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Showing 13 to 24 of 45 entries
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The metabolism of carfecillin in rat, dog and man.

Xenobiotica; the fate of foreign compounds in biological systems

Filer CW, Humphrey MJ, Jeffery DJ, Jones KH, Langley PF.
PMID: 6256982
Xenobiotica. 1980 Oct;10(10):761-9. doi: 10.3109/00498258009033804.

1. The absorption of the phenol moiety of [phenol-14C]carfecillin following oral administration to rat, dog and man was extensive, since 95%, 73% and 99% of the administered radioactivity respectively was recovered in the urine. In contrast, less than half...

Bioanalytical data in decision making: discovery and development.

Xenobiotica; the fate of foreign compounds in biological systems

Smith DA, Beaumont K, Cussans NJ, Humphrey MJ, Jezequel SG, Rance DJ, Stopher DA, Walker DK.
PMID: 1441610
Xenobiotica. 1992 Sep-Oct;22(9):1195-205. doi: 10.3109/00498259209051873.

1. Bioanalysis is traditionally associated with the development phase of drugs; its use in discovery programmes is often ignored but can have a major impact. 2. Pharmacokinetic studies conducted in conjunction with pharmacology screening can provide additional information to...

Volatile anesthetic effects on left ventricular relaxation in swine.

Anesthesiology

Humphrey LS, Stinson DC, Humphrey MJ, Finney RS, Zeller PA, Judd MR, Blanck TJ.
PMID: 2221442
Anesthesiology. 1990 Oct;73(4):731-8. doi: 10.1097/00000542-199010000-00020.
Free Article

The effects of halothane (0.5, 1.0, and 1.5%; n = 10), enflurane (1.0, 2.0, and 3.0%; n = 8), and isoflurane (0.75, 1.5, and 2.25%; n = 8) on isovolumic relaxation were studied in open-chest swine. The time constant...

Ketoconazole and fluconazole inhibition of the metabolism of cyclosporin A by human liver in vitro.

Therapeutic drug monitoring

Omar G, Whiting PH, Hawksworth GM, Humphrey MJ, Burke MD.
PMID: 9263386
Ther Drug Monit. 1997 Aug;19(4):436-45. doi: 10.1097/00007691-199708000-00013.

The effects of the important antifungal agents, ketoconazole (Ket) and fluconazole (Flu), on the microsomal metabolism of cyclosporin A (CsA) by seven human livers was measured in vitro. A total of eight CsA metabolites were identified by high-performance liquid...

Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril.

Xenobiotica; the fate of foreign compounds in biological systems

Kaye B, Brearley CJ, Cussans NJ, Herron M, Humphrey MJ, Mollatt AR.
PMID: 9364744
Xenobiotica. 1997 Oct;27(10):1091-102. doi: 10.1080/004982597240046.

1. Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo in mouse, rat, rabbit, dog and man. 2. Oral doses of [14C]-candoxatril were cleared rapidly, mostly by ester hydrolysis to candoxatrilat, in...

The availability of carfecillin and its phenol moiety in rat and dog.

Xenobiotica; the fate of foreign compounds in biological systems

Humphrey MJ, Filer CW, Jeffery DJ, Langley PF, Wadds GA.
PMID: 7456492
Xenobiotica. 1980 Oct;10(10):771-8. doi: 10.3109/00498258009033805.

1. Studies have shown that hydrolysis of carfecillin to carbenicillin and phenol in vitro occurs in blood, liver and gut tissues of rat and dog. Extremely rapid hydrolysis was observed in the blood and liver of the rat. 2....

Pharmacokinetics of ticarcillin in man.

European journal of clinical pharmacology

Davies BE, Humphrey MJ, Langley PF, Lees L, Legg B, Wadds GA.
PMID: 7140806
Eur J Clin Pharmacol. 1982;23(2):167-72. doi: 10.1007/BF00545973.

The excretion of radioactivity has been investigated in 3 healthy volunteers following rapid intravenous administration of 5 g of [35S]-ticarcillin. The radioactive dose was rapidly and completely excreted, since within 4 days 98.5% was recovered, 95% in the urine...

The systemic bioavailability of buprenorphine by various routes of administration.

The Journal of pharmacy and pharmacology

Brewster D, Humphrey MJ, Mcleavy MA.
PMID: 6115924
J Pharm Pharmacol. 1981 Aug;33(8):500-6. doi: 10.1111/j.2042-7158.1981.tb13848.x.

The systemic bioavailability of buprenorphine has been studied in female rats following single doses (200 microgram kg-1) administered by one of six different routes. Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were intravenous, 98%;...

Peptides and related drugs: a review of their absorption, metabolism, and excretion.

Drug metabolism reviews

Humphrey MJ, Ringrose PS.
PMID: 3552541
Drug Metab Rev. 1986;17(3):283-310. doi: 10.3109/03602538608998293.

No abstract available.

Metabolism and kinetics of amlodipine in man.

Xenobiotica; the fate of foreign compounds in biological systems

Beresford AP, McGibney D, Humphrey MJ, Macrae PV, Stopher DA.
PMID: 2967593
Xenobiotica. 1988 Feb;18(2):245-54. doi: 10.3109/00498258809041660.

1. The disposition of amlodipine, R,S,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl- 5- methoxycarbonyl-6-methyl-1,4-dihydropyridine has been studied in two human volunteers using single oral and intravenous doses of 14C-amlodipine. The drug was well absorbed by the oral route while the mean oral bioavailability for unchanged...

Evaluation of Pulsincap to provide regional delivery of dofetilide to the human GI tract.

International journal of pharmaceutics

Stevens HN, Wilson CG, Welling PG, Bakhshaee M, Binns JS, Perkins AC, Frier M, Blackshaw EP, Frame MW, Nichols DJ, Humphrey MJ, Wicks SR.
PMID: 11891067
Int J Pharm. 2002 Apr 02;236(1):27-34. doi: 10.1016/s0378-5173(02)00012-1.

Pulsincap formulations designed to deliver a dose of drug following a 5-h delay were prepared to evaluate the capability of the formulation to deliver dofetilide to the lower gastrointestinal (GI) tract. By the expected 5-h release time, the preparations...

Fenclofenac and thyroid hormone concentrations.

Lancet (London, England)

Humphrey MJ, Capper SJ, Kurtz AB.
PMID: 6102216
Lancet. 1980 Mar 01;1(8166):487-8. doi: 10.1016/s0140-6736(80)91034-x.

No abstract available.

Showing 13 to 24 of 45 entries