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Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling.

Pain

Keresztes A, Olson K, Nguyen P, Lopez-Pier MA, Hecksel R, Barker NK, Liu Z, Hruby V, Konhilas J, Langlais PR, Streicher JM.
PMID: 34252907
Pain. 2022 Jan 01;163(1):146-158. doi: 10.1097/j.pain.0000000000002320.

ABSTRACT: The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for...

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Keresztes A, Olson K, Nguyen P, et al. Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling. Pain. 2022;163(1):146-158doi: 10.1097/j.pain.0000000000002320.
Keresztes, A., Olson, K., Nguyen, P., Lopez-Pier, M. A., Hecksel, R., Barker, N. K., Liu, Z., Hruby, V., Konhilas, J., Langlais, P. R., & Streicher, J. M. (2022). Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling. Pain, 163(1), 146-158. https://doi.org/10.1097/j.pain.0000000000002320
Keresztes, Attila, et al. "Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling." Pain vol. 163,1 (2022): 146-158. doi: https://doi.org/10.1097/j.pain.0000000000002320
Keresztes A, Olson K, Nguyen P, Lopez-Pier MA, Hecksel R, Barker NK, Liu Z, Hruby V, Konhilas J, Langlais PR, Streicher JM. Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling. Pain. 2022 Jan 01;163(1):146-158. doi: 10.1097/j.pain.0000000000002320. PMID: 34252907; PMCID: PMC8688156.
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Understanding COVID-19: From Dysregulated Immunity to Vaccination Status Quo.

Frontiers in immunology

Escobedo RA, Singh DK, Kaushal D.
PMID: 34858417
Front Immunol. 2021 Nov 11;12:765349. doi: 10.3389/fimmu.2021.765349. eCollection 2021.

The development of vaccines against infectious diseases has helped us battle the greatest threat to public health. With the emergence of novel viruses, targeted immunotherapeutics ranging from informed vaccine development to personalized medicine may be the very thing that...

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Escobedo RA, Singh DK, Kaushal D. Understanding COVID-19: From Dysregulated Immunity to Vaccination Status Quo. Front Immunol. 2021;12:765349doi: 10.3389/fimmu.2021.765349.
Escobedo, R. A., Singh, D. K., & Kaushal, D. (2021). Understanding COVID-19: From Dysregulated Immunity to Vaccination Status Quo. Frontiers in immunology, 12765349. https://doi.org/10.3389/fimmu.2021.765349
Escobedo, Ruby A, et al. "Understanding COVID-19: From Dysregulated Immunity to Vaccination Status Quo." Frontiers in immunology vol. 12 (2021): 765349. doi: https://doi.org/10.3389/fimmu.2021.765349
Escobedo RA, Singh DK, Kaushal D. Understanding COVID-19: From Dysregulated Immunity to Vaccination Status Quo. Front Immunol. 2021 Nov 11;12:765349. doi: 10.3389/fimmu.2021.765349. eCollection 2021. PMID: 34858417; PMCID: PMC8632224.
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SHARP hydrogel for the treatment of inflammatory bowel disease.

International journal of pharmaceutics

Poláková L, Raus V, Cuchalová L, Poręba R, Hrubý M, Kučka J, Větvička D, Trhlíková O, Sedláková Z.
PMID: 34933083
Int J Pharm. 2021 Dec 18;613:121392. doi: 10.1016/j.ijpharm.2021.121392. Epub 2021 Dec 18.

Inflammatory bowel disease (IBD) is a relapsing and remitting inflammatory disease affecting millions of people worldwide. The active phase of IBD is characterized by excessive formation of reactive oxygen species (ROS) in the intestinal mucosa, which further accelerates the...

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Poláková L, Raus V, Cuchalová L, et al. SHARP hydrogel for the treatment of inflammatory bowel disease. Int J Pharm. 2021;613:121392doi: 10.1016/j.ijpharm.2021.121392.
Poláková, L., Raus, V., Cuchalová, L., Poręba, R., Hrubý, M., Kučka, J., Větvička, D., Trhlíková, O., & Sedláková, Z. (2021). SHARP hydrogel for the treatment of inflammatory bowel disease. International journal of pharmaceutics, 613121392. https://doi.org/10.1016/j.ijpharm.2021.121392
Poláková, Lenka, et al. "SHARP hydrogel for the treatment of inflammatory bowel disease." International journal of pharmaceutics vol. 613 (2021): 121392. doi: https://doi.org/10.1016/j.ijpharm.2021.121392
Poláková L, Raus V, Cuchalová L, Poręba R, Hrubý M, Kučka J, Větvička D, Trhlíková O, Sedláková Z. SHARP hydrogel for the treatment of inflammatory bowel disease. Int J Pharm. 2021 Dec 18;613:121392. doi: 10.1016/j.ijpharm.2021.121392. Epub 2021 Dec 18. PMID: 34933083.
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SHARP hydrogel for the treatment of inflammatory bowel disease.

International journal of pharmaceutics

Poláková L, Raus V, Cuchalová L, Poręba R, Hrubý M, Kučka J, Větvička D, Trhlíková O, Sedláková Z.
PMID: 34933083
Int J Pharm. 2021 Dec 18;613:121392. doi: 10.1016/j.ijpharm.2021.121392. Epub 2021 Dec 18.

Inflammatory bowel disease (IBD) is a relapsing and remitting inflammatory disease affecting millions of people worldwide. The active phase of IBD is characterized by excessive formation of reactive oxygen species (ROS) in the intestinal mucosa, which further accelerates the...

Cite
Poláková L, Raus V, Cuchalová L, et al. SHARP hydrogel for the treatment of inflammatory bowel disease. Int J Pharm. 2021;613:121392doi: 10.1016/j.ijpharm.2021.121392.
Poláková, L., Raus, V., Cuchalová, L., Poręba, R., Hrubý, M., Kučka, J., Větvička, D., Trhlíková, O., & Sedláková, Z. (2021). SHARP hydrogel for the treatment of inflammatory bowel disease. International journal of pharmaceutics, 613121392. https://doi.org/10.1016/j.ijpharm.2021.121392
Poláková, Lenka, et al. "SHARP hydrogel for the treatment of inflammatory bowel disease." International journal of pharmaceutics vol. 613 (2021): 121392. doi: https://doi.org/10.1016/j.ijpharm.2021.121392
Poláková L, Raus V, Cuchalová L, Poręba R, Hrubý M, Kučka J, Větvička D, Trhlíková O, Sedláková Z. SHARP hydrogel for the treatment of inflammatory bowel disease. Int J Pharm. 2021 Dec 18;613:121392. doi: 10.1016/j.ijpharm.2021.121392. Epub 2021 Dec 18. PMID: 34933083.
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Erratum to: Finding people like me: contact among young adults who share an open-identity sperm donor.

Human reproduction open

Scheib JE, McCormick E, Benward J, Ruby A.
PMID: 33502390
Hum Reprod Open. 2021 Jan 19;2021(1):hoaa069. doi: 10.1093/hropen/hoaa069. eCollection 2021.

[This corrects the article DOI: 10.1093/hropen/hoaa057.].

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Scheib JE, McCormick E, Benward J, et al. Erratum to: Finding people like me: contact among young adults who share an open-identity sperm donor. Hum Reprod Open. 2021;2021(1):hoaa069doi: 10.1093/hropen/hoaa069.
Scheib, J. E., McCormick, E., Benward, J., & Ruby, A. (2021). Erratum to: Finding people like me: contact among young adults who share an open-identity sperm donor. Human reproduction open, 2021(1), hoaa069. https://doi.org/10.1093/hropen/hoaa069
Scheib, J E, et al. "Erratum to: Finding people like me: contact among young adults who share an open-identity sperm donor." Human reproduction open vol. 2021,1 (2021): hoaa069. doi: https://doi.org/10.1093/hropen/hoaa069
Scheib JE, McCormick E, Benward J, Ruby A. Erratum to: Finding people like me: contact among young adults who share an open-identity sperm donor. Hum Reprod Open. 2021 Jan 19;2021(1):hoaa069. doi: 10.1093/hropen/hoaa069. eCollection 2021. PMID: 33502390; PMCID: PMC7814294.
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Erratum: Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity [Phys. Rev. Lett. 120, 223602 (2018)].

Physical review letters

Landini M, Dogra N, Kroeger K, Hruby L, Donner T, Esslinger T.
PMID: 32845694
Phys Rev Lett. 2020 Aug 07;125(6):069901. doi: 10.1103/PhysRevLett.125.069901.

This corrects the article DOI: 10.1103/PhysRevLett.120.223602.

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Landini M, Dogra N, Kroeger K, et al. Erratum: Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity [Phys. Rev. Lett. 120, 223602 (2018)]. Phys Rev Lett. 2020;125(6):069901doi: 10.1103/PhysRevLett.125.069901.
Landini, M., Dogra, N., Kroeger, K., Hruby, L., Donner, T., & Esslinger, T. (2020). Erratum: Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity [Phys. Rev. Lett. 120, 223602 (2018)]. Physical review letters, 125(6), 069901. https://doi.org/10.1103/PhysRevLett.125.069901
Landini, M, et al. "Erratum: Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity [Phys. Rev. Lett. 120, 223602 (2018)]." Physical review letters vol. 125,6 (2020): 069901. doi: https://doi.org/10.1103/PhysRevLett.125.069901
Landini M, Dogra N, Kroeger K, Hruby L, Donner T, Esslinger T. Erratum: Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity [Phys. Rev. Lett. 120, 223602 (2018)]. Phys Rev Lett. 2020 Aug 07;125(6):069901. doi: 10.1103/PhysRevLett.125.069901. PMID: 32845694.
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Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model.

Nanomaterials (Basel, Switzerland)

Novy Z, Lobaz V, Vlk M, Kozempel J, Stepanek P, Popper M, Vrbkova J, Hajduch M, Hruby M, Petrik M.
PMID: 32867391
Nanomaterials (Basel). 2020 Aug 27;10(9). doi: 10.3390/nano10091690.

Nanoparticles (NPs) represent an emerging platform for diagnosis and treatment of various diseases such as cancer, where they can take advantage of enhanced permeability and retention (EPR) effect for solid tumor accumulation. To improve their colloidal stability, prolong their...

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Novy Z, Lobaz V, Vlk M, et al. Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. Nanomaterials (Basel). 2020;10(9)doi: 10.3390/nano10091690.
Novy, Z., Lobaz, V., Vlk, M., Kozempel, J., Stepanek, P., Popper, M., Vrbkova, J., Hajduch, M., Hruby, M., & Petrik, M. (2020). Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. Nanomaterials (Basel, Switzerland), 10(9), . https://doi.org/10.3390/nano10091690
Novy, Zbynek, et al. "Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model." Nanomaterials (Basel, Switzerland) vol. 10,9 (2020). doi: https://doi.org/10.3390/nano10091690
Novy Z, Lobaz V, Vlk M, Kozempel J, Stepanek P, Popper M, Vrbkova J, Hajduch M, Hruby M, Petrik M. Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. Nanomaterials (Basel). 2020 Aug 27;10(9). doi: 10.3390/nano10091690. PMID: 32867391; PMCID: PMC7558523.
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Synthesis and characterization of geminis and implications of their micellar solution on ninhydrin and metal amino acid complex.

Royal Society open science

Kumar D, Rub MA, Asiri AM.
PMID: 32874661
R Soc Open Sci. 2020 Jul 29;7(7):200775. doi: 10.1098/rsos.200775. eCollection 2020 Jul.

In our study, three gemini dicationic surfactants with different methylene group spacer (16-6-16, 16-5-16 and 16-4-16) have been synthesized and characterized in solution by

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Kumar D, Rub MA, Asiri AM. Synthesis and characterization of geminis and implications of their micellar solution on ninhydrin and metal amino acid complex. R Soc Open Sci. 2020;7(7):200775doi: 10.1098/rsos.200775.
Kumar, D., Rub, M. A., & Asiri, A. M. (2020). Synthesis and characterization of geminis and implications of their micellar solution on ninhydrin and metal amino acid complex. Royal Society open science, 7(7), 200775. https://doi.org/10.1098/rsos.200775
Kumar, Dileep, et al. "Synthesis and characterization of geminis and implications of their micellar solution on ninhydrin and metal amino acid complex." Royal Society open science vol. 7,7 (2020): 200775. doi: https://doi.org/10.1098/rsos.200775
Kumar D, Rub MA, Asiri AM. Synthesis and characterization of geminis and implications of their micellar solution on ninhydrin and metal amino acid complex. R Soc Open Sci. 2020 Jul 29;7(7):200775. doi: 10.1098/rsos.200775. eCollection 2020 Jul. PMID: 32874661; PMCID: PMC7428287.
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Unmitigated Surgical Castration in Calves of Different Ages: Cortisol Concentrations, Heart Rate Variability, and Infrared Thermography Findings.

Animals : an open access journal from MDPI

Bergamasco L, Edwards-Callaway LN, Bello NM, Mijares SH, Cull CA, Rugan S, Mosher RA, Gehring R, Coetzee JF.
PMID: 34573687
Animals (Basel). 2021 Sep 17;11(9). doi: 10.3390/ani11092719.

The objective was to characterize physiological responses to unmitigated surgical castration in calves of varying ages. Thirty male Holstein calves of three ages [

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Bergamasco L, Edwards-Callaway LN, Bello NM, et al. Unmitigated Surgical Castration in Calves of Different Ages: Cortisol Concentrations, Heart Rate Variability, and Infrared Thermography Findings. Animals (Basel). 2021;11(9)doi: 10.3390/ani11092719.
Bergamasco, L., Edwards-Callaway, L. N., Bello, N. M., Mijares, S. H., Cull, C. A., Rugan, S., Mosher, R. A., Gehring, R., & Coetzee, J. F. (2021). Unmitigated Surgical Castration in Calves of Different Ages: Cortisol Concentrations, Heart Rate Variability, and Infrared Thermography Findings. Animals : an open access journal from MDPI, 11(9), . https://doi.org/10.3390/ani11092719
Bergamasco, Luciana, et al. "Unmitigated Surgical Castration in Calves of Different Ages: Cortisol Concentrations, Heart Rate Variability, and Infrared Thermography Findings." Animals : an open access journal from MDPI vol. 11,9 (2021). doi: https://doi.org/10.3390/ani11092719
Bergamasco L, Edwards-Callaway LN, Bello NM, Mijares SH, Cull CA, Rugan S, Mosher RA, Gehring R, Coetzee JF. Unmitigated Surgical Castration in Calves of Different Ages: Cortisol Concentrations, Heart Rate Variability, and Infrared Thermography Findings. Animals (Basel). 2021 Sep 17;11(9). doi: 10.3390/ani11092719. PMID: 34573687; PMCID: PMC8469829.
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SHARP hydrogel for the treatment of inflammatory bowel disease.

International journal of pharmaceutics

Poláková L, Raus V, Cuchalová L, Poręba R, Hrubý M, Kučka J, Větvička D, Trhlíková O, Sedláková Z.
PMID: 34933083
Int J Pharm. 2021 Dec 18;613:121392. doi: 10.1016/j.ijpharm.2021.121392. Epub 2021 Dec 18.

Inflammatory bowel disease (IBD) is a relapsing and remitting inflammatory disease affecting millions of people worldwide. The active phase of IBD is characterized by excessive formation of reactive oxygen species (ROS) in the intestinal mucosa, which further accelerates the...

Cite
Poláková L, Raus V, Cuchalová L, et al. SHARP hydrogel for the treatment of inflammatory bowel disease. Int J Pharm. 2021;613:121392doi: 10.1016/j.ijpharm.2021.121392.
Poláková, L., Raus, V., Cuchalová, L., Poręba, R., Hrubý, M., Kučka, J., Větvička, D., Trhlíková, O., & Sedláková, Z. (2021). SHARP hydrogel for the treatment of inflammatory bowel disease. International journal of pharmaceutics, 613121392. https://doi.org/10.1016/j.ijpharm.2021.121392
Poláková, Lenka, et al. "SHARP hydrogel for the treatment of inflammatory bowel disease." International journal of pharmaceutics vol. 613 (2021): 121392. doi: https://doi.org/10.1016/j.ijpharm.2021.121392
Poláková L, Raus V, Cuchalová L, Poręba R, Hrubý M, Kučka J, Větvička D, Trhlíková O, Sedláková Z. SHARP hydrogel for the treatment of inflammatory bowel disease. Int J Pharm. 2021 Dec 18;613:121392. doi: 10.1016/j.ijpharm.2021.121392. Epub 2021 Dec 18. PMID: 34933083.
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Survival in borderline resectable and locally advanced pancreatic cancer is determined by the duration and response of neoadjuvant therapy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Wijetunga AR, Chua TC, Nahm CB, Pavlakis N, Clarke S, Chan DL, Diakos C, Maloney S, Ashrafi-Zadeh A, Kneebone A, Hruby G, Jamieson NB, Gill A, Mittal A, Samra JS.
PMID: 33952409
Eur J Surg Oncol. 2021 Oct;47(10):2543-2550. doi: 10.1016/j.ejso.2021.04.005. Epub 2021 Apr 30.

BACKGROUND: Pancreatic cancer is the 8th commonest cancer and the 5th commonest cause of cancer-related death in Australia, with a 9% average 5-year survival. This study aims to investigate the effects of neoadjuvant treatment on overall survival (OS) and...

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Wijetunga AR, Chua TC, Nahm CB, et al. Survival in borderline resectable and locally advanced pancreatic cancer is determined by the duration and response of neoadjuvant therapy. Eur J Surg Oncol. 2021;47(10):2543-2550doi: 10.1016/j.ejso.2021.04.005.
Wijetunga, A. R., Chua, T. C., Nahm, C. B., Pavlakis, N., Clarke, S., Chan, D. L., Diakos, C., Maloney, S., Ashrafi-Zadeh, A., Kneebone, A., Hruby, G., Jamieson, N. B., Gill, A., Mittal, A., & Samra, J. S. (2021). Survival in borderline resectable and locally advanced pancreatic cancer is determined by the duration and response of neoadjuvant therapy. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 47(10), 2543-2550. https://doi.org/10.1016/j.ejso.2021.04.005
Wijetunga, Asanka R, et al. "Survival in borderline resectable and locally advanced pancreatic cancer is determined by the duration and response of neoadjuvant therapy." European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology vol. 47,10 (2021): 2543-2550. doi: https://doi.org/10.1016/j.ejso.2021.04.005
Wijetunga AR, Chua TC, Nahm CB, Pavlakis N, Clarke S, Chan DL, Diakos C, Maloney S, Ashrafi-Zadeh A, Kneebone A, Hruby G, Jamieson NB, Gill A, Mittal A, Samra JS. Survival in borderline resectable and locally advanced pancreatic cancer is determined by the duration and response of neoadjuvant therapy. Eur J Surg Oncol. 2021 Oct;47(10):2543-2550. doi: 10.1016/j.ejso.2021.04.005. Epub 2021 Apr 30. PMID: 33952409.
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Lateral inhibition between banks of orientation selective channels predicts shape context effects: A tilt-illusion field.

Vision research

Edwin Dickinson J, Martin RA, Badcock DR.
PMID: 34894488
Vision Res. 2021 Dec 08;192:107975. doi: 10.1016/j.visres.2021.107975. Epub 2021 Dec 08.

The perceived shapes of almost circular paths are modified by concentrically placed context paths. These induced changes have previously been attributed to curvature masking. This paper shows that, instead, they can be explained by the impacts of local tilt...

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Edwin Dickinson J, Martin RA, Badcock DR. Lateral inhibition between banks of orientation selective channels predicts shape context effects: A tilt-illusion field. Vision Res. 2021;192:107975doi: 10.1016/j.visres.2021.107975.
Edwin Dickinson, J., Martin, R. A., & Badcock, D. R. (2021). Lateral inhibition between banks of orientation selective channels predicts shape context effects: A tilt-illusion field. Vision research, 192107975. https://doi.org/10.1016/j.visres.2021.107975
Edwin Dickinson, J, et al. "Lateral inhibition between banks of orientation selective channels predicts shape context effects: A tilt-illusion field." Vision research vol. 192 (2021): 107975. doi: https://doi.org/10.1016/j.visres.2021.107975
Edwin Dickinson J, Martin RA, Badcock DR. Lateral inhibition between banks of orientation selective channels predicts shape context effects: A tilt-illusion field. Vision Res. 2021 Dec 08;192:107975. doi: 10.1016/j.visres.2021.107975. Epub 2021 Dec 08. PMID: 34894488.
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Showing 25 to 36 of 226 entries