Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 2137 to 2148 of 2167 entries
Sorted by: Best Match Show Resources per page
Impact of health literacy in patients with cardiovascular diseases: A systematic review and meta-analysis.

Patient education and counseling

Kanejima Y, Shimogai T, Kitamura M, Ishihara K, Izawa KP.
PMID: 34862114
Patient Educ Couns. 2021 Nov 27; doi: 10.1016/j.pec.2021.11.021. Epub 2021 Nov 27.

OBJECTIVE: To clarify the impacts of health literacy on mortality, readmission, and quality of life (QOL) in the secondary or tertiary prevention of cardiovascular diseases (CVD) through a meta-analysis.METHODS: Six electronic databases were searched on June 11, 2020. Observational...

Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs.

Drug metabolism and pharmacokinetics

Suzuki Y, Ishihara H.
PMID: 34757287
Drug Metab Pharmacokinet. 2021 Oct 10;41:100424. doi: 10.1016/j.dmpk.2021.100424. Epub 2021 Oct 10.

Nucleic acid therapeutics are developing into precise medicines that can manipulate specific genes. However, the development of safe and effective delivery system for the target cells has remained a challenge. Lipid nanoparticles (LNPs) have provided a revolutionary delivery system...

A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins.

Biochemical pharmacology

Segawa R, Takeda H, Yokoyama T, Ishida M, Miyata C, Saito T, Ishihara R, Nakagita T, Sasano Y, Kanoh N, Iwabuchi Y, Mizuguchi M, Hiratsuka M, Hirasawa N.
PMID: 34757034
Biochem Pharmacol. 2021 Dec;194:114819. doi: 10.1016/j.bcp.2021.114819. Epub 2021 Oct 30.

Although treatments for allergic diseases have improved, side effects and treatment resistance remain as challenges. New therapeutic drugs for allergic diseases are urgently required. Thymic stromal lymphopoietin (TSLP) is a cytokine target for prevention and treatment of allergic diseases....

Effect of Specimen Thickness and Stress Intensity Factor Range on Plasticity-Induced Fatigue Crack Closure in A7075-T6 Alloy.

Materials (Basel, Switzerland)

Masuda K, Ishihara S, Oguma N.
PMID: 33572686
Materials (Basel). 2021 Jan 31;14(3). doi: 10.3390/ma14030664.

Fatigue crack growth experiments are performed using A7075-T6 compact tension (CT) specimens with various thicknesses

Synthesis of Highly Biocompatible and Temperature-Responsive Physical Gels for Cryopreservation and 3D Cell Culture.

ACS applied bio materials

Nagao M, Sengupta J, Diaz-Dussan D, Adam M, Wu M, Acker J, Ben R, Ishihara K, Zeng H, Miura Y, Narain R.
PMID: 35016379
ACS Appl Bio Mater. 2018 Aug 20;1(2):356-366. doi: 10.1021/acsabm.8b00096. Epub 2018 Jul 20.

There is considerable interest in the cryopreservation in 3D cell culture, as structurally preserving intact cells and tissues is critical in utilizing these systems to promote cell differentiation and tissue organization. Temperature-responsive physical gels and zwitterionic polymers are useful...

Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome.

Leukemia

Yoshino S, Tanaka M, Sunami Y, Takahara T, Yamazaki Y, Homme M, Niibori-Nambu A, Osato M, Minami T, Ishihara K, Nakamura T.
PMID: 34381180
Leukemia. 2021 Aug 11; doi: 10.1038/s41375-021-01384-1. Epub 2021 Aug 11.

No abstract available.

γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis.

Cancer gene therapy

Taniguchi K, Kageyama S, Moyama C, Ando S, Ii H, Ashihara E, Horinaka M, Sakai T, Kubota S, Kawauchi A, Nakata S.
PMID: 33402732
Cancer Gene Ther. 2022 Jan;29(1):37-48. doi: 10.1038/s41417-020-00287-0. Epub 2021 Jan 05.

Metabolic reprogramming leading to aerobic glycolysis, termed the "Warburg effect," is a critical property of cancer cells. However, the precise mechanisms underlying this phenomenon are not fully understood. A growing body of evidence indicates that γ-glutamylcyclotransferase (GGCT), an enzyme...

Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs.

Drug metabolism and pharmacokinetics

Suzuki Y, Ishihara H.
PMID: 34757287
Drug Metab Pharmacokinet. 2021 Dec;41:100424. doi: 10.1016/j.dmpk.2021.100424. Epub 2021 Oct 10.

Nucleic acid therapeutics are developing into precise medicines that can manipulate specific genes. However, the development of safe and effective delivery system for the target cells has remained a challenge. Lipid nanoparticles (LNPs) have provided a revolutionary delivery system...

Clinical significance of CD8.

Molecular and clinical oncology

Harada Y, Kazama S, Morikawa T, Sonoda H, Ishi H, Emoto S, Murono K, Kaneko M, Sasaki K, Shuno Y, Nishikawa T, Tanaka T, Kawai K, Hata K, Nozawa H, Ushiku T, Tahara H, Ishihara S.
PMID: 33767856
Mol Clin Oncol. 2021 May;14(5):87. doi: 10.3892/mco.2021.2249. Epub 2021 Mar 05.

Preoperative chemoradiotherapy (CRT) for rectal cancer contributes to tumor down-staging and decreases locoregional recurrence. However, each patient shows a significantly different response to CRT. Therefore, the identification of predictive factors to CRT response would be beneficial to avoid unnecessary...

Genetic mapping identifies a rice naringenin O-glucosyltransferase that influences insect resistance.

The Plant journal : for cell and molecular biology

Yang Z, Li N, Kitano T, Li P, Spindel JE, Wang L, Bai G, Xiao Y, McCouch SR, Ishihara A, Zhang J, Yang X, Chen Z, Wei J, Ge H, Jander G, Yan J.
PMID: 33745166
Plant J. 2021 Jun;106(5):1401-1413. doi: 10.1111/tpj.15244. Epub 2021 Apr 17.

Naringenin, the biochemical precursor for predominant flavonoids in grasses, provides protection against UV damage, pathogen infection and insect feeding. To identify previously unknown loci influencing naringenin accumulation in rice (Oryza sativa), recombinant inbred lines derived from the Nipponbare and...

Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hannan R, Mohamad O, Diaz de Leon A, Manna S, Pop LM, Zhang Z, Mannala S, Christie A, Christley S, Monson N, Ishihara D, Hsu EJ, Ahn C, Kapur P, Chen M, Arriaga Y, Courtney K, Cantarel B, Wakeland EK, Fu YX, Pedrosa I, Cowell L, Wang T, Margulis V, Choy H, Timmerman RD, Brugarolas J.
PMID: 34551906
Clin Cancer Res. 2021 Dec 15;27(24):6716-6725. doi: 10.1158/1078-0432.CCR-21-2083. Epub 2021 Sep 22.

PURPOSE: This phase II clinical trial evaluated whether the addition of stereotactic ablative radiotherapy (SAbR), which may promote tumor antigen presentation, improves the overall response rate (ORR) to high-dose IL2 (HD IL2) in metastatic renal cell carcinoma (mRCC).PATIENTS AND...

Separation from a bonded partner alters neural response to inflammatory pain in monogamous rodents.

Behavioural brain research

Okuda T, Osako Y, Hidaka C, Nishihara M, Young LJ, Mitsui S, Yuri K.
PMID: 34748865
Behav Brain Res. 2022 Feb 10;418:113650. doi: 10.1016/j.bbr.2021.113650. Epub 2021 Nov 05.

Pain experience is known to be modified by social factors, but the brain mechanisms remain unspecified. We recently established an animal model of social stress-induced hyperalgesia (SSIH) using a socially monogamous rodent, the prairie vole, in which males separated...

Showing 2137 to 2148 of 2167 entries