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High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice.

Diabetology & metabolic syndrome

Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T.
PMID: 26097511
Diabetol Metab Syndr. 2015 Jun 02;7:50. doi: 10.1186/s13098-015-0047-y. eCollection 2015.

BACKGROUND: DPP-4 inhibitors reportedly exert effects on both alpha and beta cells, and promote the proliferation and survival of beta cells. We investigated the effects of anagliptin on structurally-impaired islets of Langerhans in streptozotocin (STZ)-treated mice, fed either a...

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Shinjo T, Nakatsu Y, Iwashita M, et al. High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice. Diabetol Metab Syndr. 2015;7:50doi: 10.1186/s13098-015-0047-y.
Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Nishimura, F., & Asano, T. (2015). High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice. Diabetology & metabolic syndrome, 750. https://doi.org/10.1186/s13098-015-0047-y
Shinjo, Takanori, et al. "High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice." Diabetology & metabolic syndrome vol. 7 (2015): 50. doi: https://doi.org/10.1186/s13098-015-0047-y
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T. High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice. Diabetol Metab Syndr. 2015 Jun 02;7:50. doi: 10.1186/s13098-015-0047-y. eCollection 2015. PMID: 26097511; PMCID: PMC4475295.
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An improved method for western blotting when extracting proteins from mammalian cells cultured on a collagen gel under serum-free conditions.

Cytotechnology

Ishihara S, Mizutani T, Kawabata K, Haga H.
PMID: 25005915
Cytotechnology. 2016 Jan;68(1):25-32. doi: 10.1007/s10616-014-9766-4. Epub 2014 Jul 09.

Western blotting is a widely used method for detection and quantification of specific proteins extracted from mammalian cells. In the conventional method of protein extraction, we found that collagen-containing gels interfered with detection of the p65 protein (one of...

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Ishihara S, Mizutani T, Kawabata K, et al. An improved method for western blotting when extracting proteins from mammalian cells cultured on a collagen gel under serum-free conditions. Cytotechnology. 2014;68(1):25-32doi: 10.1007/s10616-014-9766-4.
Ishihara, S., Mizutani, T., Kawabata, K., & Haga, H. (2016). An improved method for western blotting when extracting proteins from mammalian cells cultured on a collagen gel under serum-free conditions. Cytotechnology, 68(1), 25-32. https://doi.org/10.1007/s10616-014-9766-4
Ishihara, Seiichiro, et al. "An improved method for western blotting when extracting proteins from mammalian cells cultured on a collagen gel under serum-free conditions." Cytotechnology vol. 68,1 (2016): 25-32. doi: https://doi.org/10.1007/s10616-014-9766-4
Ishihara S, Mizutani T, Kawabata K, Haga H. An improved method for western blotting when extracting proteins from mammalian cells cultured on a collagen gel under serum-free conditions. Cytotechnology. 2016 Jan;68(1):25-32. doi: 10.1007/s10616-014-9766-4. Epub 2014 Jul 09. PMID: 25005915; PMCID: PMC4698262.
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Isolated Superior Mesenteric Artery Dissection with Small Intestine Ischemia.

Case reports in gastroenterology

Aimi M, Amano C, Yoshida R, Matsubara T, Mikami H, Izumi D, Okimoto E, Ishimura N, Ishihara S, Kinoshita Y.
PMID: 26600771
Case Rep Gastroenterol. 2015 Oct 21;9(3):341-6. doi: 10.1159/000441384. eCollection 2015.

Superior mesenteric artery (SMA) dissection without aortic dissection is a rare condition, and its diagnosis is considered to be difficult. Intestinal infarction is a severe complication of the disease, which may require resection of the intestine. We present a...

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Aimi M, Amano C, Yoshida R, et al. Isolated Superior Mesenteric Artery Dissection with Small Intestine Ischemia. Case Rep Gastroenterol. 2015;9(3):341-6doi: 10.1159/000441384.
Aimi, M., Amano, C., Yoshida, R., Matsubara, T., Mikami, H., Izumi, D., Okimoto, E., Ishimura, N., Ishihara, S., & Kinoshita, Y. (2015). Isolated Superior Mesenteric Artery Dissection with Small Intestine Ischemia. Case reports in gastroenterology, 9(3), 341-6. https://doi.org/10.1159/000441384
Aimi, Masahito, et al. "Isolated Superior Mesenteric Artery Dissection with Small Intestine Ischemia." Case reports in gastroenterology vol. 9,3 (2015): 341-6. doi: https://doi.org/10.1159/000441384
Aimi M, Amano C, Yoshida R, Matsubara T, Mikami H, Izumi D, Okimoto E, Ishimura N, Ishihara S, Kinoshita Y. Isolated Superior Mesenteric Artery Dissection with Small Intestine Ischemia. Case Rep Gastroenterol. 2015 Oct 21;9(3):341-6. doi: 10.1159/000441384. eCollection 2015. PMID: 26600771; PMCID: PMC4649733.
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Effect on blood pressure of daily lemon ingestion and walking.

Journal of nutrition and metabolism

Kato Y, Domoto T, Hiramitsu M, Katagiri T, Sato K, Miyake Y, Aoi S, Ishihara K, Ikeda H, Umei N, Takigawa A, Harada T.
PMID: 24818015
J Nutr Metab. 2014;2014:912684. doi: 10.1155/2014/912684. Epub 2014 Apr 10.

Background. Recent studies suggest that the daily intake of lemon (Citrus limon) has a good effect on health, but this has not been confirmed in humans. In our previous studies, it was observed that people who are conscious of...

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Kato Y, Domoto T, Hiramitsu M, et al. Effect on blood pressure of daily lemon ingestion and walking. J Nutr Metab. 2014;2014:912684doi: 10.1155/2014/912684.
Kato, Y., Domoto, T., Hiramitsu, M., Katagiri, T., Sato, K., Miyake, Y., Aoi, S., Ishihara, K., Ikeda, H., Umei, N., Takigawa, A., & Harada, T. (2014). Effect on blood pressure of daily lemon ingestion and walking. Journal of nutrition and metabolism, 2014912684. https://doi.org/10.1155/2014/912684
Kato, Yoji, et al. "Effect on blood pressure of daily lemon ingestion and walking." Journal of nutrition and metabolism vol. 2014 (2014): 912684. doi: https://doi.org/10.1155/2014/912684
Kato Y, Domoto T, Hiramitsu M, Katagiri T, Sato K, Miyake Y, Aoi S, Ishihara K, Ikeda H, Umei N, Takigawa A, Harada T. Effect on blood pressure of daily lemon ingestion and walking. J Nutr Metab. 2014;2014:912684. doi: 10.1155/2014/912684. Epub 2014 Apr 10. PMID: 24818015; PMCID: PMC4003767.
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Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon-fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols.

Chemical communications (Cambridge, England)

Nihei T, Yokotani S, Ishihara T, Konno T.
PMID: 24382421
Chem Commun (Camb). 2014 Feb 14;50(13):1543-5. doi: 10.1039/c3cc47219a.

Highly nucleophilic (Z)- or (E)-α-fluoroalkenylchromium species could be generated in a stereoselective manner via C-F bond activation of CBrF2-containing molecules, and they reacted smoothly with various aldehydes to give (E)- or (Z)-β-fluoroallylic alcohol derivatives in high yields, respectively.

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Nihei T, Yokotani S, Ishihara T, et al. Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon-fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols. Chem Commun (Camb). 2014;50(13):1543-5doi: 10.1039/c3cc47219a.
Nihei, T., Yokotani, S., Ishihara, T., & Konno, T. (2014). Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon-fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols. Chemical communications (Cambridge, England), 50(13), 1543-5. https://doi.org/10.1039/c3cc47219a
Nihei, Takashi, et al. "Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon-fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols." Chemical communications (Cambridge, England) vol. 50,13 (2014): 1543-5. doi: https://doi.org/10.1039/c3cc47219a
Nihei T, Yokotani S, Ishihara T, Konno T. Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon-fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols. Chem Commun (Camb). 2014 Feb 14;50(13):1543-5. doi: 10.1039/c3cc47219a. PMID: 24382421.
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Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes.

World journal of gastrointestinal oncology

Yamaguchi H, Kitayama J, Ishigami H, Kazama S, Nozawa H, Kawai K, Hata K, Kiyomatsu T, Tanaka T, Tanaka J, Nishikawa T, Otani K, Yasuda K, Ishihara S, Sunami E, Watanabe T.
PMID: 26600928
World J Gastrointest Oncol. 2015 Nov 15;7(11):285-91. doi: 10.4251/wjgo.v7.i11.285.

The effect of chemotherapy on peritoneal carcinomatosis (PC) of gastric cancer remains unclear. Recently, the intraperitoneal (IP) administration of taxanes [e.g., paclitaxel (PTX) and docetaxel (DOC)] during the perioperative period has shown promising results. Herein, we summarized the rationale...

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Yamaguchi H, Kitayama J, Ishigami H, et al. Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes. World J Gastrointest Oncol. 2015;7(11):285-91doi: 10.4251/wjgo.v7.i11.285.
Yamaguchi, H., Kitayama, J., Ishigami, H., Kazama, S., Nozawa, H., Kawai, K., Hata, K., Kiyomatsu, T., Tanaka, T., Tanaka, J., Nishikawa, T., Otani, K., Yasuda, K., Ishihara, S., Sunami, E., & Watanabe, T. (2015). Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes. World journal of gastrointestinal oncology, 7(11), 285-91. https://doi.org/10.4251/wjgo.v7.i11.285
Yamaguchi, Hironori, et al. "Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes." World journal of gastrointestinal oncology vol. 7,11 (2015): 285-91. doi: https://doi.org/10.4251/wjgo.v7.i11.285
Yamaguchi H, Kitayama J, Ishigami H, Kazama S, Nozawa H, Kawai K, Hata K, Kiyomatsu T, Tanaka T, Tanaka J, Nishikawa T, Otani K, Yasuda K, Ishihara S, Sunami E, Watanabe T. Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes. World J Gastrointest Oncol. 2015 Nov 15;7(11):285-91. doi: 10.4251/wjgo.v7.i11.285. PMID: 26600928; PMCID: PMC4644851.
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A case of curable dementia treated by effective endovascular embolization for dural arteriovenous fistula.

Case reports in neurology

Yoshihara T, Kanazawa R, Maeshima S, Osawa A, Ochiai I, Uemiya N, Kohyama S, Yamane F, Ishihara S.
PMID: 24847255
Case Rep Neurol. 2014 Apr 16;6(1):116-21. doi: 10.1159/000362515. eCollection 2014 Jan.

BACKGROUND: We report a case in which an effective endovascular treatment cured the worsening of dementia due to a dural arteriovenous fistula (dAVF).CASE REPORT: A 73-year-old woman suffered for 1.5 years from gait disturbance and disorientation that were suspicious...

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Yoshihara T, Kanazawa R, Maeshima S, et al. A case of curable dementia treated by effective endovascular embolization for dural arteriovenous fistula. Case Rep Neurol. 2014;6(1):116-21doi: 10.1159/000362515.
Yoshihara, T., Kanazawa, R., Maeshima, S., Osawa, A., Ochiai, I., Uemiya, N., Kohyama, S., Yamane, F., & Ishihara, S. (2014). A case of curable dementia treated by effective endovascular embolization for dural arteriovenous fistula. Case reports in neurology, 6(1), 116-21. https://doi.org/10.1159/000362515
Yoshihara, Tomoyuki, et al. "A case of curable dementia treated by effective endovascular embolization for dural arteriovenous fistula." Case reports in neurology vol. 6,1 (2014): 116-21. doi: https://doi.org/10.1159/000362515
Yoshihara T, Kanazawa R, Maeshima S, Osawa A, Ochiai I, Uemiya N, Kohyama S, Yamane F, Ishihara S. A case of curable dementia treated by effective endovascular embolization for dural arteriovenous fistula. Case Rep Neurol. 2014 Apr 16;6(1):116-21. doi: 10.1159/000362515. eCollection 2014 Jan. PMID: 24847255; PMCID: PMC4025157.
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C-selective and diastereoselective alkyl addition to β,γ-alkynyl-α-imino esters with zinc(II)ate complexes.

Angewandte Chemie (International ed. in English)

Hatano M, Yamashita K, Mizuno M, Ito O, Ishihara K.
PMID: 25598353
Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2707-11. doi: 10.1002/anie.201408916. Epub 2015 Jan 16.

Since umpolung α-imino esters contain three electrophilic centers, regioselective alkyl addition with traditional organometallic reagents has been a serious problem in the practical synthesis of versatile chiral α-amino acid derivatives. An unusual C-alkyl addition to α-imino esters using a...

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Hatano M, Yamashita K, Mizuno M, et al. C-selective and diastereoselective alkyl addition to β,γ-alkynyl-α-imino esters with zinc(II)ate complexes. Angew Chem Int Ed Engl. 2015;54(9):2707-11doi: 10.1002/anie.201408916.
Hatano, M., Yamashita, K., Mizuno, M., Ito, O., & Ishihara, K. (2015). C-selective and diastereoselective alkyl addition to β,γ-alkynyl-α-imino esters with zinc(II)ate complexes. Angewandte Chemie (International ed. in English), 54(9), 2707-11. https://doi.org/10.1002/anie.201408916
Hatano, Manabu, et al. "C-selective and diastereoselective alkyl addition to β,γ-alkynyl-α-imino esters with zinc(II)ate complexes." Angewandte Chemie (International ed. in English) vol. 54,9 (2015): 2707-11. doi: https://doi.org/10.1002/anie.201408916
Hatano M, Yamashita K, Mizuno M, Ito O, Ishihara K. C-selective and diastereoselective alkyl addition to β,γ-alkynyl-α-imino esters with zinc(II)ate complexes. Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2707-11. doi: 10.1002/anie.201408916. Epub 2015 Jan 16. PMID: 25598353.
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Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers.

Journal of neurogastroenterology and motility

Mikami H, Ishimura N, Fukazawa K, Okada M, Izumi D, Shimura S, Okimoto E, Aimi M, Ishihara S, Kinoshita Y.
PMID: 26507875
J Neurogastroenterol Motil. 2016 Jan 31;22(1):112-7. doi: 10.5056/jnm15130.

BACKGROUND/AIMS: Prokinetic drugs such as metoclopramide are frequently used as second-line therapy for patients with gastroesophageal reflux disease. However, their beneficial effects remain unclear. Esophageal motor activities and compliance of the esophagogastric junction (EGJ) are important for prevention of...

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Mikami H, Ishimura N, Fukazawa K, et al. Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers. J Neurogastroenterol Motil. 2016;22(1):112-7doi: 10.5056/jnm15130.
Mikami, H., Ishimura, N., Fukazawa, K., Okada, M., Izumi, D., Shimura, S., Okimoto, E., Aimi, M., Ishihara, S., & Kinoshita, Y. (2016). Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers. Journal of neurogastroenterology and motility, 22(1), 112-7. https://doi.org/10.5056/jnm15130
Mikami, Hironobu, et al. "Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers." Journal of neurogastroenterology and motility vol. 22,1 (2016): 112-7. doi: https://doi.org/10.5056/jnm15130
Mikami H, Ishimura N, Fukazawa K, Okada M, Izumi D, Shimura S, Okimoto E, Aimi M, Ishihara S, Kinoshita Y. Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers. J Neurogastroenterol Motil. 2016 Jan 31;22(1):112-7. doi: 10.5056/jnm15130. PMID: 26507875; PMCID: PMC4699728.
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Cirrhosis-related hyponatremia and the role of tolvaptan.

Hepatology research : the official journal of the Japan Society of Hepatology

Iwasa M, Ishihara T, Hasegawa H, Takei Y.
PMID: 26510649
Hepatol Res. 2015 Oct;45(10):E163-5. doi: 10.1111/hepr.12471.

No abstract available.

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Iwasa M, Ishihara T, Hasegawa H, et al. Cirrhosis-related hyponatremia and the role of tolvaptan. Hepatol Res. 2015;45(10):E163-5doi: 10.1111/hepr.12471.
Iwasa, M., Ishihara, T., Hasegawa, H., & Takei, Y. (2015). Cirrhosis-related hyponatremia and the role of tolvaptan. Hepatology research : the official journal of the Japan Society of Hepatology, 45(10), E163-5. https://doi.org/10.1111/hepr.12471
Iwasa, Motoh, et al. "Cirrhosis-related hyponatremia and the role of tolvaptan." Hepatology research : the official journal of the Japan Society of Hepatology vol. 45,10 (2015): E163-5. doi: https://doi.org/10.1111/hepr.12471
Iwasa M, Ishihara T, Hasegawa H, Takei Y. Cirrhosis-related hyponatremia and the role of tolvaptan. Hepatol Res. 2015 Oct;45(10):E163-5. doi: 10.1111/hepr.12471. PMID: 26510649.
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Effect of nutrient starvation on proliferation and cytokine secretion of peripheral blood lymphocytes.

Molecular and clinical oncology

Ota Y, Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T.
PMID: 27073674
Mol Clin Oncol. 2016 Apr;4(4):607-610. doi: 10.3892/mco.2016.763. Epub 2016 Feb 03.

Proliferating cancer cells are exposed to nutrient deprivation. Numerous previous studies have demonstrated how nutrient deprivation affects cancer cells; however, immune cells exposed to the identical conditions have not been completely examined. Furthermore, T-helper 2 lymphocyte predominance in certain...

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Ota Y, Ishihara S, Otani K, et al. Effect of nutrient starvation on proliferation and cytokine secretion of peripheral blood lymphocytes. Mol Clin Oncol. 2016;4(4):607-610doi: 10.3892/mco.2016.763.
Ota, Y., Ishihara, S., Otani, K., Yasuda, K., Nishikawa, T., Tanaka, T., Tanaka, J., Kiyomatsu, T., Kawai, K., Hata, K., Nozawa, H., Kazama, S., Yamaguchi, H., Sunami, E., Kitayama, J., & Watanabe, T. (2016). Effect of nutrient starvation on proliferation and cytokine secretion of peripheral blood lymphocytes. Molecular and clinical oncology, 4(4), 607-610. https://doi.org/10.3892/mco.2016.763
Ota, Yoshiko, et al. "Effect of nutrient starvation on proliferation and cytokine secretion of peripheral blood lymphocytes." Molecular and clinical oncology vol. 4,4 (2016): 607-610. doi: https://doi.org/10.3892/mco.2016.763
Ota Y, Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T. Effect of nutrient starvation on proliferation and cytokine secretion of peripheral blood lymphocytes. Mol Clin Oncol. 2016 Apr;4(4):607-610. doi: 10.3892/mco.2016.763. Epub 2016 Feb 03. PMID: 27073674; PMCID: PMC4812150.
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Reactions of community members regarding community health workers' activities as a measure of the impact of a training program in Amazonas, Brazil.

Journal of rural medicine : JRM

Kawasaki R, Sadamori T, Ferreira de Almeida T, Akiyoshi M, Nishihara M, Yoshimura T, Ohnishi M.
PMID: 26380586
J Rural Med. 2015;10(1):7-19. doi: 10.2185/jrm.2890. Epub 2014 Dec 06.

OBJECTIVES: The aim of this study was to evaluate the impact of community health worker (CHW) training on recognition and satisfaction regarding the performance of CHWs among members of the community in Amazonas, Brazil, which is a resource-poor area...

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Kawasaki R, Sadamori T, Ferreira de Almeida T, et al. Reactions of community members regarding community health workers' activities as a measure of the impact of a training program in Amazonas, Brazil. J Rural Med. 2014;10(1):7-19doi: 10.2185/jrm.2890.
Kawasaki, R., Sadamori, T., Ferreira de Almeida, T., Akiyoshi, M., Nishihara, M., Yoshimura, T., & Ohnishi, M. (2015). Reactions of community members regarding community health workers' activities as a measure of the impact of a training program in Amazonas, Brazil. Journal of rural medicine : JRM, 10(1), 7-19. https://doi.org/10.2185/jrm.2890
Kawasaki, Ryoko, et al. "Reactions of community members regarding community health workers' activities as a measure of the impact of a training program in Amazonas, Brazil." Journal of rural medicine : JRM vol. 10,1 (2015): 7-19. doi: https://doi.org/10.2185/jrm.2890
Kawasaki R, Sadamori T, Ferreira de Almeida T, Akiyoshi M, Nishihara M, Yoshimura T, Ohnishi M. Reactions of community members regarding community health workers' activities as a measure of the impact of a training program in Amazonas, Brazil. J Rural Med. 2015;10(1):7-19. doi: 10.2185/jrm.2890. Epub 2014 Dec 06. PMID: 26380586; PMCID: PMC4571745.
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