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Showing 25 to 36 of 45 entries
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In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug.

International journal of pharmaceutics

Boateng JS, Matthews KH, Auffret AD, Humphrey MJ, Stevens HN, Eccleston GM.
PMID: 19477255
Int J Pharm. 2009 Aug 13;378(1):66-72. doi: 10.1016/j.ijpharm.2009.05.038. Epub 2009 May 27.

Drug dissolution and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of drug release from the two systems. The formulations were prepared by freeze-drying (wafers) or drying...

The utilization of nicotinic acid by pregnant women.

Federation proceedings

FRAZIER EI, PORTER T, HUMPHREY MJ.
PMID: 18915875
Fed Proc. 1948 Mar;7(1):287.

No abstract available.

The effect of carbenoxolone on the subcellular distribution of ( 3 H) aldosterone in rat kidney.

The Biochemical journal

Humphrey MJ, Lindup E, Parke DV, Chakraborty J.
PMID: 4664613
Biochem J. 1972 Nov;130(2):87P-88P. doi: 10.1042/bj1300087pb.
Free PMC Article

No abstract available.

Inhibition of thyroxine binding to serum proteins by fenclofenac and related compounds.

Clinica chimica acta; international journal of clinical chemistry

Capper SJ, Humphrey MJ, Kurtz AB.
PMID: 6786805
Clin Chim Acta. 1981 Apr 27;112(1):77-83. doi: 10.1016/0009-8981(81)90270-9.

The anti-inflammatory drug fenclofenac lowers the serum concentrations of thyroxine (T4) and triidothyronine (T3) in subjects taking a regular dose of 600 mg twice daily. In eight male volunteers the concentration of T4 in serum was reduced to almost...

The effect of fenclofenac on thyroid function.

Clinical endocrinology

Kurtz AB, Capper SJ, Clifford J, Humphrey MJ, Lukinac L.
PMID: 6796298
Clin Endocrinol (Oxf). 1981 Aug;15(2):117-24. doi: 10.1111/j.1365-2265.1981.tb00645.x.

The non-steroidal anti-inflammatory agent fenclofenac competitively inhibits the binding of thyroxine(T4) and triiodothyronine (T3) by thyroxine-binding globulin(TBG). Eight male volunteers completed a 4-week study during which they took fenclofenac 600 mg twice daily. The concentration of fenclofenac in serum...

Biliary excretion, metabolism and enterohepatic circulation of buprenorphine.

Xenobiotica; the fate of foreign compounds in biological systems

Brewster D, Humphrey MJ, McLeavy MA.
PMID: 7293215
Xenobiotica. 1981 Mar;11(3):189-96. doi: 10.3109/00498258109045291.

1. After intramuscular administration of [3H]buprenorphine to rats, dogs, rhesus monkeys and one human volunteer, most of the dosed radioactivity was excreted in the faeces, indicating biliary excretion and a possible enterohepatic circulation of the drug in these species....

Severe clotting abnormalities and transient hepatic fibrosis in acute anicteric hepatitis A.

The Journal of pediatrics

Humphrey MJ, Hansen RC, Bradley DW, Nagle RB, Stillman AE.
PMID: 228018
J Pediatr. 1979 Dec;95(6):987-9. doi: 10.1016/s0022-3476(79)80288-7.

No abstract available.

Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans.

Antimicrobial agents and chemotherapy

Humphrey MJ, Jevons S, Tarbit MH.
PMID: 3004323
Antimicrob Agents Chemother. 1985 Nov;28(5):648-53. doi: 10.1128/AAC.28.5.648.
Free PMC Article

The pharmacokinetic profile of UK-49,858 (fluconazole), a novel triazole antifungal agent which is being developed for oral and intravenous use, was determined in mice, rats, dogs, and humans. Comparative data following oral and intravenous administration showed that bioavailability was...

Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces.

International journal of pharmaceutics

Boateng JS, Auffret AD, Matthews KH, Humphrey MJ, Stevens HN, Eccleston GM.
PMID: 20083177
Int J Pharm. 2010 Apr 15;389(1):24-31. doi: 10.1016/j.ijpharm.2010.01.008. Epub 2010 Jan 18.

Freeze-dried (lyophilised) wafers and solvent cast films from sodium alginate (ALG) and sodium carboxymethylcellulose (CMC) have been developed as potential drug delivery systems for mucosal surfaces including wounds. The wafers (ALG, CMC) and films (CMC) were prepared by freeze-drying...

Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug.

Drug development and industrial pharmacy

Boateng JS, Matthews KH, Auffret AD, Humphrey MJ, Eccleston GM, Stevens HN.
PMID: 21714725
Drug Dev Ind Pharm. 2012 Jan;38(1):47-54. doi: 10.3109/03639045.2011.590496. Epub 2011 Jun 30.

Drug release characteristics of freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose have been investigated and compared. In vitro drug dissolution studies were performed using an exchange cell and drug release was measured by UV spectroscopy at 272...

The utilization of nicotinic acid by pregnant women.

The Journal of nutrition

FRAZIER EI, PORTER T, HUMPHREY MJ.
PMID: 18121078
J Nutr. 1949 Apr;37(4):393-410. doi: 10.1093/jn/37.4.393.

No abstract available.

The clinical determination of protein-bound iodine.

The Journal of clinical investigation

BARKER SB, HUMPHREY MJ, SOLEY MH.
PMID: 14803557
J Clin Invest. 1951 Jan;30(1):55-62. doi: 10.1172/JCI102416.

No abstract available.

Showing 25 to 36 of 45 entries