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Showing 13 to 23 of 23 entries
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25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes.

Journal of lipid research

Wang Y, Lin W, Brown JE, Chen L, Pandak WM, Hylemon PB, Ren S.
PMID: 33705741
J Lipid Res. 2021;62:100063. doi: 10.1016/j.jlr.2021.100063. Epub 2021 Mar 08.

The oxysterol sulfate, 25-hydroxycholesterol 3-sulfate (25HC3S), has been shown to play an important role in lipid metabolism, inflammatory response, and cell survival. However, the mechanism(s) of its function in global regulation is unknown. The current study investigates the molecular...

Cite
Wang Y, Lin W, Brown JE, et al. 25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes. J Lipid Res. 2021;62:100063doi: 10.1016/j.jlr.2021.100063.
Wang, Y., Lin, W., Brown, J. E., Chen, L., Pandak, W. M., Hylemon, P. B., & Ren, S. (2021). 25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes. Journal of lipid research, 62100063. https://doi.org/10.1016/j.jlr.2021.100063
Wang, Yaping, et al. "25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes." Journal of lipid research vol. 62 (2021): 100063. doi: https://doi.org/10.1016/j.jlr.2021.100063
Wang Y, Lin W, Brown JE, Chen L, Pandak WM, Hylemon PB, Ren S. 25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes. J Lipid Res. 2021;62:100063. doi: 10.1016/j.jlr.2021.100063. Epub 2021 Mar 08. PMID: 33705741; PMCID: PMC8058565.
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25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models.

Cells

Wang Y, Pandak WM, Lesnefsky EJ, Hylemon PB, Ren S.
PMID: 34831255
Cells. 2021 Nov 05;10(11). doi: 10.3390/cells10113027.

Acetaminophen (APAP) overdose is one of the most frequent causes of acute liver failure (ALF). N-acetylcysteine (NAC) is currently being used as part of the standard care in the clinic but its usage has been limited in severe cases,...

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Wang Y, Pandak WM, Lesnefsky EJ, et al. 25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models. Cells. 2021;10(11)doi: 10.3390/cells10113027.
Wang, Y., Pandak, W. M., Lesnefsky, E. J., Hylemon, P. B., & Ren, S. (2021). 25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models. Cells, 10(11), . https://doi.org/10.3390/cells10113027
Wang, Yaping, et al. "25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models." Cells vol. 10,11 (2021). doi: https://doi.org/10.3390/cells10113027
Wang Y, Pandak WM, Lesnefsky EJ, Hylemon PB, Ren S. 25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models. Cells. 2021 Nov 05;10(11). doi: 10.3390/cells10113027. PMID: 34831255; PMCID: PMC8616185.
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Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease.

Cells

Xue R, Su L, Lai S, Wang Y, Zhao D, Fan J, Chen W, Hylemon PB, Zhou H.
PMID: 34831031
Cells. 2021 Oct 20;10(11). doi: 10.3390/cells10112806.

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been significantly increased due to the global epidemic of obesity. The disease progression from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is closely linked to inflammation, insulin resistance, and dysbiosis....

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Xue R, Su L, Lai S, et al. Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease. Cells. 2021;10(11)doi: 10.3390/cells10112806.
Xue, R., Su, L., Lai, S., Wang, Y., Zhao, D., Fan, J., Chen, W., Hylemon, P. B., & Zhou, H. (2021). Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease. Cells, 10(11), . https://doi.org/10.3390/cells10112806
Xue, Rui, et al. "Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease." Cells vol. 10,11 (2021). doi: https://doi.org/10.3390/cells10112806
Xue R, Su L, Lai S, Wang Y, Zhao D, Fan J, Chen W, Hylemon PB, Zhou H. Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease. Cells. 2021 Oct 20;10(11). doi: 10.3390/cells10112806. PMID: 34831031; PMCID: PMC8616422.
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Reply.

Hepatology (Baltimore, Md.)

Bajaj JS, Zhou H, Kang DJ, Hylemon PB.
PMID: 26105621
Hepatology. 2016 May;63(5):1736-7. doi: 10.1002/hep.27952. Epub 2015 Aug 03.

No abstract available.

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Bajaj JS, Zhou H, Kang DJ, et al. Reply. Hepatology. 2015;63(5):1736-7doi: 10.1002/hep.27952.
Bajaj, J. S., Zhou, H., Kang, D. J., & Hylemon, P. B. (2016). Reply. Hepatology (Baltimore, Md.), 63(5), 1736-7. https://doi.org/10.1002/hep.27952
Bajaj, Jasmohan S, et al. "Reply." Hepatology (Baltimore, Md.) vol. 63,5 (2016): 1736-7. doi: https://doi.org/10.1002/hep.27952
Bajaj JS, Zhou H, Kang DJ, Hylemon PB. Reply. Hepatology. 2016 May;63(5):1736-7. doi: 10.1002/hep.27952. Epub 2015 Aug 03. PMID: 26105621.
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Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus.

Scientific reports

Bajaj JS, Betrapally NS, Hylemon PB, Thacker LR, Daita K, Kang DJ, White MB, Unser AB, Fagan A, Gavis EA, Sikaroodi M, Dalmet S, Heuman DM, Gillevet PM.
PMID: 26823047
Sci Rep. 2016 Jan 29;6:20447. doi: 10.1038/srep20447.

No abstract available.

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Bajaj JS, Betrapally NS, Hylemon PB, et al. Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus. Sci Rep. 2016;6:20447doi: 10.1038/srep20447.
Bajaj, J. S., Betrapally, N. S., Hylemon, P. B., Thacker, L. R., Daita, K., Kang, D. J., White, M. B., Unser, A. B., Fagan, A., Gavis, E. A., Sikaroodi, M., Dalmet, S., Heuman, D. M., & Gillevet, P. M. (2016). Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus. Scientific reports, 620447. https://doi.org/10.1038/srep20447
Bajaj, Jasmohan S, et al. "Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus." Scientific reports vol. 6 (2016): 20447. doi: https://doi.org/10.1038/srep20447
Bajaj JS, Betrapally NS, Hylemon PB, Thacker LR, Daita K, Kang DJ, White MB, Unser AB, Fagan A, Gavis EA, Sikaroodi M, Dalmet S, Heuman DM, Gillevet PM. Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus. Sci Rep. 2016 Jan 29;6:20447. doi: 10.1038/srep20447. PMID: 26823047; PMCID: PMC4731816.
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Reply.

Hepatology (Baltimore, Md.)

Hylemon P, Nagahashi M, Takabe K, Zhou H.
PMID: 26121965
Hepatology. 2016 May;63(5):1740-1. doi: 10.1002/hep.27961. Epub 2015 Jul 31.

No abstract available.

Cite
Hylemon P, Nagahashi M, Takabe K, et al. Reply. Hepatology. 2015;63(5):1740-1doi: 10.1002/hep.27961.
Hylemon, P., Nagahashi, M., Takabe, K., & Zhou, H. (2016). Reply. Hepatology (Baltimore, Md.), 63(5), 1740-1. https://doi.org/10.1002/hep.27961
Hylemon, Phillip, et al. "Reply." Hepatology (Baltimore, Md.) vol. 63,5 (2016): 1740-1. doi: https://doi.org/10.1002/hep.27961
Hylemon P, Nagahashi M, Takabe K, Zhou H. Reply. Hepatology. 2016 May;63(5):1740-1. doi: 10.1002/hep.27961. Epub 2015 Jul 31. PMID: 26121965; PMCID: PMC4695315.
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Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.

The Journal of biological chemistry

Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, Dent P.
PMID: 27664064
J Biol Chem. 2016 Sep 23;291(39):20823. doi: 10.1074/jbc.A116.803444.

No abstract available.

Cite
Zhang G, Park MA, Mitchell C, et al. Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. J Biol Chem. 2016;291(39):20823doi: 10.1074/jbc.A116.803444.
Zhang, G., Park, M. A., Mitchell, C., Walker, T., Hamed, H., Studer, E., Graf, M., Rahmani, M., Gupta, S., Hylemon, P. B., Fisher, P. B., Grant, S., & Dent, P. (2016). Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. The Journal of biological chemistry, 291(39), 20823. https://doi.org/10.1074/jbc.A116.803444
Zhang, Guo, et al. "Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling." The Journal of biological chemistry vol. 291,39 (2016): 20823. doi: https://doi.org/10.1074/jbc.A116.803444
Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, Dent P. Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. J Biol Chem. 2016 Sep 23;291(39):20823. doi: 10.1074/jbc.A116.803444. PMID: 27664064; PMCID: PMC5034071.
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Effect of Increasing Age on Brain Dysfunction in Cirrhosis.

Hepatology communications

Liu R, Ahluwalia V, Kang JD, Ghosh SS, Zhou H, Li Y, Zhao D, Gurley E, Li X, White MB, Fagan A, Lippman HR, Wade JB, Hylemon PB, Bajaj JS.
PMID: 30619995
Hepatol Commun. 2018 Nov 30;3(1):63-73. doi: 10.1002/hep4.1286. eCollection 2019 Jan.

Patients with cirrhosis are growing older, which could have an impact on brain dysfunction beyond hepatic encephalopathy. Our aim was to study the effect of concomitant aging and cirrhosis on brain inflammation and degeneration using human and animal experiments....

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Liu R, Ahluwalia V, Kang JD, et al. Effect of Increasing Age on Brain Dysfunction in Cirrhosis. Hepatol Commun. 2018;3(1):63-73doi: 10.1002/hep4.1286.
Liu, R., Ahluwalia, V., Kang, J. D., Ghosh, S. S., Zhou, H., Li, Y., Zhao, D., Gurley, E., Li, X., White, M. B., Fagan, A., Lippman, H. R., Wade, J. B., Hylemon, P. B., & Bajaj, J. S. (2019). Effect of Increasing Age on Brain Dysfunction in Cirrhosis. Hepatology communications, 3(1), 63-73. https://doi.org/10.1002/hep4.1286
Liu, Runping, et al. "Effect of Increasing Age on Brain Dysfunction in Cirrhosis." Hepatology communications vol. 3,1 (2019): 63-73. doi: https://doi.org/10.1002/hep4.1286
Liu R, Ahluwalia V, Kang JD, Ghosh SS, Zhou H, Li Y, Zhao D, Gurley E, Li X, White MB, Fagan A, Lippman HR, Wade JB, Hylemon PB, Bajaj JS. Effect of Increasing Age on Brain Dysfunction in Cirrhosis. Hepatol Commun. 2018 Nov 30;3(1):63-73. doi: 10.1002/hep4.1286. eCollection 2019 Jan. PMID: 30619995; PMCID: PMC6312655.
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Gut microbial composition can differentially regulate bile acid synthesis in humanized mice.

Hepatology communications

Kang DJ, Hylemon PB, Gillevet PM, Sartor RB, Betrapally NS, Kakiyama G, Sikaroodi M, Takei H, Nittono H, Zhou H, Pandak WM, Yang J, Jiao C, Li X, Lippman HR, Heuman DM, Bajaj JS.
PMID: 29404434
Hepatol Commun. 2017 Feb 27;1(1):61-70. doi: 10.1002/hep4.1020. eCollection 2017 Feb.

We previously reported that alcohol drinkers with and without cirrhosis showed a significant increase in fecal bile acid secretion compared to nondrinkers. We hypothesized this may be due to activation by alcohol of hepatic cyclic adenosine monophosphate responsive element-binding...

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Kang DJ, Hylemon PB, Gillevet PM, et al. Gut microbial composition can differentially regulate bile acid synthesis in humanized mice. Hepatol Commun. 2017;1(1):61-70doi: 10.1002/hep4.1020.
Kang, D. J., Hylemon, P. B., Gillevet, P. M., Sartor, R. B., Betrapally, N. S., Kakiyama, G., Sikaroodi, M., Takei, H., Nittono, H., Zhou, H., Pandak, W. M., Yang, J., Jiao, C., Li, X., Lippman, H. R., Heuman, D. M., & Bajaj, J. S. (2017). Gut microbial composition can differentially regulate bile acid synthesis in humanized mice. Hepatology communications, 1(1), 61-70. https://doi.org/10.1002/hep4.1020
Kang, Dae Joong, et al. "Gut microbial composition can differentially regulate bile acid synthesis in humanized mice." Hepatology communications vol. 1,1 (2017): 61-70. doi: https://doi.org/10.1002/hep4.1020
Kang DJ, Hylemon PB, Gillevet PM, Sartor RB, Betrapally NS, Kakiyama G, Sikaroodi M, Takei H, Nittono H, Zhou H, Pandak WM, Yang J, Jiao C, Li X, Lippman HR, Heuman DM, Bajaj JS. Gut microbial composition can differentially regulate bile acid synthesis in humanized mice. Hepatol Commun. 2017 Feb 27;1(1):61-70. doi: 10.1002/hep4.1020. eCollection 2017 Feb. PMID: 29404434; PMCID: PMC5747030.
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Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease.

Comprehensive Physiology

Hylemon PB, Su L, Zheng PC, Bajaj JS, Zhou H.
PMID: 34964117
Compr Physiol. 2021 Dec 29;12(1):2719-2730. doi: 10.1002/cphy.c210024.

This article describes the complex interactions occurring between diet, the gut microbiome, and bile acids in the etiology of fatty liver disease. Perhaps 25% of the world's population may have nonalcoholic fatty liver disease (NAFLD) and a significant percentage...

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Hylemon PB, Su L, Zheng PC, et al. Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease. Compr Physiol. 2021;12(1):2719-2730doi: 10.1002/cphy.c210024.
Hylemon, P. B., Su, L., Zheng, P. C., Bajaj, J. S., & Zhou, H. (2021). Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease. Comprehensive Physiology, 12(1), 2719-2730. https://doi.org/10.1002/cphy.c210024
Hylemon, Phillip B, et al. "Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease." Comprehensive Physiology vol. 12,1 (2021): 2719-2730. doi: https://doi.org/10.1002/cphy.c210024
Hylemon PB, Su L, Zheng PC, Bajaj JS, Zhou H. Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease. Compr Physiol. 2021 Dec 29;12(1):2719-2730. doi: 10.1002/cphy.c210024. PMID: 34964117.
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25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes.

Journal of lipid research

Wang Y, Lin W, Brown JE, Chen L, Pandak WM, Hylemon PB, Ren S.
PMID: 33705741
J Lipid Res. 2021 Mar 08;62:100063. doi: 10.1016/j.jlr.2021.100063. Epub 2021 Mar 08.

The oxysterol sulfate, 25-hydroxycholesterol 3-sulfate (25HC3S), has been shown to play an important role in lipid metabolism, inflammatory response, and cell survival. However, the mechanism(s) of its function in global regulation is unknown. The current study investigates the molecular...

Cite
Wang Y, Lin W, Brown JE, et al. 25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes. J Lipid Res. 2021;62:100063doi: 10.1016/j.jlr.2021.100063.
Wang, Y., Lin, W., Brown, J. E., Chen, L., Pandak, W. M., Hylemon, P. B., & Ren, S. (2021). 25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes. Journal of lipid research, 62100063. https://doi.org/10.1016/j.jlr.2021.100063
Wang, Yaping, et al. "25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes." Journal of lipid research vol. 62 (2021): 100063. doi: https://doi.org/10.1016/j.jlr.2021.100063
Wang Y, Lin W, Brown JE, Chen L, Pandak WM, Hylemon PB, Ren S. 25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes. J Lipid Res. 2021 Mar 08;62:100063. doi: 10.1016/j.jlr.2021.100063. Epub 2021 Mar 08. PMID: 33705741; PMCID: PMC8058565.
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Showing 13 to 23 of 23 entries