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Showing 973 to 984 of 997 entries
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In Vitro Mitral Valve Model with Unrestricted Ventricular Access: Using Vacuum to Close the Valve and Enable Static Trans-Mitral Pressure.

Journal of cardiovascular translational research

Stephens SE, Kammien AJ, Paris JC, Applequist AP, Ingels NB, Jensen HK, Rodgers DE, Cole CR, Wenk JF, Jensen MO.
PMID: 34993757
J Cardiovasc Transl Res. 2022 Jan 06; doi: 10.1007/s12265-021-10199-5. Epub 2022 Jan 06.

Current in vitro models of the left heart establish the pressure difference required to close the mitral valve by sealing and pressurizing the ventricular side of the valve, limiting important access to the subvalvular apparatus. This paper describes and...

EPR Study of KO.

Antioxidants (Basel, Switzerland)

Misak A, Brezova V, Chovanec M, Luspai K, Nasim MJ, Grman M, Tomasova L, Jacob C, Ondrias K.
PMID: 34439533
Antioxidants (Basel). 2021 Aug 13;10(8). doi: 10.3390/antiox10081286.

Superoxide radical anion (O

Aggressive Childhood-onset Papillary Craniopharyngioma Managed With Vemurafenib, a BRAF Inhibitor.

Journal of the Endocrine Society

Chik CL, van Landeghem FKH, Easaw JC, Mehta V.
PMID: 33928205
J Endocr Soc. 2021 Mar 16;5(5):bvab043. doi: 10.1210/jendso/bvab043. eCollection 2021 May 01.

The papillary subtype of craniopharyngioma (CP) rarely occurs in children and commonly presents as a suprasellar lesion. Patients with papillary CPs frequently harbor the

Frontonasal glioma - diagnostic difficulties.

Medicine and pharmacy reports

Iacob D, Fufezan O, Popa-Stănilă R, Topoe M.
PMID: 34527906
Med Pharm Rep. 2021 Aug;94:S33-S35. doi: 10.15386/mpr-2225. Epub 2021 Aug 10.

Nasal glioma or nasal glial heterotopia represents a rare rare benign tumor of the median line. Prenatal and even postnatal imagingc diagnosis of congenital frontonasal masses is difficult. We describe the case of an infant presenting with a lateral...

Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution.

Cell

Griesemer D, Xue JR, Reilly SK, Ulirsch JC, Kukreja K, Davis JR, Kanai M, Yang DK, Butts JC, Guney MH, Luban J, Montgomery SB, Finucane HK, Novina CD, Tewhey R, Sabeti PC.
PMID: 34534445
Cell. 2021 Sep 30;184(20):5247-5260.e19. doi: 10.1016/j.cell.2021.08.025. Epub 2021 Sep 16.

3' untranslated region (3'UTR) variants are strongly associated with human traits and diseases, yet few have been causally identified. We developed the massively parallel reporter assay for 3'UTRs (MPRAu) to sensitively assay 12,173 3'UTR variants. We applied MPRAu to...

Application study of the EQ-5D-5L in oncology: linking self-reported quality of life of patients with advanced or metastatic colorectal cancer to clinical data from a German tumor registry.

Health economics review

Borchert K, Jacob C, Wetzel N, Jänicke M, Eggers E, Sauer A, Marschner N, Altevers J, Mittendorf T, Greiner W.
PMID: 33313984
Health Econ Rev. 2020 Dec 12;10(1):40. doi: 10.1186/s13561-020-00297-6.

BACKGROUND: The EQ-5D-5L questionnaire is used in oncology to generate health-related quality of life (HRQoL) weights and corresponding health states. The purpose was to explore the relationship between demographic and clinical characteristics and HRQoL among advanced or metastatic colorectal...

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis.

Biomedicines

Surdu AM, Pînzariu O, Ciobanu DM, Negru AG, Căinap SS, Lazea C, Iacob D, Săraci G, Tirinescu D, Borda IM, Cismaru G.
PMID: 33572397
Biomedicines. 2021 Feb 09;9(2). doi: 10.3390/biomedicines9020172.

Vitamin D, a crucial hormone in the homeostasis and metabolism of calcium bone, has lately been found to produce effects on other physiological and pathological processes genomically and non-genomically, including the cardiovascular system. While lower baseline vitamin D levels...

Vaccination rates and adherence in premature infants before and after pneumococcal conjugate vaccine schedule change for term infants - A claims database analysis in Germany.

Vaccine

Laurenz M, von Eiff C, Borchert K, Jacob C, Seidel K, Schley K.
PMID: 34852945
Vaccine. 2021 Nov 28; doi: 10.1016/j.vaccine.2021.11.002. Epub 2021 Nov 28.

BACKGROUND: In 2015, the German Standing Committee on Vaccination (STIKO) changed the pneumococcal conjugate vaccination (PCV) schedule for mature infants from a 3+1scheme (2, 3, 4, and 11-14 months of age) to a 2+1scheme (2, 4, and 11-14 months...

Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression.

The international journal of biochemistry & cell biology

Nordman JC.
PMID: 34823006
Int J Biochem Cell Biol. 2021 Nov 23;142:106120. doi: 10.1016/j.biocel.2021.106120. Epub 2021 Nov 23.

Excessive and recurring violent aggression is a serious concern for society and a symptom of many psychiatric diseases. Substance abuse, attack experience, and social and traumatic stress increase vulnerability to developing this type of aggression. Glutamate receptors are an...

Association of New Perioperative Benzodiazepine Use With Persistent Benzodiazepine Use.

JAMA network open

Wright JD, Cogan JC, Huang Y, Tergas AI, St Clair CM, Hou JY, Khoury-Collado F, Gockley A, Accordino M, Melamed A, Hershman DL.
PMID: 34081136
JAMA Netw Open. 2021 Jun 01;4(6):e2112478. doi: 10.1001/jamanetworkopen.2021.12478.

IMPORTANCE: Increased use of benzodiazepines has resulted in increasing rates of misuse and adverse effects associated with these drugs. Little is known about the initial exposure and source of benzodiazepines among those who use them persistently.OBJECTIVE: To examine the...

Two distinct mechanisms leading to loss of virological control in the rare group of antiretroviral therapy-naïve, transiently aviraemic children living with HIV.

Journal of virology

Vieira VA, Adland E, Grayson NE, Csala A, Richards F, Dacon C, Athavale R, Tsai MH, D'Souza R, Muenchhoff M, Bonsall D, Jooste P, Goulder PJR.
PMID: 34757843
J Virol. 2021 Nov 10;JVI0153521. doi: 10.1128/JVI.01535-21. Epub 2021 Nov 10.

HIV-specific CD8+ T-cells play a central role in immune control of adult HIV, but their contribution in paediatric infection is less well-characterised. Previously, we identified a group of ART-naïve children with persistently undetectable plasma viraemia, termed 'elite controllers', and...

Dual transcriptomic analysis reveals metabolic changes associated with differential persistence of human pathogenic bacteria in leaves of Arabidopsis and lettuce.

G3 (Bethesda, Md.)

Jacob C, Velásquez AC, Josh NA, Settles M, He SY, Melotto M.
PMID: 34550367
G3 (Bethesda). 2021 Dec 08;11(12). doi: 10.1093/g3journal/jkab331.

Understanding the molecular determinants underlying the interaction between the leaf and human pathogenic bacteria is key to provide the foundation to develop science-based strategies to prevent or decrease the pathogen contamination of leafy greens. In this study, we conducted...

Showing 973 to 984 of 997 entries