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Showing 781 to 786 of 786 entries
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Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus.

Neurobiology of aging

Rajabli F, Feliciano-Astacio BE, Cukier HN, Wang L, Griswold AJ, Hamilton-Nelson KL, Adams LD, Rodriguez VC, Mena PR, Tejada S, Celis K, Whitehead PL, Van Booven DJ, Hofmann NK, Bussies PL, Prough M, Chinea A, Feliciano NI, Vardarajan BN, Reitz C, Lee JH, Prince MJ, Jimenez IZ, Mayeux RP, Acosta H, Dalgard CL, Haines JL, Vance JM, Cuccaro ML, Beecham GW, Pericak-Vance MA.
PMID: 33902942
Neurobiol Aging. 2021 Aug;104:115.e1-115.e7. doi: 10.1016/j.neurobiolaging.2021.02.019. Epub 2021 Feb 28.

The genetic admixture of Caribbean Hispanics provides an opportunity to discover novel genetic factors in Alzheimer disease (AD). We sought to identify genetic variants for AD through a family-based design using the Puerto Rican (PR) Alzheimer Disease Initiative (PRADI)....

Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality.

Scientific reports

Ocskay K, Vinkó Z, Németh D, Szabó L, Bajor J, Gódi S, Sarlós P, Czakó L, Izbéki F, Hamvas J, Papp M, Varga M, Török I, Mickevicius A, Sallinen V, Maldonado ER, Galeev S, Mikó A, Erőss B, Imrei M, Hegyi PJ, Faluhelyi N, Farkas O, Kanizsai P, Miseta A, Nagy T, Hágendorn R, Márton Z, Szakács Z, Szentesi A, Hegyi P, Párniczky A.
PMID: 34921151
Sci Rep. 2021 Dec 17;11(1):24158. doi: 10.1038/s41598-021-03449-8.

The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin...

Increased Prevalence of Celiac Disease in Patients with Cystic Fibrosis: A Systematic Review and Meta-Analysis.

Journal of personalized medicine

Imrei M, Németh D, Szakács Z, Hegyi P, Kiss S, Alizadeh H, Dembrovszky F, Pázmány P, Bajor J, Párniczky A.
PMID: 34575636
J Pers Med. 2021 Aug 28;11(9). doi: 10.3390/jpm11090859.

OBJECTIVES: Immune regulation seems to be altered in cystic fibrosis (CF), thus potentially predisposing patients to developing autoimmune diseases (AID). In this meta-analysis, we aimed to evaluate the prevalence of celiac disease (CeD) among CF patients as by far...

Indirect standardization for rare events and a dynamic standard population rate: An analysis and simulation of U.S. military suicide mortality rates.

Suicide & life-threatening behavior

Smolenski DJ, Balcena PP, Tucker J, Curry JC.
PMID: 34415634
Suicide Life Threat Behav. 2021 Dec;51(6):1159-1174. doi: 10.1111/sltb.12798. Epub 2021 Aug 20.

INTRODUCTION: Comparing suicide mortality rates between the U.S. military and U.S. general populations is common in lay and professional literature. Standardization is required for this comparison to account for differences in the population structure, but small event counts complicate...

Identification of Proteins Deregulated by Platinum-Based Chemotherapy as Novel Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer.

Frontiers in oncology

Ryan SL, Dave KA, Beard S, Gyimesi M, McTaggart M, Sahin KB, Molloy C, Gandhi NS, Boittier E, O'Leary CG, Shah ET, Bolderson E, Baird AM, Richard DJ, O'Byrne KJ, Adams MN.
PMID: 33777753
Front Oncol. 2021 Mar 11;11:615967. doi: 10.3389/fonc.2021.615967. eCollection 2021.

Platinum-based chemotherapy remains the cornerstone of treatment for most people with non-small cell lung cancer (NSCLC), either as adjuvant therapy in combination with a second cytotoxic agent or in combination with immunotherapy. Resistance to therapy, either in the form...

Tumor Hypoxia Drives Genomic Instability.

Frontiers in cell and developmental biology

Tang M, Bolderson E, O'Byrne KJ, Richard DJ.
PMID: 33796526
Front Cell Dev Biol. 2021 Mar 16;9:626229. doi: 10.3389/fcell.2021.626229. eCollection 2021.

Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance. The enhanced tumor aggressiveness stems at least partially from hypoxia-induced genomic...

Showing 781 to 786 of 786 entries