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Genome-wide association study and functional validation implicates JADE1 in tauopathy.

Acta neuropathologica

Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF.
PMID: 34719765
Acta Neuropathol. 2022 Jan;143(1):33-53. doi: 10.1007/s00401-021-02379-z. Epub 2021 Nov 01.

Primary age-related tauopathy (PART) is a neurodegenerative pathology with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amyloid-β (Aβ) plaques. The...

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Farrell K, Kim S, Han N, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2021;143(1):33-53doi: 10.1007/s00401-021-02379-z.
Farrell, K., Kim, S., Han, N., Iida, M. A., Gonzalez, E. M., Otero-Garcia, M., Walker, J. M., Richardson, T. E., Renton, A. E., Andrews, S. J., Fulton-Howard, B., Humphrey, J., Vialle, R. A., Bowles, K. R., de Paiva Lopes, K., Whitney, K., Dangoor, D. K., Walsh, H., Marcora, E., Hefti, M. M., Casella, A., Sissoko, C. T., Kapoor, M., Novikova, G., Udine, E., Wong, G., Tang, W., Bhangale, T., Hunkapiller, J., Ayalon, G., Graham, R. R., Cherry, J. D., Cortes, E. P., Borukov, V. Y., McKee, A. C., Stein, T. D., Vonsattel, J. P., Teich, A. F., Gearing, M., Glass, J., Troncoso, J. C., Frosch, M. P., Hyman, B. T., Dickson, D. W., Murray, M. E., Attems, J., Flanagan, M. E., Mao, Q., Mesulam, M. M., Weintraub, S., Woltjer, R. L., Pham, T., Kofler, J., Schneider, J. A., Yu, L., Purohit, D. P., Haroutunian, V., Hof, P. R., Gandy, S., Sano, M., Beach, T. G., Poon, W., Kawas, C. H., Corrada, M. M., Rissman, R. A., Metcalf, J., Shuldberg, S., Salehi, B., Nelson, P. T., Trojanowski, J. Q., Lee, E. B., Wolk, D. A., McMillan, C. T., Keene, C. D., Latimer, C. S., Montine, T. J., Kovacs, G. G., Lutz, M. I., Fischer, P., Perrin, R. J., Cairns, N. J., Franklin, E. E., Cohen, H. T., Raj, T., Cobos, I., Frost, B., Goate, A., White Iii, C. L., & Crary, J. F. (2022). Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta neuropathologica, 143(1), 33-53. https://doi.org/10.1007/s00401-021-02379-z
Farrell, Kurt, et al. "Genome-wide association study and functional validation implicates JADE1 in tauopathy." Acta neuropathologica vol. 143,1 (2022): 33-53. doi: https://doi.org/10.1007/s00401-021-02379-z
Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022 Jan;143(1):33-53. doi: 10.1007/s00401-021-02379-z. Epub 2021 Nov 01. PMID: 34719765.
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Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid.

Brain pathology (Zurich, Switzerland)

Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, Gomez-Isla T, Hyman BT, Arnold SE, Spires-Jones T, Cudkowicz ME, Berry JD, Sadri-Vakili G.
PMID: 34779076
Brain Pathol. 2021 Nov 14;e13035. doi: 10.1111/bpa.13035. Epub 2021 Nov 14.

Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, several studies report alterations in tau phosphorylation in both sporadic and familial ALS. Recently, we have demonstrated that phosphorylated tau at S396 (pTau-S396) is mislocalized...

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Petrozziello T, Amaral AC, Dujardin S, et al. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain Pathol. 2021;e13035doi: 10.1111/bpa.13035.
Petrozziello, T., Amaral, A. C., Dujardin, S., Farhan, S. M. K., Chan, J., Trombetta, B. A., Kivisäkk, P., Mills, A. N., Bordt, E. A., Kim, S. E., Dooley, P. M., Commins, C., Connors, T. R., Oakley, D. H., Ghosal, A., Gomez-Isla, T., Hyman, B. T., Arnold, S. E., Spires-Jones, T., Cudkowicz, M. E., Berry, J. D., & Sadri-Vakili, G. (2021). Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain pathology (Zurich, Switzerland), e13035. https://doi.org/10.1111/bpa.13035
Petrozziello, Tiziana, et al. "Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid." Brain pathology (Zurich, Switzerland) vol. (2021): e13035. doi: https://doi.org/10.1111/bpa.13035
Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, Gomez-Isla T, Hyman BT, Arnold SE, Spires-Jones T, Cudkowicz ME, Berry JD, Sadri-Vakili G. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain Pathol. 2021 Nov 14;e13035. doi: 10.1111/bpa.13035. Epub 2021 Nov 14. PMID: 34779076.
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Conformational fingerprinting of tau variants and strains by Raman spectroscopy.

RSC advances

Devitt G, Crisford A, Rice W, Weismiller HA, Fan Z, Commins C, Hyman BT, Margittai M, Mahajan S, Mudher A.
PMID: 34381596
RSC Adv. 2021 Feb 26;11(15):8899-8915. doi: 10.1039/d1ra00870f. eCollection 2021.

Tauopathies are a group of disorders in which the deposition of abnormally folded tau protein accompanies neurodegeneration. The development of methods for detection and classification of pathological changes in protein conformation are desirable for understanding the factors that influence...

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Devitt G, Crisford A, Rice W, et al. Conformational fingerprinting of tau variants and strains by Raman spectroscopy. RSC Adv. 2021;11(15):8899-8915doi: 10.1039/d1ra00870f.
Devitt, G., Crisford, A., Rice, W., Weismiller, H. A., Fan, Z., Commins, C., Hyman, B. T., Margittai, M., Mahajan, S., & Mudher, A. (2021). Conformational fingerprinting of tau variants and strains by Raman spectroscopy. RSC advances, 11(15), 8899-8915. https://doi.org/10.1039/d1ra00870f
Devitt, George, et al. "Conformational fingerprinting of tau variants and strains by Raman spectroscopy." RSC advances vol. 11,15 (2021): 8899-8915. doi: https://doi.org/10.1039/d1ra00870f
Devitt G, Crisford A, Rice W, Weismiller HA, Fan Z, Commins C, Hyman BT, Margittai M, Mahajan S, Mudher A. Conformational fingerprinting of tau variants and strains by Raman spectroscopy. RSC Adv. 2021 Feb 26;11(15):8899-8915. doi: 10.1039/d1ra00870f. eCollection 2021. PMID: 34381596; PMCID: PMC8330415.
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Active deep learning to detect cognitive concerns in electronic health records.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Magdamo CG, Hong ZM, Noori A, Sheu YH, Deodhar M, Ye EM, Ge W, Sun H, Brenner L, Robbins GK, Mukerji S, Zafar SF, Benson N, Moura LMV, Hsu J, Arnold SE, Hyman BT, Serrano-Pozo A, Westover MB, Blacker D, Das S.
PMID: 34971026
Alzheimers Dement. 2021 Dec;17:e055362. doi: 10.1002/alz.055362.

BACKGROUND: Timely diagnosis of dementia is important to patients and their caregivers for advanced planning, yet dementia is under-diagnosed by healthcare professionals and under-coded in claims data. Sensitive and specific tools to detect cognitive concerns in diverse clinical settings...

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Magdamo CG, Hong ZM, Noori A, et al. Active deep learning to detect cognitive concerns in electronic health records. Alzheimers Dement. 2021;17:e055362doi: 10.1002/alz.055362.
Magdamo, C. G., Hong, Z. M., Noori, A., Sheu, Y. H., Deodhar, M., Ye, E. M., Ge, W., Sun, H., Brenner, L., Robbins, G. K., Mukerji, S., Zafar, S. F., Benson, N., Moura, L. M. V., Hsu, J., Arnold, S. E., Hyman, B. T., Serrano-Pozo, A., Westover, M. B., Blacker, D., & Das, S. (2021). Active deep learning to detect cognitive concerns in electronic health records. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17e055362. https://doi.org/10.1002/alz.055362
Magdamo, Colin G, et al. "Active deep learning to detect cognitive concerns in electronic health records." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17 (2021): e055362. doi: https://doi.org/10.1002/alz.055362
Magdamo CG, Hong ZM, Noori A, Sheu YH, Deodhar M, Ye EM, Ge W, Sun H, Brenner L, Robbins GK, Mukerji S, Zafar SF, Benson N, Moura LMV, Hsu J, Arnold SE, Hyman BT, Serrano-Pozo A, Westover MB, Blacker D, Das S. Active deep learning to detect cognitive concerns in electronic health records. Alzheimers Dement. 2021 Dec;17:e055362. doi: 10.1002/alz.055362. PMID: 34971026.
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Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD.

Current Alzheimer research

Bryant AG, Manhard MK, Salat DH, Rosen BR, Hyman BT, Johnson KA, Huang S, Bennett RE, Yen YF.
PMID: 34825871
Curr Alzheimer Res. 2021;18(9):711-720. doi: 10.2174/1567205018666211126113904.

BACKGROUND: Reduced cerebrovascular function and accumulation of tau pathology are key components of cognitive decline in Alzheimer's disease (AD). Recent multimodal neuroimaging studies show a correlation between cortical tau accumulation and reduced cerebral perfusion. However, animal models predict that...

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Bryant AG, Manhard MK, Salat DH, et al. Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD. Curr Alzheimer Res. 2021;18(9):711-720doi: 10.2174/1567205018666211126113904.
Bryant, A. G., Manhard, M. K., Salat, D. H., Rosen, B. R., Hyman, B. T., Johnson, K. A., Huang, S., Bennett, R. E., & Yen, Y. F. (2021). Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD. Current Alzheimer research, 18(9), 711-720. https://doi.org/10.2174/1567205018666211126113904
Bryant, Annie G, et al. "Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD." Current Alzheimer research vol. 18,9 (2021): 711-720. doi: https://doi.org/10.2174/1567205018666211126113904
Bryant AG, Manhard MK, Salat DH, Rosen BR, Hyman BT, Johnson KA, Huang S, Bennett RE, Yen YF. Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD. Curr Alzheimer Res. 2021;18(9):711-720. doi: 10.2174/1567205018666211126113904. PMID: 34825871.
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Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations.

Clinical cancer research : an official journal of the American Association for Cancer Research

Adib E, Klonowska K, Giannikou K, Do KT, Pruitt-Thompson S, Bhushan K, Milstein MI, Hedglin J, Kargus KE, Sholl LM, Tsuji J, Hyman DM, Sisk A, Shapiro GI, Vargas HA, Harding JJ, Voss MH, Iyer G, Kwiatkowski DJ.
PMID: 33727259
Clin Cancer Res. 2021 Jul 15;27(14):3845-3853. doi: 10.1158/1078-0432.CCR-20-4548. Epub 2021 Mar 16.

PURPOSE: This was a multicenter, histology-agnostic, single-arm prospective phase II trial of therapeutic activity of everolimus, an oral mTORC1 inhibitor, in patients with advanced solid tumors that harbored PATIENTS AND METHODS: Patients with tumors with inactivating RESULTS: Between November...

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Adib E, Klonowska K, Giannikou K, et al. Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations. Clin Cancer Res. 2021;27(14):3845-3853doi: 10.1158/1078-0432.CCR-20-4548.
Adib, E., Klonowska, K., Giannikou, K., Do, K. T., Pruitt-Thompson, S., Bhushan, K., Milstein, M. I., Hedglin, J., Kargus, K. E., Sholl, L. M., Tsuji, J., Hyman, D. M., Sisk, A., Shapiro, G. I., Vargas, H. A., Harding, J. J., Voss, M. H., Iyer, G., & Kwiatkowski, D. J. (2021). Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(14), 3845-3853. https://doi.org/10.1158/1078-0432.CCR-20-4548
Adib, Elio, et al. "Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,14 (2021): 3845-3853. doi: https://doi.org/10.1158/1078-0432.CCR-20-4548
Adib E, Klonowska K, Giannikou K, Do KT, Pruitt-Thompson S, Bhushan K, Milstein MI, Hedglin J, Kargus KE, Sholl LM, Tsuji J, Hyman DM, Sisk A, Shapiro GI, Vargas HA, Harding JJ, Voss MH, Iyer G, Kwiatkowski DJ. Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations. Clin Cancer Res. 2021 Jul 15;27(14):3845-3853. doi: 10.1158/1078-0432.CCR-20-4548. Epub 2021 Mar 16. PMID: 33727259; PMCID: PMC8282751.
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Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status.

Journal of geriatric oncology

Jensen CE, Vohra SN, Nyrop KA, Deal AM, Muss HB, Lichtman EI, Rubinstein SM, Wood WA, Mangieri NJ, Jamison L, Grant SJ, Tuchman SA.
PMID: 34389255
J Geriatr Oncol. 2021 Aug 10; doi: 10.1016/j.jgo.2021.08.004. Epub 2021 Aug 10.

OBJECTIVES: Findings from a brief geriatric assessment (GA) in a cohort of adults with multiple myeloma (MM) are presented, with particular attention to the utility of the GA in identifying important deficits in adults judged to have a normal...

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Jensen CE, Vohra SN, Nyrop KA, et al. Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status. J Geriatr Oncol. 2021;doi: 10.1016/j.jgo.2021.08.004.
Jensen, C. E., Vohra, S. N., Nyrop, K. A., Deal, A. M., Muss, H. B., Lichtman, E. I., Rubinstein, S. M., Wood, W. A., Mangieri, N. J., Jamison, L., Grant, S. J., & Tuchman, S. A. (2021). Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status. Journal of geriatric oncology, . https://doi.org/10.1016/j.jgo.2021.08.004
Jensen, Christopher E, et al. "Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status." Journal of geriatric oncology vol. (2021). doi: https://doi.org/10.1016/j.jgo.2021.08.004
Jensen CE, Vohra SN, Nyrop KA, Deal AM, Muss HB, Lichtman EI, Rubinstein SM, Wood WA, Mangieri NJ, Jamison L, Grant SJ, Tuchman SA. Geriatric-assessment-identified functional deficits among adults with multiple myeloma with normal performance status. J Geriatr Oncol. 2021 Aug 10; doi: 10.1016/j.jgo.2021.08.004. Epub 2021 Aug 10. PMID: 34389255.
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Impairment of visual cortical plasticity by amyloid-beta species.

Neurobiology of disease

William CM, Stern MA, Pei X, Saqran L, Ramani M, Frosch MP, Hyman BT.
PMID: 33766652
Neurobiol Dis. 2021 Jul;154:105344. doi: 10.1016/j.nbd.2021.105344. Epub 2021 Mar 22.

INTRODUCTION: A variety of transgenic and knock-in mice that express mutant alleles of Amyloid precursor protein (APP) have been used to model the effects of amyloid-beta (Aβ) on circuit function in Alzheimer's disease (AD); however phenotypes described in these...

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William CM, Stern MA, Pei X, et al. Impairment of visual cortical plasticity by amyloid-beta species. Neurobiol Dis. 2021;154:105344doi: 10.1016/j.nbd.2021.105344.
William, C. M., Stern, M. A., Pei, X., Saqran, L., Ramani, M., Frosch, M. P., & Hyman, B. T. (2021). Impairment of visual cortical plasticity by amyloid-beta species. Neurobiology of disease, 154105344. https://doi.org/10.1016/j.nbd.2021.105344
William, Christopher M, et al. "Impairment of visual cortical plasticity by amyloid-beta species." Neurobiology of disease vol. 154 (2021): 105344. doi: https://doi.org/10.1016/j.nbd.2021.105344
William CM, Stern MA, Pei X, Saqran L, Ramani M, Frosch MP, Hyman BT. Impairment of visual cortical plasticity by amyloid-beta species. Neurobiol Dis. 2021 Jul;154:105344. doi: 10.1016/j.nbd.2021.105344. Epub 2021 Mar 22. PMID: 33766652; PMCID: PMC8113107.
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Building bridges between drug development and cancer science: a tribute to José Baselga's legacy.

Annals of oncology : official journal of the European Society for Medical Oncology

Hyman DM, Soria JC, Tabernero J.
PMID: 33838220
Ann Oncol. 2021 Jul;32(7):825-828. doi: 10.1016/j.annonc.2021.03.209. Epub 2021 Apr 07.

No abstract available.

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Hyman DM, Soria JC, Tabernero J. Building bridges between drug development and cancer science: a tribute to José Baselga's legacy. Ann Oncol. 2021;32(7):825-828doi: 10.1016/j.annonc.2021.03.209.
Hyman, D. M., Soria, J. C., & Tabernero, J. (2021). Building bridges between drug development and cancer science: a tribute to José Baselga's legacy. Annals of oncology : official journal of the European Society for Medical Oncology, 32(7), 825-828. https://doi.org/10.1016/j.annonc.2021.03.209
Hyman, D M, et al. "Building bridges between drug development and cancer science: a tribute to José Baselga's legacy." Annals of oncology : official journal of the European Society for Medical Oncology vol. 32,7 (2021): 825-828. doi: https://doi.org/10.1016/j.annonc.2021.03.209
Hyman DM, Soria JC, Tabernero J. Building bridges between drug development and cancer science: a tribute to José Baselga's legacy. Ann Oncol. 2021 Jul;32(7):825-828. doi: 10.1016/j.annonc.2021.03.209. Epub 2021 Apr 07. PMID: 33838220.
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Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils.

Biochemistry

Kar M, Posey AE, Dar F, Hyman AA, Pappu RV.
PMID: 34648275
Biochemistry. 2021 Nov 02;60(43):3213-3222. doi: 10.1021/acs.biochem.1c00501. Epub 2021 Oct 14.

Glycine-rich regions feature prominently in intrinsically disordered regions (IDRs) of proteins that drive phase separation and the regulated formation of membraneless biomolecular condensates. Interestingly, the Gly-rich IDRs seldom feature poly-Gly tracts. The protein fused in sarcoma (FUS) is an...

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Kar M, Posey AE, Dar F, et al. Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils. Biochemistry. 2021;60(43):3213-3222doi: 10.1021/acs.biochem.1c00501.
Kar, M., Posey, A. E., Dar, F., Hyman, A. A., & Pappu, R. V. (2021). Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils. Biochemistry, 60(43), 3213-3222. https://doi.org/10.1021/acs.biochem.1c00501
Kar, Mrityunjoy, et al. "Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils." Biochemistry vol. 60,43 (2021): 3213-3222. doi: https://doi.org/10.1021/acs.biochem.1c00501
Kar M, Posey AE, Dar F, Hyman AA, Pappu RV. Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils. Biochemistry. 2021 Nov 02;60(43):3213-3222. doi: 10.1021/acs.biochem.1c00501. Epub 2021 Oct 14. PMID: 34648275.
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Improving Machine Learning 30-Day Mortality Prediction by Discounting Surprising Deaths.

The Journal of emergency medicine

Heyman ET, Ashfaq A, Khoshnood A, Ohlsson M, Ekelund U, Holmqvist LD, Lingman M.
PMID: 34716042
J Emerg Med. 2021 Dec;61(6):763-773. doi: 10.1016/j.jemermed.2021.09.004. Epub 2021 Oct 27.

BACKGROUND: Machine learning (ML) is an emerging tool for predicting need of end-of-life discussion and palliative care, by using mortality as a proxy. But deaths, unforeseen by emergency physicians at time of the emergency department (ED) visit, might have...

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Heyman ET, Ashfaq A, Khoshnood A, et al. Improving Machine Learning 30-Day Mortality Prediction by Discounting Surprising Deaths. J Emerg Med. 2021;61(6):763-773doi: 10.1016/j.jemermed.2021.09.004.
Heyman, E. T., Ashfaq, A., Khoshnood, A., Ohlsson, M., Ekelund, U., Holmqvist, L. D., & Lingman, M. (2021). Improving Machine Learning 30-Day Mortality Prediction by Discounting Surprising Deaths. The Journal of emergency medicine, 61(6), 763-773. https://doi.org/10.1016/j.jemermed.2021.09.004
Heyman, Ellen Tolestam, et al. "Improving Machine Learning 30-Day Mortality Prediction by Discounting Surprising Deaths." The Journal of emergency medicine vol. 61,6 (2021): 763-773. doi: https://doi.org/10.1016/j.jemermed.2021.09.004
Heyman ET, Ashfaq A, Khoshnood A, Ohlsson M, Ekelund U, Holmqvist LD, Lingman M. Improving Machine Learning 30-Day Mortality Prediction by Discounting Surprising Deaths. J Emerg Med. 2021 Dec;61(6):763-773. doi: 10.1016/j.jemermed.2021.09.004. Epub 2021 Oct 27. PMID: 34716042.
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Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Madrasi K, Das R, Mohmmadabdul H, Lin L, Hyman BT, Lauffenburger DA, Albers MW, Rissman RA, Burke JM, Apgar JF, Wille L, Gruenbaum L, Hua F.
PMID: 33938131
Alzheimers Dement. 2021 Sep;17(9):1487-1498. doi: 10.1002/alz.12312. Epub 2021 May 02.

INTRODUCTION: Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To understand why, we developed a quantitative systems pharmacology (QSP) model for seven therapeutics: aducanumab,...

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Madrasi K, Das R, Mohmmadabdul H, et al. Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease. Alzheimers Dement. 2021;17(9):1487-1498doi: 10.1002/alz.12312.
Madrasi, K., Das, R., Mohmmadabdul, H., Lin, L., Hyman, B. T., Lauffenburger, D. A., Albers, M. W., Rissman, R. A., Burke, J. M., Apgar, J. F., Wille, L., Gruenbaum, L., & Hua, F. (2021). Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(9), 1487-1498. https://doi.org/10.1002/alz.12312
Madrasi, Kumpal, et al. "Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,9 (2021): 1487-1498. doi: https://doi.org/10.1002/alz.12312
Madrasi K, Das R, Mohmmadabdul H, Lin L, Hyman BT, Lauffenburger DA, Albers MW, Rissman RA, Burke JM, Apgar JF, Wille L, Gruenbaum L, Hua F. Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease. Alzheimers Dement. 2021 Sep;17(9):1487-1498. doi: 10.1002/alz.12312. Epub 2021 May 02. PMID: 33938131; PMCID: PMC8478725.
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