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Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and .

JACC. Case reports

Mahajan AM, Itan Y, Cerrone M, Horowitz J, Borneman L, Chinitz L, Jankelson L.
PMID: 34317510
JACC Case Rep. 2021 Feb 17;3(2):242-246. doi: 10.1016/j.jaccas.2020.11.046. eCollection 2021 Feb.

Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (

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Mahajan AM, Itan Y, Cerrone M, et al. Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and . JACC Case Rep. 2021;3(2):242-246doi: 10.1016/j.jaccas.2020.11.046.
Mahajan, A. M., Itan, Y., Cerrone, M., Horowitz, J., Borneman, L., Chinitz, L., & Jankelson, L. (2021). Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and . JACC. Case reports, 3(2), 242-246. https://doi.org/10.1016/j.jaccas.2020.11.046
Mahajan, Asha M, et al. "Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and ." JACC. Case reports vol. 3,2 (2021): 242-246. doi: https://doi.org/10.1016/j.jaccas.2020.11.046
Mahajan AM, Itan Y, Cerrone M, Horowitz J, Borneman L, Chinitz L, Jankelson L. Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and . JACC Case Rep. 2021 Feb 17;3(2):242-246. doi: 10.1016/j.jaccas.2020.11.046. eCollection 2021 Feb. PMID: 34317510; PMCID: PMC8310969.
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Readability of Patient Education Materials From High-Impact Medical Journals: A 20-Year Analysis.

Journal of patient experience

Rooney MK, Santiago G, Perni S, Horowitz DP, McCall AR, Einstein AJ, Jagsi R, Golden DW.
PMID: 34179407
J Patient Exp. 2021 Mar 03;8:2374373521998847. doi: 10.1177/2374373521998847. eCollection 2021.

Comprehensive patient education is necessary for shared decision-making. While patient-provider conversations primarily drive patient education, patients also use published materials to enhance their understanding. In this investigation, we evaluated the readability of 2585 patient education materials published in high-impact...

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Rooney MK, Santiago G, Perni S, et al. Readability of Patient Education Materials From High-Impact Medical Journals: A 20-Year Analysis. J Patient Exp. 2021;8:2374373521998847doi: 10.1177/2374373521998847.
Rooney, M. K., Santiago, G., Perni, S., Horowitz, D. P., McCall, A. R., Einstein, A. J., Jagsi, R., & Golden, D. W. (2021). Readability of Patient Education Materials From High-Impact Medical Journals: A 20-Year Analysis. Journal of patient experience, 82374373521998847. https://doi.org/10.1177/2374373521998847
Rooney, Michael K, et al. "Readability of Patient Education Materials From High-Impact Medical Journals: A 20-Year Analysis." Journal of patient experience vol. 8 (2021): 2374373521998847. doi: https://doi.org/10.1177/2374373521998847
Rooney MK, Santiago G, Perni S, Horowitz DP, McCall AR, Einstein AJ, Jagsi R, Golden DW. Readability of Patient Education Materials From High-Impact Medical Journals: A 20-Year Analysis. J Patient Exp. 2021 Mar 03;8:2374373521998847. doi: 10.1177/2374373521998847. eCollection 2021. PMID: 34179407; PMCID: PMC8205335.
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T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.

JCI insight

Chun N, Ang RL, Chan M, Fairchild RL, Baldwin WM, Horwitz JK, Gelles JD, Chipuk JE, Kelliher MA, Pavlov VI, Li Y, Homann D, Heeger PS, Ting AT.
PMID: 34752416
JCI Insight. 2021 Dec 22;6(24). doi: 10.1172/jci.insight.148643.

TNF ligation of TNF receptor 1 (TNFR1) promotes either inflammation and cell survival by (a) inhibiting RIPK1's death-signaling function and activating NF-κB or (b) causing RIPK1 to associate with the death-inducing signaling complex to initiate apoptosis or necroptosis. The...

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Chun N, Ang RL, Chan M, et al. T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI Insight. 2021;6(24)doi: 10.1172/jci.insight.148643.
Chun, N., Ang, R. L., Chan, M., Fairchild, R. L., Baldwin, W. M., Horwitz, J. K., Gelles, J. D., Chipuk, J. E., Kelliher, M. A., Pavlov, V. I., Li, Y., Homann, D., Heeger, P. S., & Ting, A. T. (2021). T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI insight, 6(24), . https://doi.org/10.1172/jci.insight.148643
Chun, Nicholas, et al. "T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death." JCI insight vol. 6,24 (2021). doi: https://doi.org/10.1172/jci.insight.148643
Chun N, Ang RL, Chan M, Fairchild RL, Baldwin WM, Horwitz JK, Gelles JD, Chipuk JE, Kelliher MA, Pavlov VI, Li Y, Homann D, Heeger PS, Ting AT. T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI Insight. 2021 Dec 22;6(24). doi: 10.1172/jci.insight.148643. PMID: 34752416.
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Climate change and health beliefs, knowledge, and educational needs among disaster providers.

International journal of public health research

Bell SA, Czerwinski M, Horowitz J, Iwashyna TJ, Sarfaty M.
PMID: 34532280
Int J Public Health Res. 2019 Aug 28;9(2):1127-1134.

INTRODUCTION: Climate change has been called the greatest public health threat of our time. Increasing morbidity and mortality is expected to continue as climate-associated disasters become more prevalent. Disaster health professionals are on the front lines of addressing these...

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Bell SA, Czerwinski M, Horowitz J, et al. Climate change and health beliefs, knowledge, and educational needs among disaster providers. Int J Public Health Res. 2019;9(2):1127-1134
Bell, S. A., Czerwinski, M., Horowitz, J., Iwashyna, T. J., & Sarfaty, M. (2019). Climate change and health beliefs, knowledge, and educational needs among disaster providers. International journal of public health research, 9(2), 1127-1134.
Bell, Sue Anne, et al. "Climate change and health beliefs, knowledge, and educational needs among disaster providers." International journal of public health research vol. 9,2 (2019): 1127-1134.
Bell SA, Czerwinski M, Horowitz J, Iwashyna TJ, Sarfaty M. Climate change and health beliefs, knowledge, and educational needs among disaster providers. Int J Public Health Res. 2019 Aug 28;9(2):1127-1134. PMID: 34532280; PMCID: PMC8442764.
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Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals.

BMJ quality & safety

Chopra V, O'Malley M, Horowitz J, Zhang Q, McLaughlin E, Saint S, Bernstein SJ, Flanders S.
PMID: 33782091
BMJ Qual Saf. 2022 Jan;31(1):23-30. doi: 10.1136/bmjqs-2021-013015. Epub 2021 Mar 29.

BACKGROUND: The Michigan Appropriateness Guide for Intravenous Catheters (MAGIC) provides evidence-based criteria for peripherally inserted central catheter (PICC) use. Whether implementing MAGIC improves PICC appropriateness and reduces complications is unknown.METHODS: A quasiexperimental study design to implement MAGIC in 52...

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Chopra V, O'Malley M, Horowitz J, et al. Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals. BMJ Qual Saf. 2021;31(1):23-30doi: 10.1136/bmjqs-2021-013015.
Chopra, V., O'Malley, M., Horowitz, J., Zhang, Q., McLaughlin, E., Saint, S., Bernstein, S. J., & Flanders, S. (2022). Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals. BMJ quality & safety, 31(1), 23-30. https://doi.org/10.1136/bmjqs-2021-013015
Chopra, Vineet, et al. "Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals." BMJ quality & safety vol. 31,1 (2022): 23-30. doi: https://doi.org/10.1136/bmjqs-2021-013015
Chopra V, O'Malley M, Horowitz J, Zhang Q, McLaughlin E, Saint S, Bernstein SJ, Flanders S. Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals. BMJ Qual Saf. 2022 Jan;31(1):23-30. doi: 10.1136/bmjqs-2021-013015. Epub 2021 Mar 29. PMID: 33782091; PMCID: PMC8685627.
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GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch.

Cell communication and signaling : CCS

Nadel G, Yao Z, Wainstein E, Cohen I, Ben-Ami I, Schajnovitz A, Maik-Rachline G, Naor Z, Horwitz BA, Seger R.
PMID: 34998390
Cell Commun Signal. 2022 Jan 08;20(1):5. doi: 10.1186/s12964-021-00805-z.

BACKGROUND: G protein-coupled receptors (GPCRs) usually regulate cellular processes via activation of intracellular signaling pathways. However, we have previously shown that in several cell lines, GqPCRs induce immediate inactivation of the AKT pathway, which leads to JNK-dependent apoptosis. This...

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Nadel G, Yao Z, Wainstein E, et al. GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. Cell Commun Signal. 2022;20(1):5doi: 10.1186/s12964-021-00805-z.
Nadel, G., Yao, Z., Wainstein, E., Cohen, I., Ben-Ami, I., Schajnovitz, A., Maik-Rachline, G., Naor, Z., Horwitz, B. A., & Seger, R. (2022). GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. Cell communication and signaling : CCS, 20(1), 5. https://doi.org/10.1186/s12964-021-00805-z
Nadel, Guy, et al. "GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch." Cell communication and signaling : CCS vol. 20,1 (2022): 5. doi: https://doi.org/10.1186/s12964-021-00805-z
Nadel G, Yao Z, Wainstein E, Cohen I, Ben-Ami I, Schajnovitz A, Maik-Rachline G, Naor Z, Horwitz BA, Seger R. GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. Cell Commun Signal. 2022 Jan 08;20(1):5. doi: 10.1186/s12964-021-00805-z. PMID: 34998390; PMCID: PMC8742922.
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Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation.

Journal of Crohn's & colitis

Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton KE, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Anyane-Yeboa K, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz BH, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelhardt KR, Cant AJ, Hambleton S, Barclay A, Toth-Petroczy A, Vuzman D, Carmichael N, Bodea C, Cassa CA, Devoto M, Maas RL, Behrens EM, Giraudo CG, Snapper SB.
PMID: 33891011
J Crohns Colitis. 2021 Nov 08;15(11):1908-1919. doi: 10.1093/ecco-jcc/jjab077.

BACKGROUND AND AIMS: Very early onset inflammatory bowel disease [VEOIBD] is characterized by intestinal inflammation affecting infants and children less than 6 years of age. To date, over 60 monogenic aetiologies of VEOIBD have been identified, many characterized by...

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Ouahed J, Kelsen JR, Spessott WA, et al. Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021;15(11):1908-1919doi: 10.1093/ecco-jcc/jjab077.
Ouahed, J., Kelsen, J. R., Spessott, W. A., Kooshesh, K., Sanmillan, M. L., Dawany, N., Sullivan, K. E., Hamilton, K. E., Slowik, V., Nejentsev, S., Neves, J. F., Flores, H., Chung, W. K., Wilson, A., Anyane-Yeboa, K., Wou, K., Jain, P., Field, M., Tollefson, S., Dent, M. H., Li, D., Naito, T., McGovern, D. P. B., Kwong, A. C., Taliaferro, F., Ordovas-Montanes, J., Horwitz, B. H., Kotlarz, D., Klein, C., Evans, J., Dorsey, J., Warner, N., Elkadri, A., Muise, A. M., Goldsmith, J., Thompson, B., Engelhardt, K. R., Cant, A. J., Hambleton, S., Barclay, A., Toth-Petroczy, A., Vuzman, D., Carmichael, N., Bodea, C., Cassa, C. A., Devoto, M., Maas, R. L., Behrens, E. M., Giraudo, C. G., & Snapper, S. B. (2021). Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. Journal of Crohn's & colitis, 15(11), 1908-1919. https://doi.org/10.1093/ecco-jcc/jjab077
Ouahed, Jodie, et al. "Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation." Journal of Crohn's & colitis vol. 15,11 (2021): 1908-1919. doi: https://doi.org/10.1093/ecco-jcc/jjab077
Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton KE, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Anyane-Yeboa K, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz BH, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelhardt KR, Cant AJ, Hambleton S, Barclay A, Toth-Petroczy A, Vuzman D, Carmichael N, Bodea C, Cassa CA, Devoto M, Maas RL, Behrens EM, Giraudo CG, Snapper SB. Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021 Nov 08;15(11):1908-1919. doi: 10.1093/ecco-jcc/jjab077. PMID: 33891011; PMCID: PMC8575043.
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Imposter phenomenon in radiology: incidence, intervention, and impact on wellness.

Clinical imaging

Deshmukh S, Shmelev K, Vassiliades L, Kurumety S, Agarwal G, Horowitz JM.
PMID: 34801842
Clin Imaging. 2021 Nov 16;82:94-99. doi: 10.1016/j.clinimag.2021.11.009. Epub 2021 Nov 16.

PURPOSE: Imposter phenomenon refers to feelings of inadequacy due to inability to internalize evident success. While high achievers such as physicians have been known to exhibit imposter phenomenon, there is limited literature specific to radiologists. Our purpose was to...

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Deshmukh S, Shmelev K, Vassiliades L, et al. Imposter phenomenon in radiology: incidence, intervention, and impact on wellness. Clin Imaging. 2021;82:94-99doi: 10.1016/j.clinimag.2021.11.009.
Deshmukh, S., Shmelev, K., Vassiliades, L., Kurumety, S., Agarwal, G., & Horowitz, J. M. (2021). Imposter phenomenon in radiology: incidence, intervention, and impact on wellness. Clinical imaging, 8294-99. https://doi.org/10.1016/j.clinimag.2021.11.009
Deshmukh, Swati, et al. "Imposter phenomenon in radiology: incidence, intervention, and impact on wellness." Clinical imaging vol. 82 (2021): 94-99. doi: https://doi.org/10.1016/j.clinimag.2021.11.009
Deshmukh S, Shmelev K, Vassiliades L, Kurumety S, Agarwal G, Horowitz JM. Imposter phenomenon in radiology: incidence, intervention, and impact on wellness. Clin Imaging. 2021 Nov 16;82:94-99. doi: 10.1016/j.clinimag.2021.11.009. Epub 2021 Nov 16. PMID: 34801842.
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Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals.

BMJ quality & safety

Chopra V, O'Malley M, Horowitz J, Zhang Q, McLaughlin E, Saint S, Bernstein SJ, Flanders S.
PMID: 33782091
BMJ Qual Saf. 2022 Jan;31(1):23-30. doi: 10.1136/bmjqs-2021-013015. Epub 2021 Mar 29.

BACKGROUND: The Michigan Appropriateness Guide for Intravenous Catheters (MAGIC) provides evidence-based criteria for peripherally inserted central catheter (PICC) use. Whether implementing MAGIC improves PICC appropriateness and reduces complications is unknown.METHODS: A quasiexperimental study design to implement MAGIC in 52...

Cite
Chopra V, O'Malley M, Horowitz J, et al. Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals. BMJ Qual Saf. 2021;31(1):23-30doi: 10.1136/bmjqs-2021-013015.
Chopra, V., O'Malley, M., Horowitz, J., Zhang, Q., McLaughlin, E., Saint, S., Bernstein, S. J., & Flanders, S. (2022). Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals. BMJ quality & safety, 31(1), 23-30. https://doi.org/10.1136/bmjqs-2021-013015
Chopra, Vineet, et al. "Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals." BMJ quality & safety vol. 31,1 (2022): 23-30. doi: https://doi.org/10.1136/bmjqs-2021-013015
Chopra V, O'Malley M, Horowitz J, Zhang Q, McLaughlin E, Saint S, Bernstein SJ, Flanders S. Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals. BMJ Qual Saf. 2022 Jan;31(1):23-30. doi: 10.1136/bmjqs-2021-013015. Epub 2021 Mar 29. PMID: 33782091.
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Rapid response system adaptations at 40 US hospitals during the COVID-19 pandemic.

Resuscitation plus

Mitchell OJL, Doran O, Yuriditsky E, Root C, Teran F, Ma K, Shashaty M, Moskowitz A, Horowitz J, Abella BS.
PMID: 33870236
Resusc Plus. 2021 Jun;6:100121. doi: 10.1016/j.resplu.2021.100121. Epub 2021 Apr 12.

BACKGROUND: Management of patients with acute deterioration from novel coronavirus disease of 2019 (COVID-19) has posed a particular challenge for rapid response systems (RRSs) due to increased hospital strain and direct risk of infection to RRS team members.OBJECTIVE: We...

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Mitchell OJL, Doran O, Yuriditsky E, et al. Rapid response system adaptations at 40 US hospitals during the COVID-19 pandemic. Resusc Plus. 2021;6:100121doi: 10.1016/j.resplu.2021.100121.
Mitchell, O. J. L., Doran, O., Yuriditsky, E., Root, C., Teran, F., Ma, K., Shashaty, M., Moskowitz, A., Horowitz, J., & Abella, B. S. (2021). Rapid response system adaptations at 40 US hospitals during the COVID-19 pandemic. Resuscitation plus, 6100121. https://doi.org/10.1016/j.resplu.2021.100121
Mitchell, Oscar J L, et al. "Rapid response system adaptations at 40 US hospitals during the COVID-19 pandemic." Resuscitation plus vol. 6 (2021): 100121. doi: https://doi.org/10.1016/j.resplu.2021.100121
Mitchell OJL, Doran O, Yuriditsky E, Root C, Teran F, Ma K, Shashaty M, Moskowitz A, Horowitz J, Abella BS. Rapid response system adaptations at 40 US hospitals during the COVID-19 pandemic. Resusc Plus. 2021 Jun;6:100121. doi: 10.1016/j.resplu.2021.100121. Epub 2021 Apr 12. PMID: 33870236; PMCID: PMC8041183.
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The Relativistic Boltzmann Equation and Two Times.

Entropy (Basel, Switzerland)

Horwitz LP.
PMID: 33286575
Entropy (Basel). 2020 Jul 22;22(8). doi: 10.3390/e22080804.

We discuss a covariant relativistic Boltzmann equation which describes the evolution of a system of particles in spacetime evolving with a universal invariant parameter τ . The observed time

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Horwitz LP. The Relativistic Boltzmann Equation and Two Times. Entropy (Basel). 2020;22(8)doi: 10.3390/e22080804.
Horwitz, L. P. (2020). The Relativistic Boltzmann Equation and Two Times. Entropy (Basel, Switzerland), 22(8), . https://doi.org/10.3390/e22080804
Horwitz, L P. "The Relativistic Boltzmann Equation and Two Times." Entropy (Basel, Switzerland) vol. 22,8 (2020). doi: https://doi.org/10.3390/e22080804
Horwitz LP. The Relativistic Boltzmann Equation and Two Times. Entropy (Basel). 2020 Jul 22;22(8). doi: 10.3390/e22080804. PMID: 33286575; PMCID: PMC7818102.
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Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial.

The Lancet. Respiratory medicine

Rabe KF, Celli BR, Wechsler ME, Abdulai RM, Luo X, Boomsma MM, Staudinger H, Horowitz JE, Baras A, Ferreira MA, Ruddy MK, Nivens MC, Amin N, Weinreich DM, Yancopoulos GD, Goulaouic H.
PMID: 34302758
Lancet Respir Med. 2021 Nov;9(11):1288-1298. doi: 10.1016/S2213-2600(21)00167-3. Epub 2021 Jul 21.

BACKGROUND: Genetic data implicate IL-33 in asthma susceptibility. Itepekimab, a monoclonal antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic obstructive pulmonary disease (COPD). In this study we first aimed to test the hypothesis that genetic...

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Rabe KF, Celli BR, Wechsler ME, et al. Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. Lancet Respir Med. 2021;9(11):1288-1298doi: 10.1016/S2213-2600(21)00167-3.
Rabe, K. F., Celli, B. R., Wechsler, M. E., Abdulai, R. M., Luo, X., Boomsma, M. M., Staudinger, H., Horowitz, J. E., Baras, A., Ferreira, M. A., Ruddy, M. K., Nivens, M. C., Amin, N., Weinreich, D. M., Yancopoulos, G. D., & Goulaouic, H. (2021). Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. The Lancet. Respiratory medicine, 9(11), 1288-1298. https://doi.org/10.1016/S2213-2600(21)00167-3
Rabe, Klaus F, et al. "Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial." The Lancet. Respiratory medicine vol. 9,11 (2021): 1288-1298. doi: https://doi.org/10.1016/S2213-2600(21)00167-3
Rabe KF, Celli BR, Wechsler ME, Abdulai RM, Luo X, Boomsma MM, Staudinger H, Horowitz JE, Baras A, Ferreira MA, Ruddy MK, Nivens MC, Amin N, Weinreich DM, Yancopoulos GD, Goulaouic H. Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. Lancet Respir Med. 2021 Nov;9(11):1288-1298. doi: 10.1016/S2213-2600(21)00167-3. Epub 2021 Jul 21. PMID: 34302758.
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