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Biotransformation of tolmesoxide in animals and man.

Xenobiotica; the fate of foreign compounds in biological systems

Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Lewis CJ, Rance MJ.
PMID: 7233971
Xenobiotica. 1981 Feb;11(2):89-96. doi: 10.3109/00498258109045278.

1. The excretion and metabolism of tolmesoxide ((4,5-dimethoxy-2-methylphenyl)-methylsulphoxide) has been studied in rat, dog and man. In all species, absorption of oral doses of [14C]tolmesoxide was virtually complete and 78--99% of the 14C was excreted in the urine. 2....

Species differences in the metabolism and excretion of fenclofenac.

Xenobiotica; the fate of foreign compounds in biological systems

Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Rance MJ.
PMID: 7456491
Xenobiotica. 1980 Oct;10(10):753-60. doi: 10.3109/00498258009033803.

1. The excretion and metabolism of radiolabelled fenclofenac (2-(2,4-dichlorophenoxy)phenylacetic acid, Flenac) has been studied in five species. 2. In the rat, absorption of oral doses of fenclofenac was virtually complete and elimination occurred mainly by the bile and faeces....

Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity.

Biochemical pharmacology

Houston JB, Humphrey MJ, Matthew DE, Tarbit MH.
PMID: 2827686
Biochem Pharmacol. 1988 Feb 01;37(3):401-8. doi: 10.1016/0006-2952(88)90206-7.

The mechanism of action of azole antifungal agents is believed to involve inhibition of fungal cytochrome P-450, and, therefore, an investigation of the interaction of these drugs with mammalian cytochrome P-450 systems should provide some indication of their selectivity...

Effect of carbenoxolone on the concentrations of aldosterone in rat plasma and kidney.

The Journal of endocrinology

Humphrey MJ, Lindup WE, Chakraborty J, Parke DV.
PMID: 469454
J Endocrinol. 1979 Apr;81(1):143-51. doi: 10.1677/joe.0.0810143.

No abstract available.

Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood.

American journal of hematology

Humphrey MJ, Hutter, Tom WW.
PMID: 7270544
Am J Hematol. 1981;11(1):107-10. doi: 10.1002/ajh.2830110113.

No abstract available.

Gastrointestinal absorption of carbenoxolone in the rat determined in vitro and in situ: deviations from the pH-partition hypothesis.

The Journal of pharmacy and pharmacology

Bridges JW, Houston JB, Humphrey MJ, Lindup WE, Parke DV, Shillingford JS, Upshall DG.
PMID: 6670
J Pharm Pharmacol. 1976 Feb;28(2):117-26. doi: 10.1111/j.2042-7158.1976.tb04109.x.

The absorption of [14C] carbenoxolone from everted rat ileum in vitro and from rat stomach and ileum in situ has been examined. The rate of its mucosal to serosal transfer in vitro increases as pH increases from 5 to...

Design of toxicokinetic studies.

Xenobiotica; the fate of foreign compounds in biological systems

Smith DA, Humphrey MJ, Charuel C.
PMID: 2275214
Xenobiotica. 1990 Nov;20(11):1187-99. doi: 10.3109/00498259009046838.

1. Toxicokinetics is defined as pharmacokinetic studies in animals during actual toxicity studies or under conditions mimicking them (species, duration, dose level, etc.). 2. Toxicology studies require toxicokinetics to check whether systemic exposure reflects administered dose. In particular, it...

Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine.

Xenobiotica; the fate of foreign compounds in biological systems

Walker DK, Humphrey MJ, Smith DA.
PMID: 8009887
Xenobiotica. 1994 Mar;24(3):243-50. doi: 10.3109/00498259409043236.

1. In an isolated perfused rat liver (IPRL) model, the extensive hepatic uptake and subsequent slow redistribution of amlodipine into the perfusate have been demonstrated. The apparent liver volume for amlodipine was 920 ml compared with 38ml for nitrendipine....

Central venous access in children via the external jugular vein.

Anesthesiology

Humphrey MJ, Blitt CD.
PMID: 7091723
Anesthesiology. 1982 Jul;57(1):50-1. doi: 10.1097/00000542-198207000-00015.
Free Article

No abstract available.

Showing 37 to 45 of 45 entries