal Freedom and Social Responsibility in Slowing the Spread of COVID-19: A Rapid Qualitative Study.

Health education & behavior : the official publication of the Society for Public Health Education

Vázquez E, Chobdee J, Nasrollahzadeh N, Cheney A.
PMID: 34416843
Health Educ Behav. 2021 Aug 20;10901981211033241. doi: 10.1177/10901981211033241. Epub 2021 Aug 20.

This rapid qualitative exploratory study focused on perceptions of adopting risk-reduction measures, such as face masks, on campuses within institutions of higher education in the United States. It was intended to identify safety measures to reduce virus spread and...

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Vázquez E, Chobdee J, Nasrollahzadeh N, et al. Personal Freedom and Social Responsibility in Slowing the Spread of COVID-19: A Rapid Qualitative Study. Health Educ Behav. 2021;10901981211033241doi: 10.1177/10901981211033241.
Vázquez, E., Chobdee, J., Nasrollahzadeh, N., & Cheney, A. (2021). Personal Freedom and Social Responsibility in Slowing the Spread of COVID-19: A Rapid Qualitative Study. Health education & behavior : the official publication of the Society for Public Health Education, 10901981211033241. https://doi.org/10.1177/10901981211033241
Vázquez, Evelyn, et al. "Personal Freedom and Social Responsibility in Slowing the Spread of COVID-19: A Rapid Qualitative Study." Health education & behavior : the official publication of the Society for Public Health Education vol. (2021): 10901981211033241. doi: https://doi.org/10.1177/10901981211033241
Vázquez E, Chobdee J, Nasrollahzadeh N, Cheney A. Personal Freedom and Social Responsibility in Slowing the Spread of COVID-19: A Rapid Qualitative Study. Health Educ Behav. 2021 Aug 20;10901981211033241. doi: 10.1177/10901981211033241. Epub 2021 Aug 20. PMID: 34416843; PMCID: PMC8381218.
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Duration on ART, Alcohol Use and HIV Stage May Predict Risky Sexual Behavior in a Resource-limited Environment: A Cross-sectional Study.

Current HIV research

New-Aaron M, Kingi H, Meza JL, Goedert MH, Kibusi SM, Mkhoi ML, Mayengo CD, Charles J, Shabani S, New-Aaron TO, Sumba S, Cheney A.
PMID: 34313200
Curr HIV Res. 2021;19(5):420-433. doi: 10.2174/1570162X19666210726102027.

BACKGROUND: The intention of antiretroviral therapy (ART) and regular clinic visits are to engender safe sex attitudes among HIV-infected individuals. However, this may not be the case due to the perceived therapeutic benefits of ART and may result in...

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New-Aaron M, Kingi H, Meza JL, et al. Duration on ART, Alcohol Use and HIV Stage May Predict Risky Sexual Behavior in a Resource-limited Environment: A Cross-sectional Study. Curr HIV Res. 2021;19(5):420-433doi: 10.2174/1570162X19666210726102027.
New-Aaron, M., Kingi, H., Meza, J. L., Goedert, M. H., Kibusi, S. M., Mkhoi, M. L., Mayengo, C. D., Charles, J., Shabani, S., New-Aaron, T. O., Sumba, S., & Cheney, A. (2021). Duration on ART, Alcohol Use and HIV Stage May Predict Risky Sexual Behavior in a Resource-limited Environment: A Cross-sectional Study. Current HIV research, 19(5), 420-433. https://doi.org/10.2174/1570162X19666210726102027
New-Aaron, Moses, et al. "Duration on ART, Alcohol Use and HIV Stage May Predict Risky Sexual Behavior in a Resource-limited Environment: A Cross-sectional Study." Current HIV research vol. 19,5 (2021): 420-433. doi: https://doi.org/10.2174/1570162X19666210726102027
New-Aaron M, Kingi H, Meza JL, Goedert MH, Kibusi SM, Mkhoi ML, Mayengo CD, Charles J, Shabani S, New-Aaron TO, Sumba S, Cheney A. Duration on ART, Alcohol Use and HIV Stage May Predict Risky Sexual Behavior in a Resource-limited Environment: A Cross-sectional Study. Curr HIV Res. 2021;19(5):420-433. doi: 10.2174/1570162X19666210726102027. PMID: 34313200.
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Strengths-based career counseling: Overview and initial evaluation.

Littman-Ovadia Hadassah, Lazar-Butbul Vered, Benjamin BennyA.
UIID-AD: 1891
2014;22:403-419. doi: 10.1177/1069072713498483.

This study implemented an innovative model of individual Strengths-Based Career Counseling (SBCC), as carried out by vocational counseling psychologists, and measured its impact on unemployed job seekers. As part of a quasi-randomized pre–post intervention study, career counseling clients completed...

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Littman-Ovadia Hadassah, Lazar-Butbul Vered, Benjamin BennyA. Strengths-based career counseling: Overview and initial evaluation. 2014;22:403-419doi: 10.1177/1069072713498483.
Littman-Ovadia, H. a. d. a. s. s. a. h., Lazar-Butbul, V. e. r. e. d., & Benjamin, B. e. n. n. y. A. (2014). Strengths-based career counseling: Overview and initial evaluation. 22403-419. https://doi.org/10.1177/1069072713498483
Littman-Ovadia, Hadassah, et al. "Strengths-based career counseling: Overview and initial evaluation." vol. 22 (2014): 403-419. doi: https://doi.org/10.1177/1069072713498483
Littman-Ovadia Hadassah, Lazar-Butbul Vered, Benjamin BennyA. Strengths-based career counseling: Overview and initial evaluation. 2014;22:403-419. doi: 10.1177/1069072713498483. UIID-AD: 1891.
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