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Approaches to the rational design of selective melanocortin receptor antagonists.

Expert opinion on drug discovery

Hruby VJ, Cai M, Nyberg J, Muthu D.
PMID: 22646078
Expert Opin Drug Discov. 2011 May;6(5):543-57. doi: 10.1517/17460441.2011.565743. Epub 2011 Mar 24.

INTRODUCTION: When establishing the physiological roles of specific receptors in normal and disease states, it is critical to have selective antagonist ligands for each receptor in a receptor system with several subtypes. The melanocortin receptors have five subtypes referred...

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Hruby VJ, Cai M, Nyberg J, et al. Approaches to the rational design of selective melanocortin receptor antagonists. Expert Opin Drug Discov. 2011;6(5):543-57doi: 10.1517/17460441.2011.565743.
Hruby, V. J., Cai, M., Nyberg, J., & Muthu, D. (2011). Approaches to the rational design of selective melanocortin receptor antagonists. Expert opinion on drug discovery, 6(5), 543-57. https://doi.org/10.1517/17460441.2011.565743
Hruby, Victor J, et al. "Approaches to the rational design of selective melanocortin receptor antagonists." Expert opinion on drug discovery vol. 6,5 (2011): 543-57. doi: https://doi.org/10.1517/17460441.2011.565743
Hruby VJ, Cai M, Nyberg J, Muthu D. Approaches to the rational design of selective melanocortin receptor antagonists. Expert Opin Drug Discov. 2011 May;6(5):543-57. doi: 10.1517/17460441.2011.565743. Epub 2011 Mar 24. PMID: 22646078; PMCID: PMC4608743.
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Soil lead mineralogy by microprobe: an interlaboratory comparison.

Environmental science & technology

Link TE, Ruby MV, Davis A, Nicholson AD.
PMID: 22191845
Environ Sci Technol. 1994 May 01;28(5):985-8. doi: 10.1021/es00054a035.

No abstract available.

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Link TE, Ruby MV, Davis A, et al. Soil lead mineralogy by microprobe: an interlaboratory comparison. Environ Sci Technol. 1994;28(5):985-8doi: 10.1021/es00054a035.
Link, T. E., Ruby, M. V., Davis, A., & Nicholson, A. D. (1994). Soil lead mineralogy by microprobe: an interlaboratory comparison. Environmental science & technology, 28(5), 985-8. https://doi.org/10.1021/es00054a035
Link, T E, et al. "Soil lead mineralogy by microprobe: an interlaboratory comparison." Environmental science & technology vol. 28,5 (1994): 985-8. doi: https://doi.org/10.1021/es00054a035
Link TE, Ruby MV, Davis A, Nicholson AD. Soil lead mineralogy by microprobe: an interlaboratory comparison. Environ Sci Technol. 1994 May 01;28(5):985-8. doi: 10.1021/es00054a035. PMID: 22191845.
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Development of the small-molecule antiviral ST-246 as a smallpox therapeutic.

Future virology

Grosenbach DW, Jordan R, Hruby DE.
PMID: 21837250
Future Virol. 2011 May;6(5):653-671. doi: 10.2217/fvl.11.27.

Naturally occurring smallpox has been eradicated, yet it remains as one of the highest priority pathogens due to its potential as a biological weapon. The majority of the US population would be vulnerable in a smallpox outbreak. SIGA Technologies,...

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Grosenbach DW, Jordan R, Hruby DE. Development of the small-molecule antiviral ST-246 as a smallpox therapeutic. Future Virol. 2011;6(5):653-671doi: 10.2217/fvl.11.27.
Grosenbach, D. W., Jordan, R., & Hruby, D. E. (2011). Development of the small-molecule antiviral ST-246 as a smallpox therapeutic. Future virology, 6(5), 653-671. https://doi.org/10.2217/fvl.11.27
Grosenbach, Douglas W, et al. "Development of the small-molecule antiviral ST-246 as a smallpox therapeutic." Future virology vol. 6,5 (2011): 653-671. doi: https://doi.org/10.2217/fvl.11.27
Grosenbach DW, Jordan R, Hruby DE. Development of the small-molecule antiviral ST-246 as a smallpox therapeutic. Future Virol. 2011 May;6(5):653-671. doi: 10.2217/fvl.11.27. PMID: 21837250; PMCID: PMC3151656.
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Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting.

ACS medicinal chemistry letters

Brabez N, Saunders K, Nguyen KL, Jayasundera TB, Weber C, Lynch RM, Chassaing G, Lavielle S, Hruby VJ.
PMID: 23524643
ACS Med Chem Lett. 2013 Jan 01;4(1):98-102. doi: 10.1021/ml300312b. Epub 2012 Nov 24.

In order to develop agents for early detection and selective treatment of melanomas, high affinity and high specificity molecular tools are required. Enhanced specificity may be obtained by simultaneously binding to multiple cell surface targets

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Brabez N, Saunders K, Nguyen KL, et al. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. ACS Med Chem Lett. 2012;4(1):98-102doi: 10.1021/ml300312b.
Brabez, N., Saunders, K., Nguyen, K. L., Jayasundera, T. B., Weber, C., Lynch, R. M., Chassaing, G., Lavielle, S., & Hruby, V. J. (2013). Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. ACS medicinal chemistry letters, 4(1), 98-102. https://doi.org/10.1021/ml300312b
Brabez, Nabila, et al. "Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting." ACS medicinal chemistry letters vol. 4,1 (2013): 98-102. doi: https://doi.org/10.1021/ml300312b
Brabez N, Saunders K, Nguyen KL, Jayasundera TB, Weber C, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. ACS Med Chem Lett. 2013 Jan 01;4(1):98-102. doi: 10.1021/ml300312b. Epub 2012 Nov 24. PMID: 23524643; PMCID: PMC3601667.
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Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.

Journal of signal transduction

Fernandez RA, Sundivakkam P, Smith KA, Zeifman AS, Drennan AR, Yuan JX.
PMID: 23056939
J Signal Transduct. 2012;2012:951497. doi: 10.1155/2012/951497. Epub 2012 Sep 27.

Pulmonary circulation is an important circulatory system in which the body brings in oxygen. Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that predominantly affects women. Sustained pulmonary vasoconstriction, excessive pulmonary vascular remodeling, in situ thrombosis, and...

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Fernandez RA, Sundivakkam P, Smith KA, et al. Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension. J Signal Transduct. 2012;2012:951497doi: 10.1155/2012/951497.
Fernandez, R. A., Sundivakkam, P., Smith, K. A., Zeifman, A. S., Drennan, A. R., & Yuan, J. X. (2012). Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension. Journal of signal transduction, 2012951497. https://doi.org/10.1155/2012/951497
Fernandez, Ruby A, et al. "Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension." Journal of signal transduction vol. 2012 (2012): 951497. doi: https://doi.org/10.1155/2012/951497
Fernandez RA, Sundivakkam P, Smith KA, Zeifman AS, Drennan AR, Yuan JX. Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension. J Signal Transduct. 2012;2012:951497. doi: 10.1155/2012/951497. Epub 2012 Sep 27. PMID: 23056939; PMCID: PMC3465915.
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Big Data Readiness in Radiation Oncology: An Efficient Approach for Relabeling Radiation Therapy Structures With Their TG-263 Standard Name in Real-World Data Sets.

Advances in radiation oncology

Schuler T, Kipritidis J, Eade T, Hruby G, Kneebone A, Perez M, Grimberg K, Richardson K, Evill S, Evans B, Gallego B.
PMID: 30706028
Adv Radiat Oncol. 2018 Oct 12;4(1):191-200. doi: 10.1016/j.adro.2018.09.013. eCollection 2019.

PURPOSE: To prepare for big data analyses on radiation therapy data, we developed METHODS AND MATERIALS: The clinically relevant structures in the radiation therapy plans were identified by reference to randomized controlled trials. The Stature approach was used by...

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Schuler T, Kipritidis J, Eade T, et al. Big Data Readiness in Radiation Oncology: An Efficient Approach for Relabeling Radiation Therapy Structures With Their TG-263 Standard Name in Real-World Data Sets. Adv Radiat Oncol. 2018;4(1):191-200doi: 10.1016/j.adro.2018.09.013.
Schuler, T., Kipritidis, J., Eade, T., Hruby, G., Kneebone, A., Perez, M., Grimberg, K., Richardson, K., Evill, S., Evans, B., & Gallego, B. (2019). Big Data Readiness in Radiation Oncology: An Efficient Approach for Relabeling Radiation Therapy Structures With Their TG-263 Standard Name in Real-World Data Sets. Advances in radiation oncology, 4(1), 191-200. https://doi.org/10.1016/j.adro.2018.09.013
Schuler, Thilo, et al. "Big Data Readiness in Radiation Oncology: An Efficient Approach for Relabeling Radiation Therapy Structures With Their TG-263 Standard Name in Real-World Data Sets." Advances in radiation oncology vol. 4,1 (2019): 191-200. doi: https://doi.org/10.1016/j.adro.2018.09.013
Schuler T, Kipritidis J, Eade T, Hruby G, Kneebone A, Perez M, Grimberg K, Richardson K, Evill S, Evans B, Gallego B. Big Data Readiness in Radiation Oncology: An Efficient Approach for Relabeling Radiation Therapy Structures With Their TG-263 Standard Name in Real-World Data Sets. Adv Radiat Oncol. 2018 Oct 12;4(1):191-200. doi: 10.1016/j.adro.2018.09.013. eCollection 2019. PMID: 30706028; PMCID: PMC6349627.
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Block and Gradient Copoly(2-oxazoline) Micelles: Strikingly Different on the Inside.

The journal of physical chemistry letters

Filippov SK, Verbraeken B, Konarev PV, Svergun DI, Angelov B, Vishnevetskaya NS, Papadakis CM, Rogers S, Radulescu A, Courtin T, Martins JC, Starovoytova L, Hruby M, Stepanek P, Kravchenko VS, Potemkin II, Hoogenboom R.
PMID: 28759235
J Phys Chem Lett. 2017 Aug 17;8(16):3800-3804. doi: 10.1021/acs.jpclett.7b01588. Epub 2017 Aug 02.

Herein, we provide a direct proof for differences in the micellar structure of amphiphilic diblock and gradient copolymers, thereby unambiguously demonstrating the influence of monomer distribution along the polymer chains on the micellization behavior. The internal structure of amphiphilic...

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Filippov SK, Verbraeken B, Konarev PV, et al. Block and Gradient Copoly(2-oxazoline) Micelles: Strikingly Different on the Inside. J Phys Chem Lett. 2017;8(16):3800-3804doi: 10.1021/acs.jpclett.7b01588.
Filippov, S. K., Verbraeken, B., Konarev, P. V., Svergun, D. I., Angelov, B., Vishnevetskaya, N. S., Papadakis, C. M., Rogers, S., Radulescu, A., Courtin, T., Martins, J. C., Starovoytova, L., Hruby, M., Stepanek, P., Kravchenko, V. S., Potemkin, I. I., & Hoogenboom, R. (2017). Block and Gradient Copoly(2-oxazoline) Micelles: Strikingly Different on the Inside. The journal of physical chemistry letters, 8(16), 3800-3804. https://doi.org/10.1021/acs.jpclett.7b01588
Filippov, Sergey K, et al. "Block and Gradient Copoly(2-oxazoline) Micelles: Strikingly Different on the Inside." The journal of physical chemistry letters vol. 8,16 (2017): 3800-3804. doi: https://doi.org/10.1021/acs.jpclett.7b01588
Filippov SK, Verbraeken B, Konarev PV, Svergun DI, Angelov B, Vishnevetskaya NS, Papadakis CM, Rogers S, Radulescu A, Courtin T, Martins JC, Starovoytova L, Hruby M, Stepanek P, Kravchenko VS, Potemkin II, Hoogenboom R. Block and Gradient Copoly(2-oxazoline) Micelles: Strikingly Different on the Inside. J Phys Chem Lett. 2017 Aug 17;8(16):3800-3804. doi: 10.1021/acs.jpclett.7b01588. Epub 2017 Aug 02. PMID: 28759235.
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Why China needs your scientific expertise.

Nature

Hruby D.
PMID: 29345669
Nature. 2018 Jan 18;553(7688):S2-S3. doi: 10.1038/d41586-018-00536-1.

No abstract available.

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Hruby D. Why China needs your scientific expertise. Nature. 2018;553(7688):S2-S3doi: 10.1038/d41586-018-00536-1.
Hruby, D. (2018). Why China needs your scientific expertise. Nature, 553(7688), S2-S3. https://doi.org/10.1038/d41586-018-00536-1
Hruby, Denise. "Why China needs your scientific expertise." Nature vol. 553,7688 (2018): S2-S3. doi: https://doi.org/10.1038/d41586-018-00536-1
Hruby D. Why China needs your scientific expertise. Nature. 2018 Jan 18;553(7688):S2-S3. doi: 10.1038/d41586-018-00536-1. PMID: 29345669.
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Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity.

Physical review letters

Landini M, Dogra N, Kroeger K, Hruby L, Donner T, Esslinger T.
PMID: 29906155
Phys Rev Lett. 2018 Jun 01;120(22):223602. doi: 10.1103/PhysRevLett.120.223602.

We observe cavity mediated spin-dependent interactions in an off-resonantly driven multilevel atomic Bose-Einstein condensate that is strongly coupled to an optical cavity. Applying a driving field with adjustable polarization, we identify the roles of the scalar and the vectorial...

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Landini M, Dogra N, Kroeger K, et al. Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity. Phys Rev Lett. 2018;120(22):223602doi: 10.1103/PhysRevLett.120.223602.
Landini, M., Dogra, N., Kroeger, K., Hruby, L., Donner, T., & Esslinger, T. (2018). Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity. Physical review letters, 120(22), 223602. https://doi.org/10.1103/PhysRevLett.120.223602
Landini, M, et al. "Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity." Physical review letters vol. 120,22 (2018): 223602. doi: https://doi.org/10.1103/PhysRevLett.120.223602
Landini M, Dogra N, Kroeger K, Hruby L, Donner T, Esslinger T. Formation of a Spin Texture in a Quantum Gas Coupled to a Cavity. Phys Rev Lett. 2018 Jun 01;120(22):223602. doi: 10.1103/PhysRevLett.120.223602. PMID: 29906155.
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Optimal Pyruvate Concentration for the Recovery of Conforms from Food and Water.

Journal of food protection

Lee RM, Hartman PA.
PMID: 30991475
J Food Prot. 1989 Feb;52(2):119-121. doi: 10.4315/0362-028X-52.2.119.

Recoveries of coliforms in water and food samples were increased by adding sodium pyruvate to the Tryptic Soy Agar (TSA) base layer, and Violet Red Bile (VRBA) overlay, of the Modified VRBA procedure described in Standard Methods for the...

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Lee RM, Hartman PA. Optimal Pyruvate Concentration for the Recovery of Conforms from Food and Water. J Food Prot. 1989;52(2):119-121doi: 10.4315/0362-028X-52.2.119.
Lee, R. M., & Hartman, P. A. (1989). Optimal Pyruvate Concentration for the Recovery of Conforms from Food and Water. Journal of food protection, 52(2), 119-121. https://doi.org/10.4315/0362-028X-52.2.119
Lee, Ruby M, and Hartman, Paul A. "Optimal Pyruvate Concentration for the Recovery of Conforms from Food and Water." Journal of food protection vol. 52,2 (1989): 119-121. doi: https://doi.org/10.4315/0362-028X-52.2.119
Lee RM, Hartman PA. Optimal Pyruvate Concentration for the Recovery of Conforms from Food and Water. J Food Prot. 1989 Feb;52(2):119-121. doi: 10.4315/0362-028X-52.2.119. PMID: 30991475.
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Ocular Complications of Checkpoint Inhibitors and Immunotherapeutic Agents: A Case Series.

Ocular immunology and inflammation

Parikh RA, Chaon BC, Berkenstock MK.
PMID: 32643982
Ocul Immunol Inflamm. 2020 Jul 09;1-6. doi: 10.1080/09273948.2020.1766082. Epub 2020 Jul 09.

BACKGROUND: Ophthalmologists have a role in assessing immune-related adverse events (IRAE) in oncology patients on immunotherapy. We assessed the utility of a hospital-wide toxicity team in referring patients with new ocular symptoms for examination. We also identified new immunotherapy...

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Parikh RA, Chaon BC, Berkenstock MK. Ocular Complications of Checkpoint Inhibitors and Immunotherapeutic Agents: A Case Series. Ocul Immunol Inflamm. 2020;1-6doi: 10.1080/09273948.2020.1766082.
Parikh, R. A., Chaon, B. C., & Berkenstock, M. K. (2020). Ocular Complications of Checkpoint Inhibitors and Immunotherapeutic Agents: A Case Series. Ocular immunology and inflammation, 1-6. https://doi.org/10.1080/09273948.2020.1766082
Parikh, Ruby A, et al. "Ocular Complications of Checkpoint Inhibitors and Immunotherapeutic Agents: A Case Series." Ocular immunology and inflammation vol. (2020): 1-6. doi: https://doi.org/10.1080/09273948.2020.1766082
Parikh RA, Chaon BC, Berkenstock MK. Ocular Complications of Checkpoint Inhibitors and Immunotherapeutic Agents: A Case Series. Ocul Immunol Inflamm. 2020 Jul 09;1-6. doi: 10.1080/09273948.2020.1766082. Epub 2020 Jul 09. PMID: 32643982.
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Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response.

Case reports in oncology

van Gysen K, Kneebone A, Eade T, Guminski A, Hruby G.
PMID: 30627089
Case Rep Oncol. 2018 Nov 27;11(3):756-762. doi: 10.1159/000493913. eCollection 2018.

Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Furthermore, their interaction with radiation treatment (RT) may...

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van Gysen K, Kneebone A, Eade T, et al. Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response. Case Rep Oncol. 2018;11(3):756-762doi: 10.1159/000493913.
van Gysen, K., Kneebone, A., Eade, T., Guminski, A., & Hruby, G. (2018). Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response. Case reports in oncology, 11(3), 756-762. https://doi.org/10.1159/000493913
van Gysen, Kirsten, et al. "Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response." Case reports in oncology vol. 11,3 (2018): 756-762. doi: https://doi.org/10.1159/000493913
van Gysen K, Kneebone A, Eade T, Guminski A, Hruby G. Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response. Case Rep Oncol. 2018 Nov 27;11(3):756-762. doi: 10.1159/000493913. eCollection 2018. PMID: 30627089; PMCID: PMC6323401.
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Showing 13 to 24 of 226 entries