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Biotransformation of tolmesoxide in animals and man.

Xenobiotica; the fate of foreign compounds in biological systems

Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Lewis CJ, Rance MJ.
PMID: 7233971
Xenobiotica. 1981 Feb;11(2):89-96. doi: 10.3109/00498258109045278.

1. The excretion and metabolism of tolmesoxide ((4,5-dimethoxy-2-methylphenyl)-methylsulphoxide) has been studied in rat, dog and man. In all species, absorption of oral doses of [14C]tolmesoxide was virtually complete and 78--99% of the 14C was excreted in the urine. 2....

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Greenslade D, Havler ME, Humphrey MJ, et al. Biotransformation of tolmesoxide in animals and man. Xenobiotica. 1981;11(2):89-96doi: 10.3109/00498258109045278.
Greenslade, D., Havler, M. E., Humphrey, M. J., Jordan, B. J., Lewis, C. J., & Rance, M. J. (1981). Biotransformation of tolmesoxide in animals and man. Xenobiotica; the fate of foreign compounds in biological systems, 11(2), 89-96. https://doi.org/10.3109/00498258109045278
Greenslade, D, et al. "Biotransformation of tolmesoxide in animals and man." Xenobiotica; the fate of foreign compounds in biological systems vol. 11,2 (1981): 89-96. doi: https://doi.org/10.3109/00498258109045278
Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Lewis CJ, Rance MJ. Biotransformation of tolmesoxide in animals and man. Xenobiotica. 1981 Feb;11(2):89-96. doi: 10.3109/00498258109045278. PMID: 7233971.
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Species differences in the metabolism and excretion of fenclofenac.

Xenobiotica; the fate of foreign compounds in biological systems

Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Rance MJ.
PMID: 7456491
Xenobiotica. 1980 Oct;10(10):753-60. doi: 10.3109/00498258009033803.

1. The excretion and metabolism of radiolabelled fenclofenac (2-(2,4-dichlorophenoxy)phenylacetic acid, Flenac) has been studied in five species. 2. In the rat, absorption of oral doses of fenclofenac was virtually complete and elimination occurred mainly by the bile and faeces....

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Greenslade D, Havler ME, Humphrey MJ, et al. Species differences in the metabolism and excretion of fenclofenac. Xenobiotica. 1980;10(10):753-60doi: 10.3109/00498258009033803.
Greenslade, D., Havler, M. E., Humphrey, M. J., Jordan, B. J., & Rance, M. J. (1980). Species differences in the metabolism and excretion of fenclofenac. Xenobiotica; the fate of foreign compounds in biological systems, 10(10), 753-60. https://doi.org/10.3109/00498258009033803
Greenslade, D, et al. "Species differences in the metabolism and excretion of fenclofenac." Xenobiotica; the fate of foreign compounds in biological systems vol. 10,10 (1980): 753-60. doi: https://doi.org/10.3109/00498258009033803
Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Rance MJ. Species differences in the metabolism and excretion of fenclofenac. Xenobiotica. 1980 Oct;10(10):753-60. doi: 10.3109/00498258009033803. PMID: 7456491.
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Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity.

Biochemical pharmacology

Houston JB, Humphrey MJ, Matthew DE, Tarbit MH.
PMID: 2827686
Biochem Pharmacol. 1988 Feb 01;37(3):401-8. doi: 10.1016/0006-2952(88)90206-7.

The mechanism of action of azole antifungal agents is believed to involve inhibition of fungal cytochrome P-450, and, therefore, an investigation of the interaction of these drugs with mammalian cytochrome P-450 systems should provide some indication of their selectivity...

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Houston JB, Humphrey MJ, Matthew DE, et al. Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity. Biochem Pharmacol. 1988;37(3):401-8doi: 10.1016/0006-2952(88)90206-7.
Houston, J. B., Humphrey, M. J., Matthew, D. E., & Tarbit, M. H. (1988). Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity. Biochemical pharmacology, 37(3), 401-8. https://doi.org/10.1016/0006-2952(88)90206-7
Houston, J B, et al. "Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity." Biochemical pharmacology vol. 37,3 (1988): 401-8. doi: https://doi.org/10.1016/0006-2952(88)90206-7
Houston JB, Humphrey MJ, Matthew DE, Tarbit MH. Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity. Biochem Pharmacol. 1988 Feb 01;37(3):401-8. doi: 10.1016/0006-2952(88)90206-7. PMID: 2827686.
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Effect of carbenoxolone on the concentrations of aldosterone in rat plasma and kidney.

The Journal of endocrinology

Humphrey MJ, Lindup WE, Chakraborty J, Parke DV.
PMID: 469454
J Endocrinol. 1979 Apr;81(1):143-51. doi: 10.1677/joe.0.0810143.

No abstract available.

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Humphrey MJ, Lindup WE, Chakraborty J, et al. Effect of carbenoxolone on the concentrations of aldosterone in rat plasma and kidney. J Endocrinol. 1979;81(1):143-51doi: 10.1677/joe.0.0810143.
Humphrey, M. J., Lindup, W. E., Chakraborty, J., & Parke, D. V. (1979). Effect of carbenoxolone on the concentrations of aldosterone in rat plasma and kidney. The Journal of endocrinology, 81(1), 143-51. https://doi.org/10.1677/joe.0.0810143
Humphrey, M J, et al. "Effect of carbenoxolone on the concentrations of aldosterone in rat plasma and kidney." The Journal of endocrinology vol. 81,1 (1979): 143-51. doi: https://doi.org/10.1677/joe.0.0810143
Humphrey MJ, Lindup WE, Chakraborty J, Parke DV. Effect of carbenoxolone on the concentrations of aldosterone in rat plasma and kidney. J Endocrinol. 1979 Apr;81(1):143-51. doi: 10.1677/joe.0.0810143. PMID: 469454.
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Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood.

American journal of hematology

Humphrey MJ, Hutter, Tom WW.
PMID: 7270544
Am J Hematol. 1981;11(1):107-10. doi: 10.1002/ajh.2830110113.

No abstract available.

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Humphrey MJ, Hutter, Tom WW. Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood. Am J Hematol. 1981;11(1):107-10doi: 10.1002/ajh.2830110113.
Humphrey, M. J., Hutter, & Tom, W. W. (1981). Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood. American journal of hematology, 11(1), 107-10. https://doi.org/10.1002/ajh.2830110113
Humphrey, M J, et al. "Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood." American journal of hematology vol. 11,1 (1981): 107-10. doi: https://doi.org/10.1002/ajh.2830110113
Humphrey MJ, Hutter, Tom WW. Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood. Am J Hematol. 1981;11(1):107-10. doi: 10.1002/ajh.2830110113. PMID: 7270544.
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Gastrointestinal absorption of carbenoxolone in the rat determined in vitro and in situ: deviations from the pH-partition hypothesis.

The Journal of pharmacy and pharmacology

Bridges JW, Houston JB, Humphrey MJ, Lindup WE, Parke DV, Shillingford JS, Upshall DG.
PMID: 6670
J Pharm Pharmacol. 1976 Feb;28(2):117-26. doi: 10.1111/j.2042-7158.1976.tb04109.x.

The absorption of [14C] carbenoxolone from everted rat ileum in vitro and from rat stomach and ileum in situ has been examined. The rate of its mucosal to serosal transfer in vitro increases as pH increases from 5 to...

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Bridges JW, Houston JB, Humphrey MJ, et al. Gastrointestinal absorption of carbenoxolone in the rat determined in vitro and in situ: deviations from the pH-partition hypothesis. J Pharm Pharmacol. 1976;28(2):117-26doi: 10.1111/j.2042-7158.1976.tb04109.x.
Bridges, J. W., Houston, J. B., Humphrey, M. J., Lindup, W. E., Parke, D. V., Shillingford, J. S., & Upshall, D. G. (1976). Gastrointestinal absorption of carbenoxolone in the rat determined in vitro and in situ: deviations from the pH-partition hypothesis. The Journal of pharmacy and pharmacology, 28(2), 117-26. https://doi.org/10.1111/j.2042-7158.1976.tb04109.x
Bridges, J W, et al. "Gastrointestinal absorption of carbenoxolone in the rat determined in vitro and in situ: deviations from the pH-partition hypothesis." The Journal of pharmacy and pharmacology vol. 28,2 (1976): 117-26. doi: https://doi.org/10.1111/j.2042-7158.1976.tb04109.x
Bridges JW, Houston JB, Humphrey MJ, Lindup WE, Parke DV, Shillingford JS, Upshall DG. Gastrointestinal absorption of carbenoxolone in the rat determined in vitro and in situ: deviations from the pH-partition hypothesis. J Pharm Pharmacol. 1976 Feb;28(2):117-26. doi: 10.1111/j.2042-7158.1976.tb04109.x. PMID: 6670.
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Design of toxicokinetic studies.

Xenobiotica; the fate of foreign compounds in biological systems

Smith DA, Humphrey MJ, Charuel C.
PMID: 2275214
Xenobiotica. 1990 Nov;20(11):1187-99. doi: 10.3109/00498259009046838.

1. Toxicokinetics is defined as pharmacokinetic studies in animals during actual toxicity studies or under conditions mimicking them (species, duration, dose level, etc.). 2. Toxicology studies require toxicokinetics to check whether systemic exposure reflects administered dose. In particular, it...

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Smith DA, Humphrey MJ, Charuel C. Design of toxicokinetic studies. Xenobiotica. 1990;20(11):1187-99doi: 10.3109/00498259009046838.
Smith, D. A., Humphrey, M. J., & Charuel, C. (1990). Design of toxicokinetic studies. Xenobiotica; the fate of foreign compounds in biological systems, 20(11), 1187-99. https://doi.org/10.3109/00498259009046838
Smith, D A, et al. "Design of toxicokinetic studies." Xenobiotica; the fate of foreign compounds in biological systems vol. 20,11 (1990): 1187-99. doi: https://doi.org/10.3109/00498259009046838
Smith DA, Humphrey MJ, Charuel C. Design of toxicokinetic studies. Xenobiotica. 1990 Nov;20(11):1187-99. doi: 10.3109/00498259009046838. PMID: 2275214.
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Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine.

Xenobiotica; the fate of foreign compounds in biological systems

Walker DK, Humphrey MJ, Smith DA.
PMID: 8009887
Xenobiotica. 1994 Mar;24(3):243-50. doi: 10.3109/00498259409043236.

1. In an isolated perfused rat liver (IPRL) model, the extensive hepatic uptake and subsequent slow redistribution of amlodipine into the perfusate have been demonstrated. The apparent liver volume for amlodipine was 920 ml compared with 38ml for nitrendipine....

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Walker DK, Humphrey MJ, Smith DA. Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine. Xenobiotica. 1994;24(3):243-50doi: 10.3109/00498259409043236.
Walker, D. K., Humphrey, M. J., & Smith, D. A. (1994). Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine. Xenobiotica; the fate of foreign compounds in biological systems, 24(3), 243-50. https://doi.org/10.3109/00498259409043236
Walker, D K, et al. "Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine." Xenobiotica; the fate of foreign compounds in biological systems vol. 24,3 (1994): 243-50. doi: https://doi.org/10.3109/00498259409043236
Walker DK, Humphrey MJ, Smith DA. Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine. Xenobiotica. 1994 Mar;24(3):243-50. doi: 10.3109/00498259409043236. PMID: 8009887.
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Central venous access in children via the external jugular vein.

Anesthesiology

Humphrey MJ, Blitt CD.
PMID: 7091723
Anesthesiology. 1982 Jul;57(1):50-1. doi: 10.1097/00000542-198207000-00015.
Free Article

No abstract available.

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Humphrey MJ, Blitt CD. Central venous access in children via the external jugular vein. Anesthesiology. 1982;57(1):50-1doi: 10.1097/00000542-198207000-00015.
Humphrey, M. J., & Blitt, C. D. (1982). Central venous access in children via the external jugular vein. Anesthesiology, 57(1), 50-1. https://doi.org/10.1097/00000542-198207000-00015
Humphrey, M J, and Blitt, C D. "Central venous access in children via the external jugular vein." Anesthesiology vol. 57,1 (1982): 50-1. doi: https://doi.org/10.1097/00000542-198207000-00015
Humphrey MJ, Blitt CD. Central venous access in children via the external jugular vein. Anesthesiology. 1982 Jul;57(1):50-1. doi: 10.1097/00000542-198207000-00015. PMID: 7091723.
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Showing 37 to 45 of 45 entries